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Volumn 21, Issue 2, 2012, Pages 122-127

Novel tyrosine kinase signaling pathways: Implications in vascular remodeling

Author keywords

receptor tyrosine kinase; signal transduction; vascular remodeling

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; G PROTEIN COUPLED RECEPTOR; GROWTH ARREST SPECIFIC PROTEIN 6; MINERALOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; R 428; SIGNAL PEPTIDE; SOMATOMEDIN C RECEPTOR; TELATINIB; TRANSFORMING GROWTH FACTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR;

EID: 84857044453     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e3283503ce9     Document Type: Review
Times cited : (15)

References (46)
  • 1
    • 0034693799 scopus 로고    scopus 로고
    • The protein tyrosine kinase family of the human genome
    • Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene 2000; 19:5548-5557.
    • (2000) Oncogene , vol.19 , pp. 5548-5557
    • Robinson, D.R.1    Wu, Y.M.2    Lin, S.F.3
  • 2
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010; 141:1117-1134.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 3
    • 0034953381 scopus 로고    scopus 로고
    • Vascular smooth muscle growth: Autocrine growth mechanisms
    • Berk BC. Vascular smooth muscle growth: Autocrine growth mechanisms. Physiol Rev 2001; 81:999-1030. (Pubitemid 32606665)
    • (2001) Physiological Reviews , vol.81 , Issue.3 , pp. 999-1030
    • Berk, B.C.1
  • 4
    • 33644552719 scopus 로고    scopus 로고
    • G-protein-coupled receptors and tyrosine kinases: Crossroads in cell signaling and regulation
    • Gavi S, Shumay E, Wang HY, Malbon CC. G-protein-coupled receptors and tyrosine kinases: Crossroads in cell signaling and regulation. Trends Endocrinol Metab 2006; 17:48-54.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 48-54
    • Gavi, S.1    Shumay, E.2    Wang, H.Y.3    Malbon, C.C.4
  • 6
    • 66749092335 scopus 로고    scopus 로고
    • Cyclic stretch, reactive oxygen species, and vascular remodeling
    • Birukov KG. Cyclic stretch, reactive oxygen species, and vascular remodeling. Antioxid Redox Signal 2009; 11:1651-1667.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1651-1667
    • Birukov, K.G.1
  • 7
    • 79959692331 scopus 로고    scopus 로고
    • Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1
    • Schreier B, Dohler M, Rabe S, et al. Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1. Arterioscler Thromb Vasc Biol 2011; 31:1643-1652.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1643-1652
    • Schreier, B.1    Dohler, M.2    Rabe, S.3
  • 8
    • 79959370637 scopus 로고    scopus 로고
    • 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling
    • Singh NK, Wang D, Kundumani-Sridharan V, et al. 15-Lipoxygenase-1- enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling. J Biol Chem 2011; 286:22478-22488.
    • (2011) J Biol Chem , vol.286 , pp. 22478-22488
    • Singh, N.K.1    Wang, D.2    Kundumani-Sridharan, V.3
  • 9
    • 79551487567 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt
    • This study demonstrates that aldosterone increases vascular contractility and not arterial thickening via activation of EGFR-dependent signaling
    • Griol-Charhbili V, Fassot C, Messaoudi S, et al. Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt. Hypertension 2011; 57:238-244. This study demonstrates that aldosterone increases vascular contractility and not arterial thickening via activation of EGFR-dependent signaling.
    • (2011) Hypertension , vol.57 , pp. 238-244
    • Griol-Charhbili, V.1    Fassot, C.2    Messaoudi, S.3
  • 10
    • 79953202174 scopus 로고    scopus 로고
    • A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature
    • This report shows that ADAM17 stimulates vascular growth by activation of EGFR signals
    • Takaguri A, Kimura K, Hinoki A, et al. A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature. Hypertension 2011; 57:841-845. This report shows that ADAM17 stimulates vascular growth by activation of EGFR signals.
    • (2011) Hypertension , vol.57 , pp. 841-845
    • Takaguri, A.1    Kimura, K.2    Hinoki, A.3
  • 11
    • 79551586247 scopus 로고    scopus 로고
    • Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II
    • These findings indicate that Cav-1 is a negative regulator for AngII-mediated ADAM17 release and activated EGFR in vascular cells
    • Takaguri A, Shirai H, Kimura K, et al. Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II. J Mol Cell Cardiol 2011; 50:545-551. These findings indicate that Cav-1 is a negative regulator for AngII-mediated ADAM17 release and activated EGFR in vascular cells.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 545-551
    • Takaguri, A.1    Shirai, H.2    Kimura, K.3
  • 12
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D, Werner H, Beitner-Johnson D, Roberts CT Jr. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995; 16:143-163.
    • (1995) Endocr Rev , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts Jr., C.T.4
  • 13
    • 80052621526 scopus 로고    scopus 로고
    • Mechanical stretch augments insulininduced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor
    • Liu G, Hitomi H, Hosomi N, et al. Mechanical stretch augments insulininduced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor. Exp Cell Res 2011; 317:2420-2428.
    • (2011) Exp Cell Res , vol.317 , pp. 2420-2428
    • Liu, G.1    Hitomi, H.2    Hosomi, N.3
  • 14
    • 32644438559 scopus 로고    scopus 로고
    • Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: Role of nuclear factor-κB
    • DOI 10.1210/en.2005-0888
    • Ma Y, Zhang L, Peng T, et al. Angiotensin II stimulates transcription of insulinlike growth factor I receptor in vascular smooth muscle cells: Role of nuclear factor-kappaB. Endocrinology 2006; 147:1256-1263. (Pubitemid 43244358)
    • (2006) Endocrinology , vol.147 , Issue.3 , pp. 1256-1263
    • Ma, Y.1    Zhang, L.2    Peng, T.3    Cheng, J.4    Taneja, S.5    Zhang, J.6    Delafontaine, P.7    Du, J.8
  • 15
    • 34547639130 scopus 로고    scopus 로고
    • Emerging role of IGF-1R in stretch-induced neointimal hyperplasia in venous grafts
    • DOI 10.1161/ATVBAHA.107.148189, PII 0004360520070800000004
    • Song H, Mowbray AL, Sykes MC, Jo H. Emerging role of IGF-1R in stretchinduced neointimal hyperplasia in venous grafts. Arterioscler Thromb Vasc Biol 2007; 27:1679-1681. (Pubitemid 47207161)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.8 , pp. 1679-1681
    • Song, H.1    Mowbray, A.L.2    Sykes, M.C.3    Jo, H.4
  • 16
    • 77649165951 scopus 로고    scopus 로고
    • Mechano-sensitive transcriptional factor Egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts
    • This study demonstrates that transcriptional factor Egr-1 is responsible for increases in expression of IGF1R in response to mechanical stress
    • Wu X, Cheng J, Li P, et al. Mechano-sensitive transcriptional factor Egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts. Arterioscler Thromb Vasc Biol 2010; 30:471-476. This study demonstrates that transcriptional factor Egr-1 is responsible for increases in expression of IGF1R in response to mechanical stress.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 471-476
    • Wu, X.1    Cheng, J.2    Li, P.3
  • 17
    • 70449086337 scopus 로고    scopus 로고
    • IGF-1 receptor transactivation mediates Src-dependent cortactin phosphorylation in response to angiotensin II
    • Zahradka P, Storie B, Wright B. IGF-1 receptor transactivation mediates Src-dependent cortactin phosphorylation in response to angiotensin II. Can J Physiol Pharmacol 2009; 87:805-812.
    • (2009) Can J Physiol Pharmacol , vol.87 , pp. 805-812
    • Zahradka, P.1    Storie, B.2    Wright, B.3
  • 18
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • DOI 10.1101/gad.1653708
    • Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22:1276-1312. (Pubitemid 351717519)
    • (2008) Genes and Development , vol.22 , Issue.10 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 19
    • 16244373077 scopus 로고    scopus 로고
    • Biomechanical stress-induced signaling in smooth muscle cells: An update
    • Shaw A, Xu Q. Biomechanical stress-induced signaling in smooth muscle cells: An update. Curr Vasc Pharmacol 2003; 1:41-58.
    • (2003) Curr Vasc Pharmacol , vol.1 , pp. 41-58
    • Shaw, A.1    Xu, Q.2
  • 20
    • 0033585061 scopus 로고    scopus 로고
    • Mechanical strain increases PDGF-B and PDGF beta receptor expression in vascular smooth muscle cells
    • Ma YH, Ling S, Ives HE. Mechanical strain increases PDGF-B and PDGF beta receptor expression in vascular smooth muscle cells. Biochem Biophys Res Commun 1999; 265:606-610.
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 606-610
    • Ma, Y.H.1    Ling, S.2    Ives, H.E.3
  • 21
    • 34247113814 scopus 로고    scopus 로고
    • 1 receptor: Novel insights into mechanisms and pathophysiology
    • DOI 10.1042/CS20060342
    • Higuchi S, Ohtsu H, Suzuki H, et al. Angiotensin II signal transduction through the AT1 receptor: Novel insights into mechanisms and pathophysiology. Clin Sci (Lond) 2007; 112:417-428. (Pubitemid 46587457)
    • (2007) Clinical Science , vol.112 , Issue.7-8 , pp. 417-428
    • Higuchi, S.1    Ohtsu, H.2    Suzuki, H.3    Shirai, H.4    Frank, G.D.5    Eguchi, S.6
  • 22
    • 22144435873 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: Role of angiotensin II
    • DOI 10.1113/expphysiol.2005.030080
    • Touyz RM. Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: Role of angiotensin II. Exp Physiol 2005; 90:449-455. (Pubitemid 40980144)
    • (2005) Experimental Physiology , vol.90 , Issue.4 , pp. 449-455
    • Touyz, R.M.1
  • 23
    • 67650100411 scopus 로고    scopus 로고
    • FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression
    • Chen PY, Simons M, Friesel R. FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. J Biol Chem 2009; 284:15980-15992.
    • (2009) J Biol Chem , vol.284 , pp. 15980-15992
    • Chen, P.Y.1    Simons, M.2    Friesel, R.3
  • 24
    • 77955293472 scopus 로고    scopus 로고
    • Stimulation of plateletderived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways
    • This study demonstrates a cross-talk between PDGFRb and EGFR via stimulation of ADAM17 activity
    • Mendelson K, Swendeman S, Saftig P, Blobel CP. Stimulation of plateletderived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways. J Biol Chem 2010; 285:25024-25032. This study demonstrates a cross-talk between PDGFRb and EGFR via stimulation of ADAM17 activity.
    • (2010) J Biol Chem , vol.285 , pp. 25024-25032
    • Mendelson, K.1    Swendeman, S.2    Saftig, P.3    Blobel, C.P.4
  • 25
    • 70350365381 scopus 로고    scopus 로고
    • Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination
    • Guo X, Nie L, Esmailzadeh L, et al. Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. J Biol Chem 2009; 284:29376-29382.
    • (2009) J Biol Chem , vol.284 , pp. 29376-29382
    • Guo, X.1    Nie, L.2    Esmailzadeh, L.3
  • 26
    • 79957902010 scopus 로고    scopus 로고
    • Signal transduction by vascular endothelial growth factor receptors
    • Koch S, Tugues S, Li X, et al. Signal transduction by vascular endothelial growth factor receptors. Biochem J 2011; 437:169-183.
    • (2011) Biochem J. , vol.437 , pp. 169-183
    • Koch, S.1    Tugues, S.2    Li, X.3
  • 27
    • 78049438298 scopus 로고    scopus 로고
    • Placental growth factor mediates aldosterone-dependent vascular injury in mice
    • Authors reported vascular-specific aldosterone-dependent activation of VEGFR-1 pathway in response to arterial injury
    • Jaffe IZ, Newfell BG, Aronovitz M, et al. Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest 2010; 120: 3891-3900. Authors reported vascular-specific aldosterone-dependent activation of VEGFR-1 pathway in response to arterial injury.
    • (2010) J Clin Invest , vol.120 , pp. 3891-3900
    • Jaffe, I.Z.1    Newfell, B.G.2    Aronovitz, M.3
  • 28
    • 77954953944 scopus 로고    scopus 로고
    • Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
    • Storkebaum E, Ruiz de Almodovar C, Meens M, et al. Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery. Circulation 2010; 122:273-281.
    • (2010) Circulation , vol.122 , pp. 273-281
    • Storkebaum, E.1    Ruiz De Almodovar, C.2    Meens, M.3
  • 29
    • 64949196619 scopus 로고    scopus 로고
    • G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development
    • Pang J, Hoefen R, Pryhuber GS, et al. G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation 2009; 119:1524-1532.
    • (2009) Circulation , vol.119 , pp. 1524-1532
    • Pang, J.1    Hoefen, R.2    Pryhuber, G.S.3
  • 30
    • 77749254869 scopus 로고    scopus 로고
    • Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis
    • Stockmann C, Kerdiles Y, Nomaksteinsky M, et al. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci USA 2010; 107:4329-4334.
    • (2010) Proc Natl Acad Sci US.A. , vol.107 , pp. 4329-4334
    • Stockmann, C.1    Kerdiles, Y.2    Nomaksteinsky, M.3
  • 31
    • 66449098872 scopus 로고    scopus 로고
    • VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
    • Farkas L, Farkas D, Ask K, et al. VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. J Clin Invest 2009; 119:1298-1311.
    • (2009) J Clin Invest , vol.119 , pp. 1298-1311
    • Farkas, L.1    Farkas, D.2    Ask, K.3
  • 32
    • 77956633519 scopus 로고    scopus 로고
    • VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling
    • This report suggests that VEGFR-1 is expressed on T lymphocytes and augments T cell recruitment to the vessel wall during neointima formation
    • Zhang J, Silva T, Yarovinsky T, et al. VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circ Res 2010; 107:408-417. This report suggests that VEGFR-1 is expressed on T lymphocytes and augments T cell recruitment to the vessel wall during neointima formation.
    • (2010) Circ Res , vol.107 , pp. 408-417
    • Zhang, J.1    Silva, T.2    Yarovinsky, T.3
  • 33
    • 57149102486 scopus 로고    scopus 로고
    • Systems biology of vascular endothelial growth factors
    • Mac Gabhann F, Popel AS. Systems biology of vascular endothelial growth factors. Microcirculation 2008; 15:715-738.
    • (2008) Microcirculation , vol.15 , pp. 715-738
    • Mac Gabhann, F.1    Popel, A.S.2
  • 34
    • 0029910706 scopus 로고    scopus 로고
    • Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases
    • DOI 10.1074/jbc.271.47.30022
    • Nagata K, Ohashi K, Nakano T, et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem 1996; 271:30022-30027. (Pubitemid 26389640)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.47 , pp. 30022-30027
    • Nagata, K.1    Ohashi, K.2    Nakano, T.3    Arita, H.4    Zong, C.5    Hanafusa, H.6    Mizuno, K.7
  • 35
    • 0032487404 scopus 로고    scopus 로고
    • Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats
    • Melaragno MG, Wuthrich DA, Poppa V, et al. Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats. Circ Res 1998; 83:697-704. (Pubitemid 28462783)
    • (1998) Circulation Research , vol.83 , Issue.7 , pp. 697-704
    • Melaragno, M.G.1    Wuthrich, D.A.2    Poppa, V.3    Gill, D.4    Lindner, V.5    Berk, B.C.6    Corson, M.A.7
  • 38
    • 77953809222 scopus 로고    scopus 로고
    • Gas6-Axl pathway: The role of redoxdependent association of Axl with nonmuscle myosin II.B
    • This report suggests that ROS-dependent posttranslational modification of nonmuscle myosin heavy chain-IIB lead to Axl binding and migration of VSMCs
    • Cavet ME, Smolock EM, Menon P, et al. Gas6-Axl pathway: The role of redoxdependent association of Axl with nonmuscle myosin IIB. Hypertension 2010; 56:105-111. This report suggests that ROS-dependent posttranslational modification of nonmuscle myosin heavy chain-IIB lead to Axl binding and migration of VSMCs.
    • (2010) Hypertension , vol.56 , pp. 105-111
    • Cavet, M.E.1    Smolock, E.M.2    Menon, P.3
  • 39
    • 77956182620 scopus 로고    scopus 로고
    • Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress
    • Small molecule inhibitors of Axl are effective in blocking ligand-independent (oxidative stress) activation of VSMCs
    • Smolock EM, Korshunov VA. Pharmacological inhibition of Axl affects smooth muscle cell functions under oxidative stress. Vasc Pharmacol 2010; 53:185-192. Small molecule inhibitors of Axl are effective in blocking ligand-independent (oxidative stress) activation of VSMCs.
    • (2010) Vasc Pharmacol , vol.53 , pp. 185-192
    • Smolock, E.M.1    Korshunov, V.A.2
  • 40
    • 76749123429 scopus 로고    scopus 로고
    • R428 a selective small molecule inhibitor of Axl kinase blocks tumor spread and prolongs survival in models of metastatic breast cancer
    • This is the first report effectiveness of small molecule inhibitor of Axl ( R428) in mouse models of tumorigenesis in vivo
    • Holland SJ, Pan A, Franci C, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res 2010; 70:1544-1554. This is the first report effectiveness of small molecule inhibitor of Axl (R428) in mouse models of tumorigenesis in vivo.
    • (2010) Cancer Res , vol.70 , pp. 1544-1554
    • Holland, S.J.1    Pan, A.2    Franci, C.3
  • 41
    • 79955034059 scopus 로고    scopus 로고
    • Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice
    • Lijnen HR, Christiaens V, Scroyen L. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther 2011; 337:457-464.
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 457-464
    • Lijnen, H.R.1    Christiaens, V.2    Scroyen, L.3
  • 42
    • 52449109523 scopus 로고    scopus 로고
    • Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe/ mice
    • Thorp E, Cui D, Schrijvers DM, et al. Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe/ mice. Arterioscler Thromb Vasc Biol 2008; 28:1421-1428.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1421-1428
    • Thorp, E.1    Cui, D.2    Schrijvers, D.M.3
  • 43
    • 50249097337 scopus 로고    scopus 로고
    • Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis
    • Lutgens E, Tjwa M, Garcia de Frutos P, et al. Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol 2008; 216:55-63.
    • (2008) J Pathol , vol.216 , pp. 55-63
    • Lutgens, E.1    Tjwa, M.2    Garcia De Frutos, P.3
  • 44
    • 80053030745 scopus 로고    scopus 로고
    • Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase C{delta}, and p38 mitogen-Activated protein kinase (MAPK)
    • This study demonstrates ROS-dependent mechanisms by which ADAM17 cleaves Mertk in immune cells
    • Thorp E, Vaisar T, Subramanian M, et al. Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase C{delta}, and p38 mitogen-Activated protein kinase (MAPK). J Biol Chem 2011; 286:33335-33344. This study demonstrates ROS-dependent mechanisms by which ADAM17 cleaves Mertk in immune cells.
    • (2011) J Biol Chem , vol.286 , pp. 33335-33344
    • Thorp, E.1    Vaisar, T.2    Subramanian, M.3
  • 45
    • 50349101200 scopus 로고    scopus 로고
    • Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor
    • Steeghs N, Gelderblom H, Roodt JO, et al. Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res 2008; 14:3470-3476.
    • (2008) Clin Cancer Res , vol.14 , pp. 3470-3476
    • Steeghs, N.1    Gelderblom, H.2    Roodt, J.O.3
  • 46
    • 79959723693 scopus 로고    scopus 로고
    • Contrary effects of the receptor tyrosine kinase inhibitor vandetanib on constitutive and flow-stimulated nitric oxide elaboration in humans
    • This study provides NO-dependent mechanism of increase in blood pressure after treatment with vandetanib
    • Mayer EL, Dallabrida SM, Rupnick MA, et al. Contrary effects of the receptor tyrosine kinase inhibitor vandetanib on constitutive and flow-stimulated nitric oxide elaboration in humans. Hypertension 2011; 58:85-92. This study provides NO-dependent mechanism of increase in blood pressure after treatment with vandetanib.
    • (2011) Hypertension , vol.58 , pp. 85-92
    • Mayer, E.L.1    Dallabrida, S.M.2    Rupnick, M.A.3


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