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Volumn 21, Issue 2, 2012, Pages 163-170

New insights into hypertension-associated erectile dysfunction

Author keywords

antihypertensives; endothelial dysfunction; erectile dysfunction; hypertension

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN 1; HYDROGEN SULFIDE; NEBIVOLOL; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE V INHIBITOR; VASODILATOR AGENT;

EID: 84857043055     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32835021bd     Document Type: Review
Times cited : (88)

References (51)
  • 1
    • 0033964459 scopus 로고    scopus 로고
    • Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study
    • Johannes CB, Araujo AB, Feldman HA, et al. Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study. J Urology 2000; 163:460-463. (Pubitemid 30060493)
    • (2000) Journal of Urology , vol.163 , Issue.2 , pp. 460-463
    • Johannes, C.B.1    Araujo, A.B.2    Feldman, H.A.3    Derby, C.A.4    Kleinman, K.P.5    McKinlay, J.B.6
  • 2
    • 0032810944 scopus 로고    scopus 로고
    • The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences
    • DOI 10.1046/j.1464-410x.1999.00142.x
    • Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999; 84:50-56. (Pubitemid 29346774)
    • (1999) BJU International , vol.84 , Issue.1 , pp. 50-56
    • Aytac, I.A.1    McKinlay, J.B.2    Krane, R.J.3
  • 3
    • 0033822704 scopus 로고    scopus 로고
    • Hypertension is associated with severe erectile dysfunction
    • Burchardt M, Burchardt T, Baer L, et al. Hypertension is associated with severe erectile dysfunction. J Urol 2000; 164:1188-1191.
    • (2000) J Urol , vol.164 , pp. 1188-1191
    • Burchardt, M.1    Burchardt, T.2    Baer, L.3
  • 5
    • 69949108553 scopus 로고    scopus 로고
    • The endothelial-erectile dysfunction connection: An essential update
    • Costa C, Virag R. The endothelial-erectile dysfunction connection: An essential update. J Sex Med 2009; 6:2390-2404.
    • (2009) J Sex Med , vol.6 , pp. 2390-2404
    • Costa, C.1    Virag, R.2
  • 6
    • 78650798186 scopus 로고    scopus 로고
    • Erectile dysfunction: A disease marker for cardiovascular disease
    • Review discussing the evidences of erectile dysfunction as a marker for CV.D.
    • Shin D, Pregenzer G Jr., Gardin JM. Erectile dysfunction: A disease marker for cardiovascular disease. Cardiol Rev 2011; 19:5-11. Review discussing the evidences of erectile dysfunction as a marker for CVD.
    • (2011) Cardiol Rev , vol.19 , pp. 5-11
    • Shin, D.1    Pregenzer Jr., G.2    Gardin, J.M.3
  • 7
    • 74249112406 scopus 로고    scopus 로고
    • Anatomy, physiology, and pathophysiology of erectile dysfunction
    • An overview about pathophysiological aspects in erectile dysfunction
    • Gratzke C, Angulo J, Chitaley K, et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 2010; 7 (1 Pt 2):445-475. An overview about pathophysiological aspects in erectile dysfunction.
    • (2010) J Sex Med , vol.7 , Issue.1 PART 2 , pp. 445-475
    • Gratzke, C.1    Angulo, J.2    Chitaley, K.3
  • 8
    • 30044441553 scopus 로고    scopus 로고
    • Erectile dysfunction as an early sign of cardiovascular disease
    • DOI 10.1038/sj.ijir.3901425
    • Billups KL. Erectile dysfunction as an early sign of cardiovascular disease. Int J Impot Res 2005; 17 (Suppl 1):S19-S24. (Pubitemid 43049373)
    • (2005) International Journal of Impotence Research , vol.17 , Issue.SUPPL. S1
    • Billups, K.L.1
  • 9
    • 74049141326 scopus 로고    scopus 로고
    • Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: Findings from a linked-data study
    • Study evaluating evidences of erectile dysfunction as a strong predictive of subsequent atherosclerosis
    • Chew KK, Finn J, Stuckey B, et al. Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: Findings from a linked-data study. J Sex Med 2010; 7 (1 Pt 1):192-202. Study evaluating evidences of erectile dysfunction as a strong predictive of subsequent atherosclerosis.
    • (2010) J Sex Med , vol.7 , Issue.1 PART 1 , pp. 192-202
    • Chew, K.K.1    Finn, J.2    Stuckey, B.3
  • 10
    • 78149469722 scopus 로고    scopus 로고
    • RhoA/Rho-kinase and vascular diseases: What is the link?
    • Review discussing the role of Rho-kinase plays in many vascular diseases, such as atherosclerosis, hypertension and erectile dysfunction
    • Nunes KP, Rigsby CS, Webb RC. RhoA/Rho-kinase and vascular diseases: What is the link? Cell Mol Life Sci 2010; 67:3823-3836. Review discussing the role of Rho-kinase plays in many vascular diseases, such as atherosclerosis, hypertension and erectile dysfunction.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3823-3836
    • Nunes, K.P.1    Rigsby, C.S.2    Webb, R.C.3
  • 11
    • 61849097698 scopus 로고    scopus 로고
    • Angiotensin II signaling and its implication in erectile dysfunction
    • Jin LM. Angiotensin II signaling and its implication in erectile dysfunction. J Sex Med 2009; 6 (Suppl 3):302-310.
    • (2009) J Sex Med , vol.6 , Issue.SUPPL. 3 , pp. 302-310
    • Jin, L.M.1
  • 12
    • 0035513463 scopus 로고    scopus 로고
    • Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction
    • Becker AJ, Uckert S, Stief CG, et al. Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction. Urology 2001; 58:805-810.
    • (2001) Urology , vol.58 , pp. 805-810
    • Becker, A.J.1    Uckert, S.2    Stief, C.G.3
  • 13
    • 62549094375 scopus 로고    scopus 로고
    • Vascular smooth muscle cell signaling mechanisms for contraction to angiotensin II and endothelin-1
    • Wynne BM, Chiao CW, Webb RC. Vascular smooth muscle cell signaling mechanisms for contraction to angiotensin II and endothelin-1. J Am Soc Hypertens 2009; 3:84-95.
    • (2009) J Am Soc Hypertens , vol.3 , pp. 84-95
    • Wynne, B.M.1    Chiao, C.W.2    Webb, R.C.3
  • 14
    • 0030867963 scopus 로고    scopus 로고
    • Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: In vitro studies in canines
    • Comiter CV, Sullivan MP, Yalla SV, Kifor I. Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: In vitro studies in canines. Int J Impot Res 1997; 9:135-140. (Pubitemid 27427269)
    • (1997) International Journal of Impotence Research , vol.9 , Issue.3 , pp. 135-140
    • Comiter, C.V.1    Sullivan, M.P.2    Yalla, S.V.3    Kifor, I.4
  • 15
    • 79955868290 scopus 로고    scopus 로고
    • Effect of angiotensin II and its receptor antagonists on human corpus cavernous contractility and oxidative stress: Modulation of nitric oxide mediated relaxation
    • This study shows AngII peptide distribution in human penile tissue and the effect of its receptor antagonism on the nitric oxide/cGMP pathways
    • Ertemi H, Mumtaz FH, Howie AJ, et al. Effect of angiotensin II and its receptor antagonists on human corpus cavernous contractility and oxidative stress: Modulation of nitric oxide mediated relaxation. J Urol 2011; 185:2414-2420. This study shows AngII peptide distribution in human penile tissue and the effect of its receptor antagonism on the nitric oxide/cGMP pathways.
    • (2011) J Urol , vol.185 , pp. 2414-2420
    • Ertemi, H.1    Mumtaz, F.H.2    Howie, A.J.3
  • 16
    • 61649116241 scopus 로고    scopus 로고
    • Losartan, an angiotensin type I receptor, restores erectile function by downregulation of cavernous renin-Angiotensin system in streptozocin-induced diabetic rats
    • Yang R, Yang B, Wen Y, et al. Losartan, an angiotensin type I receptor, restores erectile function by downregulation of cavernous renin-Angiotensin system in streptozocin-induced diabetic rats. J Sex Med 2009; 6:696-707.
    • (2009) J Sex Med , vol.6 , pp. 696-707
    • Yang, R.1    Yang, B.2    Wen, Y.3
  • 17
    • 40349113071 scopus 로고    scopus 로고
    • NADPH oxidase activation: A mechanism of hypertension-associated erectile dysfunction
    • DOI 10.1111/j.1743-6109.2007.00733.x
    • Jin L, Lagoda G, Leite R, et al. NADPH oxidase activation: A mechanism of hypertension-Associated erectile dysfunction. J Sex Med 2008; 5:544-551. (Pubitemid 351337880)
    • (2008) Journal of Sexual Medicine , vol.5 , Issue.3 , pp. 544-551
    • Jin, L.1    Lagoda, G.2    Leite, R.3    Webb, R.C.4    Burnett, A.L.5
  • 19
    • 0025990879 scopus 로고
    • Endothelin: Localization synthesis, activity, and receptor types in human penile corpus cavernosum
    • Saenz de Tejada I, Carson MP, de las Morenas A, et al. Endothelin: Localization, synthesis, activity, and receptor types in human penile corpus cavernosum. Am J Physiol 1991; 261:H1078-H1085.
    • (1991) Am J Physiol , vol.261
    • Saenz De Tejada, I.1    Carson, M.P.2    De Las Morenas, A.3
  • 20
    • 0026634071 scopus 로고
    • Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit
    • Holmquist F, Kirkeby HJ, Larsson B, et al. Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit. J Pharmacol Exp Ther 1992; 261:795-802.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 795-802
    • Holmquist, F.1    Kirkeby, H.J.2    Larsson, B.3
  • 25
    • 77953933815 scopus 로고    scopus 로고
    • Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation
    • Allahdadi KJ, Hannan JL, Tostes RC, Webb RC. Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation. J Sex Med 2010; 7:2096-2103.
    • (2010) J Sex Med , vol.7 , pp. 2096-2103
    • Allahdadi, K.J.1    Hannan, J.L.2    Tostes, R.C.3    Webb, R.C.4
  • 26
    • 30744469377 scopus 로고    scopus 로고
    • Ultrastructural comparison of penile cavernous tissue between hypertensive and normotensive rats
    • DOI 10.1038/sj.ijir.3901329, PII 3901329
    • Jiang R, Chen JH, Jin J, et al. Ultrastructural comparison of penile cavernous tissue between hypertensive and normotensive rats. Int J Impot Res 2005; 17:417-423. (Pubitemid 43093242)
    • (2005) International Journal of Impotence Research , vol.17 , Issue.5 , pp. 417-423
    • Jiang, R.1    Chen, J.H.2    Jin, J.3    Shen, W.4    Li, Q.M.5
  • 29
    • 61849119487 scopus 로고    scopus 로고
    • Targeting vascular structure for the treatment of sexual dysfunction
    • Hale TM, Hannan JL, Carrier S, et al. Targeting vascular structure for the treatment of sexual dysfunction. J Sex Med 2009; 6 (Suppl 3):210-220.
    • (2009) J Sex Med , vol.6 , Issue.SUPPL. 3 , pp. 210-220
    • Hale, T.M.1    Hannan, J.L.2    Carrier, S.3
  • 30
    • 77956266974 scopus 로고    scopus 로고
    • Endothelium-derived vasoactive factors and hypertension: Possible roles in pathogenesis and as treatment targets
    • Feletou M, Kohler R, Vanhoutte PM. Endothelium-derived vasoactive factors and hypertension: Possible roles in pathogenesis and as treatment targets. Curr Hypertens Rep 2010; 12:267-275.
    • (2010) Curr Hypertens Rep , vol.12 , pp. 267-275
    • Feletou, M.1    Kohler, R.2    Vanhoutte, P.M.3
  • 31
    • 46049116275 scopus 로고    scopus 로고
    • Antioxidant treatment with α-tocopherol improves erectile function in hypertensive rats
    • DOI 10.1291/hypres.31.1007
    • Ushiyama M, Kuramochi T, Yagi S, Katayama S. Antioxidant treatment with alpha-tocopherol improves erectile function in hypertensive rats. Hypertens Res 2008; 31:1007-1013. (Pubitemid 351895045)
    • (2008) Hypertension Research , vol.31 , Issue.5 , pp. 1007-1013
    • Ushiyama, M.1    Kuramochi, T.2    Yagi, S.3    Katayama, S.4
  • 32
    • 2342616744 scopus 로고    scopus 로고
    • Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide
    • DOI 10.1291/hypres.27.253
    • Ushiyama M, Morita T, Kuramochi T, et al. Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Hypertens Res 2004; 27:253-261. (Pubitemid 38594397)
    • (2004) Hypertension Research , vol.27 , Issue.4 , pp. 253-261
    • Ushiyama, M.1    Morita, T.2    Kuramochi, T.3    Yagi, S.4    Katayama, S.5
  • 33
    • 33646371004 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction
    • DOI 10.2164/jandrol.05136
    • Agarwal A, Nandipati KC, Sharma RK, et al. Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction. J Androl 2006; 27:335-347. (Pubitemid 43667981)
    • (2006) Journal of Andrology , vol.27 , Issue.3 , pp. 335-347
    • Agarwal, A.1    Nandipati, K.C.2    Sharma, R.K.3    Zippe, C.D.4    Raina, R.5
  • 35
    • 0035377997 scopus 로고    scopus 로고
    • The effect of nitric oxide and peroxynitrite on rabbit cavernosal smooth muscle relaxation
    • Khan MA, Thompson CS, Mumtaz FH, et al. The effect of nitric oxide and peroxynitrite on rabbit cavernosal smooth muscle relaxation. World J Urol 2001; 19:220-224.
    • (2001) World J Urol , vol.19 , pp. 220-224
    • Khan, M.A.1    Thompson, C.S.2    Mumtaz, F.H.3
  • 36
    • 54949084607 scopus 로고    scopus 로고
    • H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase
    • Yang G, Wu L, Jiang B, et al. H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase. Science 2008; 322:587-590.
    • (2008) Science , vol.322 , pp. 587-590
    • Yang, G.1    Wu, L.2    Jiang, B.3
  • 37
    • 34548312390 scopus 로고    scopus 로고
    • Hydrogen sulphide: A novel endogenous gasotransmitter facilitates erectile function
    • DOI 10.1111/j.1743-6109.2007.00561.x
    • Srilatha B, Adaikan PG, Li L, Moore PK. Hydrogen sulphide: A novel endogenous gasotransmitter facilitates erectile function. J Sex Med 2007; 4:1304-1311. (Pubitemid 47337674)
    • (2007) Journal of Sexual Medicine , vol.4 , Issue.5 , pp. 1304-1311
    • Srilatha, B.1    Adaikan, P.G.2    Li, L.3    Moore, P.K.4
  • 38
  • 39
    • 33645408052 scopus 로고    scopus 로고
    • Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction: A pilot study
    • Srilatha B, Adaikan PG, Moore PK. Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction: A pilot study. Eur J Pharmacol 2006; 535 (1-3):280-282.
    • (2006) Eur J Pharmacol , vol.535 , Issue.1-3 , pp. 280-282
    • Srilatha, B.1    Adaikan, P.G.2    Moore, P.K.3
  • 40
    • 79960456030 scopus 로고    scopus 로고
    • Effects of hydrogen sulfide on erectile function and its possible mechanism(s) of action
    • This review describes the hydrogen sulfide effect on erectile function and possible mechanisms through which hydrogen sulfide may exert its pro-erectile actions
    • Liaw RL, Srilatha B, Adaikan PG. Effects of hydrogen sulfide on erectile function and its possible mechanism(s) of action. J Sex Med 2011; 8:1853-1864. This review describes the hydrogen sulfide effect on erectile function and possible mechanisms through which hydrogen sulfide may exert its pro-erectile actions.
    • (2011) J Sex Med , vol.8 , pp. 1853-1864
    • Liaw, R.L.1    Srilatha, B.2    Adaikan, P.G.3
  • 41
    • 79955851849 scopus 로고    scopus 로고
    • Hydrogen sulfide and erectile function: A novel therapeutic target
    • This review describes the physiological role of hydrogen sulfide in the control of penile tone and proposes that drugs that can stimulate hydrogen sulfide signaling may be used as therapeutic approach to treat erectile dysfunction
    • d'Emmanuele di Villa Bianca R, Sorrentino R, Mirone V, Cirino G. Hydrogen sulfide and erectile function: A novel therapeutic target. Nat Rev Urol 2011; 8:286-289. This review describes the physiological role of hydrogen sulfide in the control of penile tone and proposes that drugs that can stimulate hydrogen sulfide signaling may be used as therapeutic approach to treat erectile dysfunction.
    • (2011) Nat Rev Urol , vol.8 , pp. 286-289
    • D'Emmanuele Di Villa Bianca, R.1    Sorrentino, R.2    Mirone, V.3    Cirino, G.4
  • 42
    • 79551710542 scopus 로고    scopus 로고
    • Vital signs: Prevalence, treatment, and control of hypertension: United States,1999-2002 and 2005-2008
    • Vital signs: Prevalence, treatment, and control of hypertension: United States, 1999-2002 and 2005-2008. Morb Mortal Wkly Rep 2011; 60:103-108.
    • (2011) Morb Mortal Wkly Rep , vol.60 , pp. 103-108
  • 43
    • 33645300782 scopus 로고    scopus 로고
    • Hypertension, antihypertensive therapy, and erectile dysfunction
    • Papatsoris AG, Korantzopoulos PG. Hypertension, antihypertensive therapy, and erectile dysfunction. Angiology 2006; 57:47-52.
    • (2006) Angiology , vol.57 , pp. 47-52
    • Papatsoris, A.G.1    Korantzopoulos, P.G.2
  • 44
    • 33745934926 scopus 로고    scopus 로고
    • The effect of antihypertensive drugs on erectile function: A proposed management algorithm
    • Doumas M, Douma S. The effect of antihypertensive drugs on erectile function: A proposed management algorithm. J Clin Hypertens (Greenwich) 2006; 8:359-364.
    • (2006) J Clin Hypertens (Greenwich) , vol.8 , pp. 359-364
    • Doumas, M.1    Douma, S.2
  • 45
    • 79955903804 scopus 로고    scopus 로고
    • The role of beta-blockers as first-line therapy in hypertension
    • Review reporting available evidence supporting the efficacy of b-blockers in reducing BP and cardiovascular morbidity
    • De Caterina AR, Leone AM. The role of beta-blockers as first-line therapy in hypertension. Curr Atheroscler Rep 2011; 13:147-153. Review reporting available evidence supporting the efficacy of b-blockers in reducing BP and cardiovascular morbidity.
    • (2011) Curr Atheroscler Rep , vol.13 , pp. 147-153
    • De Caterina, A.R.1    Leone, A.M.2
  • 46
    • 74549156270 scopus 로고    scopus 로고
    • Erectile dysfunction in highrisk hypertensive patients treated with beta-blockade agents
    • Cordero A, Bertomeu-Martinez V, Mazon P, et al. Erectile dysfunction in highrisk hypertensive patients treated with beta-blockade agents. Cardiovasc Ther 2010; 28:15-22.
    • (2010) Cardiovasc Ther , vol.28 , pp. 15-22
    • Cordero, A.1    Bertomeu-Martinez, V.2    Mazon, P.3
  • 49
    • 79958038502 scopus 로고    scopus 로고
    • Endothelins and erectile dysfunction
    • Review discussing the role of endothelin in the penile tissue and the cause of erectile dysfunction, and discussing recent findings about ET antagonism effect on erectile dysfunction
    • Ritchie R, Sullivan M. Endothelins and erectile dysfunction. Pharmacol Res 2011; 63:496-501. Review discussing the role of endothelin in the penile tissue and the cause of erectile dysfunction, and discussing recent findings about ET antagonism effect on erectile dysfunction.
    • (2011) Pharmacol Res , vol.63 , pp. 496-501
    • Ritchie, R.1    Sullivan, M.2
  • 50
    • 76749132472 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension
    • Montani D, Chaumais MC, Savale L, et al. Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension. Adv Ther 2009; 26:813-825.
    • (2009) Adv Ther , vol.26 , pp. 813-825
    • Montani, D.1    Chaumais, M.C.2    Savale, L.3
  • 51
    • 77955240555 scopus 로고    scopus 로고
    • Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling
    • This article provides evidence that the new generation of b-blocker, nebivolol, may have positive effects on erectile function by activation of the nitric oxide/cGMP pathway
    • Angulo J, Wright HM, Cuevas P, et al. Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling. J Sex Med 2010; 7:2681-2697. This article provides evidence that the new generation of b-blocker, nebivolol, may have positive effects on erectile function by activation of the nitric oxide/cGMP pathway.
    • (2010) J Sex Med , vol.7 , pp. 2681-2697
    • Angulo, J.1    Wright, H.M.2    Cuevas, P.3


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