Effect of angiotensin II and its receptor antagonists on human corpus cavernous contractility and oxidative stress: Modulation of nitric oxide mediated relaxation

Journal of Urology

Volumn 185, Issue 6, 2011, Pages 2414-2420

  Ertemi, Hani ^a   Mumtaz, Faiz H ^b   Howie, Alexander J ^a   Mikhailidis, Dimitri P ^a   Thompson, Cecil S ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b CHASE FARM HOSPITAL   (United Kingdom)

Author keywords

angiotensin II; erectile dysfunction; muscle; nitric oxide; penis; smooth

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; APOCYNIN; ATROPINE; GUANETHIDINE; INDOMETACIN; LOSARTAN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; CORPUS CAVERNOUS CONTRACTILITY; ELECTRIC FIELD; GENDER REASSIGNMENT SURGERY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; OXIDATIVE STRESS; PENIS ERECTION; PRIORITY JOURNAL; SEX TRANSFORMATION; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM;

ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONISTS; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NITRIC OXIDE; OXIDATIVE STRESS; PENIS; RECEPTORS, ANGIOTENSIN;

EID: 79955868290     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2011.02.2645     Document Type: Article

References (30)

1. A.L. Burnett Nitric oxide in the penis: physiology and pathology J Urol 157 1997 320
2. F. Trigo-Rocha, G.L. Hsu, and C.F. Donatucci The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic, noncholinergic: neurotransmission in canine penile erection J Urol 149 1993 872
3. F. Firoozi, P.A. Longhurst, and M.D. White Invivo and invitro response of corpus cavernosum to phosphodiesterase-5 inhibition in the hypercholesterolaemic rabbit BJU Int 96 2005 164
4. F. Holmquist, K. Persson, and A. Garcia-Pascual Phospholipase C activation by endothelin-1 and noradrenaline in isolated penile erectile tissue from rabbit J Urol 147 1992 1632
5. C.V. Corniter, M.P. Sullivan, and S.V. Yalla Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: in vitro studies in canines Int J Impotence Res 9 1997 135
6. A.J. Becker, S. Uckert, and C.G. Stief Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction Urology 58 2001 805
7. V.O. Puntmann, M.B. Hussain, and M. Mayr Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease Vasc Pharmacol 43 2005 277
8. Y. Iwamoto, K. Song, and S. Takai Multiple pathways of angiotensin I conversion and their functional role in the canine penile corpus cavernosum J Pharmacol Exp Ther 298 2001 43
9. I. Kifor, G.H. Williams, and M.A. Vickers Tissue angiotensin II as a modulator of erectile function 1. Angiotensin peptide content, secretion and effects in the corpus cavernosum. J Urol 157 1997 1920
10. M. Nakamaru, E.K. Jackson, and T. Inagami Role of vascular angiotensin II released by β-adrenergic stimulation in rats J Cardiol Pharmacol 8 1986 S1
11. C. Yan, D. Kim, and T. Aizawa Functional interplay between angiotensin II and nitric oxide Arterioscler Thromb Vasc Biol 23 2003 26
12. J.K. Park, S.Z. Kim, and S.H. Kim Renin angiotensin system in rabbit corpus cavernosum: functional characterization of angiotensin II receptors J Urol 158 1997 653
13. I.H. Schulman, M.S. Zhou, and L. Raij Interaction between nitric oxide and angiotensin II in the endothelium: role in atherosclerosis and hypertension J Hypertens 24 suppl 2006 S45
14. T. Kawazoe, H. Kosaka, and H. Yoneyama Acute production of vascular superoxide by Ang-II but not by catecholamines J Hypertens 18 2000 179
15. H. Ertemi, F. Mumtaz, and J. Bellringer The regulation of angiotensin II-induced contraction and non adrenergic-non cholinergic neurotransmission in human corpus cavernosal tissue: a role for losartan J Urol 183 2010 e342
16. V. Mirone, R. Sorrentino, and R. di VillaBianca A standard procedure for using human corpus cavernosum strips to evaluate drug activity J Pharmacol Toxicol Methods 44 2000 477
17. T. Hidaka, I. Tsuneyoshi, and W.A. Boyle 3rd Marked synergism between vasopressin and angiotensin II in a human isolated artery Crit Care Med 33 2005 2613
18. E. Klinge, and N.O. Sjstrand Comparative study of some isolated mammalian smooth muscle effectors of penile erection Acta Physiol Scand 100 1977 354
19. J.N. Cohn What is the role of angiotensin-receptor blockade in cardiovascular protection? Am Heart J 152 2006 859
20. M. de Gasparo Angiotensin II and nitric oxide interaction Heart Failure Rev 7 2002 347
21. W.D. Kempinas, J.D. Suarez, and N.L. Roberts Rat epididymal sperm quantity, quality and transit time after guanethidine-induced sympathectomy Biol Reprod 59 1998 890
22. S.J. Raboin, S. Gulley, and S.C. Henley Effect of sympathectomy and demedullation on increased myenteric and dorsal vagal complex Fos-like immunoreactivity by cholecystokinin-8 Regul Pept 134 2006 141
23. A. Nap, M. Pfaffendorf, and P.A. van Zwieten Characterisation of a modified approach to the study of sympathetic neurotransmission and its presynaptic modulation in the isolated rabbit thoracic aorta J Pharmacol Toxicol Methods 46 2002 145
24. M.A. Khan, C.S. Thompson, and F.H. Mumtaz The effect of nitric oxide and peroxynitrite on rabbit cavernosal muscle relaxation World J Urol 19 2001 220
25. R.M. Touyz, and E.L. Schiffrin Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways J Hypertens 19 2001 1245
26. M.C. Cruzado, N.R. Risler, and R.M. Miatello Vascular smooth muscle cell NAD(P)H activity during the development of hypertension: effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation Am J Hypertens 18 2005 81
27. H.D. Wang, D.G. Johns, and S. Xu Role of superoxide anion in regulating pressor and vascular hypertrophic responses to Ang-II Am J Physiol Heart Circ Physiol 282 2002 H1697
28. H. Cai, and D.G. Harrison Endothelial dysfunction in cardiovascular disease: the role of oxidative stress Circ Res 87 2000 840
29. C.R. White, T.A. Brock, and L.Y. Chang Superoxide and peroxynitrite in atherosclerosis Proc Natl Acad Sci USA 91 1994 1044
30. C. Lu, L.Y. Su, and R.M. Lee Superoxide anion mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation Eur J Pharmacol 589 2008 188