Association study of polymorphisms in the SOST gene region and parameters of bone strength and body composition in both young and elderly men: Data from the Odense Androgen Study

Calcified Tissue International

Volumn 90, Issue 1, 2012, Pages 30-39

  Piters, Elke ^a   De Freitas, Fenna ^a   Nielsen, Torben Leo ^b   Andersen, Marianne ^b   Brixen, Kim ^b   Van Hul, Wim ^a  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Osteoporosis: genetic association; Osteoporosis: genetic polymorphism; Wnt signaling

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; BONE DENSITY; BONE STRENGTH; COHORT ANALYSIS; CONTROLLED STUDY; FEMUR NECK; GENE FREQUENCY; GENE PRODUCT; GENETIC ASSOCIATION; GEOMETRY; HIP; HUMAN; HUMAN EXPERIMENT; MALE; MUSCULOSKELETAL SYSTEM PARAMETERS; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SOST GENE;

ADULT; AGED; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; BONE MORPHOGENETIC PROTEINS; COHORT STUDIES; DENMARK; FEMUR NECK; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENOTYPE; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 84857041836     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-011-9546-5     Document Type: Article

References (52)

1. Consensus Development Conference 1993 Consensus Development Conference: diagnosis, prophylaxis, and treatment of osteoporosis Am J Med 94 646 650 10.1016/0002-9343(93)90218-E (Pubitemid 23166713)
2. O Johnell JA Kanis 2006 An estimate of the worldwide prevalence and disability associated with osteoporotic fractures Osteoporos Int 17 1726 1733 16983459 10.1007/s00198-006-0172-4 1:STN:280:DC%2BD28nitVSksQ%3D%3D (Pubitemid 44607392)
3. A Leboime CB Confavreux N Mehsen J Paccou C David C Roux 2010 Osteoporosis and mortality Joint Bone Spine 77 Suppl 2 S107 S112 21211746 10.1016/S1297-319X(10)70004-X
4. Y Chen H Shen F Yang PY Liu N Tang RR Recker HW Deng 2009 Choice of study phenotype in osteoporosis genetic research J Bone Miner Metab 27 121 126 19184673 10.1007/s00774-008-0020-z
5. S Ferrari 2008 Human genetics of osteoporosis Best Pract Res Clin Endocrinol Metab 22 723 735 19028354 10.1016/j.beem.2008.08.007 1:CAS:528:DC%2BD1cXhsVWmsbnP
6. AM Sims N Shephard K Carter T Doan A Dowling EL Duncan J Eisman G Jones G Nicholson R Prince E Seeman G Thomas JA Wass MA Brown 2008 Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes J Bone Miner Res 23 499 506 18021006 10.1359/jbmr.071113 1:CAS:528:DC%2BD1cXltFyhsLs%3D (Pubitemid 351501890)
7. QY Huang GH Li AW Kung 2009 The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis Bone 45 289 294 19371798 10.1016/j.bone.2009. 03.676 1:CAS:528:DC%2BD1MXotFylsbk%3D
8. U Styrkarsdottir BV Halldorsson S Gretarsdottir DF Gudbjartsson GB Walters T Ingvarsson T Jonsdottir J Saemundsdottir S Snorradottir JR Center TV Nguyen P Alexandersen JR Gulcher JA Eisman C Christiansen G Sigurdsson A Kong U Thorsteinsdottir K Stefansson 2009 New sequence variants associated with bone mineral density Nat Genet 41 15 17 19079262 10.1038/ng.284 1:CAS:528: DC%2BD1cXhsV2hsrjK
9. LM Yerges L Klei JA Cauley K Roeder CM Kammerer SP Moffett KE Ensrud CS Nestlerode LM Marshall AR Hoffman C Lewis TF Lang E Barrett-Connor RE Ferrell ES Orwoll JM Zmuda 2009 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men J Bone Miner Res 24 2039 2049 19453261 10.1359/jbmr.090524 1:CAS:528:DC%2BC3cXht1Wns7w%3D
10. JB Richards FK Kavvoura F Rivadeneira U Styrkarsdottir K Estrada BV Halldorsson YH Hsu MC Zillikens SG Wilson BH Mullin N Amin YS Aulchenko LA Cupples P Deloukas S Demissie A Hofman A Kong D Karasik JB van Meurs BA Oostra HA Pols G Sigurdsson U Thorsteinsdottir N Soranzo FM Williams Y Zhou SH Ralston G Thorleifsson CM van Duijn DP Kiel K Stefansson AG Uitterlinden JP Ioannidis TD Spector 2009 Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture Ann Intern Med 151 528 537 19841454
11. JM Liu MJ Zhang L Zhao B Cui ZB Li HY Zhao LH Sun B Tao M Li G Ning 2010 Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women J Clin Endocrinol Metab 95 E112 E120 20554715 10.1210/jc.2009-2768
12. U Styrkarsdottir BV Halldorsson DF Gudbjartsson NL Tang JM Koh SM Xiao TC Kwok GS Kim JC Chan S Cherny SH Lee A Kwok S Ho S Gretarsdottir JP Kostic ST Palsson G Sigurdsson PC Sham BJ Kim AW Kung SY Kim J Woo PC Leung A Kong U Thorsteinsdottir K Stefansson 2010 European bone mineral density loci are also associated with BMD in East-Asian populations PLoS One 5 e13217 20949110 10.1371/journal.pone.0013217
13. X Li Y Zhang H Kang W Liu P Liu J Zhang SE Harris D Wu 2005 Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling J Biol Chem 280 19883 19887 15778503 10.1074/jbc.M413274200 1:CAS:528:DC%2BD2MXktFylsbs%3D (Pubitemid 41379516)
14. M Semenov K Tamai X He 2005 SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor J Biol Chem 280 26770 26775 15908424 10.1074/jbc.M504308200 1:CAS:528:DC%2BD2MXmt1Ggs7k%3D (Pubitemid 41040710)
15. C Krause O Korchynskyi K de Rooij SE Weidauer DJ de Gorter RL van Bezooijen S Hatsell AN Economides TD Mueller CW Lowik P Ten Dijke 2010 Distinct modes of inhibition by sclerostin on bone morphogenetic protein and wnt signaling pathways J Biol Chem 285 41614 41626 20952383 10.1074/jbc.M110.153890 1:CAS:528:DC%2BC3cXhs1Wju7bJ
16. W Balemans M Ebeling N Patel E Van Hul P Olson M Dioszegi C Lacza W Wuyts J Van Den Ende P Willems AF Paes-Alves S Hill M Bueno FJ Ramos P Tacconi FG Dikkers C Stratakis K Lindpaintner B Vickery D Foernzler W Van Hul 2001 Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) Hum Mol Genet 10 537 543 11181578 10.1093/hmg/10.5.537 1:CAS:528:DC%2BD3MXhslSitbw%3D (Pubitemid 32184286)
17. ME Brunkow JC Gardner J Van Ness BW Paeper BR Kovacevich S Proll JE Skonier L Zhao PJ Sabo Y Fu RS Alisch L Gillett T Colbert P Tacconi D Galas H Hamersma P Beighton J Mulligan 2001 Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein Am J Hum Genet 68 577 589 11179006 10.1086/318811 1:CAS:528:DC%2BD3MXit1altbk%3D (Pubitemid 32202753)
18. W Balemans N Patel M Ebeling E Van Hul W Wuyts C Lacza M Dioszegi FG Dikkers P Hildering PJ Willems JB Verheij K Lindpaintner B Vickery D Foernzler W Van Hul 2002 Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease J Med Genet 39 91 97 11836356 10.1136/jmg.39.2.91 1:CAS:528:DC%2BD38XitV2itbo%3D (Pubitemid 34146376)
19. K Staehling-Hampton S Proll BW Paeper L Zhao P Charmley A Brown JC Gardner D Galas RC Schatzman P Beighton S Papapoulos H Hamersma ME Brunkow 2002 A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population Am J Med Genet 110 144 152 12116252 10.1002/ajmg.10401 (Pubitemid 34569019)
20. CA Kim R Honjo D Bertola L Albano L Oliveira S Jales J Siqueira A Castilho W Balemans E Piters K Jennes W Van Hul 2008 A known SOST gene mutation causes sclerosteosis in a familial and an isolated case from Brazilian origin Genet Test 12 475 479 19072561 10.1089/gte.2008.0036 1:CAS:528: DC%2BD1cXhsFajsrzF
21. E Piters C Culha M Moester R Van Bezooijen D Adriaensen T Mueller S Weidauer K Jennes F de Freitas C Lowik JP Timmermans W Van Hul S Papapoulos 2010 First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function Hum Mutat 31 E1526 E1543 20583295 10.1002/humu.21274 1:CAS:528:DC%2BC3cXpslagtbo%3D
22. A Eddleston M Marenzana AR Moore P Stephens M Muzylak D Marshall MK Robinson 2009 A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis J Bone Miner Res 24 1662 1671 19419292 10.1359/jbmr.090403 1:CAS:528:DC%2BD1MXhtlGgurfM
23. X Li MS Ominsky KS Warmington S Morony J Gong J Cao Y Gao V Shalhoub B Tipton R Haldankar Q Chen A Winters T Boone Z Geng QT Niu HZ Ke PJ Kostenuik WS Simonet DL Lacey C Paszty 2009 Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis J Bone Miner Res 24 578 588 19049336 10.1359/jbmr.081206 1:CAS:528:DC%2BD1MXksF2lu7c%3D
24. MS Ominsky F Vlasseros J Jolette SY Smith B Stouch G Doellgast J Gong Y Gao J Cao K Graham B Tipton J Cai R Deshpande L Zhou MD Hale DJ Lightwood AJ Henry AG Popplewell AR Moore MK Robinson DL Lacey WS Simonet C Paszty 2010 Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength J Bone Miner Res 25 948 959 20200929 10.1002/jbmr.14 1:CAS:528:DC%2BC3cXnt1Kisrg%3D
25. D Padhi G Jang B Stouch L Fang E Posvar 2010 Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody J Bone Miner Res 26 19 26 10.1002/jbmr.173
26. W Balemans D Foernzler C Parsons M Ebeling A Thompson DM Reid K Lindpaintner SH Ralston W Van Hul 2002 Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms Bone 31 515 519 12398949 10.1016/S8756-3282(02)00844-X 1:CAS:528:DC%2BD38XotVCjsr8%3D (Pubitemid 35175456)
27. AG Uitterlinden PP Arp BW Paeper P Charmley S Proll F Rivadeneira Y Fang JB van Meurs TB Britschgi JA Latham RC Schatzman HA Pols ME Brunkow 2004 Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites Am J Hum Genet 75 1032 1045 15514891 10.1086/426458 1:CAS:528:DC%2BD2cXhtVegsrnL (Pubitemid 39532072)
28. N Crabtree M Lunt G Holt H Kroger H Burger S Grazio KT Khaw RS Lorenc J Nijs J Stepan JA Falch T Miazgowski P Raptou HA Pols J Dequeker S Havelka K Hoszowski I Jajic S Czekalski G Lyritis AJ Silman J Reeve 2000 Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS study Bone 27 151 159 10865223 10.1016/S8756-3282(00)00300-8 1:STN:280:DC%2BD3cvisVCgtw%3D%3D (Pubitemid 30365091)
29. TL Nielsen K Wraae K Brixen AP Hermann M Andersen C Hagen 2006 Prevalence of overweight, obesity and physical inactivity in 20- to 29-year-old, Danish men relation to sociodemography, physical dysfunction and low socioeconomic status: the Odense Androgen Study Int J Obes (Lond) 30 805 815 10.1038/sj.ijo.0803197 1:STN:280:DC%2BD283jtFGmtQ%3D%3D
30. TL Nielsen K Wraae KT Brixen M Andersen C Hagen 2004 The Odense Androgen Study [in Danish] Ugeskr Laeger 166 1449 1451 15146816
31. E Piters W Balemans TL Nielsen M Andersen E Boudin K Brixen W Van Hul 2010 Common genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: results from the Odense Androgen Study Calcif Tissue Int 86 271 281 20101398 10.1007/s00223-010-9334-7 1:CAS:528:DC%2BC3cXjvVGns7o%3D
32. Gauderman WJ, Morrison MJ (2006) QUANTO 1.1: a computer program for power and sample size calculations for genetic-epidemiology studies. http://hydra.usc.edu/gxe. Accessed 17 June 2011
33. G Lettre C Lange JN Hirschhorn 2007 Genetic model testing and statistical power in population-based association studies of quantitative traits Genet Epidemiol 31 358 362 17352422 10.1002/gepi.20217 (Pubitemid 46642100)
34. M Hoiberg TL Nielsen K Wraae B Abrahamsen C Hagen M Andersen K Brixen 2007 Population-based reference values for bone mineral density in young men Osteoporos Int 18 1507 1514 17534538 10.1007/s00198-007-0399-8 1:STN:280:DC%2BD2srosVCrsg%3D%3D (Pubitemid 47512682)
35. S Mencej-Bedrac J Prezelj T Kocjan R Komadina J Marc 2009 Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population Calcif Tissue Int 85 501 506 19898734 10.1007/s00223-009-9306-y 1:CAS:528:DC%2BD1MXhsFSrt7bK
36. K Brixen S Beckers A Peeters E Piters W Balemans TL Nielsen K Wraae L Bathum C Brasen C Hagen M Andersen W Van Hul B Abrahamsen 2007 Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense Androgen Study Calcif Tissue Int 81 421 429 18058054 10.1007/s00223-007-9088-z 1:CAS:528:DC%2BD2sXhsVKrt7zF
37. TA Pearson TA Manolio 2008 How to interpret a genome-wide association study JAMA 299 1335 1344 18349094 10.1001/jama.299.11.1335 1:CAS:528: DC%2BD1cXjsV2ku7g%3D (Pubitemid 351439079)
38. U Styrkarsdottir BV Halldorsson S Gretarsdottir DF Gudbjartsson GB Walters T Ingvarsson T Jonsdottir J Saemundsdottir JR Center TV Nguyen Y Bagger JR Gulcher JA Eisman C Christiansen G Sigurdsson A Kong U Thorsteinsdottir K Stefansson 2008 Multiple genetic loci for bone mineral density and fractures N Engl J Med 358 2355 2365 18445777 10.1056/NEJMoa0801197 1:CAS:528: DC%2BD1cXmsVKgtb4%3D (Pubitemid 351749159)
39. JB Richards F Rivadeneira M Inouye TM Pastinen N Soranzo SG Wilson T Andrew M Falchi R Gwilliam KR Ahmadi AM Valdes P Arp P Whittaker DJ Verlaan M Jhamai V Kumanduri M Moorhouse JB van Meurs A Hofman HA Pols D Hart G Zhai BS Kato BH Mullin F Zhang P Deloukas AG Uitterlinden TD Spector 2008 Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study Lancet 371 1505 1512 18455228 10.1016/S0140-6736(08)60599-1 1:CAS:528:DC%2BD1cXlsFGisr0%3D
40. F Rivadeneira MC Zillikens CE De Laet A Hofman AG Uitterlinden TJ Beck HA Pols 2007 Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam study J Bone Miner Res 22 1781 1790 17638578 10.1359/jbmr.070712 (Pubitemid 351235145)
41. DP Kiel S Demissie J Dupuis KL Lunetta JM Murabito D Karasik 2007 Genome-wide association with bone mass and geometry in the Framingham heart study BMC Med Genet 8 Suppl 1 S14 17903296 10.1186/1471-2350-8-S1-S14 (Pubitemid 351958747)
42. Y Chen DH Xiong YF Guo F Pan Q Zhou F Zhang HW Deng 2010 Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry Bone 46 129 136 19786129 10.1016/j.bone.2009.09.025 1:CAS:528:DC%2BD1MXhsFynsrrO
43. LJ Zhao XG Liu YZ Liu YJ Liu CJ Papasian BY Sha F Pan YF Guo L Wang H Yan DH Xiong ZH Tang TL Yang XD Chen Y Guo J Li H Shen F Zhang SF Lei RR Recker HW Deng 2010 Genome-wide association study for femoral neck bone geometry J Bone Miner Res 25 320 329 20175129 10.1359/jbmr.090726 1:CAS:528:DC%2BC3cXksl2ksLw%3D
44. JB van Meurs TA Trikalinos SH Ralston S Balcells ML Brandi K Brixen DP Kiel BL Langdahl P Lips O Ljunggren R Lorenc B Obermayer-Pietsch C Ohlsson U Pettersson DM Reid F Rousseau S Scollen W Van Hul L Agueda K Akesson LI Benevolenskaya SL Ferrari G Hallmans A Hofman LB Husted M Kruk S Kaptoge D Karasik MK Karlsson M Lorentzon L Masi FE McGuigan D Mellstrom L Mosekilde X Nogues HA Pols J Reeve W Renner F Rivadeneira NM van Schoor K Weber JP Ioannidis AG Uitterlinden 2008 Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis JAMA 299 1277 1290 18349089 10.1001/jama.299.11.1277 (Pubitemid 351439074)
45. F Rivadeneira U Styrkarsdottir K Estrada BV Halldorsson YH Hsu JB Richards MC Zillikens FK Kavvoura N Amin YS Aulchenko LA Cupples P Deloukas S Demissie E Grundberg A Hofman A Kong D Karasik JB van Meurs B Oostra T Pastinen HA Pols G Sigurdsson N Soranzo G Thorleifsson U Thorsteinsdottir FM Williams SG Wilson Y Zhou SH Ralston CM van Duijn T Spector DP Kiel K Stefansson JP Ioannidis AG Uitterlinden 2009 Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies Nat Genet 41 1199 1206 19801982 10.1038/ng.446 1:CAS:528:DC%2BD1MXht1Wgsb7L
46. S Li JH Zhao J Luan RN Luben SA Rodwell KT Khaw KK Ong NJ Wareham RJ Loos 2010 Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies Am J Clin Nutr 91 184 190 19812171 10.3945/ajcn.2009.28403 1:CAS:528:DC%2BD1MXhs1WlsbbP
47. SE Ross N Hemati KA Longo CN Bennett PC Lucas RL Erickson OA MacDougald 2000 Inhibition of adipogenesis by Wnt signaling Science 289 950 953 10937998 10.1126/science.289.5481.950 1:CAS:528:DC%2BD3cXlvFSmu7s%3D (Pubitemid 30659947)
48. YJ Liu XG Liu L Wang C Dina H Yan JF Liu S Levy CJ Papasian BM Drees JJ Hamilton D Meyre J Delplanque YF Pei L Zhang RR Recker P Froguel HW Deng 2008 Genome-wide association scans identified CTNNBL1 as a novel gene for obesity Hum Mol Genet 17 1803 1813 18325910 10.1093/hmg/ddn072 1:CAS:528: DC%2BD1cXmsFKis7Y%3D (Pubitemid 351791507)
49. FS Mirza ID Padhi LG Raisz JA Lorenzo 2010 Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women J Clin Endocrinol Metab 95 1991 1997 20156921 10.1210/jc.2009-2283
50. UI Modder JA Clowes K Hoey JM Peterson L McCready MJ Oursler BL Riggs S Khosla 2011 Regulation of circulating sclerostin levels by sex steroids in women and in men J Bone Miner Res 26 27 34 20499362 10.1002/jbmr.128 1:CAS:528:DC%2BC3MXhtlCgsrw%3D
51. A Gaudio P Pennisi C Bratengeier V Torrisi B Lindner RA Mangiafico I Pulvirenti G Hawa G Tringali CE Fiore 2010 Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss J Clin Endocrinol Metab 95 2248 2253 20305005 10.1210/jc.2010-0067 1:CAS:528:DC%2BC3cXmtFegu7Y%3D
52. MT Drake B Srinivasan UI Modder JM Peterson LK McCready BL Riggs D Dwyer M Stolina P Kostenuik S Khosla 2010 Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women J Clin Endocrinol Metab 95 5056 5062 20631014 10.1210/jc.2010-0720 1:CAS:528:DC%2BC3cXhsV2nsbnP