S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine

Atherosclerosis

Volumn 221, Issue 1, 2012, Pages 48-54

  Sipkens, Jessica A ^a   Hahn, Nynke E ^a   Blom, Henk J ^a   Lougheed, Sinéad M ^a   Stehouwer, Coen D A ^b   Rauwerda, Jan A ^a   Krijnen, Paul A J ^a   van Hinsbergh, Victor W M ^a   Niessen, Hans W M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Endothelial cells; Homocysteine; NADPH oxidase; S Adenosylhomocysteine

Indexed keywords

3 NITROTYROSINE; ADENOSINE DIALDEHYDE; CASPASE 3; CYTOCHROME C; DIPHENYLIODONIUM SALT; HOMOCYSTEINE; HYDROGEN PEROXIDE; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; S ADENOSYLHOMOCYSTEINE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; UMBILICAL VEIN ENDOTHELIAL CELL;

ADENOSINE; APOPTOSIS; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HOMOCYSTEINE; HUMANS; HYDROGEN PEROXIDE; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; ONIUM COMPOUNDS; PHOSPHATIDYLSERINES; S-ADENOSYLHOMOCYSTEINE; TYROSINE;

EID: 84857035537     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.11.032     Document Type: Article

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