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Volumn 68, Issue 1, 2008, Pages 22-30

Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study

Author keywords

Atherosclerosis; Homocysteine; Methylenetetrahydrofolate reductase; SNP

Indexed keywords

C REACTIVE PROTEIN; HOMOCYSTEINE; METHYLENETETRAHYDROFOLIC ACID;

EID: 38549097696     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510701487735     Document Type: Article
Times cited : (9)

References (40)
  • 1
    • 0026056004 scopus 로고
    • Carotid atherosclerosis measured by B-mode ultrasound in populations: Associations with cardiovascular risk factors in the ARIC study
    • Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C. Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 1991;134:250-6.
    • (1991) Am J Epidemiol , vol.134 , pp. 250-256
    • Heiss, G.1    Sharrett, A.R.2    Barnes, R.3    Chambless, L.E.4    Szklo, M.5    Alzola, C.6
  • 2
    • 0033531215 scopus 로고    scopus 로고
    • Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    • O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK, Jr.. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999;340:14-22.
    • (1999) N Engl J Med , vol.340 , pp. 14-22
    • O'Leary, D.H.1    Polak, J.F.2    Kronmal, R.A.3    Manolio, T.A.4    Burke, G.L.5    Wolfson Jr., S.K.6
  • 3
    • 0034159755 scopus 로고    scopus 로고
    • Carotid wall thickness is predictive of incident clinical stroke: The Atherosclerosis Risk in Communities (ARIC) study
    • Chambless LE, Folsom AR, Clegg LX, et al. Carotid wall thickness is predictive of incident clinical stroke: The Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol 2000;151:478-87.
    • (2000) Am J Epidemiol , vol.151 , pp. 478-487
    • Chambless, L.E.1    Folsom, A.R.2    Clegg, L.X.3
  • 4
    • 0036150671 scopus 로고    scopus 로고
    • Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: A longitudinal study
    • Boutouyrie P, Tropeano AI, Asmar R, et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: A longitudinal study. Hypertension 2002;39:10-15.
    • (2002) Hypertension , vol.39 , pp. 10-15
    • Boutouyrie, P.1    Tropeano, A.I.2    Asmar, R.3
  • 5
    • 0031688759 scopus 로고    scopus 로고
    • Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease
    • Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 1998;32:570-4.
    • (1998) Hypertension , vol.32 , pp. 570-574
    • Blacher, J.1    Pannier, B.2    Guerin, A.P.3    Marchais, S.J.4    Safar, M.E.5    London, G.M.6
  • 6
    • 0035960440 scopus 로고    scopus 로고
    • Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: A prospective study
    • Tounian P, Aggoun Y, Dubern B, et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 2001;358:1400-4.
    • (2001) Lancet , vol.358 , pp. 1400-1404
    • Tounian, P.1    Aggoun, Y.2    Dubern, B.3
  • 7
    • 24744460540 scopus 로고    scopus 로고
    • Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: The Cardiovascular Risk in Young Finns Study
    • Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JS, Raitakari OT. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: The Cardiovascular Risk in Young Finns Study. Circulation 2005;112:1486-93.
    • (2005) Circulation , vol.112 , pp. 1486-1493
    • Juonala, M.1    Järvisalo, M.J.2    Mäki-Torkko, N.3    Kähönen, M.4    Viikari, J.S.5    Raitakari, O.T.6
  • 8
    • 17744378195 scopus 로고    scopus 로고
    • The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: The Amsterdam Growth and Health Longitudinal Study
    • Ferreira I, Henry RM, Twisk JW, van Mechelen W, Kemper HC, Stehouwer CD. The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: The Amsterdam Growth and Health Longitudinal Study. Arch Intern Med 2005;165:875-82.
    • (2005) Arch Intern Med , vol.165 , pp. 875-882
    • Ferreira, I.1    Henry, R.M.2    Twisk, J.W.3    van Mechelen, W.4    Kemper, H.C.5    Stehouwer, C.D.6
  • 9
    • 0026690858 scopus 로고
    • Ultrasonic measurement of the elastic modulus of the common carotid artery. The Atherosclerosis Risk in Communities (ARIC) Study
    • Riley WA, Barnes RW, Evans GW, Burke GL. Ultrasonic measurement of the elastic modulus of the common carotid artery. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 1992;23:952-6.
    • (1992) Stroke , vol.23 , pp. 952-956
    • Riley, W.A.1    Barnes, R.W.2    Evans, G.W.3    Burke, G.L.4
  • 10
    • 0026478022 scopus 로고
    • Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
    • Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-15.
    • (1992) Lancet , vol.340 , pp. 1111-1115
    • Celermajer, D.S.1    Sorensen, K.E.2    Gooch, V.M.3
  • 11
    • 8144222977 scopus 로고    scopus 로고
    • Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: The Cardiovascular Risk in Young Finns Study
    • Juonala M, Viikari JS, Laitinen T, et al. Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: The Cardiovascular Risk in Young Finns Study. Circulation 2004;110:2918-23.
    • (2004) Circulation , vol.110 , pp. 2918-2923
    • Juonala, M.1    Viikari, J.S.2    Laitinen, T.3
  • 12
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. J Am Med Assoc 2002;288:2015-22.
    • (2002) J Am Med Assoc , vol.288 , pp. 2015-2022
  • 13
    • 0023892344 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease
    • Kang SS, Wong PW, Zhou JM, et al. Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism 1988;37:611-13.
    • (1988) Metabolism , vol.37 , pp. 611-613
    • Kang, S.S.1    Wong, P.W.2    Zhou, J.M.3
  • 15
    • 0032497941 scopus 로고    scopus 로고
    • Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis
    • Brattström L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis. Circulation 1998;98:2520-6.
    • (1998) Circulation , vol.98 , pp. 2520-2526
    • Brattström, L.1    Wilcken, D.E.2    Ohrvik, J.3    Brudin, L.4
  • 16
    • 0034855515 scopus 로고    scopus 로고
    • An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis
    • Kawamoto R, Kohara K, Tabara Y, et al. An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis. J Hum Genet 2001;46:506-10.
    • (2001) J Hum Genet , vol.46 , pp. 506-510
    • Kawamoto, R.1    Kohara, K.2    Tabara, Y.3
  • 17
    • 0033545888 scopus 로고    scopus 로고
    • Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
    • McQuillan BM, Beilby JP, Nidorf M, Thompson PL, Hung J. Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS). Circulation 1999;99:2383-8.
    • (1999) Circulation , vol.99 , pp. 2383-2388
    • McQuillan, B.M.1    Beilby, J.P.2    Nidorf, M.3    Thompson, P.L.4    Hung, J.5
  • 18
    • 5644288746 scopus 로고    scopus 로고
    • Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European Canadians
    • Kelemen LE, Anand SS, Hegele RA, et al. Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European Canadians. Atherosclerosis 2004;176:361-70.
    • (2004) Atherosclerosis , vol.176 , pp. 361-370
    • Kelemen, L.E.1    Anand, S.S.2    Hegele, R.A.3
  • 19
    • 4043109751 scopus 로고    scopus 로고
    • Homocysteine and carotid intima-media thickness: A critical appraisal of the evidence
    • Durga J, Verhoef P, Bots ML, Schouten E. Homocysteine and carotid intima-media thickness: A critical appraisal of the evidence. Atherosclerosis 2004;176:1-19.
    • (2004) Atherosclerosis , vol.176 , pp. 1-19
    • Durga, J.1    Verhoef, P.2    Bots, M.L.3    Schouten, E.4
  • 20
    • 23944523794 scopus 로고    scopus 로고
    • Correlation of plasma homocysteine level with arterial stiffness and pulse pressure in hemodialysis patients
    • Tsai JC, Kuo HT, Chiu YW, et al. Correlation of plasma homocysteine level with arterial stiffness and pulse pressure in hemodialysis patients. Atherosclerosis 2005;182:121-7.
    • (2005) Atherosclerosis , vol.182 , pp. 121-127
    • Tsai, J.C.1    Kuo, H.T.2    Chiu, Y.W.3
  • 21
    • 23444452249 scopus 로고    scopus 로고
    • Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype
    • Williams C, Kingwell BA, Burke K, McPherson J, Dart AM. Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am J Clin Nutr 2005;82:26-31.
    • (2005) Am J Clin Nutr , vol.82 , pp. 26-31
    • Williams, C.1    Kingwell, B.A.2    Burke, K.3    McPherson, J.4    Dart, A.M.5
  • 22
    • 0036181008 scopus 로고    scopus 로고
    • Influence of methylenetetrahydrofolate reductase genotype, exercise and other risk factors on endothelial function in healthy individuals
    • Pullin CH, Wilson JF, Ashfield-Watt PA, et al. Influence of methylenetetrahydrofolate reductase genotype, exercise and other risk factors on endothelial function in healthy individuals. Clin Sci (Lond) 2002;102:45-50.
    • (2002) Clin Sci (Lond) , vol.102 , pp. 45-50
    • Pullin, C.H.1    Wilson, J.F.2    Ashfield-Watt, P.A.3
  • 23
    • 9144264259 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men
    • Imamura A, Okumura K, Matsui H, et al. Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men. Can J Cardiol 2004;20:1229-34.
    • (2004) Can J Cardiol , vol.20 , pp. 1229-1234
    • Imamura, A.1    Okumura, K.2    Matsui, H.3
  • 24
    • 0242410275 scopus 로고    scopus 로고
    • Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: The Cardiovascular Risk in Young Finns Study
    • Raitakari OT, Juonala M, Kähönen M, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: The Cardiovascular Risk in Young Finns Study. J Am Med Assoc 2003;290:2277-83.
    • (2003) J Am Med Assoc , vol.290 , pp. 2277-2283
    • Raitakari, O.T.1    Juonala, M.2    Kähönen, M.3
  • 25
    • 1842506518 scopus 로고    scopus 로고
    • The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: Risk factor levels, secular trends and east-west difference
    • Juonala M, Viikari JS, Hutri-Kähönen N, et al. The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: Risk factor levels, secular trends and east-west difference. J Intern Med 2004;255:457-68.
    • (2004) J Intern Med , vol.255 , pp. 457-468
    • Juonala, M.1    Viikari, J.S.2    Hutri-Kähönen, N.3
  • 26
    • 84990161111 scopus 로고
    • Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children's and families' state of health
    • Åkerblom HK, Viikari J, Uhari M, et al. Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children's and families' state of health. Acta Paediatr Scand Suppl 1985;318:49-63.
    • (1985) Acta Paediatr Scand Suppl , vol.318 , pp. 49-63
    • Åkerblom, H.K.1    Viikari, J.2    Uhari, M.3
  • 27
    • 0033006003 scopus 로고    scopus 로고
    • Allelic discrimination using fluorogenic probes and the 5′ nuclease assay
    • Livak KJ. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 1999;14:143-9.
    • (1999) Genet Anal , vol.14 , pp. 143-149
    • Livak, K.J.1
  • 29
    • 0037477386 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population
    • Inamoto N, Katsuya T, Kokubo Y, et al. Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population. Stroke 2003;34:1628-33.
    • (2003) Stroke , vol.34 , pp. 1628-1633
    • Inamoto, N.1    Katsuya, T.2    Kokubo, Y.3
  • 30
    • 0035006125 scopus 로고    scopus 로고
    • APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort)
    • Pallaud C, Sass C, Zannad F, Siest G, Visvikis S. APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort). Clin Genet 2001;59:316-24.
    • (2001) Clin Genet , vol.59 , pp. 316-324
    • Pallaud, C.1    Sass, C.2    Zannad, F.3    Siest, G.4    Visvikis, S.5
  • 31
    • 0034966495 scopus 로고    scopus 로고
    • Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women
    • Passaro A, Vanini A, Calzoni F, et al. Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women. Atherosclerosis 2001;157:175-80.
    • (2001) Atherosclerosis , vol.157 , pp. 175-180
    • Passaro, A.1    Vanini, A.2    Calzoni, F.3
  • 32
    • 0032703305 scopus 로고    scopus 로고
    • Serum homocysteine, MTHFR gene polymorphism, and carotid intimal-medial thickness in NIDDM subjects
    • Mazza A, Motti C, Nulli A, et al. Serum homocysteine, MTHFR gene polymorphism, and carotid intimal-medial thickness in NIDDM subjects. J Thromb Thrombolysis 1999;8:207-12.
    • (1999) J Thromb Thrombolysis , vol.8 , pp. 207-212
    • Mazza, A.1    Motti, C.2    Nulli, A.3
  • 33
    • 14944365901 scopus 로고    scopus 로고
    • Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness
    • Durga J, Bots ML, Schouten EG, Kok FJ, Verhoef P. Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness. Atherosclerosis 2005;179:285-92.
    • (2005) Atherosclerosis , vol.179 , pp. 285-292
    • Durga, J.1    Bots, M.L.2    Schouten, E.G.3    Kok, F.J.4    Verhoef, P.5
  • 34
    • 27744471516 scopus 로고    scopus 로고
    • Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate?
    • Lewis SJ, Ebrahim S, Davey Smith G. Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate? Br Med J 2005;331:1053.
    • (2005) Br Med J , vol.331 , pp. 1053
    • Lewis, S.J.1    Ebrahim, S.2    Davey Smith, G.3
  • 35
    • 12344309062 scopus 로고    scopus 로고
    • Homocysteine and stroke: Evidence on a causal link from Mendelian randomisation
    • Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: Evidence on a causal link from Mendelian randomisation. Lancet 2005;365:224-32.
    • (2005) Lancet , vol.365 , pp. 224-232
    • Casas, J.P.1    Bautista, L.E.2    Smeeth, L.3    Sharma, P.4    Hingorani, A.D.5
  • 36
    • 0032759352 scopus 로고    scopus 로고
    • Plasma homocysteine, aortic stiffness, and renal function in hypertensive patients
    • Bortolotto LA, Safar ME, Billaud E, et al. Plasma homocysteine, aortic stiffness, and renal function in hypertensive patients. Hypertension 1999;34:837-42.
    • (1999) Hypertension , vol.34 , pp. 837-842
    • Bortolotto, L.A.1    Safar, M.E.2    Billaud, E.3
  • 37
    • 0035188835 scopus 로고    scopus 로고
    • Acute methionine loading does not alter arterial stiffness in humans
    • Wilkinson IB, Megson IL, MacCallum T, et al. Acute methionine loading does not alter arterial stiffness in humans. J Cardiovasc Pharmacol 2001;37:1-5.
    • (2001) J Cardiovasc Pharmacol , vol.37 , pp. 1-5
    • Wilkinson, I.B.1    Megson, I.L.2    MacCallum, T.3
  • 38
    • 0344851600 scopus 로고    scopus 로고
    • Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine
    • Nestel PJ, Chronopoulos A, Cehun M. Arterial stiffness is rapidly induced by raising the plasma homocysteine concentration with methionine. Atherosclerosis 2003;171:83-6.
    • (2003) Atherosclerosis , vol.171 , pp. 83-86
    • Nestel, P.J.1    Chronopoulos, A.2    Cehun, M.3
  • 39
    • 18744415133 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene C677T mutation is related to the defects in the internal elastic lamina of the artery wall
    • Hämelahti P, Järvinen O, Sisto T, et al. Methylenetetrahydrofolate reductase gene C677T mutation is related to the defects in the internal elastic lamina of the artery wall. Eur J Clin Invest 2002;32:869-73.
    • (2002) Eur J Clin Invest , vol.32 , pp. 869-873
    • Hämelahti, P.1    Järvinen, O.2    Sisto, T.3
  • 40
    • 0032547964 scopus 로고    scopus 로고
    • Higher export rate of homocysteine in a human endothelial cell line than in other human cell lines
    • Hultberg B, Andersson A, Isaksson A. Higher export rate of homocysteine in a human endothelial cell line than in other human cell lines. Biochim Biophys Acta 1998;1448:61-9.
    • (1998) Biochim Biophys Acta , vol.1448 , pp. 61-69
    • Hultberg, B.1    Andersson, A.2    Isaksson, A.3


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