Antinociceptive properties of coumarins, steroid and dihydrostyryl-2- pyrones from Polygala sabulosa (Polygalaceae) in mice

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 1, 2006, Pages 107-112

  Meotti, Flavia Carla ^a,c   Ardenghi, Juliana V ^b   Pretto, Juliana B ^b   Souza, Márcia M ^b   D'Ávila Moura, Janaína ^c   Cunha Jr , Anildo ^c   Soldi, Cristian ^c   Pizzolatti, Moacir Geraldo ^c   Santos, Adair R S ^c  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

7 PRENYLOXY 6 METHOXYCOUMARIN; ACETIC ACID; ACETIC ACID ETHYL ESTER; ACETYLSALICYLIC ACID; ACETYLSCOPOLETIN; ALCOHOL; ALPHA SPINASTEROL; ANTINOCICEPTIVE AGENT; BENZOYLSCOPOLETIN; BUTANOL; COUMARIN DERIVATIVE; DICHLOROMETHANE; DIHYDROSTYRYL 2 PYRONE DERIVATIVE; PARACETAMOL; PLANT EXTRACT; PYRONE DERIVATIVE; SCOPOLETIN; STEROID; STYRYL 2 PYRONE; UNCLASSIFIED DRUG; WATER;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; DRUG STRUCTURE; INFLAMMATION; MALE; MOUSE; NONHUMAN; POLYGALA SABULOSA; POLYGALACEAE; PROTON NUCLEAR MAGNETIC RESONANCE; VISCERAL PAIN;

ABDOMINAL PAIN; ACETIC ACID; ANALGESICS; ANIMALS; COUMARINS; MALE; MICE; PAIN MEASUREMENT; PLANT EXTRACTS; POLYGALA; PYRONES; STIGMASTEROL;

EID: 29944445826     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.1.0013     Document Type: Article

References (35)

1. Cervero, F., Laird, J. M. A. (2003) Role of ions channels in mechanisms controlling gastrointestinal pain pathways. Curr. Opin. Pharmacol. 3: 608-612
2. Collier, H. O. J., Dinneen, J. C., Johnson, C. A., Schneider, C. (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. Chemother. 32: 295-310
3. Cristiano, R., Pizzolatti, M. G., Delle Monache, F., Rezende, C. M., Branco, A. (2003) Two xanthones from Polygala paniculata and confirmation of the 1-hydroxy-2,3,5-trimethoxy-xanthone at trace level by HRGC-MS. Z. Naturforsch. 58: 490-494
4. Cyong, J. C., Ki, S. M., Iijima, K., Kobayashi, T., Furuya, M. (2000) Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine. Am. J. Chin. Med. 28: 351-360
5. De Campos, R. O. P., Santos, A. R. S., Vaz, Z. R., Pinheiro, T. R., Pizzolatti, M. G., Cechinel, V., Delle Monache, F., Yunes, R. A., Calixto, J. B. (1997) Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias (Polygalaceae). Life Sci. 61: 1619-1624
6. Feng, Y., Cui, M., Willis, W. (2003) Gabapentin markedly reduces acetic acid-induced visceral nociception. Anesthesiology 98: 729-733
7. Ikeda, Y., Ueno, A., Naraba, H., Oh-ishi, S. (2001) Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. Life Sci. 69: 2911-2919
8. Kako, M., Miura, T., Nishiyama, Y., Ichimaru, M., Moriyasu, M., Kato, A. (1996) Hypoglycemic effect of the rhizomes of Polygala senega in normal and diabetic mice and its main component, the triterpenoid glycoside senegin-II. Planta Med. 62: 440-443
9. Kim, H., Jang, S. I., Kim, Y., Chung, H., Yun, Y., Kang, T., Jeong, O., Kim, Y. (2004) Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 246.7 cells. Fitoterapia 75: 261-266
10. 2A receptor stimulation in mice. Biol. Pharm. Bull. 27: 906-909
11. Mak, N. K., Lung, H. L., Wong, R. N., Leung, H. W., Tsang, H. Y., Leung, K. N. (2001) Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells. Planta Med. 67: 400-405
12. Mata, R., Rojas, A., Acevedo, L., Estrada, S., Calzada, F., Rojas, I., Bye, R., Linares, E. (1997) Smooth muscle relaxing flavonoids and terpenoids from Conyza filaginoides. Planta Med. 63: 31-35
13. Muschietti, L., Gorzalczany, S., Ferraro, G., Acevedo, C., Martino, V. (2001) Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium. Planta Med. 67: 743-744
14. Ng, T. B., Liu, F., Lu, Y., Cheng, C. H., Wang, Z. (2003) Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 136: 109-115
15. Pinheiro, T. R., Cechinel, F. V., Santos, A. R. S., Calixto, J. B., Delle Monache, F., Pizzolatti, M. G., Yunes, R. A. (1998) Three xanthones from Polygala cyparissias. Phytochemistry 48: 725-728
16. Pizzolatti, M. G., Luciano, C., Delle Monache, F. (2000) Styryl- and dihydrostyryl-2-pyrones derivatives from Polygala sabulosa. Phytochemistry 55: 819-822
17. Pizzolatti, M. G., Koga, A. H., Grisard, E. C., Steindel, M. (2003) Trypanocidal activity of extracts from Brazilian Atlantic Rain Forest plant species. Phytomedicine 10: 422-426
18. Pizzolatti, M. G., Cunha, Jr. A, Pereira, W. S., Delle Monache, F. (2004) A new styryl-2-pyrone derivative from Polygala sabulosa. Biochem. Syst. Ecol. 32: 603-606
19. Prado, W. A. (2001) Involvement of calcium in pain and antinociception. Braz. J. Med. Biol. Res. 34: 449-461
20. Reichert, J. A., Daughters, R. S., Rivard, R., Simone, D. A. (2001) Peripheral and preemptive opioid antinociception in a mouse visceral pain model. Pain 89: 221-227
21. Ribeiro, R. A., Vale, M. L., Thomazzi, S. M., Paschoalato, A. B. P., Poole, S., Ferreira, S. H., Cunha, F. Q. (2000) Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. Pharmacol. 387: 111-118.
22. Santos, A. R. S., Niero, R., Filho, V. C., Yunes, R. A., Pizzolatti, M. G., Delle Monache, F., Calixto, J. B. (1995) Antinociceptive properties of steroids isolated from Phyllanthus corcovadensis in mice. Planta Med. 61: 329-332
23. Santos, A. R. S., Vedana, E. M., De Freitas, G. A. (1998) Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. Inflamm. Res. 47: 302-307
24. Silván, A. M., Abad, M. J., Bermejo, P., Sollhuber, M., Villar, A. (1996) Antiinflammatory activity of coumarins from Santolina oblongifolia. J. Nat. Prod. 59: 1183-1185
25. Somlyo, A. P., Somlyo, A. V. (1994) Signal transduction and regulation in smooth muscle. Nature 372: 231-236
26. Tanaka, S., Ikeshiro, Y., Tabata, M., Konoshima, M. (1977) Antinociceptive substances from the roots of Angelica acutiloba. Arzneimittelforschung 27: 2039-2045
27. Vaz, Z. R., Cechinel, V., Yunes, R. A., Calixto, J. B. (1996) Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice. J. Phamacol. Exp. Ther. 278: 304-312
28. Villasenor, I. M., Domingo, A. P. (2000) Anticarcinogenicity potential of spinasterol isolated from squash flowers. Teratog. Carcinog. Mutagen. 20: 99-105
29. Villasenor, I. M., Lemon, P., Palileo, A., Bremner, J. B. (1996) Antigenotoxic spinasterol from Cucurbita maxima flowers. Mutat. Res. 360: 89-93
30. Vineger, R., Truax, J. F., Selph, J. L., Johnston, P. R. (1979) Antagonism of pain and hyperalgesia. Anti-inflammatory drugs. In: Vane, J. R., Ferreira, S. H. (eds) Handbook of experimental pharmacology. Vol. 50/II, Springer Verlag, Berlin, pp 208-222
31. Ward, D. T. (2004) Calcium receptor-mediated intracellular signalling. Cell Calcium 35: 217-228
32. Wasicky, R. (1945) Anais da Faculdade de Farmácia e Odontologia da Universidade de São Paulo, vol. 4, São Paulo, p. 179
33. Wurdack, J. J., Smith, L. B. (1971) Flora ilustrada catarinese: Polygalaceae. Itajai, SC, Brazil, p. 28.
34. Zhang, D., Miyase, T., Kuroyanagi, M., Umehara, K., Noguchi, H. (1998) Polygala saponins from roots of Polygala glomerata. Phytochemistry 47: 459-466
35. Zimmermann, M. (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110