QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT)

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 4, 2012, Pages 1388-1395

  Mavel, Sylvie ^a,b   Mincheva, Zoya ^a   Méheux, Nathalie ^a   Carcenac, Yvan ^a   Guilloteau, Denis ^a,b   Abarbri, Mohamed ^a   Emond, Patrick ^a,b  

^a UNIVERSITÉ DE TOURS   (France)

^b CHU BRETONNEAU   (France)

Author keywords

3D QSAR; Dopamine transporter; Iodine; Tropane

Indexed keywords

4 CHLORO 1,1,1 TRIFLUORO 2 IODOBUT 2 EN 1 OL; 4 CHLORO 1,1,1 TRIFLUORO 2 IODOBUT 2 ENE; 4 CHLORO 1,1,1 TRIFLUORO 3 IODOBUT 2 ENE; 4,4,4 TRIFLUORO 2 (TRIBUTYLSTANNYL)BUT 2 EN 1 OL; 4,4,4 TRIFLUORO 2 IODOBUT 2 EN 1 OL; 4,4,4 TRIFLUORO 3 IODOBUT 2 EN 1 OL; COCAINE; DOPAMINE TRANSPORTER; FLUORINE; IODINE; LIGAND; METHYL 3 (4 TOLYL) 2 (4,4,4 TRIFLUORO 2 IODOBUT 2 ENYL) 8 AZABICYCLO[3.2.1]OCTANE 2BETA CARBOXYLIC ACID METHYL ESTER; METHYL 3 (4 TOLYL) 2 (4,4,4 TRIFLUORO 3 IODOBUT 2 ENYL) 8 AZABICYCLO[3.2.1]OCTANE 2BETA CARBOXYLIC ACID METHYL ESTER; PHENYLTROPANE DERIVATIVE; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; LIGANDS; MODELS, MOLECULAR; PHENOLS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 84857035385     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.014     Document Type: Article

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