Synthesis and ligand binding of nortropane derivatives: N-substituted 2β-carbomethoxy-3β-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)- 2β-carbomethoxy-3β-(3',4'-disubstituted phenyl)nortropane. New high- affinity and selective compounds for the dopamine transporter

Journal of Medicinal Chemistry

Volumn 40, Issue 9, 1997, Pages 1366-1372

  Emond, Patrick ^a   Garreau, Lucette ^a   Chalon, Sylvie ^a   Boazi, Miriam ^a   Caillet, Mireille ^a   Bricard, Jacques ^a   Frangin, Yves ^a   Mauclaire, Laurent ^a,b   Besnard, Jean Claude ^a   Guilloteau, Denis ^a  

^a INSERM   (France)

^b CIS Bio International   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2BETA CARBOMETHOXY 3BETA (4' IODOPHENYL)NORTROPANE; NORTROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DOPAMINE BRAIN LEVEL; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; NORADRENALIN BRAIN LEVEL; PARKINSON DISEASE; RAT; SEROTONIN BRAIN LEVEL;

ANIMALS; BRAIN; CARRIER PROTEINS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUOXETINE; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; NORTROPANES; PAROXETINE; PIPERAZINES; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SYMPORTERS;

EID: 14444270841     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960795d     Document Type: Article

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