Crystal structure of NAD +-dependent Peptoniphilus asaccharolyticus glutamate dehydrogenase reveals determinants of cofactor specificity

Journal of Structural Biology

Volumn 177, Issue 2, 2012, Pages 543-552

  Oliveira, Tânia ^a,e   Panjikar, Santosh ^b   Carrigan, John B ^c   Hamza, Muaawia ^d   Sharkey, Michael A ^d   Engel, Paul C ^d   Khan, Amir R ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b AUSTRALIAN SYNCHROTRON   (Australia)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Catalysis; Cofactor; Enzyme structure; Glutamate dehydrogenase; Nicotinamide adenine dinucleotide; Peptoniphilus asaccharolyticus; X ray crystallography

Indexed keywords

GLUTAMATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NUCLEOTIDE; SELENOMETHIONINE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM; BINDING SITE; CRYSTAL STRUCTURE; DIFFRACTION; ENZYME SPECIFICITY; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MUTAGENESIS; NONHUMAN; PEPTONIPHILUS ASACCHAROLYTICUS; PRIORITY JOURNAL; PROTEIN BINDING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; APOENZYMES; BACTERIAL PROTEINS; BINDING SITES; CALORIMETRY; CLOSTRIDIUM; CRYSTALLOGRAPHY, X-RAY; GLUTAMATE DEHYDROGENASE; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAD; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); MAMMALIA; PEPTONIPHILUS ASACCHAROLYTICUS;

EID: 84857033532     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2011.10.006     Document Type: Article

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