-
1
-
-
0038708118
-
Age-related macular degeneration: Etiology, pathogenesis, and therapeutic strategies
-
Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol. 2003;48:257-293.
-
(2003)
Surv Ophthalmol
, vol.48
, pp. 257-293
-
-
Ambati, J.1
Ambati, B.K.2
Yoo, S.H.3
Ianchulev, S.4
Adamis, A.P.5
-
2
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature. 2005;438:967-974.
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
3
-
-
0029758823
-
Basic fibro-blast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes
-
Frank RN, Amin RH, Eliott D, Puklin JE, Abrams GW. Basic fibro-blast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes. Am J Ophthalmol. 1996;122:393-403.
-
(1996)
Am J Ophthalmol
, vol.122
, pp. 393-403
-
-
Frank, R.N.1
Amin, R.H.2
Eliott, D.3
Puklin, J.E.4
Abrams, G.W.5
-
4
-
-
33749445317
-
Ranibizumab for neovas-cular age-related macular degeneration
-
Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovas-cular age-related macular degeneration. N Engl J Med. 2006;355: 1419-1431.
-
(2006)
N Engl J Med
, vol.355
, pp. 1419-1431
-
-
Rosenfeld, P.J.1
Brown, D.M.2
Heier, J.S.3
-
5
-
-
33749451356
-
Ranibizumab versus verte-porfin for neovascular age-related macular degeneration
-
Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verte-porfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432-1444.
-
(2006)
N Engl J Med
, vol.355
, pp. 1432-1444
-
-
Brown, D.M.1
Kaiser, P.K.2
Michels, M.3
-
6
-
-
68949120732
-
Results of one-yeaŕs treatment with ranibizumab for exudative age-related macular degeneration in a clinical setting
-
Cohen SY, Dubois L, Tadayoni R, et al. Results of one-yeaŕs treatment with ranibizumab for exudative age-related macular degeneration in a clinical setting. Am J Ophthalmol. 2009;148:409-413.
-
(2009)
Am J Ophthalmol
, vol.148
, pp. 409-413
-
-
Cohen, S.Y.1
Dubois, L.2
Tadayoni, R.3
-
7
-
-
75149116508
-
Intravitreal bevacizumab and ranibizumab for age-related macular degeneration: A multicenter, retrospective study
-
Fong DS, Custis P, Howes J, Hsu JW. Intravitreal bevacizumab and ranibizumab for age-related macular degeneration: a multicenter, retrospective study. Ophthalmology. 2010;117:298-302.
-
(2010)
Ophthalmology
, vol.117
, pp. 298-302
-
-
Fong, D.S.1
Custis, P.2
Howes, J.3
Hsu, J.W.4
-
8
-
-
0038748037
-
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model
-
Reich SJ, Fosnot J, Kuroki A, et al. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis. 2003;9:210-216.
-
(2003)
Mol Vis
, vol.9
, pp. 210-216
-
-
Reich, S.J.1
Fosnot, J.2
Kuroki, A.3
-
9
-
-
31444440290
-
Suppression of ocular neovascu-larization with siRNA targeting VEGF receptor 1
-
Shen J, Samul R, Silva RL, et al. Suppression of ocular neovascu-larization with siRNA targeting VEGF receptor 1. Gene Ther. 2006; 13:225-234.
-
(2006)
Gene Ther
, vol.13
, pp. 225-234
-
-
Shen, J.1
Samul, R.2
Silva, R.L.3
-
11
-
-
4344651353
-
Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
-
Chiu YL, Ali A, Chu CY, Cao H, Rana TM. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol. 2004;11:1165-1175.
-
(2004)
Chem Biol
, vol.11
, pp. 1165-1175
-
-
Chiu, Y.L.1
Ali, A.2
Chu, C.Y.3
Cao, H.4
Rana, T.M.5
-
12
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E, Zhu P, Lee SK, et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005;23:709-717.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
-
13
-
-
33746608192
-
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
-
Saleh MC, van Rij RP, Hekele A, et al. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol. 2006;8:793-802.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 793-802
-
-
Saleh, M.C.1
van Rij, R.P.2
Hekele, A.3
-
14
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol. 2003;21:635-637.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
-
15
-
-
20144389695
-
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
Hornung V, Guenthner-Biller M, Bourquin C, et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005;11: 263-270.
-
(2005)
Nat Med
, vol.11
, pp. 263-270
-
-
Hornung, V.1
Guenthner-Biller, M.2
Bourquin, C.3
-
16
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol. 2005;23:457-462.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
Maclachlan, I.6
-
17
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol. 2003;5:834-839
-
(2003)
Nat Cell Biol
, vol.5
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
de Veer, M.J.3
Silverman, R.H.4
Williams, B.R.5
-
18
-
-
41649115210
-
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
-
Kleinman ME, Yamada K, Takeda A, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008;452:591-597.
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
Yamada, K.2
Takeda, A.3
-
19
-
-
54949095836
-
Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
-
Robbins M, Judge A, Ambegia E, et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum Gene Ther. 2008;19:991-999
-
(2008)
Hum Gene Ther
, vol.19
, pp. 991-999
-
-
Robbins, M.1
Judge, A.2
Ambegia, E.3
-
20
-
-
66349125020
-
Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth
-
Cho WG, Albuquerque RJ, Kleinman ME, et al. Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth. Proc Natl Acad Sci USA. 2009;106:7137-7142.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 7137-7142
-
-
Cho, W.G.1
Albuquerque, R.J.2
Kleinman, M.E.3
-
21
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kB by Toll-like receptor 3
-
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kB by Toll-like receptor 3. Nature. 2001;413:732-738.
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
22
-
-
23044445303
-
Crystal structure of human Toll-like receptor 3 (TLR3) ectodomain
-
Choe J, Kelker MS, Wilson IA Crystal structure of human Toll-like receptor 3 (TLR3) ectodomain. Science. 2005;309:581-585.
-
(2005)
Science
, vol.309
, pp. 581-585
-
-
Choe, J.1
Kelker, M.S.2
Wilson, I.A.3
-
23
-
-
34147116078
-
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain
-
Ranjith-Kumar CT, Miller W, Xiong J, et al. Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. J Biol Chem. 2007;282:7668-7678.
-
(2007)
J Biol Chem
, vol.282
, pp. 7668-7678
-
-
Ranjith-Kumar, C.T.1
Miller, W.2
Xiong, J.3
-
24
-
-
34249332076
-
C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission
-
Takada E, Okahira S, Sasai M, Funami K, Seya T, Matsumoto M. C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission. Mol Immunol. 2007;44: 3633-3640.
-
(2007)
Mol Immunol
, vol.44
, pp. 3633-3640
-
-
Takada, E.1
Okahira, S.2
Sasai, M.3
Funami, K.4
Seya, T.5
Matsumoto, M.6
-
25
-
-
38349115933
-
The TLR3 signaling complex forms by cooperative receptor dimerization
-
Leonard JN, Ghirlando R, Askins J, et al. The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A. 2008;105:258-263.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 258-263
-
-
Leonard, J.N.1
Ghirlando, R.2
Askins, J.3
-
26
-
-
7544225495
-
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
-
Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol. 2004;11:1060-1067.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 1060-1067
-
-
Sarkar, S.N.1
Peters, K.L.2
Elco, C.P.3
Sakamoto, S.4
Pal, S.5
Sen, G.C.6
-
27
-
-
2442605662
-
Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kB activation and apoptosis pathways
-
Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kB activation and apoptosis pathways. J Biol Chem. 2004;279:15652-15661.
-
(2004)
J Biol Chem
, vol.279
, pp. 15652-15661
-
-
Han, K.J.1
Su, X.2
Xu, L.G.3
Bin, L.H.4
Zhang, J.5
Shu, H.B.6
-
28
-
-
17144413785
-
Apoptosis induced by the Toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
-
Kaiser WJ, Offermann MK. Apoptosis induced by the Toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif.JImmunol. 2005;174:4942-4952.
-
(2005)
JImmunol
, vol.174
, pp. 4942-4952
-
-
Kaiser, W.J.1
Offermann, M.K.2
-
29
-
-
33645755382
-
TLR3 can directly trigger apoptosis in human cancer cells
-
Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T. TLR3 can directly trigger apoptosis in human cancer cells.JImmunol. 2006; 176:4894-4901.
-
(2006)
JImmunol
, vol.176
, pp. 4894-4901
-
-
Salaun, B.1
Coste, I.2
Rissoan, M.C.3
Lebecque, S.J.4
Renno, T.5
-
30
-
-
54849148000
-
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
-
Yang Z, Stratton C, Francis PJ, et al. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008;359:1456-1463.
-
(2008)
N Engl J Med
, vol.359
, pp. 1456-1463
-
-
Yang, Z.1
Stratton, C.2
Francis, P.J.3
-
31
-
-
0034652459
-
Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12
-
Duda DG, Sunamura M, Lozonschi L, et al. Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12. Cancer Res. 2000;60:1111-1116.
-
(2000)
Cancer Res
, vol.60
, pp. 1111-1116
-
-
Duda, D.G.1
Sunamura, M.2
Lozonschi, L.3
-
32
-
-
0035915810
-
Interleukin 12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer
-
Oshikawa K, Rakhmilevich AL, Shi F, Sondel PM, Yang N, Mahvi DM. Interleukin 12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer. Hum Gene Ther. 2001;12:149-160.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 149-160
-
-
Oshikawa, K.1
Rakhmilevich, A.L.2
Shi, F.3
Sondel, P.M.4
Yang, N.5
Mahvi, D.M.6
-
33
-
-
33645731313
-
Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis
-
Battle TE, Lynch RA, Frank DA. Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res. 2006;66:3649-3657.
-
(2006)
Cancer Res
, vol.66
, pp. 3649-3657
-
-
Battle, T.E.1
Lynch, R.A.2
Frank, D.A.3
-
34
-
-
33646188259
-
3' UTR seed matches, but not overall identity, are associated with RNAi off-targets
-
Birmingham A, Anderson EM, Reynolds A, et al. 3' UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Methods. 2006;3:199-204.
-
(2006)
Nat Methods
, vol.3
, pp. 199-204
-
-
Birmingham, A.1
Anderson, E.M.2
Reynolds, A.3
-
35
-
-
33144488589
-
Drusen complement components C3a and C5a promote choroidal neovascularization
-
Nozaki M, Raisler BJ, Sakurai E, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci USA. 2006;103:2328-2333.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 2328-2333
-
-
Nozaki, M.1
Raisler, B.J.2
Sakurai, E.3
-
36
-
-
0042844768
-
Macrophage depletion inhibits experimental choroidal neovascularization
-
Sakurai E, Anand A, Ambati BK, van Rooijen N, Ambati J. Macrophage depletion inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:3578-3585.
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, pp. 3578-3585
-
-
Sakurai, E.1
Anand, A.2
Ambati, B.K.3
van Rooijen, N.4
Ambati, J.5
-
37
-
-
32444431828
-
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A
-
Nozaki M, Sakurai E, Raisler BJ, et al. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J Clin Invest. 2006;116:422-429.
-
(2006)
J Clin Invest
, vol.116
, pp. 422-429
-
-
Nozaki, M.1
Sakurai, E.2
Raisler, B.J.3
-
38
-
-
38549129761
-
Upregulation of VEGF in murine retina via monocyte recruitment after retinal scatter laser photocoagulation
-
Itaya M, Sakurai E, Nozaki M, et al. Upregulation of VEGF in murine retina via monocyte recruitment after retinal scatter laser photocoagulation. Invest Ophthalmol Vis Sci. 2007;48:5677-5683.
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, pp. 5677-5683
-
-
Itaya, M.1
Sakurai, E.2
Nozaki, M.3
-
39
-
-
0030994732
-
Expression of vascular endothelial growth factor in experimental choroidal neovascularization
-
Ishibashi T, Hata Y, Yoshikawa H, Nakagawa K, Sueishi K, Inomata H. Expression of vascular endothelial growth factor in experimental choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol. 1997;235:159-167.
-
(1997)
Graefes Arch Clin Exp Ophthalmol
, vol.235
, pp. 159-167
-
-
Ishibashi, T.1
Hata, Y.2
Yoshikawa, H.3
Nakagawa, K.4
Sueishi, K.5
Inomata, H.6
-
40
-
-
0033771172
-
Choroidal neovascularization in the rat induced by adenovirus mediated expression of vascular endothelial growth factor
-
Baffi J, Byrnes G, Chan CC, Csaky KG. Choroidal neovascularization in the rat induced by adenovirus mediated expression of vascular endothelial growth factor. Invest Ophthalmol Vis Sci. 2000;41:3582-3589.
-
(2000)
Invest Ophthalmol Vis Sci
, vol.41
, pp. 3582-3589
-
-
Baffi, J.1
Byrnes, G.2
Chan, C.C.3
Csaky, K.G.4
-
41
-
-
0036129304
-
Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
-
Krzystolik MG, Afshari MA, Adamis AP, et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 2002;120:338-346.
-
(2002)
Arch Ophthalmol
, vol.120
, pp. 338-346
-
-
Krzystolik, M.G.1
Afshari, M.A.2
Adamis, A.P.3
-
42
-
-
11144239923
-
Pegaptanib for neovascular age-related macular degeneration
-
Gragoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR. Pegaptanib for neovascular age-related macular degeneration. NEnglJMed. 2004;351:2805-2816.
-
(2004)
NEnglJMed
, vol.351
, pp. 2805-2816
-
-
Gragoudas, E.S.1
Adamis, A.P.2
Cunningham Jr., E.T.3
Feinsod, M.4
Guyer, D.R.5
-
43
-
-
1242297011
-
Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization
-
Tolentino MJ, Brucker AJ, Fosnot J, et al. Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization. Retina. 2004;24:132-138.
-
(2004)
Retina
, vol.24
, pp. 132-138
-
-
Tolentino, M.J.1
Brucker, A.J.2
Fosnot, J.3
-
44
-
-
48949119355
-
Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium
-
Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008;294: L1068-L1075
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
-
-
Koff, J.L.1
Shao, M.X.2
Ueki, I.F.3
Nadel, J.A.4
-
45
-
-
58749111615
-
Role of viral induced vascular endothelial growth factor (VEGF) production in pleural effusion and malignant mesothelioma
-
Wornle M, Sauter M, Kastenmuller K, et al. Role of viral induced vascular endothelial growth factor (VEGF) production in pleural effusion and malignant mesothelioma. Cell Biol Int. 2009;33:180-186.
-
(2009)
Cell Biol Int
, vol.33
, pp. 180-186
-
-
Wornle, M.1
Sauter, M.2
Kastenmuller, K.3
-
46
-
-
0041343279
-
An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
-
Pinhal-Enfield G, Ramanathan M, Hasko G, et al. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol. 2003;163:711-721.
-
(2003)
Am J Pathol
, vol.163
, pp. 711-721
-
-
Pinhal-Enfield, G.1
Ramanathan, M.2
Hasko, G.3
-
47
-
-
22844437401
-
Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: Submacular surgery trials report no. 7
-
Grossniklaus HE, Miskala PH, Green WR, et al. Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7. Arch Ophthalmol. 2005;123:914-921.
-
(2005)
Arch Ophthalmol
, vol.123
, pp. 914-921
-
-
Grossniklaus, H.E.1
Miskala, P.H.2
Green, W.R.3
-
48
-
-
69549084457
-
Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells
-
Nakada E, Walley KR, Nakada T, Hu Y, von Dadelszen P, Boyd JH. Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells. Placenta. 2009;30:774-779
-
(2009)
Placenta
, vol.30
, pp. 774-779
-
-
Nakada, E.1
Walley, K.R.2
Nakada, T.3
Hu, Y.4
von Dadelszen, P.5
Boyd, J.H.6
-
49
-
-
33750430869
-
Corneal avascularity is due to soluble VEGF receptor-1
-
Ambati BK, Nozaki M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993-997.
-
(2006)
Nature
, vol.443
, pp. 993-997
-
-
Ambati, B.K.1
Nozaki, M.2
Singh, N.3
|