Bacterial and viral sialidases: Contribution of the conserved active site glutamate to catalysis

Biochemistry

Volumn 51, Issue 1, 2012, Pages 433-441

  Chan, Jefferson ^a   Watson, Jacqueline N ^a,b   Lu, April ^a   Cerda, Viviana C ^a   Borgford, Thor J ^a,c   Bennet, Andrew J ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b 76 North Star Dr   (Canada)

^c DOUGLAS COLLEGE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION FREE ENERGY; ACTIVE SITE; ASPARTATES; ASPARTIC ACIDS; CATALYTIC ACCELERATION; CATALYTIC CYCLES; CONSERVED RESIDUES; CYSTEINE RESIDUES; DEGLYCOSYLATION; GLUTAMIC ACID; KINETIC STUDY; MECHANISM OF ACTION; MUTANT ENZYMES; NATURAL SUBSTRATES; RATE LIMITING; SIALIDASES; SOLVENT KINETIC ISOTOPE EFFECTS;

AMINO ACIDS; HYDROLYSIS; ISOTOPES;

CATALYSIS;

ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; SIALIDASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROLYSIS; INFLUENZA VIRUS; MICROMONOSPORA; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

BACULOVIRIDAE; CATALYSIS; CATALYTIC DOMAIN; CLOSTRIDIUM PERFRINGENS; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; GLUTAMIC ACID; HUMANS; INFLUENZA A VIRUS; MICROMONOSPORA; MUTAGENESIS, SITE-DIRECTED; NEURAMINIDASE; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); MICROMONOSPORA VIRIDIFACIENS;

EID: 84856943451     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201019n     Document Type: Article

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