Elucidation of the role of functional amino acid residues of the small sialidase from Clostridium perfringens by site-directed mutagenesis

Biological Chemistry

Volumn 382, Issue 2, 2001, Pages 313-319

  Kleineidam, R G ^a   Kruse, S ^a   Roggentin, P ^a   Schauer, R ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Clostridium perfringens; Enzyme catalysis; Sialidase; Site directed mutagenesis; Variants

Indexed keywords

AMINO ACID; ANTIINFECTIVE AGENT; ARGININE DERIVATIVE; ASPARTIC ACID DERIVATIVE; BACTERIAL DNA; BACTERIAL ENZYME; DOUBLE STRANDED DNA; GLUTAMIC ACID DERIVATIVE; GLYCOCONJUGATE; GLYCOLIPID; GLYCOPROTEIN; HYDROXYL GROUP; N ACETYLNEURAMINIC ACID DERIVATIVE; OLIGOSACCHARIDE; OXYGENASE; PHENYLALANINE; RECOMBINANT ENZYME; SIALIC ACID DERIVATIVE; SIALIDASE; THREONINE; TYROSINE DERIVATIVE; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL VIRULENCE; BINDING AFFINITY; CATALYSIS; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME PURIFICATION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTON TRANSPORT; SALMONELLA TYPHIMURIUM; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; X RAY ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CLOSTRIDIUM PERFRINGENS; CONSERVED SEQUENCE; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURAMINIDASE;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM PERFRINGENS; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0035077586     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.038     Document Type: Article

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