Myeloid takl acts as a negative regulator of the LPS response and mediates resistance to endotoxemia

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Eftychi, Christina ^a   Karagianni, Niki ^a,b   Alexiou, Maria ^a,c   Apostolaki, Maria ^a   Kollias, George ^a  

^a BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

^b Biomedcode Hellas SA   (Greece)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD16 ANTIGEN; CD34 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 7; STEM CELL FACTOR RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CYTOKINE; MAP KINASE KINASE KINASE 7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; ENZYME ACTIVATION; GRANULOCYTE; INNATE IMMUNITY; MONOCYTE; NEUTROPHIL; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; SURVIVAL; TRANSCRIPTION REGULATION; ANIMAL; BLOOD; DRUG ANTAGONISM; IMMUNOLOGY; MACROPHAGE; MOUSE; MOUSE MUTANT;

MUS;

ANIMALS; CYTOKINES; ENDOTOXEMIA; IMMUNITY, INNATE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE KINASES; MICE; MICE, KNOCKOUT; NEUTROPHILS; NF-KAPPA B;

EID: 84856927634     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031550     Document Type: Article

References (27)

1. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, et al. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270: 2008-2011.
2. Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, et al. (2010) TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 17: 481-496.
3. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, et al. (2010) Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A 107: 844-849.
4. Jadrich JL, O'Connor MB, Coucouvanis E, (2006) The TGF beta activated kinase TAK1 regulates vascular development in vivo. Development 133: 1529-1541.
5. Kajino-Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, et al. (2008) Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol 181: 1143-1152.
6. Liu HH, Xie M, Schneider MD, Chen ZJ, (2006) Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A 103: 11677-11682.
7. Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, et al. (2006) TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem 281: 19610-19617.
8. Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, et al. (2005) Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 6: 1087-1095.
9. Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, et al. (2006) TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol 18: 1405-1411.
10. Sayama K, Hanakawa Y, Nagai H, Shirakata Y, Dai X, et al. (2006) Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis. J Biol Chem 281: 22013-22020.
11. Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19: 2668-2681.
12. Tang M, Wei X, Guo Y, Breslin P, Zhang S, et al. (2008) TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med 205: 1611-1619.
13. Wan YY, Chi H, Xie M, Schneider MD, Flavell RA, (2006) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 7: 851-858.
14. Vidal S, Khush RS, Leulier F, Tzou P, Nakamura M, et al. (2001) Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev 15: 1900-1912.
15. Courties G, Seiffart V, Presumey J, Escriou V, Scherman D, et al. (2010) In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells. Blood.
16. Medzhitov R, Janeway C Jr, (2000) Innate immune recognition: mechanisms and pathways. Immunol Rev 173: 89-97.
17. Beutler B, Rietschel ET, (2003) Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 3: 169-176.
18. Dinarello CA, (1997) Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 112: 321S-329S.
19. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, et al. (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93: 5860-5865.
20. Clausen BE, Burkhardt C, Reith W, Renkawitz R, Forster I, (1999) Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8: 265-277.
21. Akashi K, Traver D, Miyamoto T, Weissman IL, (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197.
22. Ye M, Iwasaki H, Laiosa CV, Stadtfeld M, Xie H, et al. (2003) Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19: 689-699.
23. Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, et al. (2007) NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130: 918-931.
24. Sarkar S, Han J, Sinsimer KS, Liao B, Foster RL, et al. (2011) RNA-binding protein AUF1 regulates lipopolysaccharide-induced IL10 expression by activating IkappaB kinase complex in monocytes. Mol Cell Biol 31: 602-615.
25. Kontgen F, Stewart CL, (1993) Simple screening procedure to detect gene targeting events in embryonic stem cells. Methods Enzymol 225: 878-890.
26. Farley FW, Soriano P, Steffen LS, Dymecki SM, (2000) Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28: 106-110.
27. Tzima S, Victoratos P, Kranidioti K, Alexiou M, Kollias G, (2009) Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206: 1167-1179.