-
1
-
-
77950948813
-
Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy
-
Abdollahi A, Folkman J. Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy. Drug Resist Updat 13: 16-28, 2010.
-
(2010)
Drug Resist Updat
, vol.13
, pp. 16-28
-
-
Abdollahi, A.1
Folkman, J.2
-
2
-
-
77952773418
-
VHL and HIF signalling in renal cell carcinogenesis
-
Baldewijns MM, van Vlodrop IJ, Vermeulen PB, Soetekouw PM, van Engeland M, de Bruine AP. VHL and HIF signalling in renal cell carcinogenesis. J Pathol 221: 125-138, 2010.
-
(2010)
J Pathol
, vol.221
, pp. 125-138
-
-
Baldewijns, M.M.1
van Vlodrop, I.J.2
Vermeulen, P.B.3
Soetekouw, P.M.4
van Engeland, M.5
de Bruine, A.P.6
-
3
-
-
58149354867
-
Quo vadis with targeted drugs in the 21st century?
-
Bergh J. Quo vadis with targeted drugs in the 21st century? J Clin Oncol 27: 2-5, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2-5
-
-
Bergh, J.1
-
4
-
-
79956328903
-
Molecular mechanisms and clinical applications of angiogenesis
-
Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 473: 298-307, 2011.
-
(2011)
Nature
, vol.473
, pp. 298-307
-
-
Carmeliet, P.1
Jain, R.K.2
-
5
-
-
48649098245
-
von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
-
discussion 865-866
-
Choueiri TK, Vaziri SA, Jaeger E, Elson P, Wood L, Bhalla IP, Small EJ, Weinberg V, Sein N, Simko J, Golshayan AR, Sercia L, Zhou M, Waldman FM, Rini BI, Bukowski RM, Ganapathi R. von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 180: 860-865, 2008, discussion 865-866.
-
(2008)
J Urol
, vol.180
, pp. 860-865
-
-
Choueiri, T.K.1
Vaziri, S.A.2
Jaeger, E.3
Elson, P.4
Wood, L.5
Bhalla, I.P.6
Small, E.J.7
Weinberg, V.8
Sein, N.9
Simko, J.10
Golshayan, A.R.11
Sercia, L.12
Zhou, M.13
Waldman, F.M.14
Rini, B.I.15
Bukowski, R.M.16
Ganapathi, R.17
-
6
-
-
33947504730
-
Sunitinib: from rational design to clinical efficacy
-
Chow LQ, Eckhardt SG. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 25: 884-896, 2007.
-
(2007)
J Clin Oncol
, vol.25
, pp. 884-896
-
-
Chow, L.Q.1
Eckhardt, S.G.2
-
7
-
-
44849093414
-
A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities
-
Christensen JG. A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities. Ann Oncol 18(Suppl. 10): x3-x10, 2007.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 10
-
-
Christensen, J.G.1
-
8
-
-
75449088610
-
FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
-
Cohen MH, Shen YL, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist 14: 1131-1138, 2009.
-
(2009)
Oncologist
, vol.14
, pp. 1131-1138
-
-
Cohen, M.H.1
Shen, Y.L.2
Keegan, P.3
Pazdur, R.4
-
9
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
-
Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368: 1329-1338, 2006.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
McArthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
Desai, J.11
Fletcher, C.D.12
George, S.13
Bello, C.L.14
Huang, X.15
Baum, C.M.16
Casali, P.G.17
-
10
-
-
57849117384
-
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
-
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45: 228-247, 2009.
-
(2009)
Eur J Cancer
, vol.45
, pp. 228-247
-
-
Eisenhauer, E.A.1
Therasse, P.2
Bogaerts, J.3
Schwartz, L.H.4
Sargent, D.5
Ford, R.6
Dancey, J.7
Arbuck, S.8
Gwyther, S.9
Mooney, M.10
Rubinstein, L.11
Shankar, L.12
Dodd, L.13
Kaplan, R.14
Lacombe, D.15
Verweij, J.16
-
11
-
-
47949089077
-
VEGF-targeted therapy: mechanisms of anti-tumour activity
-
Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 8: 579-591, 2008.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
12
-
-
77952300540
-
Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival
-
Escudier B, Bellmunt J, Negrier S, Bajetta E, Melichar B, Bracarda S, Ravaud A, Golding S, Jethwa S, Sneller V. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 28: 2144-2150, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2144-2150
-
-
Escudier, B.1
Bellmunt, J.2
Negrier, S.3
Bajetta, E.4
Melichar, B.5
Bracarda, S.6
Ravaud, A.7
Golding, S.8
Jethwa, S.9
Sneller, V.10
-
13
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, Rolland F, Demkow T, Hutson TE, Gore M, Freeman S, Schwartz B, Shan M, Simantov R, Bukowski RM. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356: 125-134, 2007.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
14
-
-
4143136640
-
Vascular endothelial growth factor: basic science and clinical progress
-
Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25: 581-611, 2004.
-
(2004)
Endocr Rev
, vol.25
, pp. 581-611
-
-
Ferrara, N.1
-
15
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
16
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 27: 4733-4740, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
Mikkelsen, T.4
Schiff, D.5
Abrey, L.E.6
Yung, W.K.7
Paleologos, N.8
Nicholas, M.K.9
Jensen, R.10
Vredenburgh, J.11
Huang, J.12
Zheng, M.13
Cloughesy, T.14
-
17
-
-
77955747734
-
A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression
-
Geretti E, van Meeteren LA, Shimizu A, Dudley AC, Claesson-Welsh L, Klagsbrun M. A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression. Mol Cancer Res 8: 1063-1073, 2010.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 1063-1073
-
-
Geretti, E.1
van Meeteren, L.A.2
Shimizu, A.3
Dudley, A.C.4
Claesson-Welsh, L.5
Klagsbrun, M.6
-
18
-
-
77956123282
-
Cardiovascular safety of VEGF-targeting therapies: current evidence and handling strategies
-
Girardi F, Franceschi E, Brandes AA. Cardiovascular safety of VEGF-targeting therapies: current evidence and handling strategies. Oncologist 15: 683-694, 2010.
-
(2010)
Oncologist
, vol.15
, pp. 683-694
-
-
Girardi, F.1
Franceschi, E.2
Brandes, A.A.3
-
19
-
-
77950688983
-
Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?
-
Gotink KJ, Verheul HM. Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Angiogenesis 13: 1-14, 2010.
-
(2010)
Angiogenesis
, vol.13
, pp. 1-14
-
-
Gotink, K.J.1
Verheul, H.M.2
-
20
-
-
80054808967
-
Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
-
Gu FM, Li QL, Gao Q, Jiang JH, Huang XY, Pan JF, Fan J, Zhou J. Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3. World J Gastroenterol 17: 3922-3932, 2011.
-
(2011)
World J Gastroenterol
, vol.17
, pp. 3922-3932
-
-
Gu, F.M.1
Li, Q.L.2
Gao, Q.3
Jiang, J.H.4
Huang, X.Y.5
Pan, J.F.6
Fan, J.7
Zhou, J.8
-
21
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100: 57-70, 2000.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
22
-
-
54549123309
-
VEGF-A splicing: the key to anti-angiogenic therapeutics?
-
Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 8: 880-887, 2008.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 880-887
-
-
Harper, S.J.1
Bates, D.O.2
-
23
-
-
42949106096
-
A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes
-
Herbert JM, Stekel D, Sanderson S, Heath VL, Bicknell R. A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes. BMC Genomics 9: 153, 2008.
-
(2008)
BMC Genomics
, vol.9
, pp. 153
-
-
Herbert, J.M.1
Stekel, D.2
Sanderson, S.3
Heath, V.L.4
Bicknell, R.5
-
24
-
-
77954035012
-
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial
-
Herbst RS, Sun Y, Eberhardt WE, Germonpre P, Saijo N, Zhou C, Wang J, Li L, Kabbinavar F, Ichinose Y, Qin S, Zhang L, Biesma B, Heymach JV, Langmuir P, Kennedy SJ, Tada H, Johnson BE. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 11: 619-626, 2010.
-
(2010)
Lancet Oncol
, vol.11
, pp. 619-626
-
-
Herbst, R.S.1
Sun, Y.2
Eberhardt, W.E.3
Germonpre, P.4
Saijo, N.5
Zhou, C.6
Wang, J.7
Li, L.8
Kabbinavar, F.9
Ichinose, Y.10
Qin, S.11
Zhang, L.12
Biesma, B.13
Heymach, J.V.14
Langmuir, P.15
Kennedy, S.J.16
Tada, H.17
Johnson, B.E.18
-
25
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 1011-1027, 2005.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
26
-
-
8544249895
-
Tumor-associated endothelial cells with cytogenetic abnormalities
-
Hida K, Hida Y, Amin DN, Flint AF, Panigrahy D, Morton CC, Klagsbrun M. Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 64: 8249-8255, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 8249-8255
-
-
Hida, K.1
Hida, Y.2
Amin, D.N.3
Flint, A.F.4
Panigrahy, D.5
Morton, C.C.6
Klagsbrun, M.7
-
27
-
-
69249149975
-
Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors
-
Hillman GG, Singh-Gupta V, Zhang H, Al-Bashir AK, Katkuri Y, Li M, Yunker CK, Patel AD, Abrams J, Haacke EM. Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors. Neoplasia 11: 910-920, 2009.
-
(2009)
Neoplasia
, vol.11
, pp. 910-920
-
-
Hillman, G.G.1
Singh-Gupta, V.2
Zhang, H.3
Al-Bashir, A.K.4
Katkuri, Y.5
Li, M.6
Yunker, C.K.7
Patel, A.D.8
Abrams, J.9
Haacke, E.M.10
-
28
-
-
80051669505
-
Review: incidence and clinical significance of Bevacizumab-related non-surgical and surgical serious adverse events in metastatic colorectal cancer
-
Hompes D, Ruers T. Review: incidence and clinical significance of Bevacizumab-related non-surgical and surgical serious adverse events in metastatic colorectal cancer. Eur J Surg Oncol 37: 737-746, 2011.
-
(2011)
Eur J Surg Oncol
, vol.37
, pp. 737-746
-
-
Hompes, D.1
Ruers, T.2
-
29
-
-
67649195467
-
Adaptation of skeletal muscle microvasculature to increased or decreased blood flow: role of shear stress, nitric oxide and vascular endothelial growth factor
-
Hudlicka O, Brown MD. Adaptation of skeletal muscle microvasculature to increased or decreased blood flow: role of shear stress, nitric oxide and vascular endothelial growth factor. J Vasc Res 46: 504-512, 2009.
-
(2009)
J Vasc Res
, vol.46
, pp. 504-512
-
-
Hudlicka, O.1
Brown, M.D.2
-
30
-
-
58149337448
-
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
-
Hu-Lowe DD, Zou HY, Grazzini ML, Hallin ME, Wickman GR, Amundson K, Chen JH, Rewolinski DA, Yamazaki S, Wu EY, McTigue MA, Murray BW, Kania RS, O'Connor P, Shalinsky DR, Bender SL. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 14: 7272-7283, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7272-7283
-
-
Hu-Lowe, D.D.1
Zou, H.Y.2
Grazzini, M.L.3
Hallin, M.E.4
Wickman, G.R.5
Amundson, K.6
Chen, J.H.7
Rewolinski, D.A.8
Yamazaki, S.9
Wu, E.Y.10
McTigue, M.A.11
Murray, B.W.12
Kania, R.S.13
O'Connor, P.14
Shalinsky, D.R.15
Bender, S.L.16
-
31
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350: 2335-2342, 2004.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
32
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
-
Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7: 987-989, 2001.
-
(2001)
Nat Med
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
33
-
-
78649537524
-
Biomarkers to predict the clinical efficacy of bevacizumab in cancer
-
Jubb AM, Harris AL. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol 11: 1172-1183, 2010.
-
(2010)
Lancet Oncol
, vol.11
, pp. 1172-1183
-
-
Jubb, A.M.1
Harris, A.L.2
-
34
-
-
34250365240
-
Mechanisms of adverse effects of anti-VEGF therapy for cancer
-
Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer 96: 1788-1795, 2007.
-
(2007)
Br J Cancer
, vol.96
, pp. 1788-1795
-
-
Kamba, T.1
McDonald, D.M.2
-
35
-
-
65549164757
-
Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies
-
Kanthou C, Tozer GM. Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies. Int J Exp Pathol 90: 284-294, 2009.
-
(2009)
Int J Exp Pathol
, vol.90
, pp. 284-294
-
-
Kanthou, C.1
Tozer, G.M.2
-
36
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, O'Callaghan CJ, Tu D, Tebbutt NC, Simes RJ, Chalchal H, Shapiro JD, Robitaille S, Price TJ, Shepherd L, Au HJ, Langer C, Moore MJ, Zalcberg JR. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 359: 1757-1765, 2008.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
O'Callaghan, C.J.4
Tu, D.5
Tebbutt, N.C.6
Simes, R.J.7
Chalchal, H.8
Shapiro, J.D.9
Robitaille, S.10
Price, T.J.11
Shepherd, L.12
Au, H.J.13
Langer, C.14
Moore, M.J.15
Zalcberg, J.R.16
-
37
-
-
0036780251
-
Clinical translation of angiogenesis inhibitors
-
Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2: 727-739, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 727-739
-
-
Kerbel, R.1
Folkman, J.2
-
38
-
-
0035692285
-
Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches
-
Kerbel RS, Yu J, Tran J, Man S, Viloria-Petit A, Klement G, Coomber BL, Rak J. Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches. Cancer Metastasis Rev 20: 79-86, 2001.
-
(2001)
Cancer Metastasis Rev
, vol.20
, pp. 79-86
-
-
Kerbel, R.S.1
Yu, J.2
Tran, J.3
Man, S.4
Viloria-Petit, A.5
Klement, G.6
Coomber, B.L.7
Rak, J.8
-
39
-
-
79952740612
-
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
-
Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, Fack F, Thorsen F, Taxt T, Bartos M, Jirik R, Miletic H, Wang J, Stieber D, Stuhr L, Moen I, Rygh CB, Bjerkvig R, Niclou SP. Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A 108: 3749-3754, 2011.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3749-3754
-
-
Keunen, O.1
Johansson, M.2
Oudin, A.3
Sanzey, M.4
Rahim, S.A.5
Fack, F.6
Thorsen, F.7
Taxt, T.8
Bartos, M.9
Jirik, R.10
Miletic, H.11
Wang, J.12
Stieber, D.13
Stuhr, L.14
Moen, I.15
Rygh, C.B.16
Bjerkvig, R.17
Niclou, S.P.18
-
40
-
-
0027197245
-
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
-
Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362: 841-844, 1993.
-
(1993)
Nature
, vol.362
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
Armanini, M.4
Gillett, N.5
Phillips, H.S.6
Ferrara, N.7
-
41
-
-
79952036599
-
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
-
Kindler HL, Ioka T, Richel DJ, Bennouna J, Letourneau R, Okusaka T, Funakoshi A, Furuse J, Park YS, Ohkawa S, Springett GM, Wasan HS, Trask PC, Bycott P, Ricart AD, Kim S, Van Cutsem E. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol 12: 256-262, 2011.
-
(2011)
Lancet Oncol
, vol.12
, pp. 256-262
-
-
Kindler, H.L.1
Ioka, T.2
Richel, D.J.3
Bennouna, J.4
Letourneau, R.5
Okusaka, T.6
Funakoshi, A.7
Furuse, J.8
Park, Y.S.9
Ohkawa, S.10
Springett, G.M.11
Wasan, H.S.12
Trask, P.C.13
Bycott, P.14
Ricart, A.D.15
Kim, S.16
Van Cutsem, E.17
-
42
-
-
77955887676
-
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
-
Kindler HL, Niedzwiecki D, Hollis D, Sutherland S, Schrag D, Hurwitz H, Innocenti F, Mulcahy MF, O'Reilly E, Wozniak TF, Picus J, Bhargava P, Mayer RJ, Schilsky RL, Goldberg RM. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 28: 3617-3622, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3617-3622
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
Sutherland, S.4
Schrag, D.5
Hurwitz, H.6
Innocenti, F.7
Mulcahy, M.F.8
O'Reilly, E.9
Wozniak, T.F.10
Picus, J.11
Bhargava, P.12
Mayer, R.J.13
Schilsky, R.L.14
Goldberg, R.M.15
-
43
-
-
70449523183
-
Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
-
Kumar R, Crouthamel MC, Rominger DH, Gontarek RR, Tummino PJ, Levin RA, King AG. Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors. Br J Cancer 101: 1717-1723, 2009.
-
(2009)
Br J Cancer
, vol.101
, pp. 1717-1723
-
-
Kumar, R.1
Crouthamel, M.C.2
Rominger, D.H.3
Gontarek, R.R.4
Tummino, P.J.5
Levin, R.A.6
King, A.G.7
-
44
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Haussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359: 378-390, 2008.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Haussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
45
-
-
79958261031
-
Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer
-
Loupakis F, Ruzzo A, Salvatore L, Cremolini C, Masi G, Frumento P, Schirripa M, Catalano V, Galluccio N, Canestrari E, Vincenzi B, Santini D, Bencardino K, Ricci V, Manzoni M, Danova M, Tonini G, Magnani M, Falcone A, Graziano F. Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer. BMC Cancer 11: 247, 2011.
-
(2011)
BMC Cancer
, vol.11
, pp. 247
-
-
Loupakis, F.1
Ruzzo, A.2
Salvatore, L.3
Cremolini, C.4
Masi, G.5
Frumento, P.6
Schirripa, M.7
Catalano, V.8
Galluccio, N.9
Canestrari, E.10
Vincenzi, B.11
Santini, D.12
Bencardino, K.13
Ricci, V.14
Manzoni, M.15
Danova, M.16
Tonini, G.17
Magnani, M.18
Falcone, A.19
Graziano, F.20
more..
-
46
-
-
77952093536
-
Circulating endothelial cells as biomarkers in clinical oncology
-
Mancuso P, Bertolini F. Circulating endothelial cells as biomarkers in clinical oncology. Microvasc Res 79: 224-228, 2010.
-
(2010)
Microvasc Res
, vol.79
, pp. 224-228
-
-
Mancuso, P.1
Bertolini, F.2
-
47
-
-
77954700380
-
Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Miles DW, Chan A, Dirix LY, Cortes J, Pivot X, Tomczak P, Delozier T, Sohn JH, Provencher L, Puglisi F, Harbeck N, Steger GG, Schneeweiss A, Wardley AM, Chlistalla A, Romieu G. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 28: 3239-3247, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3239-3247
-
-
Miles, D.W.1
Chan, A.2
Dirix, L.Y.3
Cortes, J.4
Pivot, X.5
Tomczak, P.6
Delozier, T.7
Sohn, J.H.8
Provencher, L.9
Puglisi, F.10
Harbeck, N.11
Steger, G.G.12
Schneeweiss, A.13
Wardley, A.M.14
Chlistalla, A.15
Romieu, G.16
-
48
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K, Wang M, Gralow J, Dickler M, Cobleigh M, Perez EA, Shenkier T, Cella D, Davidson NE. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357: 2666-2676, 2007.
-
(2007)
N Engl J Med
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
Dickler, M.4
Cobleigh, M.5
Perez, E.A.6
Shenkier, T.7
Cella, D.8
Davidson, N.E.9
-
49
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, Garcia-del-Muro X, Sosman JA, Solska E, Wilding G, Thompson JA, Kim ST, Chen I, Huang X, Figlin RA. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27: 3584-3590, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Oudard, S.6
Negrier, S.7
Szczylik, C.8
Pili, R.9
Bjarnason, G.A.10
Garcia-del-Muro, X.11
Sosman, J.A.12
Solska, E.13
Wilding, G.14
Thompson, J.A.15
Kim, S.T.16
Chen, I.17
Huang, X.18
Figlin, R.A.19
-
50
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356: 115-124, 2007.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
51
-
-
74249092481
-
Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
-
Murukesh N, Dive C, Jayson GC. Biomarkers of angiogenesis and their role in the development of VEGF inhibitors. Brit J Cancer 102: 8-18, 2010.
-
(2010)
Brit J Cancer
, vol.102
, pp. 8-18
-
-
Murukesh, N.1
Dive, C.2
Jayson, G.C.3
-
52
-
-
20344367537
-
Tumour vascular targeting
-
Neri D, Bicknell R. Tumour vascular targeting. Nat Rev Cancer 5: 436-446, 2005.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 436-446
-
-
Neri, D.1
Bicknell, R.2
-
53
-
-
68349083476
-
PET imaging of angiogenesis
-
Niu G, Chen X. PET imaging of angiogenesis. PET Clin 4: 17-38, 2009.
-
(2009)
PET Clin
, vol.4
, pp. 17-38
-
-
Niu, G.1
Chen, X.2
-
54
-
-
70350721785
-
Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging
-
O'Connor JP, Carano RA, Clamp AR, Ross J, Ho CC, Jackson A, Parker GJ, Rose CJ, Peale FV, Friesenhahn M, Mitchell CL, Watson Y, Roberts C, Hope L, Cheung S, Reslan HB, Go MA, Pacheco GJ, Wu X, Cao TC, Ross S, Buonaccorsi GA, Davies K, Hasan J, Thornton P, del Puerto O, Ferrara N, van Bruggen N, Jayson GC. Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging. Clin Cancer Res 15: 6674-6682, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6674-6682
-
-
O'Connor, J.P.1
Carano, R.A.2
Clamp, A.R.3
Ross, J.4
Ho, C.C.5
Jackson, A.6
Parker, G.J.7
Rose, C.J.8
Peale, F.V.9
Friesenhahn, M.10
Mitchell, C.L.11
Watson, Y.12
Roberts, C.13
Hope, L.14
Cheung, S.15
Reslan, H.B.16
Go, M.A.17
Pacheco, G.J.18
Wu, X.19
Cao, T.C.20
Ross, S.21
Buonaccorsi, G.A.22
Davies, K.23
Hasan, J.24
Thornton, P.25
del Puerto, O.26
Ferrara, N.27
van Bruggen, N.28
Jayson, G.C.29
more..
-
55
-
-
33646107369
-
VEGF receptor signalling-in control of vascular function
-
Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling-in control of vascular function. Nat Rev Mol Cell Biol 7: 359-371, 2006.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 359-371
-
-
Olsson, A.K.1
Dimberg, A.2
Kreuger, J.3
Claesson-Welsh, L.4
-
56
-
-
12444297983
-
The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels
-
Osusky KL, Hallahan DE, Fu A, Ye F, Shyr Y, Geng L. The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels. Angiogenesis 7: 225-233, 2004.
-
(2004)
Angiogenesis
, vol.7
, pp. 225-233
-
-
Osusky, K.L.1
Hallahan, D.E.2
Fu, A.3
Ye, F.4
Shyr, Y.5
Geng, L.6
-
57
-
-
33845991161
-
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
-
Pan Q, Chanthery Y, Liang WC, Stawicki S, Mak J, Rathore N, Tong RK, Kowalski J, Yee SF, Pacheco G, Ross S, Cheng Z, Le Couter J, Plowman G, Peale F, Koch AW, Wu Y, Bagri A, Tessier-Lavigne M, Watts RJ. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 11: 53-67, 2007.
-
(2007)
Cancer Cell
, vol.11
, pp. 53-67
-
-
Pan, Q.1
Chanthery, Y.2
Liang, W.C.3
Stawicki, S.4
Mak, J.5
Rathore, N.6
Tong, R.K.7
Kowalski, J.8
Yee, S.F.9
Pacheco, G.10
Ross, S.11
Cheng, Z.12
Le Couter, J.13
Plowman, G.14
Peale, F.15
Koch, A.W.16
Wu, Y.17
Bagri, A.18
Tessier-Lavigne, M.19
Watts, R.J.20
more..
-
58
-
-
42449148407
-
Neuropilins: structure, function and role in disease
-
Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J 411: 211-226, 2008.
-
(2008)
Biochem J
, vol.411
, pp. 211-226
-
-
Pellet-Many, C.1
Frankel, P.2
Jia, H.3
Zachary, I.4
-
59
-
-
77952097702
-
RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline
-
van Persijn van Meerten EL, Gelderblom H, Bloem JL. RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline. Eur Radiol 20: 1456-1467, 2000.
-
(2000)
Eur Radiol
, vol.20
, pp. 1456-1467
-
-
van Persijn van Meerten, E.L.1
Gelderblom, H.2
Bloem, J.L.3
-
60
-
-
62449124416
-
Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
-
Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N, Manegold C. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 27: 1227-1234, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1227-1234
-
-
Reck, M.1
von Pawel, J.2
Zatloukal, P.3
Ramlau, R.4
Gorbounova, V.5
Hirsh, V.6
Leighl, N.7
Mezger, J.8
Archer, V.9
Moore, N.10
Manegold, C.11
-
61
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
-
Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N, Manegold C. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 21: 1804-1809, 2010.
-
(2010)
Ann Oncol
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
von Pawel, J.2
Zatloukal, P.3
Ramlau, R.4
Gorbounova, V.5
Hirsh, V.6
Leighl, N.7
Mezger, J.8
Archer, V.9
Moore, N.10
Manegold, C.11
-
62
-
-
79955767772
-
Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
-
Rini BI, Cohen DP, Lu DR, Chen I, Hariharan S, Gore ME, Figlin RA, Baum MS, Motzer RJ. Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 103: 763-773, 2011.
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 763-773
-
-
Rini, B.I.1
Cohen, D.P.2
Lu, D.R.3
Chen, I.4
Hariharan, S.5
Gore, M.E.6
Figlin, R.A.7
Baum, M.S.8
Motzer, R.J.9
-
63
-
-
77952318310
-
Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 28: 2137-2143, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
Stadler, W.M.4
Vaena, D.A.5
Archer, L.6
Atkins, J.N.7
Picus, J.8
Czaykowski, P.9
Dutcher, J.10
Small, E.J.11
-
64
-
-
56749161699
-
Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Ou SS, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 26: 5422-5428, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5422-5428
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
Stadler, W.M.4
Vaena, D.A.5
Ou, S.S.6
Archer, L.7
Atkins, J.N.8
Picus, J.9
Czaykowski, P.10
Dutcher, J.11
Small, E.J.12
-
65
-
-
79953874259
-
RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
-
Robert NJ, Dieras V, Glaspy J, Brufsky AM, Bondarenko I, Lipatov ON, Perez EA, Yardley DA, Chan SY, Zhou X, Phan SC, O'Shaughnessy J. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 29: 1252-1260, 2011.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1252-1260
-
-
Robert, N.J.1
Dieras, V.2
Glaspy, J.3
Brufsky, A.M.4
Bondarenko, I.5
Lipatov, O.N.6
Perez, E.A.7
Yardley, D.A.8
Chan, S.Y.9
Zhou, X.10
Phan, S.C.11
O'Shaughnessy, J.12
-
66
-
-
80051713290
-
Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial
-
Robert NJ, Saleh MN, Paul D, Generali D, Gressot L, Copur MS, Brufsky AM, Minton SE, Giguere JK, Smith JW 2nd, Richards PD, Gernhardt D, Huang X, Liau KF, Kern KA, Davis J. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial. Clin Breast Cancer 11: 82-92, 2011.
-
(2011)
Clin Breast Cancer
, vol.11
, pp. 82-92
-
-
Robert, N.J.1
Saleh, M.N.2
Paul, D.3
Generali, D.4
Gressot, L.5
Copur, M.S.6
Brufsky, A.M.7
Minton, S.E.8
Giguere, J.K.9
Smith 2nd, J.W.10
Richards, P.D.11
Gernhardt, D.12
Huang, X.13
Liau, K.F.14
Kern, K.A.15
Davis, J.16
-
67
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Lichinitser M, Yang TS, Rivera F, Couture F, Sirzen F, Cassidy J. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 26: 2013-2019, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
Scheithauer, W.4
Figer, A.5
Wong, R.6
Koski, S.7
Lichinitser, M.8
Yang, T.S.9
Rivera, F.10
Couture, F.11
Sirzen, F.12
Cassidy, J.13
-
68
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355: 2542-2550, 2006.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
69
-
-
77951639655
-
Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
-
Scagliotti G, Novello S, von Pawel J, Reck M, Pereira JR, Thomas M, Abrao Miziara JE, Balint B, De Marinis F, Keller A, Aren O, Csollak M, Albert I, Barrios CH, Grossi F, Krzakowski M, Cupit L, Cihon F, Dimatteo S, Hanna N. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 28: 1835-1842, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1835-1842
-
-
Scagliotti, G.1
Novello, S.2
von Pawel, J.3
Reck, M.4
Pereira, J.R.5
Thomas, M.6
Abrao Miziara, J.E.7
Balint, B.8
De Marinis, F.9
Keller, A.10
Aren, O.11
Csollak, M.12
Albert, I.13
Barrios, C.H.14
Grossi, F.15
Krzakowski, M.16
Cupit, L.17
Cihon, F.18
Dimatteo, S.19
Hanna, N.20
more..
-
70
-
-
46449091500
-
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
-
Siegel AB, Cohen EI, Ocean A, Lehrer D, Goldenberg A, Knox JJ, Chen H, Clark-Garvey S, Weinberg A, Mandeli J, Christos P, Mazumdar M, Popa E, Brown RS Jr, Rafii S, Schwartz JD. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 26: 2992-2998, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2992-2998
-
-
Siegel, A.B.1
Cohen, E.I.2
Ocean, A.3
Lehrer, D.4
Goldenberg, A.5
Knox, J.J.6
Chen, H.7
Clark-Garvey, S.8
Weinberg, A.9
Mandeli, J.10
Christos, P.11
Mazumdar, M.12
Popa, E.13
Brown Jr, R.S.14
Rafii, S.15
Schwartz, J.D.16
-
71
-
-
82455199216
-
Final overall survival results and effect of prolonged (≥1year) first-line bevacizumab-containing therapy for metastatic breast cancer in the ATHENA trial
-
Smith I, Pierga JY, Biganzoli L, Cortes-Funes H, Thomssen C, Saracchini S, Nisenbaum B, Pelaez I, Duenne AA, Pritchard KI. Final overall survival results and effect of prolonged (≥1year) first-line bevacizumab-containing therapy for metastatic breast cancer in the ATHENA trial. Breast Cancer Res Treat 130: 133-43, 2011.
-
(2011)
Breast Cancer Res Treat
, vol.130
, pp. 133-143
-
-
Smith, I.1
Pierga, J.Y.2
Biganzoli, L.3
Cortes-Funes, H.4
Thomssen, C.5
Saracchini, S.6
Nisenbaum, B.7
Pelaez, I.8
Duenne, A.A.9
Pritchard, K.I.10
-
72
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. BRAF mutation predicts sensitivity to MEK inhibition. Nature 439: 358-362, 2006.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
Sawai, A.4
Getz, G.5
Basso, A.6
Ye, Q.7
Lobo, J.M.8
She, Y.9
Osman, I.10
Golub, T.R.11
Sebolt-Leopold, J.12
Sellers, W.R.13
Rosen, N.14
-
73
-
-
34347332447
-
Neuropilins in physiological and pathological angiogenesis
-
Staton CA, Kumar I, Reed MW, Brown NJ. Neuropilins in physiological and pathological angiogenesis. J Pathol 212: 237-248, 2007.
-
(2007)
J Pathol
, vol.212
, pp. 237-248
-
-
Staton, C.A.1
Kumar, I.2
Reed, M.W.3
Brown, N.J.4
-
74
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, Zarba JJ, Chen M, McCann L, Pandite L, Roychowdhury DF, Hawkins RE. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 28: 1061-1068, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
Barrios, C.H.7
Salman, P.8
Gladkov, O.A.9
Kavina, A.10
Zarba, J.J.11
Chen, M.12
McCann, L.13
Pandite, L.14
Roychowdhury, D.F.15
Hawkins, R.E.16
-
75
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJ, Schrama JG, Erdkamp FL, Vos AH, van Groeningen CJ, Sinnige HA, Richel DJ, Voest EE, Dijkstra JR, Vink-Borger ME, Antonini NF, Mol L, van Krieken JH, Dalesio O, Punt CJ. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 360: 563-572, 2009.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
Erdkamp, F.L.7
Vos, A.H.8
van Groeningen, C.J.9
Sinnige, H.A.10
Richel, D.J.11
Voest, E.E.12
Dijkstra, J.R.13
Vink-Borger, M.E.14
Antonini, N.F.15
Mol, L.16
van Krieken, J.H.17
Dalesio, O.18
Punt, C.J.19
-
76
-
-
34249294557
-
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
-
Verheul HM, Pinedo HM. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 7: 475-485, 2007.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 475-485
-
-
Verheul, H.M.1
Pinedo, H.M.2
-
77
-
-
20044375603
-
Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro
-
Wang Y, Fei D, Vanderlaan M, Song A. Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro. Angiogenesis 7: 335-345, 2004.
-
(2004)
Angiogenesis
, vol.7
, pp. 335-345
-
-
Wang, Y.1
Fei, D.2
Vanderlaan, M.3
Song, A.4
-
78
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10: 145-147, 2004.
-
(2004)
Nat Med
, vol.10
, pp. 145-147
-
-
Willett, C.G.1
Boucher, Y.2
di Tomaso, E.3
Duda, D.G.4
Munn, L.L.5
Tong, R.T.6
Chung, D.C.7
Sahani, D.V.8
Kalva, S.P.9
Kozin, S.V.10
Mino, M.11
Cohen, K.S.12
Scadden, D.T.13
Hartford, A.C.14
Fischman, A.J.15
Clark, J.W.16
Ryan, D.P.17
Zhu, A.X.18
Blaszkowsky, L.S.19
Chen, H.X.20
Shellito, P.C.21
Lauwers, G.Y.22
Jain, R.K.23
more..
-
79
-
-
0035895711
-
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
-
Zachary I, Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49: 568-581, 2001.
-
(2001)
Cardiovasc Res
, vol.49
, pp. 568-581
-
-
Zachary, I.1
Gliki, G.2
|