Mucoadhesive bilayer buccal tablet of carvedilol-loaded chitosan microspheres: In vitro, pharmacokinetic and pharmacodynamic investigations

Journal of Microencapsulation

Volumn 29, Issue 2, 2012, Pages 126-137

  Yedurkar, Pramod ^a   Dhiman, Munish Kumar ^a   Petkar, Kailash ^a   Sawant, Krutika ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

bilayer tablets; bioavailability; chitosan; microparticles; mucosal drug delivery

Indexed keywords

CARBOMER; CARVEDILOL; CHITOSAN; LACTOSE; MAGNESIUM STEARATE; MICROSPHERE; PLACEBO; TRIACYLGLYCEROL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; BULK DENSITY; CONTROLLED STUDY; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; HEART RATE; HUMAN; HYPERTENSION; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN ARTERIAL PRESSURE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; RAT; SPRAY DRYING; SUSTAINED DRUG RELEASE; TABLET COMPRESSION; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TABLET THICKNESS; TENSILE STRENGTH; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADHESIVENESS; ADRENERGIC BETA-ANTAGONISTS; ADULT; ANIMALS; CARBAZOLES; CHEEK; CHITOSAN; HUMANS; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOUTH MUCOSA; PARTICLE SIZE; PROPANOLAMINES; RABBITS; RATS; RATS, WISTAR; SOLUBILITY; TABLETS;

EID: 84856865450     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2011.630109     Document Type: Article

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