Composite method to quantify powder flow as a screening method in early tablet or capsule formulation development

AAPS PharmSciTech

Volumn 1, Issue 3, 2000, Pages

  Taylor, Michael K ^a   Ginsburg, Jeri ^b   Hickey, Anthony J ^c   Gheyas, Ferdous ^c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GLAXOSMITHKLINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Angle of repose; Avalanching; Compressibility index; Critical orifice; Powder flow; Principal components analysis

Indexed keywords

ACICLOVIR; CALCIUM CARBONATE; EXCIPIENT; MICROCRYSTALLINE CELLULOSE; ONDANSETRON; CELLULOSE; LACTOSE;

ARTICLE; CHEMICAL COMPOSITION; COMPRESSIVE STRENGTH; CONTROLLED STUDY; DRUG CAPSULE; DRUG FORMULATION; DRUG SCREENING; DRUG SYNTHESIS; FLOW RATE; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; REPRODUCIBILITY; SCORING SYSTEM; TABLET FORMULATION; CHEMISTRY; MATHEMATICAL COMPUTING; MICROCAPSULE; POWDER; TABLET;

CAPSULES; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; LACTOSE; MATHEMATICAL COMPUTING; PARTICLE SIZE; POWDERS; REPRODUCIBILITY OF RESULTS; TABLETS;

EID: 23144449203     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt010318     Document Type: Article

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