Controlled release pulmonary administration of curcumin using swellable biocompatible microparticles

Molecular Pharmaceutics

Volumn 9, Issue 2, 2012, Pages 269-280

  El Sherbiny, Ibrahim M ^a,b   Smyth, Hugh D C ^b  

^a MANSOURA UNIVERSITY   (Egypt)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

chitosan; curcumin; drug delivery; lung; microspheres; nanoparticles; PEG; PLGA; pulmonary; sustained

Indexed keywords

CHITOSAN; CURCUMIN; DRUG CARRIER; MICROSPHERE; NANOPARTICLE; POLYMER; TUMOR NECROSIS FACTOR ALPHA;

AEROSOL; ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BIODEGRADATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY; DENSITY; DRUG DELIVERY SYSTEM; HYDROGEL; IN VITRO STUDY; MACROPHAGE; MEMBRANE MICROPARTICLE; MOISTURE; MOUSE; NONHUMAN; PARTICLE SIZE; PHYSICOCHEMICAL MODEL; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; BIOCOMPATIBLE MATERIALS; CELL CULTURE TECHNIQUES; CHITOSAN; CURCUMIN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HYDROGELS; LACTIC ACID; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICROSPHERES; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POWDERS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84856862040     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200351y     Document Type: Article

References (43)

1. Patton, J. S.; Byron, P. R. Inhaling medicines: delivering drugs to the body through the lungs Nat. Rev. Drug Discovery 2007, 6, 67-74 (Pubitemid 46020287)
2. Lu, D.; Hickey, A. J. Pulmonary vaccine delivery Expert Rev. Vaccines 2007, 6, 213-226 (Pubitemid 46607457)
3. Hickey, A. J. Inhalation aerosols: physical and biological basis for therapy; Marcel Dekker: New York, 1996.
4. Laube, B. L. The expanding role of aerosols in systemic drug delivery, gene therapy, and vaccination Respir. Care. 2005, 50, 1161-1176
5. Wu, L.; da Rocha, S. R. P. Biocompatible and biodegradable copolymer stabilizers for hydrofluoroalkane dispersions: a colloidal probe microscopy investigation Langmuir 2007, 23, 12104-12110 (Pubitemid 350197378)
6. Suh, J.; Choy, K. L.; Lai, S. K.; Suk, J. S.; Tang, B. C.; Prabhu, S.; Hanes, J. PEGylation of nanoparticles improves their cytoplasmic transport Int. J. Nanomed. 2007, 2, 735-741
7. Wu, L.; Al-Haydari, M.; da Rocha, S. R. Novel propellant-driven inhalation formulations: engineering polar drug particles with surface-trapped hydrofluoroalkane-philes Eur. J. Pharm. Sci. 2008, 33, 146-158
8. Shoyele, S. A.; Cawthorne, S. Particle engineering techniques for inhaled biopharmaceuticals Adv. Drug Delivery Rev. 2006, 58, 1009-1029 (Pubitemid 44712022)
9. Patton, J. S.; Bukar, J.; Nagarajan, S. Inhaled insulin Adv. Drug Delivery Rev. 1999, 35, 235-247 (Pubitemid 29073616)
10. Wang, Y. Y.; Lai, S. K.; Suk, J. S.; Pace, A.; Cone, R.; Hanes, J. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier Angew. Chem., Int. Ed. 2008, 47, 9726-9729
11. Grenha, A.; Seijo, B.; Remuñán-López, C. Microencapsulated chitosan nanoparticles for lung protein delivery Eur. J. Pharm. Sci. 2005, 25, 427-437 (Pubitemid 40853870)
12. Dickinson, P. A.; Howells, S. W.; Kellaway, I. W. Novel nanoparticles for pulmonary drug administration J. Drug Targeting 2001, 9, 295-302 (Pubitemid 32776364)
13. Dellamary, L. A.; Tarara, T. E.; Smith, D. J.; Woelk, C. H.; Adractas, A.; Costello, M. L.; Gill, H.; Weers, J. G. Hollow porous particles in metered dose inhalers Pharm. Res. 2000, 17, 168-174 (Pubitemid 30158365)
14. Edwards, D. A.; Hanes, J.; Caponetti, G.; Hrkach, J.; Ben-Jebria, A.; Eskew, M. L.; Mintzes, J.; Deaver, D.; Lotan, N.; Langer, R. Large porous particles for pulmonary drug delivery Science 1997, 276, 1868-1872
15. Yang, Y.; Bajaj, N.; Xua, P.; Ohnd, K.; Tsifanskye, M. D.; Yeo, Y. Development of highly porous large PLGA microparticles for pulmonary drug delivery Biomaterials 2009, 30, 1947-1953
16. Koushik, K.; Dhanda, D.; Cheruvu, N.; Kompella, U. Pulmonary delivery of deslorelin: large-porous PLGA particles and HP?CD complexes Pharm. Res. 2004, 21, 1119-1126 (Pubitemid 38954195)
17. El-Sherbiny, I. M.; Smyth, H. D. C. Biodegradable nano-micro carrier systems for sustained pulmonary drug delivery: (I) self-assembled nanoparticles encapsulated in respirable/swellable semi-IPN microspheres Int. J. Pharm. 2010, 395, 132-141
18. El-Sherbiny, I. M.; McGill, S.; Smyth, H. D. C. Swellable microparticles as carriers for sustained pulmonary drug delivery J. Pharm. Sci. 2010, 99, 2343-2356
19. El-Sherbiny, I. M.; Smyth, H. D. C. Novel cryomilled physically crosslinked biodegradable hydrogel microparticles as carriers for inhalation therapy J. Microencapsul. 2010, 27, 657-668
20. Ammon, H. P. T; Wahl, M. A. Pharmacology of curcuma longa Planta Med. 1991, 57, 1-7
21. Cheng, A. L.; Hsu, C. H.; Lin, J. K.; Hsu, N. M.; Ho, Y. F.; Shen, T. S.; Ko, J. Y.; Lin, J. T.; Lin, B. R.; Ming-Shiang, W.; Yu, H. S.; Jee, S. H.; Chen, G. S.; Chen, T. M.; Chen, C. A.; Lai, M. K.; Pu, Y. S.; Pan, M. H.; Wang, Y. J.; Tsai, C. C.; Hsieh, C. Y. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions Anticancer Res. 2001, 21, 2895-2900
22. Mukhopadhyay, A.; Basu, N.; Ghatak, N.; Gujral, P. K. Antiinflammatory and irritant activities of curcumin analogues in rats Agents Actions 1982, 12, 508-515 (Pubitemid 13218984)
23. Reddy, A. C.; Lokesh, B. R. Effect of dietary turmeric (Curcuma longa) on iron induced lipid peroxidation in the rat liver Food Chem. Toxicol. 1994, 32, 279-283 (Pubitemid 24128085)
24. Huang, M.; Newmark, H. L.; Frenkel, K. Inhibitory effects of curcumin on tumorigenesis in mice J. Cell Biochem. 1997, 67, 26-34 (Pubitemid 28222116)
25. Egan, M. E.; Pearson, M.; Weiner, S. A.; Rajendran, V.; Rubin, D.; Glöckner-Pagel, J.; Canny, S.; Du, K.; Lukacs, G. L.; Caplan, M. J. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects Science 2004, 304, 600-602 (Pubitemid 38541921)
26. Sethi, G.; Sung, B.; Aggarwal, B. B. The role of curcumin in modern medicine. Herbal Drugs: Ethnomedicine to Modern Medicine; Ramawat, K. G., Ed.; Springer-Verlag: Berlin, Heidelberg, 2009; Chapter 7, pp 97-113.
27. Dhillon, N.; Aggarwal, B. B.; Newman, R. A.; Wolff, R. A.; Kunnumakkara, A. B.; Abbruzzese, J. L.; Ng, C. S.; Badmaev, V.; Kurzrock, R. Phase II Trial of curcumin in patients with advanced pancreatic cancer Clin. Cancer Res. 2008, 14, 4491-4499
28. Selvam, P.; El-Sherbiny, I. M.; Smyth, H. D. Swellable hydrogel particles for controlled release pulmonary administration using propellant-driven metered dose inhalers J. Aerosol Med. Pulm. Drug Delivery 2011, 24, 25-34
29. Oberdorster, G. Pulmonary effects of inhaled ultrafine particles Int. Arch. Occup. Environ. Health 2001, 74, 1-8 (Pubitemid 32123735)
30. Krenis, L. J.; Strauss, B. Effect of size and concentration of latex particles on respiration of human blood leucocytes Proc. Soc. Exp. Biol. 1961, 107, 748-750
31. Kawaguchi, H.; Koiwai, N.; Ohtsuka, Y.; Miyamoto, M.; Sasakawa, S. Phagocytosis of latex particles by leukocytes. I. Dependence of phagocytosis on the size and surface potential of particles Biomaterials 1986, 7, 61-66 (Pubitemid 16151617)
32. Rudt, S.; Muller, R. H. In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration J. Controlled Release 1992, 22, 263-271
33. Heyder, J.; Rudolf, G. Mathematical models of particle deposition in the human respiratory tract J. Aerosol Sci. 1984, 15, 697-707 (Pubitemid 15437588)
34. Astete, C. E.; Sabliov, C. M. Synthesis and characterization of PLGA nanoparticles J. Biomater. Sci., Polym. Ed. 2006, 17, 247-289 (Pubitemid 47279194)
35. Majeti, N. V.; Kumar, R. A review of chitin and chitosan applications React. Funct. Polym. 2000, 46, 1-27
36. Parka, J. H.; Kwon, S.; Lee, M.; Chung, H.; Kim, J. H.; Kim, Y. S.; Park, R. W.; Kim, I. S.; Seo, S. B.; Kwon, I. C.; Jeong, S. Y. Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: In vivo biodistribution and anti-tumor activity Biomaterials 2006, 27, 119-126 (Pubitemid 41225375)
37. Cartiera, M. S.; Ferreira, E. C.; Caputo, C.; Egan, M. E.; Caplan, M. J.; Saltzman, M. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin Mol. Pharmaceutics 2010, 7, 86-93
38. Hirano, S.; Tsuchida, H.; Nagao, N. N-Acetylation in chitosan and the rate of its enzymic hydrolysis Biomaterials 1989, 10, 574-6
39. Ganz, T Antimicrobial polypeptides in host defense of the respiratory tract J. Clin. Invest. 2002, 109, 693-697 (Pubitemid 34263142)
40. Guinesi, L. S.; Cavalheiro, E. T. G. The use of DSC curves to determine the acetylation degree of chitin/chitosan samples Thermochim. Acta 2006, 444, 128-133
41. Kittur, F. S.; Prashanth, K. V. H.; Sankar, K. U.; Tharanthan, R. N. Characterization of chitin, chitosan and their carboxymethyl derivatives by differential scanning calorimetry Carbohydr. Polym. 2002, 49, 185-193 (Pubitemid 34410793)
42. Murillo, M.; Gamazo, C.; Goni, M. M.; Irache, J. M.; Blanco-Peto, M. J. Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis Int. J. Pharm. 2002, 242, 341-344
43. Pillai, O.; Panchagnula, R. Polymers in drug delivery Curr. Opin. Chem. Biol. 2001, 5, 447-451 (Pubitemid 32900518)