The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin

Chemico-Biological Interactions

Volumn 196, Issue 1-2, 2012, Pages 1-10

  Gherezghiher, Teshome B ^a   Michalsen, Bradley ^a   Chandrasena, R Esala P ^a   Qin, Zhihui ^a   Sohn, Johann ^a   Thatcher, Gregory R J ^a   Bolton, Judy L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cytochrome P450; Equilenin; Estrogen; LY2066948; o Quinone; SERM

Indexed keywords

1 NAPHTHOL; AFIMOXIFENE; ALKALINE PHOSPHATASE; CYTOCHROME P450 1B1; CYTOCHROME P450 3A4; EQUILENIN; GLUTATHIONE; LY 2066948; MONOPHENOL MONOOXYGENASE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; AMINO ACID SEQUENCE; ANIMAL TISSUE; ANTIESTROGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG OXIDATION; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; NONHUMAN; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; EQUILENIN; FEMALE; HALF-LIFE; INHIBITORY CONCENTRATION 50; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; NAPHTHALENES; OXIDATION-REDUCTION; PIPERIDINES; QUINONES; RATS; RATS, SPRAGUE-DAWLEY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TANDEM MASS SPECTROMETRY;

EQUIDAE; RATTUS;

EID: 84856766976     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.01.004     Document Type: Article

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