When silence is broken: Polycomb group proteins in heart development

Circulation Research

Volumn 110, Issue 3, 2012, Pages 372-374

  Dobreva, Gergana ^a   Braun, Thomas ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 1; POLYCOMB REPRESSIVE COMPLEX 2; RETINOBLASTOMA BINDING PROTEIN 2; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EZH1; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

CATALYSIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CHROMATIN; CHROMATIN STRUCTURE; CONGENITAL HEART MALFORMATION; DISEASE ASSOCIATION; EMBRYO DEVELOPMENT; EPIGENETICS; GENE EXPRESSION; GENE SILENCING; HEART DEVELOPMENT; HEART MUSCLE CELL; HISTONE UBIQUITINATION; HUMAN; HYPOPLASIA; MEDICAL LITERATURE; MORPHOGENESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN METHYLATION; REVIEW;

ANIMALS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; REPRESSOR PROTEINS;

EID: 84856747157     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.263145     Document Type: Review

References (20)

1. Wang L, Brown JL, Cao R, Zhang Y, Kassis JA, Jones RS. Hierarchical recruitment of polycomb group silencing complexes. Mol Cell. 2004;14: 637-646. (Pubitemid 38739085)
2. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. Role of histone h3 lysine 27 methylation in polycomb-group silencing. Science. 2002;298:1039-1043. (Pubitemid 35247314)
3. Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D. Ezh1 and ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 2008;32:503-518.
4. Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. Ezh1 mediates methylation on histone h3 lysine 27 and complements ezh2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008;32:491-502.
5. Mousavi K, Zare H, Wang AH, Sartorelli V. Polycomb protein Ezh1 promotes RNA polymerase II elongation. Mol Cell. Published online before print December 22, 2011. doi: 10.1016/j.molcel.2011.11.019. http://www.sciencedirect.com/ science/article/pii/S1097276511009099. Accessed January 14, 2012.
6. He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou D, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012;110:406-415.
7. Faust C, Schumacher A, Holdener B, Magnuson T. The eed mutation disrupts anterior mesoderm production in mice. Development. 1995;121: 273-285.
8. O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T. The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol. 2001;21:4330-4336. (Pubitemid 32565314)
9. Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004;23:4061-4071. (Pubitemid 39472427)
10. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature. 2006;441: 349-353. (Pubitemid 44050199)
11. Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev. 2011;25: 485-498.
12. Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, Komuro I, Hara J, Miwa T, Yamauchi-Takihara K, Takihara Y. The polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J Clin Invest. 2002;110:177-184. (Pubitemid 34787354)
13. Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell. 2009;139:1290-1302.
14. Pasini D, Cloos PA, Walfridsson J, Olsson L, Bukowski JP, Johansen JV, Bak M, Tommerup N, Rappsilber J, Helin K. Jarid2 regulates binding of the polycomb repressive complex 2 to target genes in ES cells. Nature. 2010;464:306-310.
15. Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 2010;24: 368-380.
16. Lee Y, Song AJ, Baker R, Micales B, Conway SJ, Lyons GE. Jumonji, a nuclear protein that is necessary for normal heart development. Circ Res. 2000;86:932-938. (Pubitemid 30324304)
17. Mysliwiec MR, Carlson CD, Tietjen J, Hung H, Ansari AZ, Lee Y. Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart. J Biol Chem. 2012;287: 1235-1241.
18. Nakajima K, Inagawa M, Uchida C, Okada K, Tane S, Kojima M, Kubota M, Noda M, Ogawa S, Shirato H, Sato M, Suzuki-Migishima R, Hino T, Satoh Y, Kitagawa M, Takeuchi T. Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Development. 2011;138:1771-1782.
19. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science. 2005;310:306-310. (Pubitemid 41457195)
20. Palacios D, Mozzetta C, Consalvi S, Caretti G, Saccone V, Proserpio V, Marquez VE, Valente S, Mai A, Forcales SV, Sartorelli V, Puri PL. TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration. Cell Stem Cell. 2010;7:455-469.