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Volumn 55, Issue 1, 2012, Pages 215-225

Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C 2C 12 muscle and AML12 liver cell lines

Author keywords

Amylin; Endoplasmic reticulum stress; Hypothalamus; Intracellular signalling pathway; Leptin; Liver; Muscle

Indexed keywords

AMYLIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR SUBSTRATE 1; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STAT3 PROTEIN;

EID: 84856744317     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2332-0     Document Type: Article
Times cited : (30)

References (42)
  • 1
    • 15544362925 scopus 로고    scopus 로고
    • The gut and energy balance: Visceral allies in the obesity wars
    • DOI 10.1126/science.1109951
    • Badman MK, Flier JS (2005) The gut and energy balance: visceral allies in the obesity wars. Science 307: 1909-1914 (Pubitemid 40404693)
    • (2005) Science , vol.307 , Issue.5717 , pp. 1909-1914
    • Badman, M.K.1    Flier, J.S.2
  • 3
  • 4
    • 79959409408 scopus 로고    scopus 로고
    • Efficacy of metreleptin in obese type II diabetics: Cellular and molecular pathways underlying leptin tolerance
    • Moon HS, Matarese G, Brennan AM et al (2011) Efficacy of metreleptin in obese type II diabetics: cellular and molecular pathways underlying leptin tolerance. Diabetes 60: 1647-1656
    • (2011) Diabetes , vol.60 , pp. 1647-1656
    • Moon, H.S.1    Matarese, G.2    Brennan, A.M.3
  • 5
    • 79951716553 scopus 로고    scopus 로고
    • Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues; In vitro and ex vivo studies in humans
    • Moon HS, Chamberland JP, Diakopoulos KN et al (2010) Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues; in vitro and ex vivo studies in humans. Diabetes Care 34: 132-138
    • (2010) Diabetes Care , vol.34 , pp. 132-138
    • Moon, H.S.1    Chamberland, J.P.2    Diakopoulos, K.N.3
  • 7
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Baker MB et al
    • Pelleymounter MA, Cullen MJ, Baker MB et al (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2
  • 8
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • DOI 10.1210/en.141.7.2328
    • Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB (2000) In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141: 2328-2339 (Pubitemid 32269051)
    • (2000) Endocrinology , vol.141 , Issue.7 , pp. 2328-2339
    • Kim, Y.-B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 9
    • 62449325306 scopus 로고    scopus 로고
    • Implications of amylin receptor agonism: Integrated neurohormonal mechanisms and therapeutic applications
    • Roth JD, Maier H, Chen S, Roland BL (2009) Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications. Arch Neurol 66: 306-310
    • (2009) Arch Neurol , vol.66 , pp. 306-310
    • Roth, J.D.1    Maier, H.2    Chen, S.3    Roland, B.L.4
  • 10
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • Ravussin E, Smith SR, Mitchell JA et al (2009) Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity (Silver Spring) 17: 1736-1743
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1736-1743
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3
  • 12
    • 54349121294 scopus 로고    scopus 로고
    • Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: Magnitude and mechanisms
    • Trevaskis JL, Coffey T, Cole R et al (2008) Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms. Endocrinology 149: 5679-5687
    • (2008) Endocrinology , vol.149 , pp. 5679-5687
    • Trevaskis, J.L.1    Coffey, T.2    Cole, R.3
  • 13
    • 48649084313 scopus 로고    scopus 로고
    • Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide- Interventional studies in humans
    • Hwang JJ, Chan JL, Ntali G, Malkova D, Mantzoros CS (2008) Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide- Interventional studies in humans. Diabetes Care 31: 945-951
    • (2008) Diabetes Care , vol.31 , pp. 945-951
    • Hwang, J.J.1    Chan, J.L.2    Ntali, G.3    Malkova, D.4    Mantzoros, C.S.5
  • 14
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • Ozcan L, Ergin AS, Lu A et al (2009) Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9: 35-51
    • (2009) Cell Metab , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3
  • 15
    • 73649125333 scopus 로고    scopus 로고
    • Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharideinduced endoplasmic reticulum stress
    • Hagiwara S, Iwasaka H, Shingu C et al (2009) Heat shock protein 72 protects insulin-secreting beta cells from lipopolysaccharideinduced endoplasmic reticulum stress. Int J Hyperthermia 25: 626-633
    • (2009) Int J Hyperthermia , vol.25 , pp. 626-633
    • Hagiwara, S.1    Iwasaka, H.2    Shingu, C.3
  • 16
    • 38049030825 scopus 로고    scopus 로고
    • Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3 T3-L1 cells
    • Moon HS, Chung CS, Lee HG, Kim TG, Choi YJ, Cho CS (2007) Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3 T3-L1 cells. Obesity (Silver Spring) 15: 2571-2582
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 2571-2582
    • Moon, H.S.1    Chung, C.S.2    Lee, H.G.3    Kim, T.G.4    Choi, Y.J.5    Cho, C.S.6
  • 17
    • 19744367530 scopus 로고    scopus 로고
    • Intracellular signal transduction pathways induced by leptin in C2C12 cells
    • DOI 10.1016/j.cellbi.2005.03.008, PII S1065699505000648
    • Maroni P, Bendinelli P, Piccoletti R (2005) Intracellular signal transduction pathways induced by leptin in C2C12 cells. Cell Biol Int 29: 542-550 (Pubitemid 41138217)
    • (2005) Cell Biology International , vol.29 , Issue.7 , pp. 542-550
    • Maroni, P.1    Bendinelli, P.2    Piccoletti, R.3
  • 20
    • 0345168238 scopus 로고    scopus 로고
    • The role of leptin receptor signaling in feeding and neuroendocrine function
    • DOI 10.1016/j.tem.2003.10.003
    • Bates SH, Myers MG (2003) The role of leptin receptor signalling in feeding and neuroendocrine function. Trends Endocrinol Metab 14: 447-452 (Pubitemid 37517345)
    • (2003) Trends in Endocrinology and Metabolism , vol.14 , Issue.10 , pp. 447-452
    • Bates, S.H.1    Myers Jr., M.G.2
  • 21
    • 73649137524 scopus 로고    scopus 로고
    • Mechanisms of amylin/leptin synergy in rodent models
    • Turek VF, Trevaskis JL, Levin BE et al (2010) Mechanisms of amylin/leptin synergy in rodent models. Endocrinology 151: 143-152
    • (2010) Endocrinology , vol.151 , pp. 143-152
    • Turek, V.F.1    Trevaskis, J.L.2    Levin, B.E.3
  • 22
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • DOI 10.1146/annurev.biochem.67.1.821
    • Hardie DG, Carling D, Carlson M (1998) The AMP-activated/ SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67: 821-855 (Pubitemid 28411146)
    • (1998) Annual Review of Biochemistry , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 24
    • 0032704115 scopus 로고    scopus 로고
    • Chronic activation of 5?-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
    • Holmes BF, Kurth-Kraczek EJ, Winder WW (1999) Chronic activation of 5?-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. J Appl Physiol 87: 1990-1995
    • (1999) J Appl Physiol , vol.87 , pp. 1990-1995
    • Holmes, B.F.1    Kurth-Kraczek, E.J.2    Winder, W.W.3
  • 25
    • 2342439732 scopus 로고    scopus 로고
    • Leptin signaling in the central nervous system and the periphery
    • Bjorbaek C, Kahn BB (2004) Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 59: 305-331
    • (2004) Recent Prog Horm Res , vol.59 , pp. 305-331
    • Bjorbaek, C.1    Kahn, B.B.2
  • 26
    • 34250182374 scopus 로고    scopus 로고
    • Leptin stimulates fatty acid oxidation and peroxisome proliferator- activated receptor β gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the β2 form of amp-activated protein kinase
    • DOI 10.1128/MCB.02222-06
    • Suzuki A, Okamoto S, Lee S, Saito K, Shiuchi T, Minokoshi Y (2007) Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol 27: 4317-4327 (Pubitemid 46906556)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.12 , pp. 4317-4327
    • Suzuki, A.1    Okamoto, S.2    Lee, S.3    Saito, K.4    Shiuchi, T.5    Minokoshi, Y.6
  • 27
    • 62749109421 scopus 로고    scopus 로고
    • Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
    • Rahmouni K, Sigmund CD, Haynes WG, Mark AL (2009) Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes 58: 536-542
    • (2009) Diabetes , vol.58 , pp. 536-542
    • Rahmouni, K.1    Sigmund, C.D.2    Haynes, W.G.3    Mark, A.L.4
  • 28
    • 70350545480 scopus 로고    scopus 로고
    • Obesity, the PI3K/Akt signal pathway and colon cancer
    • Huang XF, Chen JZ (2009) Obesity, the PI3K/Akt signal pathway and colon cancer. Obes Rev 10: 610-616
    • (2009) Obes Rev , vol.10 , pp. 610-616
    • Huang, X.F.1    Chen, J.Z.2
  • 30
    • 17844383522 scopus 로고    scopus 로고
    • Effect of leptin on proliferative activity and vascular endothelial growth factor (VEGF) secretion from cultured endothelial cells HECA10 in vitro
    • Misztal-Dethloff B, Stepien H, Komorowski J (2004) Effect of leptin on proliferative activity and vascular endothelial growth factor (VEGF) secretion from cultured endothelial cells HECa10 in vitro. Endocr Regul 38: 161-166 (Pubitemid 43001070)
    • (2004) Endocrine Regulations , vol.38 , Issue.4 , pp. 161-166
    • Misztal-Dethloff, B.1    Stepien, H.2    Komorowski, J.3
  • 31
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • DOI 10.1126/science.274.5290.1185
    • Cohen B, Novick D, Rubinstein M (1996) Modulation of insulin activities by leptin. Science 274: 1185-1188 (Pubitemid 26389283)
    • (1996) Science , vol.274 , Issue.5290 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 34
    • 79955547570 scopus 로고    scopus 로고
    • Identification of molecules derived from human fibroblast feeder cells that support the proliferation of human embryonic stem cells
    • Anisimov SV, Christophersen NS, Correia AS et al (2010) Identification of molecules derived from human fibroblast feeder cells that support the proliferation of human embryonic stem cells. Cell Mol Biol Lett 16: 79-88
    • (2010) Cell Mol Biol Lett , vol.16 , pp. 79-88
    • Anisimov, S.V.1    Christophersen, N.S.2    Correia, A.S.3
  • 36
    • 57649137956 scopus 로고    scopus 로고
    • Leptin stimulates both JAK2- dependent and JAK2-independent signaling pathways
    • Jiang L, Li Z, Rui L (2008) Leptin stimulates both JAK2- dependent and JAK2-independent signaling pathways. J Biol Chem 283: 28066-28073
    • (2008) J Biol Chem , vol.283 , pp. 28066-28073
    • Jiang, L.1    Li, Z.2    Rui, L.3
  • 39
    • 21844471790 scopus 로고    scopus 로고
    • Role of leptin in energy-deprivation states: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    • DOI 10.1016/S0140-6736(05)66830-4, PII S0140673605668304
    • Chan JL, Mantzoros CS (2005) Role of leptin in energydeprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet 366: 74-85 (Pubitemid 40956533)
    • (2005) Lancet , vol.366 , Issue.9479 , pp. 74-85
    • Chan, J.L.1    Mantzoros, C.S.2
  • 40
    • 33745781499 scopus 로고    scopus 로고
    • Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy
    • DOI 10.1210/jc.2005-1545
    • Lee JH, Chan JL, Sourlas E, Raptopoulos V, Mantzoros CS (2006) Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab 91: 2605-2611 (Pubitemid 44024625)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.7 , pp. 2605-2611
    • Lee, J.H.1    Chan, J.L.2    Sourlas, E.3    Raptopoulos, V.4    Mantzoros, C.S.5
  • 41
    • 74949143243 scopus 로고    scopus 로고
    • Narrative review: The role of leptin in human physiology: Emerging clinical applications
    • Kelesidis T, Kelesidis I, Chou S, Mantzoros CS (2010) Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med 152: 93-100
    • (2010) Ann Intern Med , vol.152 , pp. 93-100
    • Kelesidis, T.1    Kelesidis, I.2    Chou, S.3    Mantzoros, C.S.4
  • 42
    • 74049157079 scopus 로고    scopus 로고
    • Adiponectin in insulin resistance: Lessons from translational research
    • Ziemke F, Mantzoros CS (2010) Adiponectin in insulin resistance: lessons from translational research. Am J Clin Nutr 91: 258S-261S
    • (2010) Am J Clin Nutr , vol.91
    • Ziemke, F.1    Mantzoros, C.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.