The effects of sildenafil on rectal sensitivity and tone in patients with the irritable bowel syndrome

Alimentary Pharmacology and Therapeutics

Volumn 35, Issue 5, 2012, Pages 577-586

  Goncalves De Medeiros M T ^a   De Oliveira, R B ^b   Dos Santos, A A ^a   De Leopoldino, D M ^a   Oliveira Lima, M C ^a   Arrais Nobre, R ^a   Nobre e Souza, M A ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; SILDENAFIL;

ABDOMINAL PAIN; ADULT; ANXIETY DISORDER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEFECATION; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFECT; FEMALE; GASTROINTESTINAL TRACT FUNCTION; HAMILTON SCALE; HUMAN; INTESTINE FUNCTION; IRRITABLE COLON; MAJOR DEPRESSION; MALE; PAIN; PATIENT COMPLIANCE; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; RECTAL SENSITIVITY; RECTAL TONE; SENSATION; SENSORIMOTOR FUNCTION; SUPRALIMINAR PAIN; VISUAL ANALOG SCALE;

ADULT; DEFECATION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; MOOD DISORDERS; MUSCLE TONUS; NITRIC OXIDE; PAIN MEASUREMENT; PAIN THRESHOLD; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PSYCHIATRIC STATUS RATING SCALES; PURINES; RECTUM; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; SULFONES;

EID: 84856714741     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2011.04977.x     Document Type: Article

References (35)

1. Drossman DA, Camilleri M, Mayer EA, Whitehead WE,. AGA technical review on irritable bowel syndrome. Gastroenterology 2002; 123: 2108-31. (Pubitemid 35408332)
2. Ritchie J,. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973; 14: 125-32.
3. Loder PB, Kamm MA, Nicholls RJ, Phillips RK,. 'Reversible chemical sphincterotomy' by local application of glyceryl trinitrate. Br J Surg 1994; 81: 1386-9. (Pubitemid 24275183)
4. Tomita R, Fujisaki S, Ikeda T, Fukuzawa M,. Role of nitric oxide in the colon of patients with slow-transit constipation. Dis Colon Rectum 2002; 45: 593-600. (Pubitemid 34507232)
5. Kuiken SD, Klooker TK, Tytgat GN, Lei A, Boeckxstaens GE,. Possible role of nitric oxide in visceral hypersensitivity in patients with irritable bowel syndrome. Neurogastroenterol Motil 2006; 18: 115-22.
6. Toda N, Herman AG,. Gastrointestinal function regulation by nitrergic efferent nerves. Pharmacol Rev 2005; 57: 315-38. (Pubitemid 41196953)
7. Bortolotti M, Mari C, Lopilato C, Porrazzo G, Miglioli M,. Effects of sildenafil on esophageal motility of patients with idiopathic achalasia. Gastroenterology 2000; 118: 253-7. (Pubitemid 30067497)
8. Sarnelli G, Sifrim D, Janssens J, Tack J,. Influence of sildenafil on gastric sensorimotor function in humans. Am J Physiol Gastrointest Liver Physiol 2004; 287: G988-92. (Pubitemid 39423690)
9. Milone M, DiBaise JK,. A pilot study of the effects of sildenafil on stool characteristics, colon transit, anal sphincter function, and rectal sensation in healthy men. Dig Dis Sci 2005; 50: 1005-11. (Pubitemid 40863998)
10. Azpiroz F, Salvioli B,. Barostat Measurements. In:, Schuster M, Crowell M, Koch K, eds. Schuster Atlas of Gastrointestinal Motility in Health and Disease. London: BC Decker Inc, 2002; 151-70.
11. Lee KJ, Kim JH, Cho SW,. Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2005; 22: 981-8. (Pubitemid 41634880)
12. Thumshirn M, Camilleri M, Choi MG, Zinsmeister AR,. Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans. Gastroenterology 1999; 116: 573-85. (Pubitemid 29106765)
13. Delvaux M, Louvel D, Lagier E, Scherrer B, Abitbol JL, Frexinos J,. The kappa agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome. Gastroenterology 1999; 116: 38-45. (Pubitemid 29013491)
14. Geeraerts B, Vandenberghe J, Van Oudenhove L, et al,. Influence of experimentally induced anxiety on gastric sensorimotor function in humans. Gastroenterology 2005; 129: 1437-44. (Pubitemid 41597386)
15. Fritz E, Hammer J, Schmidt B, Eherer AJ, Hammer HF,. Stimulation of the nitric oxide-guanosine 3', 5'-cyclic monophosphate pathway by sildenafil: effect on rectal muscle tone, distensibility, and perception in health and in irritable bowel syndrome. Am J Gastroenterol 2003; 98: 2253-60. (Pubitemid 37305367)
16. Amorim P,. Mini International Neuropsychiatric Interview (MINI): validation of a short structural diagnostic psychiatric interview. Revista Brasileira de Psiquiatria 2008; 22: 10.
17. Hamilton M,. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
18. Hamilton M,. The assessment of anxiety states by rating. Br J Med Psychol 1959; 32: 50-5.
19. Simren M, Silny J, Holloway R, Tack J, Janssens J, Sifrim D,. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Gut 2003; 52: 784-90. (Pubitemid 36613482)
20. Eherer AJ, Schwetz I, Hammer HF, et al,. Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders. Gut 2002; 50: 758-64. (Pubitemid 34539035)
21. Verne GN, Robinson ME, Price DD,. Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome. Pain 2001; 93: 7-14. (Pubitemid 32530837)
22. D'Agostino R, Balanger A, D'Agostino R Jr,. A suggestion for using powerful and informative tests of normality. Am Statistician 1990; 44: 6.
23. Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada JR,. Gastric tone determines the sensitivity of the stomach to distention. Gastroenterology 1995; 108: 330-6.
24. Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP,. Molecular mechanism of cGMP-mediated smooth muscle relaxation. J Cell Physiol 2000; 184: 409-20. (Pubitemid 30625505)
25. Galie N, Ghofrani HA, Torbicki A, et al,. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005; 353: 2148-57. (Pubitemid 41653106)
26. Moreland RB, Goldstein I, Traish A,. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells. Life Sci 1998; 62: 309-18.
27. Rossoni G, Manfredi B, De Gennaro Colonna V, Berti M, Guazzi M, Berti F,. Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat. Br J Pharmacol 2007; 150: 567-76. (Pubitemid 46355556)
28. Devan BD, Bowker JL, Duffy KB, et al,. Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Psychopharmacology (Berl) 2006; 183: 439-45. (Pubitemid 41721145)
29. Domek-Lopacinska K, Strosznajder JB,. Cyclic GMP metabolism and its role in brain physiology. J Physiol Pharmacol 2005; 56 (Suppl 2): 15-34. (Pubitemid 44933666)
30. Prickaerts J, de Vente J, Honig W, Steinbusch HW, Blokland A,. cGMP, but not cAMP, in rat hippocampus is involved in early stages of object memory consolidation. Eur J Pharmacol 2002; 436: 83-7. (Pubitemid 34142401)
31. Zhang L, Zhang RL, Wang Y, et al,. Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke 2005; 36: 847-52.
32. Zhang R, Wang Y, Zhang L, et al,. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 2002; 33: 2675-80. (Pubitemid 35266440)
33. Almy TP, Tulin M,. Alterations in colonic function in man under stress; experimental production of changes simulating the irritable colon. Gastroenterology 1947; 8: 616-26.
34. Zar S, Benson MJ, Kumar D,. Rectal afferent hypersensitivity and compliance in irritable bowel syndrome: differences between diarrhoea- predominant and constipation-predominant subgroups. Eur J Gastroenterol Hepatol 2006; 18: 151-8. (Pubitemid 43361600)
35. Steens J, Van Der Schaar PJ, Penning C, Brussee J, Masclee AA,. Compliance, tone and sensitivity of the rectum in different subtypes of irritable bowel syndrome. Neurogastroenterol Motil 2002; 14: 241-7. (Pubitemid 34639451)