Possible role of nitric oxide in visceral hypersensitivity in patients with irritable bowel syndrome

Neurogastroenterology and Motility

Volumn 18, Issue 2, 2006, Pages 115-122

  Kuiken, S D ^a   Klooker, T K ^a   Tytgat, G N ^a   Lei, A ^a   Boeckxstaens, G E ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Barostat; Human; Irritable bowel syndrome; NG monomethyl L arginine; Nitric oxide; Perception; Rectal distension; Sensation

Indexed keywords

N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLACEBO;

ADULT; ARTICLE; BAROSTAT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPERSENSITIVITY; IRRITABLE COLON; MALE; PAIN; PATHOPHYSIOLOGY; PATIENT; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOLUNTEER;

ADULT; BLOOD PRESSURE; COMPLIANCE; DILATATION; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; FEMALE; HUMANS; HYPERALGESIA; IRRITABLE BOWEL SYNDROME; MALE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; PAIN THRESHOLD; RECTUM; VISCERA;

EID: 33645082944     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2005.00731.x     Document Type: Article

References (29)

1. Mayer EA Gebhart GF Basic and clinical aspects of visceral hyperalgesia Gastroenterology 1994 107 271 93
2. Bueno L Fioramonti J Delvaux M et al. Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations Gastroenterology 1997 112 1714 43
3. Cervero F Laird JM Visceral pain Lancet 1999 353 2145 8
4. Mertz H Review article: visceral hypersensitivity Aliment Pharmacol Ther 2003 17 623 33
5. Ritchie J Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome Gut 1973 14 125 32
6. Mertz H Naliboff B Munakata J et al. Altered rectal perception is a biological marker of patients with irritable bowel syndrome Gastroenterology 1995 109 40 52
7. Bouin M Plourde V Boivin M et al. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds Gastroenterology 2002 122 1771 7
8. Thompson WG Longstreth GF Drossman DA et al. Functional bowel disorders and functional abdominal pain Gut 1999 45 Suppl. 2 II43 7
9. Holzer P Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain Eur J Pharmacol 2001 429 177 93
10. Coutinho SV Gebhart GF A role for spinal nitric oxide in mediating visceral hyperalgesia in the rat Gastroenterology 1999 116 1399 408
11. Coutinho SV Urban MO Gebhart GF Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia Pain 1998 78 59 69
12. Kuiken SD Vergeer M Heisterkamp SH et al. Role of nitric oxide in gastric motor and sensory functions in healthy subjects Gut 2002 51 212 8
13. Tack J Demedts I Meulemans A et al. Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans Gut 2002 51 219 24
14. Sandrini G Tassorelli C Cecchini AP et al. Effects of nimesulide on nitric oxide-induced hyperalgesia in humans - a neurophysiological study Eur J Pharmacol 2002 450 259 62
15. Hirsch DP Holloway RH Tytgat GN et al. Involvement of nitric oxide in human transient lower esophageal sphincter relaxations and esophageal primary peristalsis Gastroenterology 1998 115 1374 80
16. Russo A Fraser R Adachi K et al. Evidence that nitric oxide mechanisms regulate small intestinal motility in humans Gut 1999 44 72 6
17. Kuiken SD Tytgat GN Boeckxstaens GE Role of endogenous nitric oxide in regulating antropyloroduodenal motility in humans Am J Gastroenterol 2002 97 1661 7
18. Kuiken SD Tytgat GN Boeckxstaens GE The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: a double blind, randomized, placebo controlled study Clin Gastroenterol Hepatol 2003 1 219 28
19. Azpiroz F Malagelada J-R Physiological variations in canine gastric tone measured by an electronic barostat Am J Physiol 1985 247 229 37
20. Corsetti M Vos R Demedts I et al. Nitric oxide and colonic sensory and motor responses to distension in healthy subjects [abstract] Gastroenterology 2002 122 A62
21. Whitehead WE Delvaux M Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. The Working Team of Glaxo-Wellcome Research, UK Dig Dis Sci 1997 42 223 41
22. Bradette M Delvaux M Staumont G et al. Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone Dig Dis Sci 1994 39 1171 8
23. Delvaux M Louvel D Lagier E et al. The kappa agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome Gastroenterology 1999 116 38 45
24. Lembo T Naliboff BD Matin K et al. Irritable bowel syndrome patients show altered sensitivity to exogenous opioids Pain 2000 87 137 47
25. Fritz E Hammer J Schmidt B Eherer AJ Hammer HF Stimulation of the nitric oxide-guanosine 3′, 5′-cyclic monophosphate pathway by sildenafil: effect on rectal muscle tone, distensibility, and perception in health and in irritable bowel syndrome Am J Gastroenterol 2003 98 2253 60
26. Mizuta Y Takahashi T Owyang C Nitrergic regulation of colonic transit in rats Am J Physiol 1999 277 G275 9
27. Zheng Z Shimamura K Anthony TL et al. Nitric oxide is a sensory nerve neurotransmitter in the mesenteric artery of guinea pig J Auton Nerv Syst 1997 67 137 44
28. Coutinho SV Urban MO Gebhart GF The role of CNS NMDA receptors and nitric oxide in visceral hyperalgesia Eur J Pharmacol 2001 429 319 25
29. Willert RP Woolf C Hobson A et al. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl- d -aspartate receptor Gastroenterology 2004 126 683 92