Influence of sildenafil on gastric sensorimotor function in humans

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 287, Issue 5 50-5, 2004, Pages

  Sarnelli, Giovanni ^a   Sifrim, Daniel ^a   Janssens, Jozef ^a   Tack, Jan ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Gastric accommodation; Gastric emptying; Gastric sensitivity; Nitric oxide

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; PLACEBO; SILDENAFIL;

ADULT; ARTICLE; BAROSTAT; CLINICAL TRIAL; COMPLIANCE (PHYSICAL); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOOD INTAKE; HUMAN; LIQUID; MALE; NORMAL HUMAN; PERCEPTION; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSORIMOTOR FUNCTION; SINGLE BLIND PROCEDURE; SOLID; STOMACH DISTENSION; STOMACH EMPTYING; STOMACH FUNCTION; STOMACH VOLUME;

ADULT; BALLOON DILATATION; FASTING; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; HUMANS; MALE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; POSTPRANDIAL PERIOD; PRESSURE; SENSATION; SINGLE-BLIND METHOD; STOMACH;

EID: 7044228115     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00419.2003     Document Type: Article

References (43)

1. Azpiroz F and Malagelada JR. Physiological variations in canine tone measured by an electronic barostat. Am J Physiol Gastrointest Liver Physiol 248: G229-G237, 1985.
2. Azpiroz F and Malagelada JR. Vagally mediated gastric relaxation induced by intestinal nutrients in the dog. Am J Physiol Gastrointest Liver Physiol 251: G727-G735, 1986.
3. Azpiroz F and Malagelada JR. Importance of vagal input in maintaining gastric tone in the dog. J Physiol 384: 511-524, 1987.
4. Barbier AJ and Lefebvre RA. Involvement of the L-arginine-nitric oxide pathway in nonadrenergic noncholinergic relaxation of the cat gastric fundus. J Pharmacol Exp Ther 266: 172-178, 1993.
5. Boeckxstaens GE, Pelckmans PA, Bogers JJ, Bult H, De Man JG, Oosterbosch L, Herman AG, and Van Maercke YM. Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus. J Pharmacol Exp Ther 256: 441-447, 1991.
6. Bortolotti M, Mari C, Lopilato C, La Rovere L, and Miglioli M. Sildenafil inhibits gastroduodenal motility. Aliment Pharmacol Ther 15: 157-61, 2001.
7. Bortolotti M, Mari C, Lopilato C, Porrazzo G, and Miglioli M. Effects of sildenafil on esophageal motility of patients with idiopathic achalasia. Gastroenterology 118: 253-257, 2000.
8. Camilleri M, Malagelada JR, Brown ML, Becker G, and Zinsmeister AR. Relation between antral motility and gastric emptying of solids and liquids in humans. Am J Physiol Gastrointest Liver Physiol 249: G580-G585, 1985.
9. Carvajal JA, Germain AM, Huidobro-Toro JP, and Weiner CP Molecular mechanism of cGMP-mediated smooth muscle relaxation. J Cell Physiol 184: 409-420, 2000.
10. Corbin JD and Francis SH. Cyclic GMP phosphodiesterase-5: target of Sildenafil. J Biol Chem 274: 13729-13732, 1999.
11. 1 receptor-mediated relaxation of gastric fundus. Am J Physiol Gastrointest Liver Physiol 276: G373-G377, 1999.
12. Delgado-Aros S, Kim DY, Burton DD, Thomforde GM, Stephens D, Brinkmann BH, Vella A, and Camilleri M. Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans. Am J Physiol Gastrointest Liver Physiol 282: G424-G431, 2002.
13. Desai KM, Sessa WC, and Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 35: 477-479, 1991.
14. Gilja OH, Hausken T, Wilhelmsen I, and Berstad A. Impaired accommodation of proximal stomach to a meal in functional dyspepsia. Dig Dis Sci 41: 689-696, 1996.
15. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, and Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 338: 1397-1404, 1988.
16. Grundy D, Gharib-Naseri MK, and Hutson D. Role of nitric oxide and vasoactive intestinal polypeptide in vagally mediated relaxation of the gastric corpus in the anaesthetized ferret. J Auton Nerv Syst 43: 241-246, 1993.
17. Horowitz M, Dent J, Fraser R, Sun W, and Hebbard G. Role and integration of mechanisms controlling gastric emptying. Dig Dis Sci Suppl 39: 7S-13S, 1994.
18. Huang PL, Dawson TM, Bredt DS, Snyder SH, and Fishman MC. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75: 1273-1286, 1993.
19. Indireshkumar K, Brasseur JG, Faas H, Hebbard GS, Kunz P, Dent J, Feinle C, Li M, Boesiger P, Fried M, and Schwizer W. Relative contributions of "pressure pump" and "peristaltic pump" to gastric emptying. Am J Physiol Gastrointest Liver Physiol 278: G604-G616, 2000.
20. Konturek JW, Thor P, and Domschke W. Effects of nitric oxide on antral motility and gastric emptying in humans. Eur J Gastroenterol Hepatol 7: 97-102, 1995.
21. Kuiken SD, Vergeer M, Heisterkamp SH, Tytgat GN, and Boeckxstaens GE. Role of nitric oxide in gastric motor and sensory functions in healthy subjects. Gut 51: 212-218, 2002.
22. Li CG and Rand MJ. Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic, noncholinergic inhibitory transmission to smooth muscle of the rat gastric fundus. Eur J Pharmacol 191: 303-309, 1990.
23. Lidums I, Hebbard GS, and Holloway RH. Effect of atropine on proximal gastric motor and sensory function in normal subjects. Gut 47: 30-36, 2000.
24. Lingenfelser T, Blackshaw LA, Sun WM, and Dent J. Pyloric motor response to central and peripheral nitric oxide in the ferret. Neurogastroenterol Motil 9: 167-175, 1997.
25. Maes BD, Ghoos YF, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, and Vantrappen G. Combined carbon-13-glycine/carbon-14-octanoic acid breath test to monitor gastric emptying rates of liquids and solids. J Nucl Med 35: 824-831, 1994.
26. Meulemans AL, Eelen JGM, and Schuurkes JAJ. NO mediates gastric relaxation after brief vagal stimulation in anesthetized dogs. Am J Physiol Gastrointest Liver Physiol 269: G255-G261, 1995.
27. Meulemans AL, Helsen LF, and Schuurkes JAJ. The role of nitric oxide (NO) in 5-HT-induced relaxations of the guinea-pig stomach. Naunyn Schmiedebergs Arch Pharmacol 348: 424-430, 1993.
28. Moreland RB, Goldstein I, and Traish A. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells. Life Sci 62: 309-318, 1998.
29. Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, and Malagelada JR. Gastric tone determines the sensitivity of the stomach to distension. Gastroenterology 108: 330-336, 1995.
30. Paterson CA, Anvari M, Tougas G, and Huizinga JD. Determinants of occurrence and volume of transpyloric flow during gastric emptying of liquids in dogs: importance of vagal input Dig Dis Sci 45: 1509-1516, 2000.
31. Salet GA, Samsom M, Roelofs JM, van Berge Henegouwen GP, Smout AJ, and Akkermans LM. Responses to gastric distention in functional dyspepsia. Gut 42: 823-829, 1998.
32. Sarnelli G, Caenepeel P, Geypens B, Janssens J, and Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 98: 783-788, 2003.
33. Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, Marengo M, and Corinaldesi R. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 110: 1036-1042, 1996.
34. Sun WM, Doran S, Jones KL, Ooi E, Boeckxstaens G, Hebbard GS, Lingenfelser T, Morley JE, Dent J, and Horowitz M. Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility. Am J Physiol Gastrointest Liver Physiol 275: G1173-G1178, 1998.
35. Tack J, Broeckaert D, Coulie B, and Janssens J. The influence of cisapride on gastric tone and the perception of gastric distension. Aliment Pharmacol Ther 12: 761-766, 1998.
36. Tack J, Caenepeel P, Fischler B, Piessevaux H, and Janssens J. Symptoms associated to hypersensitivity to gastric distensions in functional dyspepsia. Gastroenterology 121: 526-535, 2001.
37. Tack J, Demedts I, Meulemans A, Schuurkes J, and Janssens J. Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in man. Gut 51: 219-224, 2002.
38. Tack J, Piessevaux H, Coulie B, Caenepeel P, and Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 115: 1346-1352, 1998.
39. Takahashi T and Owyang C. Vagal control of nitric oxide and vasoactive intestinal peptide release in the regulation of gastric relaxation. J Physiol 484: 481-492, 1995.
40. 2- adrenergic agents in humans. Gastroenterology 116: 573-585, 1999.
41. Tonini M, De Giorgio R, De Ponti F, Sternini C, Spelta V, Dionigi P, Barbara G, Stanghellini V, and Corinaldesi R. Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations. Br J Pharmacol 129: 12-20, 2000.
42. Troncon LE, Bennett RJ, Ahluwalia NK, and Thompson DG. Abnormal distribution of food during gastric emptying in functional dyspepsia patients. Gut 35: 327-332, 1994.
43. Watkins CC, Sawa A, Jeffrey S, Blackshaw S, Barrow RK, Snyder SH, and Ferris CD. Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. J Clin Invest 106: 373-384, 2000.