Adrenomedullin reduces mesangial cell number and glomerular inflammation in experimental mesangioproliferative glomerulonephritis

Kidney International

Volumn 68, Issue 3, 2005, Pages 1086-1095

  Plank, Christian ^a   Hartner, Andrea ^b   Klanke, Bernd ^b   Geissler, Bettina ^b   Porst, Markus ^b   Amann, Kerstin ^b   Hilgers, Karl F ^b   Rascher, Wolfgang ^b   Dötsch, Jörg ^b  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b NONE

Author keywords

Adrenomedullin; Apoptosis; Glomerulosclerosis; Mesangioproliferative glomerulonephritis; Proliferation; Thy1.1

Indexed keywords

ADRENOMEDULLIN; COLLAGEN TYPE 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; KIDNEY CORTEX; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MESANGIUM CELL; MONOCYTE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE;

ADRENOMEDULLIN; ANIMALS; BODY WEIGHT; CELL COUNT; FIBROSIS; GLOMERULAR MESANGIUM; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; MALE; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; URINE; VASODILATOR AGENTS;

EID: 32644484891     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2005.00501.x     Document Type: Article

References (42)

1. KITAMURA K, SAKATA J, KANGAWA K, et al: Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem Biophys Res Commun 194:720-725, 1993
2. ETO T, KITAMURA K: Adrenomedullin and its role in renal diseases. Nephron 89:121-134, 2001
3. POYNER DR, SEXTON PM, MARSHALL I, et al: International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54:233-246, 2002
4. PARAMESWARAN N, NOWAK W, HALL CS, et al: Cellular and molecular actions of adrenomedullin in glomerular mesangial cells. Peptides 22:1919-1924, 2001
5. KOHNO M, YASUNARI K, MINAMI M, et al: Regulation of rat mesangial cell migration by platelet-derived growth factor, angiotensin II, and adrenomedullin. J Am Soc Nephrol 10:2495-2502, 1999
6. PARAMESWARAN N, NAMBI P, BROOKS DP, SPIELMAN WS: Regulation of glomerular mesangial cell proliferation in culture by adrenomedullin. Eur J Pharmacol 372:85-95, 1999
7. DOTSCH J, SCHOOF E, SCHOCKLMANN HO, et al: Nitric oxide increases adrenomedullin receptor function in rat mesangial cells. Kidney Int 61:1707-1713, 2002
8. CHAO J, JIN L, LIN KF, CHAO L: Adrenomedullin gene delivery reduces blood pressure in spontaneously hypertensive rats. Hypertens Res 20:269-277, 1997
9. CHAO J, KATO K, ZHANG JJ, et al: Human adrenomedullin gene delivery protects against cardiovascular remodeling and renal injury. Peptides 22:1731-1737, 2001
10. ZHANG JJ, YOSHIDA H, CHAO L, CHAO J: Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis, and renal damage in hypertensive dahl salt-sensitive rats. Hum Gene Ther 11:1817-1827, 2000
11. NISHIKIMI T, MORI Y, KOBAYASHI N, et al: Renoprotective effect of chronic adrenomedullin infusion in Dahl salt-sensitive rats. Hypertension 39:1077-1082, 2002
12. MORI Y, NISHIKIMI T, KOBAYASHI N, et al: Long-term adrenomedullin infusion improves survival in malignant hypertensive rats. Hypertension 40:107-113, 2002
13. BAGCHUS WM, HOEDEMAEKER PJ, ROZING J, BAKKER WW: Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. A sequential histological and ultrastructural study in the rat. Lab Invest 55:680-687, 1986
14. MATSUMOTO M, FUJIMOTO S, IWATSUBO S, et al: Adrenomedullin (AM) and receptor-activity-modifying proteins in glomeruli with Thy.1 glomerulonephritis. Clin Exp Nephrol 8:316-321, 2004
15. HILGERS KF, PETERS J, VEELKEN R, et al: Increased vascular angiotensin formation in female rats harboring the mouse Ren-2 gene. Hypertension 19:687-691, 1992
16. RUPPRECHT HD, DANN P, SUKHATME VP, et al: Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: Correlation with mitogenicity. Am J Physiol 263:F623-636, 1992
17. UNO Y, HORII A, UMEMOTO M, et al: Effects of hypergravity on morphology and osteopontin expression in the rat otolith organs. J Vestib Res 10:283-289, 2000
18. KONISHI A, TAZAWA C, MIKI Y, et al: The possible roles of mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 2 in cardiac fibrosis in the spontaneously hypertensive rat. J Steroid Biochem Mol Biol 85:439-442, 2003
19. CARL M, AKAGI Y, WEIDNER S, et al: Specific inhibition of Egr-1 prevents mesangial cell hypercellularity in experimental nephritis. Kidney Int 63:1302-1312, 2003
20. HAAS CS, AMANN K, SCHITTNY J, et al: Glomerular and renal vascular structural changes in alpha8 integrin-deficient mice. J Am Soc Nephrol 14:2288-2296, 2003
21. HARTNER A, PORST M, GAUER S, et al: Glomerular osteopontin expression and macrophage infiltration in glomerulosclerosis of DOCA-salt rats. Am J Kidney Dis 38:153-164, 2001
22. PARAMESWARAN N, NAMBI P, HALL CS, et al: Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells. Eur J Pharmacol 388:133-138, 2000
23. SEGAWA K, MINAMI K, SATA T, et al: Inhibitory effect of adrenomedullin on rat mesangial cell mitogenesis. Nephron 74:577-579, 1996
24. CHINI EN, CHOI E, GRANDE JP, et al: Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Biochem Biophys Res Commun 215:868-873, 1995
25. LIU X, ZHANG Z, ZHANG X, et al: The localization of adrenomedullin in rat kidney tissue and its inhibitory effect on the growth of cultured rat mesangial cells. Chin Med Sci J 17:129-133, 2002
26. MICHIBATA H, MUKOYAMA M, TANAKA I, et al: Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells. Kidney Int 53:979-985, 1998
27. OSAJIMA A, UEZONO Y, TAMURA M, et al: Adrenomedullin-sensitive receptors are preferentially expressed in cultured rat mesangial cells. Eur J Pharmacol 315:319-325, 1996
28. HUGO C, SHANKLAND SJ, BOWEN-POPE DF, et al: Extraglomerular origin of the mesangial cell after injury. A new role of the juxta-glomerular apparatus. J Clin Invest 100:786-794, 1997
29. CHENG QL, ORIKASA M, MORIOKA T, et al: Progressive renal lesions induced by administration of monoclonal antibody 1-22-3 to unilaterally nephrectomized rats. Clin Exp Immunol 102:181-185, 1995
30. KHAN AI, KATO J, ISHIYAMA Y, et al: Effect of chronically infused adrenomedullin in two-kidney, one-clip hypertensive rats. Eur J Pharmacol 333:187-190, 1997
31. KANDLER MA, VON DER HARDT K, MAHFOUD S, et al: Pilot intervention: Aerosolized adrenomedullin reduces pulmonary hypertension. J Pharmacol Exp Ther 306:1021-1026, 2003
32. VON DER HARDT K, KANDLER MA, POPP K, et al: Aerosolized adrenomedullin suppresses pulmonary transforming growth factor-beta1 and interleukin-1 beta gene expression in vivo. Eur J Pharmacol 457:71-76, 2002
33. CLEMENTI G, CARUSO A, CUTULI VM, et al: Effects of centrally of peripherally injected adrenomedullin on reserpine-induced gastric lesions. Eur J Pharmacol 360:51-54, 1998
34. PETERS H, BORDER WA, NOBLE NA: Targeting TGF-beta overexpression: Maximizing the antifibrotic actions of angiotensin II blockade in anti-Thy1 glomerulonephritis. Nephrol Dial Transplant 14(Suppl 4):22-23, 1999
35. HARAGUCHI M, BORDER WA, HUANG Y, NOBLE NA: t-PA promotes glomerular plasmin generation and matrix degradation in experimental glomerulonephritis. Kidney Int 59:2146-2155, 2001
36. BITZER M, STERZEL RB, BOTTINGER EP: Transforming growth factor-beta in renal disease. Kidney Blood Press Res 21:1-12, 1998
37. FOGO AB: Hypertensive risk factors in kidney disease in African Americans. Kidney Int (Suppl):S17-21, 2003
38. YAGI M, YAMAMOTO T, NAGANO N, et al: Transient expression of type I collagen in glomeruli with anti-Thy-1 antibody-induced mesangial proliferative lesions. Pathol Int 45:409-414, 1995
39. DONADIO JV, GRANDE JP: IgA nephropathy. N Engl J Med 347:738-748, 2002
40. KUBO A, NISHITANI Y, MINAMINO N, et al: Adrenomedullin gene transcription is decreased in peripheral blood mononuclear cells of patients with IgA nephropathy. Nephron 85:201-206, 2000
41. NAGAYA N, NISHIKIMI T, UEMATSU M, et al: Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension. Heart 84:653-658, 2000
42. NAGAYA N, SATOH T, NISHIKIMI T, et al: Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure. Circulation 101:498-503, 2000