12- to 22-membered bridged β-lactams as potential penicillin-binding protein inhibitors

Chemistry - An Asian Journal

Volumn 7, Issue 2, 2012, Pages 425-434

  Sliwa, Aline ^a   Dive, Georges ^b   Marchand Brynaert, Jacqueline ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

ab initio calculations; enzymes; inhibitors; macrocycles; metathesis

Indexed keywords

AB INITIO CALCULATIONS; ACTIVE SITE; CARBOXY GROUPS; INHIBITION EFFECT; MACROCYCLES; METATHESIS; NON-TRADITIONAL; NUCLEOPHILIC ATTACK; PENICILLIN-BINDING PROTEINS; POTENTIAL INHIBITORS; POTENTIAL LIGAND; REACTION MODEL; RING CLOSING METATHESIS; RING OPENING; SIDE-CHAINS; STERIC HINDRANCES;

BIOSYNTHESIS; CALCULATIONS; CORROSION INHIBITORS; ENZYMES; PROTEINS;

AMIDES;

ANTIINFECTIVE AGENT; BETA LACTAM; MACROCYCLIC COMPOUND; PENICILLIN BINDING PROTEIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG EFFECT; PROTEIN BINDING; SYNTHESIS; THERMODYNAMICS;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; COMPUTER SIMULATION; MACROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; PENICILLIN-BINDING PROTEINS; PROTEIN BINDING; THERMODYNAMICS;

EID: 84856708470     PISSN: 18614728     EISSN: 1861471X     Source Type: Journal    
DOI: 10.1002/asia.201100732     Document Type: Article

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