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Angewandte Chemie - International Edition

Volumn 51, Issue 3, 2012, Pages 642-646

Conformational selection versus induced fit in kinases: The case of PI3K-Iγ

(4) D'Abramo, Marco a Rabal, Obdulia a,b Oyarzabal, Julen a,b Gervasio, Francesco Luigi a

a Centro Nacional de Investigaciones Oncológicas (Spain)

b UNIVERSITY OF NAVARRA (Spain)

Author keywords

conformational selection; induced fit; kinases; molecular dynamics; molecular recognition

Indexed keywords

BINDING EVENTS; CONFORMATIONAL SELECTION; FREE-ENERGY CALCULATIONS; INDUCED FIT; KINASES; MOLECULAR DYNAMICS SIMULATIONS; PHOSPHOINOSITIDE 3-KINASE;

BINDING ENERGY; DYNAMICS; FREE ENERGY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION;

ENZYMES;

APOPROTEIN; LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3R3 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN CONFORMATION;

APOPROTEINS; BINDING SITES; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84855765478 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201103264 Document Type: Article

Times cited : (16)

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