Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress

Basic Research in Cardiology

Volumn 106, Issue 6, 2011, Pages 1147-1158

  Kröller Schön, Swenja ^a,b   Schulz, Eberhard ^a   Wenzel, Philip ^a,b   Kleschyov, Andrei L ^a   Hortmann, Marcus ^a   Torzewski, Michael ^c   Oelze, Matthias ^a   Renné, Thomas ^d   Daiber, Andreas ^a   Münzel, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c ROBERT BOSCH HOSPITAL   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Endothelial function; Heart rate; Ivabradine; Oxidative stress

Indexed keywords

ANGIOTENSIN 1A RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IVABRADINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERIC REPEAT BINDING FACTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL AGING; CELL PROTECTION; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; HEART RATE VARIABILITY; HUMAN; HUMAN CELL; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TELOMERE HOMEOSTASIS; UPREGULATION;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BENZAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HEART RATE; HEMODYNAMICS; HUMANS; HYPERTENSION; IMMUNOBLOTTING; LUMINESCENCE; MALE; MICE; MICE, KNOCKOUT; NEUTROPHILS; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84856691765     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-011-0227-3     Document Type: Article

References (35)

1. Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840-844
2. Custodis F, Baumhakel M, Schlimmer N, List F, Gensch C, Bohm M, Laufs U (2008) Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation 117:2377-2387. doi:10.1161/CIRCULATIONAHA.107.746537 (Pubitemid 351653554)
3. Custodis F, Schirmer SH, Baumhakel M, Heusch G, Bohm M, Laufs U Vascular pathophysiology in response to increased heart rate. J Am Coll Cardiol 56:1973-1983. doi:10.1016/j.jacc.2010. 09.014
4. Daiber A, August M, Baldus S, Wendt M, Oelze M, Sydow K, Kleschyov AL, Munzel T (2004) Measurement of NAD (P) H oxidasederived superoxide with the luminol analogue L-012. Free Radic Biol Med 36:101-111. doi:10.1016/j. freeradbiomed.2003. 10.012 (Pubitemid 38068295)
5. Goettsch C, Goettsch W, Brux M, Haschke C, Brunssen C, Muller G, Bornstein SR, Duerrschmidt N, Wagner AH, Morawietz H Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells. Basic Res Cardiol 106:551-561. doi:10.1007/s00395-011-0170-3
6. Gokce N, Keaney JF Jr, Hunter LM, Watkins MT, Menzoian JO, Vita JA (2002) Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation 105:1567-1572. doi:10.1161/01. CIR.0000012543.55874.47 (Pubitemid 34297634)
7. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104:2673-2678. doi:10.1161/hc4601. 099485 (Pubitemid 33108132)
8. Heusch G (2008) Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents. Br J Pharmacol 153:1589-1601. doi:10.1038/sj.bjp. 0707673 (Pubitemid 351535988)
9. Heusch G (2008) Pleiotropic action (s) of the bradycardic agent ivabradine: cardiovascular protection beyond heart rate reduction. Br J Pharmacol 155:970-971. doi:10.1038/bjp. 2008.347
10. Heusch G, Skyschally A, Gres P, van Caster P, Schilawa D, Schulz R (2008) Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction. Eur Heart J 29:2265-2275. doi:10.1093/eurheartj/ehn337
11. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T (2001) Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88:E14-E22. doi:10.1161/01. RES.88.2.e14
12. Hishikawa K, Oemar BS, Yang Z, Luscher TF (1997) Pulsatile stretch stimulates superoxide production and activates nuclear factor-kappa B in human coronary smooth muscle. Circ Res 81:797-803 (Pubitemid 27467214)
13. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111:1201-1209. doi:10.1172/JCI14172 (Pubitemid 36519937)
14. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy S, Gamez G, Griendling KK, Harrison DG (2005) Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. Am J Physiol Heart Circ Physiol 288:H7-H12. doi:10.1152/ajpheart.00637.2004 (Pubitemid 40023821)
15. Levine HJ (1997) Rest heart rate and life expectancy. J Am Coll Cardiol 30:1104-1106. doi:10.1016/S0735-1097(97) 00246-5 (Pubitemid 27435908)
16. Li YL, Tran TP, Muelleman R, Schultz HD (2008) Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel. Cardiovasc Res 79:715-721. doi:10.1093/cvr/cvn141
17. Liu Y, Gutterman DD (2009) Vascular control in humans: focus on the coronary microcirculation. Basic Res Cardiol 104:211-227. doi:10.1007/s00395- 009-0775-y
18. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods 25:402-408. doi:10.1006/meth. 2001.1262 (Pubitemid 34164012)
19. Mollnau H, Wendt M, Szocs K, Lassegue B, Schulz E, Oelze M, Li H, Bodenschatz M, August M, Kleschyov AL, Tsilimingas N, Walter U, Forstermann U, Meinertz T, Griendling K, Munzel T (2002) Effects of angiotensin II infusion on the expression and function of NAD (P) H oxidase and components of nitric oxide/cGMP signaling. Circ Res 90:E58-E65. doi:10.1161/01. RES. 0000012569.55432.02
20. Morawietz H Endothelial NADPH oxidases: friends or foes? Basic Res Cardiol 106:521-525. doi:10.1007/s00395-011-0188-6
21. Munzel T, Daiber A, Ullrich V, Mulsch A (2005) Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent protein kinase. Arterioscler Thromb Vasc Biol 25:1551-1557. doi:10.1161/01. ATV.0000168896.64927.bb (Pubitemid 41098921)
22. Munzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG (1995) Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J Clin Invest 95:187-194. doi: 10.1172/JCI117637
23. Murdoch CE, Alom-Ruiz SP, Wang M, Zhang M, Walker S, Yu B, Brewer A, Shah AM Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol 106:527-538. doi:10.1007/s00395-011-0179-7
24. Oelze M, Daiber A, Brandes RP, Hortmann M, Wenzel P, Hink U, Schulz E, Mollnau H, von Sandersleben A, Kleschyov AL, Mulsch A, Li H, Forstermann U, Munzel T (2006) Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 48:677-684. doi:10.1161/01. HYP.0000239207.82326.29 (Pubitemid 44843872)
25. Popp R, Fleming I, Busse R (1998) Pulsatile stretch in coronary arteries elicits release of endothelium-derived hyperpolarizing factor: a modulator of arterial compliance. Circ Res 82:696-703 (Pubitemid 28160710)
26. Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG (1996) Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 97:1916-1923. doi: 10.1172/JCI118623
27. Reunanen A, Karjalainen J, Ristola P, Heliovaara M, Knekt P, Aromaa A (2000) Heart rate and mortality. J Intern Med 247:231-239. doi:10.1046/j.1365- 2796.2000.00602.x (Pubitemid 30108357)
28. Schachinger V, Britten MB, Zeiher AM (2000) Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101:1899-1906 (Pubitemid 30225269)
29. Schulz E, Dopheide J, Schuhmacher S, Thomas SR, Chen K, Daiber A, Wenzel P, Munzel T, Keaney JF Jr (2008) Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation 118:1347-1357. doi:10.1161/CIRCULATIONAHA.108.784289
30. Silacci P, Desgeorges A, Mazzolai L, Chambaz C, Hayoz D (2001) Flow pulsatility is a critical determinant of oxidative stress in endothelial cells. Hypertension 38:1162-1166. doi:10.1161/hy1101.095993 (Pubitemid 34252823)
31. Sirker A, Zhang M, Shah AM NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies. Basic Res Cardiol 106:735-747. doi:10.1007/s00395-011-0190-z
32. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison DG (1995) Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol 269:C1371-C1378
33. van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413. doi:10.1016/S0092-8674(00) 80932-0 (Pubitemid 28093017)
34. Wenzel P, Oelze M, Coldewey M, Hortmann M, Seeling A, Hink U, Mollnau H, Stalleicken D, Weiner H, Lehmann J, Li H, Forstermann U, Munzel T, Daiber A (2007) Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates. Arterioscler Thromb Vasc Biol 27:1729-1735. doi:10.1161/ATVBAHA.107.143909 (Pubitemid 47207167)
35. Wenzel P, Schulz E, Oelze M, Muller J, Schuhmacher S, Alhamdani MS, Debrezion J, Hortmann M, Reifenberg K, Fleming I, Munzel T, Daiber A (2008) AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats. Free Radic Biol Med 45:619-626. doi:10.1016/j.freeradbiomed.2008.05.009