MHC class II and CD9 in human eosinophils localize to detergent-resistant membrane microdomains

American Journal of Respiratory Cell and Molecular Biology

Volumn 46, Issue 2, 2012, Pages 188-195

  Akuthota, Praveen ^a   Melo, Rossana C N ^a,b   Spencer, Lisa A ^a   Weller, Peter F ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Antigen presentation; CD9; Eosinophils; HLA DR; Immunoelectron microscopy

Indexed keywords

CD69 ANTIGEN; CD9 ANTIGEN; GANGLIOSIDE GM1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; METHYL BETA CYCLODEXTRIN; SUPERANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL MEMBRANE; CYTOKINE PRODUCTION; DETERGENT RESISTANT MEMBRANE MICRODOMAIN; ELECTRON MICROSCOPY; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOLOCALIZATION; IMMUNOPRECIPITATION; LYMPHOCYTE PROLIFERATION; MEMBRANE DAMAGE; PROTEIN CROSS LINKING; PROTEIN DEPLETION; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

ANTIGENS, CD9; CD4-POSITIVE T-LYMPHOCYTES; DETERGENTS; EOSINOPHILS; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MEMBRANES, ARTIFICIAL;

MURINAE;

EID: 84856683094     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0335OC     Document Type: Article

References (41)

1. Jacobsen EA, Taranova AG, Lee NA, Lee JJ. Eosinophils: singularly destructive effector cells or purveyors of immunoregulation? J Allergy Clin Immunol 2007;119:1313-1320. (Pubitemid 46855871)
2. Lucey DR, Nicholson-Weller A, Weller PF. Mature human eosinophils have the capacity to express HLA-DR. Proc Natl Acad Sci USA 1989;86:1348-1351. (Pubitemid 19061543)
3. Tamura N, Ishii N, Nakazawa M, Nagoya M, Yoshinari M, Amano T, Nakazima H, Minami M. Requirement of CD80 and CD86 molecules for antigen presentation by eosinophils. Scand J Immunol 1996;44:229-238. (Pubitemid 26273758)
4. Shi HZ, Humbles A, Gerard C, Jin Z, Weller PF. Lymph node trafficking and antigen presentation by endobronchial eosinophils. J Clin Invest 2000;105:945-953. (Pubitemid 30203067)
5. Padigel UM, Hess JA, Lee JJ, Lok JB, Nolan TJ, Schad GA, Abraham D. Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice. J Infect Dis 2007;196:1844-1851. (Pubitemid 351411946)
6. Padigel UM, Lee JJ, Nolan TJ, Schad GA, Abraham D. Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. Infect Immun 2006;74:3232-3238. (Pubitemid 43794511)
7. Wang HB, Ghiran I, Matthaei K, Weller PF. Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. J Immunol 2007;179:7585-7592.
8. Dykstra M, Cherukuri A, Sohn HW, Tzeng SJ, Pierce SK. Location is everything: lipid rafts and immune cell signaling. Annu Rev Immunol 2003;21:457-481. (Pubitemid 37174538)
9. Huby RD, Dearman RJ, Kimber I. Intracellular phosphotyrosine induction by major histocompatibility complex Class II requires co-aggregation with membrane rafts. J Biol Chem 1999;274:22591-22596.
10. Anderson HA, Hiltbold EM, Roche PA. Concentration of MHC Class II molecules in lipid rafts facilitates antigen presentation. Nat Immunol 2000;1:156-162.
11. Eren E, Yates J, Cwynarski K, Preston S, Dong R, Germain C, Lechler R, Huby R, Ritter M, Lombardi G. Location of major histocompatibility complex Class II molecules in rafts on dendritic cells enhances the efficiency of T-cell activation and proliferation. Scand J Immunol 2006;63:7-16.
12. Yoon J, Terada A, Kita H. CD66b regulates adhesion and activation of human eosinophils. J Immunol 2007;179:8454-8462.
13. Fernvik E, Hallden G, Hed J, Lundahl J. Intracellular and surface distribution of CD9 in human eosinophils. APMIS 1995;103:699-706.
14. Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T. Functional expression of transmembrane 4 superfamily molecules on human eosinophils. Int Arch Allergy Immunol 1999;120:38-44. (Pubitemid 29457360)
15. Kim JT, Gleich GJ, Kita H. Roles of CD9 molecules in survival and activation of human eosinophils. J Immunol 1997;159:926-933. (Pubitemid 127484247)
16. Sloma I, Zilber MT, Vasselon T, Setterblad N, Cavallari M, Mori L, De Libero G, Charron D, Mooney N, Gelin C. Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. J Immunol 2008;180:980-987.
17. Zilber MT, Setterblad N, Vasselon T, Doliger C, Charron D, Mooney N, Gelin C. MHC Class II/CD38/CD9: a lipid-raft-dependent signaling complex in human monocytes. Blood 2005;106:3074-3081. (Pubitemid 41565903)
18. Unternaehrer JJ, Chow A, Pypaert M, Inaba K, Mellman I. The tetraspanin CD9 mediates lateral association of MHC Class II molecules on the dendritic cell surface. Proc Natl Acad Sci USA 2007;104:234-239. (Pubitemid 46068015)
19. Akuthota P, Spencer LA, Radke AL, Ghiran I, Weller PF. Association of the tetraspanin CD9 with MHC Class II in human eosinophils. Am J Respir Crit Care Med 2008;177:A601.
20. Akuthota P, Spencer LA, Radke AL, Weller PF.MHC Class II and CD9 localize to lipid rafts in human eosinophils. Am J Respir Crit Care Med 2009;179:A3697.
21. Neves JS, Perez SA, Spencer LA, Melo RC, Weller PF. Subcellular fractionation of human eosinophils: isolation of functional specific granules on isoosmotic density gradients. J Immunol Methods 2009;344:64-72.
22. Merritt EA, Sarfaty S, van den Akker F, L'Hoir C, Martial JA, Hol WG. Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide. Protein Sci 1994;3:166-175. (Pubitemid 24086350)
23. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31-39.
24. Harder T, Scheiffele P, Verkade P, Simons K. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J Cell Biol 1998;141:929-942. (Pubitemid 28243961)
25. Kovalenko OV, Yang X, Kolesnikova TV, Hemler ME. Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. Biochem J 2004;377:407-417. (Pubitemid 38142196)
26. Mawhorter SD, Kazura JW, Boom WH. Human eosinophils as antigen-presenting cells: relative efficiency for superantigen- and antigeninduced CD4+ T-cell proliferation. Immunology 1994;81:584-591. (Pubitemid 24246508)
27. Hara T, Jung LK, Bjorndahl JM, Fu SM. Human T cell activation: III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens. J Exp Med 1986;164:1988-2005. (Pubitemid 17217978)
28. Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E. Lateral organization of membrane proteins: tetraspanins spin their web. Biochem J 2009;420:133-154.
29. Fujita A, Cheng J, Hirakawa M, Furukawa K, Kusunoki S, Fujimoto T. Gangliosides GM1 and GM3 in the living cell membrane form clusters susceptible to cholesterol depletion and chilling. Mol Biol Cell 2007;18:2112-2122. (Pubitemid 46911363)
30. Hemler ME. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol 2005;6:801-811. (Pubitemid 41726118)
31. Becart S, Setterblad N, Ostrand-Rosenberg S, Ono SJ, Charron D, Mooney N. Intracytoplasmic domains of MHC Class II molecules are essential for lipid-raft-dependent signaling. J Cell Sci 2003;116:2565-2575. (Pubitemid 36790137)
32. Bouillon M, El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W. Lipid raft-dependent and -independent signaling through HLA-DR molecules. J Biol Chem 2003;278:7099-7107. (Pubitemid 36800707)
33. Goebel J, Forrest K, Flynn D, Rao R, Roszman TL. Lipid rafts, major histocompatibility complex molecules, and immune regulation. Hum Immunol 2002;63:813-820. (Pubitemid 35246762)
34. Poloso NJ, Roche PA. Association of MHC Class II-peptide complexes with plasma membrane lipid microdomains. Curr Opin Immunol 2004;16:103-107. (Pubitemid 38202217)
35. Setterblad N, Becart S, Charron D, Mooney N. B cell lipid rafts regulate both peptide-dependent and peptide-independent APC-T cell interaction. J Immunol 2004;173:1876-1886. (Pubitemid 38971622)
36. Setterblad N, Roucard C, Bocaccio C, Abastado JP, Charron D, Mooney N. Composition of MHC Class II-enriched lipid microdomains is modified during maturation of primary dendritic cells. J Leukoc Biol 2003;74:40-48. (Pubitemid 38040435)
37. Demotz S, Grey HM, SetteA. Theminimal number of Class IIMHC-antigen complexes needed for T cell activation. Science 1990;249:1028-1030.
38. Harding CV, Unanue ER. Quantitation of antigen-presenting cell MHC Class II/peptide complexes necessary for T-cell stimulation. Nature 1990;46:574-576.
39. Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, Marshall RP, Bradding P, Green RH, Wardlaw AJ, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973-984.
40. Nair P, PizzichiniMM, KjarsgaardM, Inman MD, Efthimiadis A, Pizzichini E, Hargreave FE, O'Byrne PM. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360:985-993.
41. Wechsler ME. Pulmonary eosinophilic syndromes. Immunol Allergy Clin North Am 2007;27:477-492. (Pubitemid 47380243)