Differential expression of nanog1 and nanogp8 in colon cancer cells

Biochemical and Biophysical Research Communications

Volumn 418, Issue 2, 2012, Pages 199-204

  Ishiguro, Tatsuya ^a   Sato, Ai ^a   Ohata, Hirokazu ^a   Sakai, Hiroaki ^a   Nakagama, Hitoshi ^a   Okamoto, Koji ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Cancer; Nanog; Stem cells

Indexed keywords

NANOG1 PROTEIN; NANOGP8 PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL FRACTIONATION; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRAIN HT29; CELLULAR DISTRIBUTION; COLON CANCER; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; TUMOR XENOGRAFT;

ANIMALS; CELL PROLIFERATION; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HOMEODOMAIN PROTEINS; HT29 CELLS; HUMANS; MICE; NEOPLASM TRANSPLANTATION; PSEUDOGENES; RNA, SMALL INTERFERING; TERATOMA;

EID: 84856661037     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.10.123     Document Type: Article

References (48)

1. Kashyap V., Rezende N.C., Scotland K.B., Shaffer S.M., Persson J.L., Gudas L.J., Mongan N.P. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Development 2009, 18:1093-1108.
2. Loh Y.H., Wu Q., Chew J.L., Vega V.B., Zhang W., Chen X., Bourque G., George J., Leong B., Liu J., Wong K.Y., Sung K.W., Lee C.W., Zhao X.D., Chiu K.P., Lipovich L., Kuznetsov V.A., Robson P., Stanton L.W., Wei C.L., Ruan Y., Lim B., Ng H.H. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genetics 2006, 38:431-440.
3. Chambers I., Tomlinson S.R. The transcriptional foundation of pluripotency. Development 2009, 136:2311-2322.
4. Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., Gifford D.K., Melton D.A., Jaenisch R., Young R.A. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122:947-956.
5. Chiou S.H., Wang M.L., Chou Y.T., Chen C.J., Hong C.F., Hsieh W.J., Chang H.T., Chen Y.S., Lin T.W., Hsu H.S., Wu C.W. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Research 2010, 70:10433-10444.
6. Chiou S.H., Yu C.C., Huang C.Y., Lin S.C., Liu C.J., Tsai T.H., Chou S.H., Chien C.S., Ku H.H., Lo J.F. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clinical Cancer Research 2008, 14:4085-4095.
7. Ezeh U.I., Turek P.J., Reijo R.A., Clark A.T. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005, 104:2255-2265.
8. Wen J., Park J.Y., Park K.H., Chung H.W., Bang S., Park S.W., Song S.Y. Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis. Pancreas 2010, 39:622-626.
9. Pan Y., Jiao J., Zhou C., Cheng Q., Hu Y., Chen H. Nanog is highly expressed in ovarian serous cystadenocarcinoma and correlated with clinical stage and pathological grade. Pathobiology 2010, 77:283-288.
10. Meng H.M., Zheng P., Wang X.Y., Liu C., Sui H.M., Wu S.J., Zhou J., Ding Y.Q., Li J.M. Overexpression of nanog predicts tumor progression and poor prognosis in colorectal cancer. Cancer Biology Therapy 2010, 9.
11. Ye F., Zhou C., Cheng Q., Shen J., Chen H. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. BMC Cancer 2008, 8:108.
12. Pan G., Thomson J.A. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Research 2007, 17:42-49.
13. Mathieu J., Zhang Z., Zhou W., Wang A.J., Heddleston J.M., Pinna C.M., Hubaud A., Stadler B., Choi M., Bar M., Tewari M., Liu A., Vessella R., Rostomily R., Born D., Horwitz M., Ware C., Blau C.A., Cleary M.A., Rich J.N., Ruohola-Baker H. HIF induces human embryonic stem cell markers in cancer cells. Cancer Research 2011, 71:4640-4652.
14. Po A., Ferretti E., Miele E., De Smaele E., Paganelli A., Canettieri G., Coni S., Di Marcotullio L., Biffoni M., Massimi L., Di Rocco C., Screpanti I., Gulino A. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO Journal 2010, 29:2646-2658.
15. Zbinden M., Duquet A., Lorente-Trigos A., Ngwabyt S.N., Borges I., Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. EMBO Journal 2010, 29:2659-2674.
16. Niwa H., Ogawa K., Shimosato D., Adachi K. A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature 2009, 460:118-122.
17. Vallier L., Mendjan S., Brown S., Chng Z., Teo A., Smithers L.E., Trotter M.W., Cho C.H., Martinez A., Rugg-Gunn P., Brons G., Pedersen R.A. Activin/nodal signalling maintains pluripotency by controlling Nanog expression. Development 2009, 136:1339-1349.
18. Xu R.H., Sampsell-Barron T.L., Gu F., Root S., Peck R.M., Pan G., Yu J., Antosiewicz-Bourget J., Tian S., Stewart R., Thomson J.A. NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell 2008, 3:196-206.
19. Rodda D.J., Chew J.L., Lim L.H., Loh Y.H., Wang B., Ng H.H., Robson P. Transcriptional regulation of nanog by OCT4 and SOX2. Journal of Biological Chemistry 2005, 280:24731-24737.
20. Kuroda T., Tada M., Kubota H., Kimura H., Hatano S.Y., Suemori H., Nakatsuji N., Tada T. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Molecular and Cellular Biology 2005, 25:2475-2485.
21. Zhang P., Andrianakos R., Yang Y., Liu C., Lu W. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. Journal of Biological Chemistry 2010, 285:9180-9189.
22. Chan K.K., Zhang J., Chia N.Y., Chan Y.S., Sim H.S., Tan K.S., Oh S.K., Ng H.H., Choo A.B. KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem Cells 2009, 27:2114-2125.
23. Savarese F., Davila A., Nechanitzky R., De La Rosa-Velazquez I., Pereira C.F., Engelke R., Takahashi K., Jenuwein T., Kohwi-Shigematsu T., Fisher A.G., Grosschedl R. Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes and Development 2009, 23:2625-2638.
24. Baltus G.A., Kowalski M.P., Tutter A.V., Kadam S. A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2. Journal of Biological Chemistry 2009, 284:6998-7006.
25. Takao Y., Yokota T., Koide H. Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells. Biochemical and Biophysical Research Communications 2007, 353:699-705.
26. Wu Q., Chen X., Zhang J., Loh Y.H., Low T.Y., Zhang W., Sze S.K., Lim B., Ng H.H. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. Journal of Biological Chemistry 2006, 281:24090-24094.
27. Han M.K., Song E.K., Guo Y., Ou X., Mantel C., Broxmeyer H.E. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2008, 2:241-251.
28. Lin T., Chao C., Saito S., Mazur S.J., Murphy M.E., Appella E., Xu Y. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nature Cell Biology 2005, 7:165-171.
29. Villasante A., Piazzolla D., Li H., Gomez-Lopez G., Djabali M., Serrano M. Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells. Cell Cycle 2011, 10:1488-1498.
30. Hattori N., Imao Y., Nishino K., Ohgane J., Yagi S., Tanaka S., Shiota K. Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes to Cells 2007, 12:387-396.
31. Tay Y.M., Tam W.L., Ang Y.S., Gaughwin P.M., Yang H., Wang W., Liu R., George J., Ng H.H., Perera R.J., Lufkin T., Rigoutsos I., Thomson A.M., Lim B. MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells 2008, 26:17-29.
32. Tay Y., Zhang J., Thomson A.M., Lim B., Rigoutsos I., Nanog MicroRNAs to Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008, 455:1124-1128.
33. Liang J., Wan M., Zhang Y., Gu P., Xin H., Jung S.Y., Qin J., Wong J., Cooney A.J., Liu D., Songyang Z. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nature Cell Biology 2008, 10:731-739.
34. Torres J., Watt F.M. Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Nature Cell Biology 2008, 10:194-201.
35. Karantzali E., Lekakis V., Ioannou M., Hadjimichael C., Papamatheakis J., Kretsovali A. Sall1 regulates embryonic stem cell differentiation in association with nanog. Journal of Biological Chemistry 2011, 286:1037-1045.
36. Liu N., Feng X., Fang Z., Ma F., Lu S., Lu M., Han Z. Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation. Journal of Cellular Biochemistry 2008, 104:2348-2362.
37. Silva J., Nichols J., Theunissen T.W., Guo G., van Oosten A.L., Barrandon O., Wray J., Yamanaka S., Chambers I., Smith A. Nanog is the gateway to the pluripotent ground state. Cell 2009, 138:722-737.
38. Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C., Izpisua Belmonte J.C. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proceedings of the National Academy of Sciences United States of America 2006, 103:10294-10299.
39. Fairbanks D.J., Maughan P.J. Evolution of the NANOG pseudogene family in the human and chimpanzee genomes. BMC Evolutionary Biology 2006, 6:12.
40. Booth H.A., Holland P.W. Eleven daughters of NANOG. Genomics 2004, 84:229-238.
41. Zhang J., Wang X., Li M., Han J., Chen B., Wang B., Dai J. NANOGP8 is a retrogene expressed in cancers. FEBS Journal 2006, 273:1723-1730.
42. Jeter C.R., Badeaux M., Choy G., Chandra D., Patrawala L., Liu C., Calhoun-Davis T., Zaehres H., Daley G.Q., Tang D.G. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 2009, 27:993-1005.
43. Jeter C.R., Liu B., Liu X., Chen X., Liu C., Calhoun-Davis T., Repass J., Zaehres H., Shen J.J., Tang D.G. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene 2011.
44. Nirasawa S., Kobayashi D., Tsuji N., Kuribayashi K., Watanabe N. Diagnostic relevance of overexpressed Nanog gene in early lung cancers. Oncology Reports 2009, 22:587-591.
45. Hart A.H., Hartley L., Parker K., Ibrahim M., Looijenga L.H., Pauchnik M., Chow C.W., Robb L. The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer 2005, 104:2092-2098.
46. Ambady S., Malcuit C., Kashpur O., Kole D., Holmes W.F., Hedblom E., Page R.L., Dominko T. Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells. International Journal of Developmental Biology 2010, 54:1743-1754.
47. Zhang J., Wang X., Chen B., Suo G., Zhao Y., Duan Z., Dai J. Expression of Nanog gene promotes NIH3T3 cell proliferation. Biochemical and Biophysical Research Communications 2005, 338:1098-1102.
48. Okamoto K., Kashima K., Pereg Y., Ishida M., Yamazaki S., Nota A., Teunisse A., Migliorini D., Kitabayashi I., Marine J.C., Prives C., Shiloh Y., Jochemsen A.G., Taya Y. DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Molecular and Cellular Biology 2005, 25:9608-9620.