A role for Epha2 in cell migration and refractive organization of the ocular lens

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 2, 2012, Pages 551-559

  Shi, Yanrong ^a   de Maria, Alicia ^a   Bennett, Thomas ^a   Shiels, Alan ^a   Bassnett, Steven ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANE PROTEIN; EPHRIN RECEPTOR A2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CATARACT; CELL DIFFERENTIATION; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CELL SIZE; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EPITHELIUM CELL; EYE REFRACTION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; LASER REFRACTOMETRY; LENS; LENS CAPSULE; LENS EPITHELIUM; LENS FIBER; LENS FIBER CELL; LENS INTERNAL COMPOSITION; LENS POWER; LENS SHAPE; LENS TRANSPARENCY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REFRACTOMETRY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATARACT; CELL MOVEMENT; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; IMMUNOHISTOCHEMISTRY; LENS, CRYSTALLINE; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; RECEPTOR, EPHA2; REFRACTION, OCULAR;

EID: 84856647872     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8568     Document Type: Article

References (38)

1. Pitulescu ME, Adams RH. Eph/ephrin molecules-a hub for signaling and endocytosis. Genes Dev. 2010;24:2480-2492.
2. Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell. 2008;133:38-52.
3. Hirai H, Maru Y, Hagiwara K, Nishida J, Takaku F. A novel putative tyrosine kinase receptor encoded by the eph gene. Science. 1987; 238:1717-1720.
4. Unified nomenclature for Eph family receptors and their ligands, the ephrins: Eph Nomenclature Committee. Cell. 1997;90:403- 404.
5. Himanen JP, Chumley MJ, Lackmann M, et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci. 2004;7:501-509.
6. Lindberg RA, Hunter T. CDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990;10:6316-6324.
7. Mori T, Wanaka A, Taguchi A, Matsumoto K, Tohyama M. Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Brain Res Mol Brain Res. 1995;29:325-335.
8. Easty DJ, Guthrie BA, Maung K, et al. Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression. Cancer Res. 1995; 55:2528-2532.
9. Walker-Daniels J, Coffman K, Azimi M, et al. Overexpression of the EphA2 tyrosine kinase in prostate cancer. Prostate. 1999;41:275- 280.
10. Zelinski DP, Zantek ND, Stewart JC, Irizarry AR, Kinch MS. EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res. 2001;61:2301-2306.
11. Bassnett S, Wilmarth PA, David LL. The membrane proteome of the mouse lens fiber cell. Mol Vis. 2009;15:2448-2463.
12. Shiels A, Bennett TM, Knopf HL, et al. The EPHA2 gene is associated with cataracts linked to chromosome 1p. Mol Vis. 2008;14: 2042-2055.
13. Zhang T, Hua R, Xiao W, et al. Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract. Hum Mutat. 2009;30:E603-E611.
14. Kaul H, Riazuddin SA, Shahid M, et al. Autosomal recessive congenital cataract linked to EPHA2 in a consanguineous Pakistani family. Mol Vis. 2010;16:511-517.
15. Jun G, Guo H, Klein BEK, et al. EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet. 2009;5.
16. Tan W, Hou S, Jiang Z, Hu Z, Yang P, Ye J. Association of EPHA2 polymorphisms and age-related cortical cataract in a Han Chinese population. Mol Vis. 2011;17:1553-1558.
17. Brantley-Sieders DM, Caughron J, Hicks D, Pozzi A, Ruiz JC, Chen J. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci. 2004;117: 2037-2049.
18. Alizadeh A, Clark J, Seeberger T, Hess J, Blankenship T, FitzGerald PG. Characterization of a mutation in the lens-specific CP49 in the 129 strain of mouse. Invest Ophthalmol Vis Sci. 2004; 45:884-891.
19. De Maria A, Shi Y, Luo X, Van Der Weyden L, Bassnett S. Cadm1 expression and function in the mouse lens. Invest Ophthalmol Vis Sci. 2011;52:2293-2299.
20. Bassnett S, Shi Y. A method for determining cell number in the undisturbed epithelium of the mouse lens. Mol Vision. 2010;16: 2294-2300.
21. Bassnett S, Shi Y, Vrensen GF. Biological glass: structural determinants of eye lens transparency. Philos Trans R Soc Lond B Biol Sci. 2011;366:1250-1264.
22. Bassnett S, Shi YR, Barton K, De Maria A, Petrash JM, Shiels A. The stratified syncytium of the vertebrate lens. J Cell Sci. 2009;122: 1607-1615.
23. Bassnett S. On the mechanism of organelle degradation in the vertebrate lens. Exp Eye Res. 2009;88:133-139.
24. Kuszak JR, Zoltoski RK, Tiedemann CE. Development of lens sutures. Int J Dev Biol. 2004;48:889-902.
25. Palmquist BM, Philipson B, Fagerholm P. Nuclear cataract-a mi-croradiographic study. Acta Ophthalmol. 1988;66:671-677.
26. Campbell MC. Measurement of refractive index in an intact crystalline lens. Vision Res. 1984;24:409-415.
27. FitzGerald PG, Fudge DS, McCuaig JV, et al. Intermediate filaments regulate tissue size and stiffness in the murine lens. Invest Oph-thalmol Vis Sci. 2011;52:3860-3867.
28. FitzGerald PG, Yoon KH, Blankenship T, Shibata B. Resisting the effects of aging: a function for the fiber cell beaded filament. Invest Ophthalmol Vis Sci. 2008;49:1030-1036.
29. Skarnes WC, Mitchell KJ, Pinson KI, et al. Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet. 2001;28:241-249.
30. Bassnett S, Winzenburger PA. Morphometric analysis of fibre cell growth in the developing chicken lens. Exp Eye Res. 2003;76:291- 302.
31. Zhou RP, Cooper MA, Son AI, Komlos D, Suna YH, Kleiman NJ. Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract. Proc Natl Acad Sci USA. 2008;105:16620-16625.
32. O'Leary DDM, Feldheim DA. Visual map development: bidirectional signaling, bifunctional guidance molecules, and competition. Csh Perspect Biol. 2010;2.
33. Greenberg ME, Sahin M, Greer PL, et al. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 2005;46:191-204.
34. Lattin JE, Schroder K, Su AI, et al. Expression analysis of G protein-coupled receptors in mouse macrophages. Immunome Res. 2008;4:5.
35. Maddala R, Deng PF, Costello JM, Wawrousek EF, Zigler JS, Rao VP. Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. Lab Invest. 2004;84:679-692.
36. Maddala R, Reneker LW, Pendurthi B, Rao PV. Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. Dev Biol. 2008; 315:217-231.
37. Brantley-Sieders DM, Zhuang G, Hicks D, et al. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tu-morigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest. 2008;118:64-78.
38. Shiels A, King JM, Mackay DS, Bassnett S. Refractive defects and cataracts in mice lacking lens intrinsic membrane protein-2. Invest Ophthalmol Vis Sci. 2007;48:500-508.