Mechanism regulating proasthmatic effects of prolonged homologous β2-adrenergic receptor desensitization in airway smooth muscle

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 297, Issue 4, 2009, Pages

  Nino, Gustavo ^a   Hu, Aihua ^a   Grunstein, Judith S ^a   Grunstein, Michael M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Asthma; cAMP signaling; G proteins; Long acting 2 agonists; Phosphodiesterase 4; Salmeterol

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV D5; PROTEIN SUBUNIT; SALMETEROL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; MORBIDITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RABBIT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; ASTHMA; BLOTTING, WESTERN; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DESENSITIZATION, IMMUNOLOGIC; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; PHOSPHORIC DIESTER HYDROLASES; PHOSPHORYLATION; PROTEINS; RABBITS; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 70349766924     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00079.2009     Document Type: Article

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