Rhinovirus-induced exacerbations of asthma: How is the β2- adrenoceptor implicated?

American Journal of Respiratory Cell and Molecular Biology

Volumn 43, Issue 2, 2010, Pages 227-233

  Trian, Thomas ^a,b   Moir, Lyn M ^a,b   Ge, Qi ^a,b   Burgess, Janette K ^a,b   Kuo, Curtis ^a   King, Nicholas J C ^a   Reddel, Helen K ^b   Black, Judith L ^a,b   Oliver, Brian G ^a,b   McParland, Brent E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

2 adrenergic receptor; Asthma; Human airway smooth muscle cell; Rhinovirus

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; DEXAMETHASONE; FLUTICASONE; FORSKOLIN;

ADULT; AGED; AIRWAY; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CELL CULTURE; CONTROLLED STUDY; DESENSITIZATION; DISEASE EXACERBATION; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; LUNG INFECTION; MALE; PROTEIN FUNCTION; RHINOVIRUS; RHINOVIRUS INFECTION; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; SUPERNATANT; ULTRAVIOLET IRRADIATION; VIRUS INACTIVATION; BIOLOGICAL MODEL; BRONCHUS; CULTURE MEDIUM; CYTOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PICORNAVIRUS INFECTION; VIROLOGY;

RHINOVIRUS;

ADULT; AGED; AGED, 80 AND OVER; ASTHMA; BRONCHI; CULTURE MEDIA, CONDITIONED; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PICORNAVIRIDAE INFECTIONS; RECEPTORS, ADRENERGIC, BETA-2; RHINOVIRUS;

EID: 77955507554     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0126OC     Document Type: Article

References (29)

1. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O'Toole S, Myint SH, Tyrrell DA, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995;310:1225-1229.
2. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ 1993;307:982-986. (Pubitemid 23306765)
3. Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, Johnston SL. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 2002;359:831-834. (Pubitemid 34233753)
4. Sin DD, Man J, Sharpe H, Gan WQ, Man SF. Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis. JAMA 2004;292:367-376. (Pubitemid 38944262)
5. Johnston NW, Johnston SL, Duncan JM, Greene JM, Kebadze T, Keith PK, Roy M, Waserman S, Sears MR. The September epidemic of asthma exacerbations in children: a search for etiology. J Allergy Clin Immunol 2005;115:132-138. (Pubitemid 40075433)
6. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, Custovic A. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006;61:376-382. (Pubitemid 43723318)
7. Venarske DL, Busse WW, Griffin MR, Gebretsadik T, Shintani AK, Minton PA, Peebles RS, Hamilton R, Weisshaar E, Vrtis R, et al. The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking. J Infect Dis 2006;193:1536-1543. (Pubitemid 43794583)
8. Reddel H, Ware S, Marks G, Salome C, Jenkins C, Woolcock A. Differences between asthma exacerbations and poor asthma control. Lancet 1999;353:364-369. (Pubitemid 29088164)
9. Papadopoulos NG, Bates PJ, Bardin PG, Papi A, Leir SH, Fraenkel DJ, Meyer J, Lackie PM, Sanderson G, Holgate ST, et al. Rhinoviruses infect the lower airways. J Infect Dis 2000;181:1875-1884.
10. Wos M, Sanak M, Soja J, Olechnowicz H, Busse WW, Szczeklik A. The presence of rhinovirus in lower airways of patients with bronchial asthma. Am J Respir Crit Care Med 2008;177:1082-1089. (Pubitemid 351717566)
11. Message SD, Laza-Stanca V, Mallia P, Parker HL, Zhu J, Kebadze T, Contoli M, Sanderson G, Kon OM, Papi A, et al. Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci USA 2008;105:13562-13567.
12. Ammit AJ, Moir LM, Oliver BG, Hughes JM, Alkhouri H, Ge Q, Burgess JK, Black JL, Roth M. Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2007;292:L199-L206. (Pubitemid 46103444)
13. Krimmer DI, Loseli M, Hughes JM, Oliver BG, Moir LM, Hunt NH, Black JL, Burgess JK. CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. Allergy 2009;64:1074-1082.
14. Oliver BG, Johnston SL, Baraket M, Burgess JK, King NJ, Roth M, Lim S, Black JL. Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respir Res 2006;7:71. (Pubitemid 44202723)
15. Oliver BG, Lim S, Wark P, Laza-Stanca V, King N, Black JL, Burgess JK, Roth M, Johnston SL. Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax 2008;63:519-525. (Pubitemid 351831162)
16. Bartlett NW, Walton RP, Edwards MR, Aniscenko J, Caramori G, Zhu J, Glanville N, Choy KJ, Jourdan P, Burnet J, et al. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med 2008;14:199-204.
17. Spiegel A, Shivtiel S, Kalinkovich A, Ludin A, Netzer N, Goichberg P, Azaria Y, Resnick I, Hardan I, Ben-Hur H, et al. Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling. Nat Immunol 2007;8:1123-1131.
18. Fernandes D, Guida E, Koutsoubos V, Harris T, Vadiveloo P, Wilson JW, Stewart AG. Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. Am J Respir Cell Mol Biol 1999;21:77-88.
19. Moore PE, Laporte JD, Abraham JH, Schwartzman IN, Yandava CN, Silverman ES, Drazen JM, Wand MP, Panettieri RA, Jr., Shore SA. Polymorphism of the beta(2)-adrenergic receptor gene and desensitization in human airway smooth muscle. Am J Respir Crit Care Med 2000;162:2117-2124.
20. Billington CK, Pascual RM, Hawkins ML, Penn RB, Hall IP. Interleukin- 1beta and rhinovirus sensitize adenylyl cyclase in human airway smooth-muscle cells. Am J Respir Cell Mol Biol 2001;24:633-639.
21. Kelsen SG, Anakwe O, Aksoy MO, Reddy PJ, Dhanasekaran N. IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells. Am J Physiol 1997;273:L694-L700. (Pubitemid 27423938)
22. Wornle M, Sauter M, Kastenmuller K, Ribeiro A, Mussack T, Ladurner R, Sitter T. Role of Toll-Like Receptor 3, RIG-I, and MDA5 in the expression of mesothelial IL-8 induced by viral RNA. Appl Biochem Biotechnol 2010;160:1179-1187.
23. Funkhouser AW, Kang JA, Tan A, Li J, Zhou L, Abe MK, Solway J, Hershenson MB. Rhinovirus 16 3C protease induces interleukin-8 and granulocyte-macrophage colony-stimulating factor expression in human bronchial epithelial cells. Pediatr Res 2004;55:13-18.
24. Johnston NW, Johnston SL, Norman GR, Dai J, Sears MR. The September epidemic of asthma hospitalization: school children as disease vectors. J Allergy Clin Immunol 2006;117:557-562.
25. Rowe BH, Keller JL, Oxman AD. Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis. Am J Emerg Med 1992;10:301-310.
26. Panickar J, Lakhanpaul M, Lambert PC, Kenia P, Stephenson T, Smyth A, Grigg J. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med 2009;360:329-338.
27. Ducharme FM, Lemire C, Noya FJ, Davis GM, Alos N, Leblond H, Savdie C, Collet JP, Khomenko L, Rivard G, et al. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med 2009;360:339-353.
28. Cooper PR, Panettieri RA Jr. Steroids completely reverse albuterol-induced beta(2)-adrenergic receptor tolerance in human small airways. J Allergy Clin Immunol 2008;122:734-740.
29. Moore PE, Cunningham G, Calder MM, DeMatteo AD Jr, Peeples ME, Summar ML, Peebles RS, Jr. Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle. Am J Respir Cell Mol Biol 2006;35:559-564.