Clinical manifestations of cutaneous metastases: A review with special emphasis on cutaneous metastases mimicking keratoacanthoma

American Journal of Clinical Dermatology

Volumn 13, Issue 2, 2012, Pages 103-112

  Riahi, Ryan R ^a   Cohen, Philip R ^b,c,d  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Adenocarcinoma; Cancer; Carcinoma; keratoacanthoma

Indexed keywords

BREAST CANCER; BREAST CARCINOMA; CANCER MORPHOLOGY; CANCER PATIENT; CANCER SURVIVAL; CHONDROSARCOMA; CLINICAL FEATURE; DIGESTIVE SYSTEM CANCER; DISEASE COURSE; DISTANT METASTASIS; ESOPHAGEAL ADENOCARCINOMA; FINGER; HISTOPATHOLOGY; HUMAN; KERATOACANTHOMA; LUNG CANCER; METASTASIS; NAIL BED; PRIMARY TUMOR; PRIORITY JOURNAL; REVIEW; SCALP; SKIN METASTASIS; SKIN NODULE; UMBILICUS;

EID: 84856598415     PISSN: 11750561     EISSN: 11791888     Source Type: Journal    
DOI: 10.2165/11590640-000000000-00000     Document Type: Review

References (56)

1. Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma. J Am Acad Dermatol 1990; 22: 19-26
2. Marks JG,Miller JJ. Lookingbill andMark's principles of dermatology. 4th ed. Chapter 5. Epidermal growths. Philadelphia: Saunders Elsevier, 2006: 51-69
3. Reich A, Kobierzycka M, Woźniak Z, et al. Keratoacanthoma-like cutaneous metastasis of lung cancer: a learning point.ActaDermVenereol 2006; 86: 459-60 (Pubitemid 44450111)
4. Cotton DW, Fairris GM. Metastatic breast carcinoma on the lip: case report. Dermatologica 1985; 171: 362-5 (Pubitemid 16200750)
5. Hunziker N, Djalali A, Laugier P. Cutaneous metastasis of bronchial cancer simulating keratoacanthoma. Bull Soc Fr Dermatol Syphiligr 1969; 76: 552
6. Cassarino DS, Xue W, Shannon KJ. Widespread cutaneous and perioral metastases of mesothelioma. J Cutan Pathol 2003; 30: 582-5 (Pubitemid 37255558)
7. Aramburu-Gonzalez JA, Rodriguez-Justo M, Jimenez- Reyes J, et al. A case of soft tissue mesenchymal chondrosarcoma metastatic to skin, clinically mimicking keratoacanthoma. Am J Dermatopathol 1999; 21: 392-4 (Pubitemid 29359947)
8. Conner KB, Cohen PR. Cutaneous metastasis of breast carcinoma presenting as alopecia neoplastica. South Med J 2009; 102: 385-9
9. Peterson JL, McMarlin SL. Metastatic renal-cell carcinoma presenting as a cutaneous horn. J Dermatol Surg Oncol 1983; 9: 815-8 (Pubitemid 13021093)
10. Reich A, Wozniak Z, Szepietowski J. Zosteriform cutaneous metastasis. Dermatol Klin 2006; 8: 49-51
11. Park JM, Kim DS, Oh SH, et al. A case of esophageal adenocarcinoma metastasized to the scalp. Ann Dermatol 2009; 21: 164-7
12. Richmond HM, Duvic M, Macfarlane DF. Primary and metastatic malignant tumors of the scalp: an update. Am J Clin Dermatol 2010; 11: 233-46
13. Krunic AL, Chen HM, Lopatka K. Signet-ring cell carcinoma of the gallbladder with skin metastases. Australas J Dermatol 2007; 48: 187-9 (Pubitemid 47197700)
14. Lu CI, Wong WR, Hong HS. Distant cutaneous metastases of cholangiocarcinoma: report of two cases of a previously unreported condition. J Am Acad Dermatol 200; 51: 108-11
15. Fernandez-Flores A. Cutaneous metastases: a study of 78 biopsies from 69 patients. Am J Dermatopathol 2010; 32: 222-39
16. Nashan D,Müller ML, Braun-Falco M, et al. Cutaneous metastases of visceral tumours: a review. J Cancer Res Clin Oncol 2009; 135: 1-14.
17. Frey L, Vetter-Kauczok C, Gesierich A, et al. Cutaneous metastases as the first clinical sign of metastatic gastric carcinoma. J Dtsch Dermatol Ges 2009; 7: 893-5
18. Lifshitz OH, Berlin JM, Taylor JS, et al. Metastatic gastric adenocarcinoma presenting as an enlarging plaque on the scalp. Cutis 2005; 76: 194-6 (Pubitemid 41413668)
19. Wang WL, Hornick JL, Mallipeddi R, et al. Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: a series of 5 cases with molecular analysis. Am J Dermatopathol 2009; 31: 297-300
20. Aguilar A, Schoendorff C, Lopez Redondo MJ, et al. Epidermotropic metastases from internal carcinomas. Am J Dermatopathol 1991; 13: 452-8
21. Quinn TR, Duncan LM, Zembowicz A, et al. Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature. Am J Dermatopathol 2005; 27: 306-12 (Pubitemid 41232482)
22. Alwaheeb S, Ghazarian D, Boerner SL, et al. Cutaneous manifestations of thyroid cancer: a report of four cases and review of the literature. J Clin Pathol 2004; 57: 435-8 (Pubitemid 38446267)
23. Ulamec M, Soldo-BelićA, VucićM, et al. Melanoma with second myxoid stromal changes after personally applied prolonged phototherapy. Am J Dermatopathol 2008; 30: 185-7 (Pubitemid 351441997)
24. Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 1993; 29: 228-36 (Pubitemid 23221903)
25. Reingold IM. Cutaneous metastases from internal carcinoma. Cancer 1966; 19: 162-8
26. Collier DA, Busam K, Salob S. Cutaneous metastasis of osteosarcoma. J Am Acad Dermatol 2003; 49: 757-60 (Pubitemid 37210304)
27. Rosen T. Cutaneous metastases. Med Clin North Am 1980; 64: 885-900 (Pubitemid 11198627)
28. Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995; 33: 161-82
29. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a meta-analysis of data. South Med J 2003; 96: 164-7 (Pubitemid 36268589)
30. Brodland DG. Metastasis: a primer for dermatologists. Dermatol Surg 1996; 22: 228-33 (Pubitemid 26088387)
31. Cohen PR. Skin clues to primary and metastatic malignancy. Am Fam Physician 1995; 51: 1199-204
32. Rolz-Cruz G, Kim CC. Tumor invasion of the skin. Dermatol Clin 2008; 26: 89-102 (Pubitemid 350102012)
33. Nashan D, Meiss F, Braun-Falco M, et al. Cutaneous metastases from internal malignancies. Dermatol Ther 2010; 23: 567-80
34. Cohen PR. Metastatic tumors to the nail unit: subungual metastases. Dermatol Surg 2001; 27: 280-93 (Pubitemid 32246072)
35. Cohen PR, Buzdar AU. Metastatic breast carcinoma mimicking an acute paronychia of the great toe: case report and review of subungual metastases.Am J Clin Oncol 1993; 16: 86-91 (Pubitemid 23074790)
36. Vine JE, Cohen PR. Renal cell carcinoma metastatic to the thumb: a case report and review of subungual metastases from all primary sites. Clin Exp Dermatol 1996; 21: 377-80 (Pubitemid 27075327)
37. Chodkiewicz HM, Cohen PR. Systemic mastocytosis-associated leonine facies and eyebrow loss. South Med J 2011; 104: 236-8
38. Cohen PR, Rapini RP, Beran M. Infiltrated blue-gray plaques in a patient with leukemia: chloroma (granulocytic sarcoma). Arch Dermatol 1987; 123: 251, 254
39. Hager CM, Cohen PR. Cutaneous lesions of metastatic visceral malignancy mimicking pyogenic granuloma. Cancer Invest 1999; 17: 385-90 (Pubitemid 29359884)
40. Cohen PR. Primary alopecia neoplastica versus secondary alopecia neoplastica: a new classification for neoplasm-associated scalp hair loss. J Cutan Pathol 2009; 36: 917-8
41. Manteaux A, Cohen PR, Rapini RP. Zosteriform and epidermotropic metastasis: report of two cases. J Dermatol Surg Oncol 1992; 18: 97-100
42. Cohen PR, Schulze KE, Teller CF, et al. Intralesional methotrexate for keratoacanthoma of the nose. Skinmed 2005; 4: 393-5
43. Cohen PR, Schulze KE, Nelson BR. Pancytopenia after a single intradermal infiltration of methotrexate. J Drugs Dermatol 2005; 4: 648-51
44. Schwartz RA. Keratoacanthoma: a clinico-pathologic enigma. Dermatol Surg 2004; 30: 326-33 (Pubitemid 38313991)
45. Nebesio CL, Goulet RJ, Helft PR, et al. Metastatic esophageal carcinoma masquerading as inflammatory breast carcinoma. Int J Dermatol 2007; 46: 303-5 (Pubitemid 46390292)
46. Fereidooni F, Kovacs K, Azizi MR, et al. Skin metastasis from an occult esophageal adenocarcinoma. Can J Gastroenterol 2005; 19: 673-6 (Pubitemid 43013519)
47. Roh EK, Nord R, Jukic DM. Scalp metastasis from esophageal adenocarcinoma. Cutis 2006; 77: 106-8 (Pubitemid 43434315)
48. Adyanthaya R. Multiple cutaneous metastases from esophageal adenocarcinoma. J Gastrointest Cancer 2008; 39: 22-5
49. Cappell MS, Lufadeju A, Challa A, et al. Seeding of the percutaneous endoscopic gastrostomy tract from esophageal squamous cell cancer presenting as an acutely bleeding malignant gastric ulcer: a novel clinioendoscopic presentation. South Med J 2008; 101: 35-9
50. Smith HJ. Infrequent patterns of upper gastrointestinal tract malignancy. Gastrointest Radiol 1978 Jun; 3: 129-33 (Pubitemid 9236730)
51. Yasaka N, Ando I, Kukita A. An acral 'inflammatory' cutaneous metastasis of oesophageal carcinoma. Br J Dermatol 1999; 141: 938-9
52. Umebayashi Y. Metastasis of esophageal carcinoma manifesting as whitlowlike lesions. J Dermatol 1998; 25: 256-9 (Pubitemid 28216922)
53. Reichel M, Wheeland RG. Inflammatory carcinoma masquerading as erythema annulare centrifugum. Acta Derm Venereol 1993; 73: 138-40 (Pubitemid 23163739)
54. Dessinioti C, Georgala S, Chatziolou E, et al. What is your diagnosis? The diagnosis: cutaneous metastases from non-small cell lung carcinoma [photo quiz]. Cutis 2011; 87: 277, 281-3
55. Sariya D, Ruth K, Adams-McDonnell R, et al. Clinicopathologic correlation of cutaneous metastases: experience from a cancer center. Arch Dermatol 2007; 143: 613-20 (Pubitemid 46799848)
56. Cohen PR. Lung cancer-associated scalp hair loss: a rare cause of secondary alopecia neoplastica [letter]. Cutis. In press