Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: A series of 5 cases with molecular analysis

American Journal of Dermatopathology

Volumn 31, Issue 3, 2009, Pages 297-300

  Wang, Wei Lien ^a   Hornick, Jason L ^b   Mallipeddi, Raj ^c   Zelger, Bettina G ^d   Rother, Joshua D ^a,e   Yang, Dan ^a,e   Lev, Dina C ^a,e   Trent, Jonathan C ^a,e   Prieto, Victor G ^a   Brenn, Thomas ^f   Calonje, Eduardo ^c   Lazar, Alexander J F ^a,e  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

^e Sarcoma Research Center   (United States)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cutaneous; Gastrointestinal stromal tumor; GIST; Metastasis; Skin

Indexed keywords

CD34 ANTIBODY; EPIRUBICIN; IMATINIB; STEM CELL FACTOR RECEPTOR; SUNITINIB;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER LOCALIZATION; CELL STRUCTURE; CLINICAL ARTICLE; CLINICAL FEATURE; EXON; FEMALE; FOLLOW UP; GASTROINTESTINAL STROMAL TUMOR; GENE DELETION; GENE MUTATION; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER METASTASIS; MALE; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; SKIN METASTASIS; TUMOR VOLUME; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METASTASIS; MIDDLE AGED; MORTALITY; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; SKIN TUMOR; SOFT TISSUE TUMOR; SUBCUTANEOUS TISSUE; TIME; TREATMENT OUTCOME;

ADULT; AGED; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; GASTROINTESTINAL STROMAL TUMORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS C-KIT; SKIN NEOPLASMS; SOFT TISSUE NEOPLASMS; SUBCUTANEOUS TISSUE; TIME FACTORS; TREATMENT OUTCOME;

EID: 66149109140     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e31818acb1a     Document Type: Article

References (16)

1. Demetri GD, Benjamin RS, Blanke CD, et al. NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST) - update of the NCCN clinical practice guidelines. J Natl Compr Canc Netw. 2007;5(Suppl 2):S1-S29; quiz S30.
2. Rubin BP, Heinrich MC, Corless CL. Gastrointestinal stromal tumour. Lancet. 2007;369:1731-1741.
3. Agaram NP, Laquaglia MP, Ustun B, et al. Molecular characterization of pediatric gastrointestinal stromal tumors. Clin Cancer Res. 2008;14: 3204-3215.
4. Chen LL, Trent JC, Wu EF, et al. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. 2004;64:5913-5919.
5. Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol. 2005;29:52-68.
6. Miettinen M, Makhlouf H, Sobin LH, et al. Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol. 2006;30:477-489.
7. Shabahang M, Livingstone AS. Cutaneous metastases from a gastrointestinal stromal tumor of the stomach: reviewof literature. Dig Surg. 2002; 19:64-65.
8. Anagnostoulis S, Mimidis K, Papadopoulos V, et al. Subcutaneous metastasis from a gastrointestinal stromal tumor of the stomach: a case report. J BUON. 2007;12:549-552.
9. Rao UN, Hanan SH, Lotze MT, et al. Distant skin and soft tissue metastases from sarcomas. J Surg Oncol. 1998;69:94-98.
10. Vandergriff T, Krathen RA, Orengo I. Cutaneous metastasis of leiomyosarcoma. Dermatol Surg. 2007;33:634-637.
11. Lasota J, Corless CL, Heinrich MC, et al. Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases. Mod Pathol. 2008;21: 476-484.
12. Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer. 2006;42:1093-1103.
13. McAuliffe J, Wang W-L, Pavan G, et al. Unlucky number 13? Differential effects of exon 13 mutation in GIST. Mol Oncol. 2008;2:161-163.
14. Lasota J, Miettinen M. Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours. Histopathology. 2008;53:1-22.
15. Lazar AJ, Trent JC, Lev D. Sarcoma molecular testing: diagnosis and prognosis. Curr Oncol Rep. 2007;9:309-315.
16. Heinrich MC, Corless CL, Blanke CD, et al. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol. 2006; 24:4764-4774.