Biologic correlates of 18F-FDG uptake on PET in pulmonary pleomorphic carcinoma

Lung Cancer

Volumn 71, Issue 2, 2011, Pages 144-150

  Kaira, Kyoichi ^a   Endo, Masahiro ^a   Abe, Masato ^a   Nakagawa, Kazuo ^a   Ohde, Yasuhisa ^a   Okumura, Takehiro ^a   Takahashi, Toshiaki ^a   Murakami, Haruyasu ^a   Tsuya, Asuka ^a   Nakamura, Yukiko ^a   Naito, Tateaki ^a   Hayashi, Isamu ^a   Kondo, Haruhiko ^a   Nakajima, Takashi ^a   Yamamoto, Nobuyuki ^a  

^a SHIZUOKA CANCER CENTER   (Japan)

Author keywords

18F FDG PET; Angiogenesis; Glut; Hypoxia; Pulmonary pleomorphic carcinoma

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P53; VASCULOTROPIN; BIOLOGICAL MARKER; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; ARTICLE; CANCER PATIENT; CELL CYCLE REGULATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DRUG UPTAKE; FEMALE; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG PLEOMORPHIC CARCINOMA; MALE; MICROVASCULATURE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SECTION; TUMOR VASCULARIZATION; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY; SCINTISCANNING;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RETROSPECTIVE STUDIES;

EID: 78650931011     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2010.05.021     Document Type: Article

References (33)

1. Chang Y.L., Lee Y.C., Shih J.Y., Wu C.T. Pulmonary pleomorphic (spindle) cell carcinoma: peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma. Lung Cancer 2001, 34:91-97.
2. Travis W.D., Brambilla E., Muller-Hermelink H.K. Pathology and genetics of tumours of the lung, pleura, thymus and heart 2004, IARC Press, Lyon, p. 53-8.
3. Fishback N.F., Travis W.D., Moran C.A., Guinee D.G., McCarthy W.F., Koss M.N. Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases. Cancer 1994, 15:2936-2945.
4. Rossi G., Cavazza A., Sturm N., Migaldi M., Facciolongo N., Longo L., et al. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 78 cases. Am J Surg Pathol 2003, 27:311-324.
5. Mochizuki T., Ishii G., Nagai K., Yoshida J., Nishimura M., Mizuno T., et al. Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases. Am J Surg Pathol 2008, 32:1727-1735.
6. Ito K, Oizumi S, Fukumoto S, Harada M, Ishida T, Fujita Y, et al. Clinical characteristics of pleomorphic carcinoma of the lung. Lung Cancer; 2010; 68:204-10.
7. Vansteenkiste J.F., Stroobants S.G., De Leyn P.R., Dupont P.J., Bogaert J., Maes A., et al. Lymph node staging in non-small-cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients. J Clin Oncol 1998, 16:2142-2149.
8. Brock C.S., Meikle S.R., Price P. Dose fluorine-18 fluorodeoxyglucose metabolic imaging of tumor benefit oncology?. Eur J Nucl Med 1997, 24:691-705.
9. Hoffman J.M., Waskin H.A., Schifter T., Hanson M.W., Gray L., Rosenfeld S., et al. The use of FDG-PET in differentiating infectious from malignant central nervous system lesions in patients with AIDS. J Nucl Med 1992, 33:838.
10. Higashi K., Ueda Y., Sakurai A., Wang X.M., Xu L., Murakami M., et al. Correlation of Glut-1 glucose transporter expression with [18F] FDG uptake in non-small cell lung cancer. Eur J Nucl Med 2000, 27:1778-1785.
11. Chung J.H., Cho K.J., Lee S.S., Baek H.J., Park J.H., Cheon G.J., et al. Over expression of Glut 1 in lymphoid follicles correlates with false-positive 18F-FDG PET results in lung cancer staging. J Nucl Med 2004, 45:999-1003.
12. Vleugel M.M., Greijer A.E., Shvarts A., van der Groep P., van Berkel M., Aarbodem Y., et al. Differential prognostic impact of hypoxia induced and diffuse HIF-1 alpha expression in invasive breast cancer. J Clin Pathol 2005, 58:172-177.
13. Elson D.A., Ryan H.E., Snow J.W., Johnson R., Arbeit J.M. Coordinate up-regulation of hypoxia inducible factor (HIF)-1a and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing 1. Cancer Res 2000, 60:6189-6195.
14. Burgman P., Odonoghue J.A., Humm J.L., Ling C.C. Hypoxia-induced increase in FDG uptake in MCF7 cells. J Nucl Med 2001, 42:170-175.
15. Thomas G.V., Tran C., Mellinghoff I.K., Welsbie D.S., Chan E., Fueger B., et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006, 12:122-127.
16. Guo J., Higashi K., Ueda Y., Oguchi M., Takegami T., Toga H., et al. Microvessel density: correlation with 18F-FDG uptake and prognosis impact in lung adenocarcinomas. J Nucl Med 2006, 47:419-425.
17. Kaira K., Oriuchi N., Shimizu K., Ishikita T., Higuchi T., Imai H., et al. Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer. Cancer Sci 2009, 100:753-758.
18. Ryan H.E., Polni M., McNulty W., Elson D., Gassmann M., Arbeit J.M., et al. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res 2000, 60:4010-4015.
19. Endo M., Nakagawa K., Ohde Y., Okumura T., Kondo H., Igawa S., et al. Utility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumors. Lung Cancer 2008, 61:350-355.
20. van Baardwijk A., Dooms C., van Suylen R.J., Verbeken E., Hochstenbag M., Dehing-Oberije C., et al. The maximum uptake of 18F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1α and GLUT-1 in non-small cell lung cancer. Eur J Cancer 2007, 43:1392-1398.
21. Chung J.H., Cho K.J., Lee S.S., Baek H.J., Park J.H., Cheon G.J., et al. Over expression of Glut1 in lymphoid follicles correlates with false-positive 18F-FDG PET results in lung cancer staging. J Nucl Med 2004, 45:999-1003.
22. Riedl C.C., Akhurst T., Larson S., Stanziale S.F., Tuorto S., Bhargava A., et al. 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases. J Nucl Med 2007, 48:771-775.
23. Weidner N., Semple J.P., Welch W.R., Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 1991, 324:1-8.
24. Mineo T.C., Ambrogi V., Baldi A., Rabitti C., Bollero P., Vincenzi B., et al. Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumor vessel invasion after radical surgery for IB-IIA non-small cell lung cancer impact of VEGF, CD31. J Clin Pathol 2004, 57:591-597.
25. Isselbacher K.J. Sugar and amino acid transport by cells in culture: differences between normal and malignant cells. N Engl J Med 1972, 286:929-933.
26. Mueckler M. Facilitative glucose transporters. Eur J Biochem 1994, 219:713-725.
27. Yamamoto T., Seino Y., Fukumoto H., Koh G., Yano H., Inagaki N., et al. Over-expression of facilitative glucose transporter genes in human cancers. Biochem Biophys Res Commun 1990, 170:223-230.
28. Younes M., Brown R.W., Stephenson M., Gondo M., Cagle P.T. Over expression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer 1997, 80:1046-1051.
29. De Geus-Oei L.F., van Krieken J.H., Aliredjo R.P., Krabbe P.F., Frielink C., Verhagen A.F., et al. Biological correlates of FDG uptake in non-small cell lung cancer. Lung Cancer 2007, 55:79-87.
30. Pelosi G., Fraggetta F., Nappi O., Pastorino U., Maisonneuve P., Pasini F., et al. Pleomorphic carcinoma of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. Am J Surg Pathol 2003, 27:1203-1225.
31. Clavo A.C., Brown R.S., Wahl R.L. Fluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxia. J Nucl Med 1995, 36:1625-1632.
32. Chen C., Pore N., Behrooz A., Ismail-Beigi F., Maity A. Regulation of glut1 nRNA by hypoxia-inducible factor-1: interaction between H-ras and hypoxia. J Biol Chem 2001, 276:9519-9525.
33. Taylor M.D., Smith P.W., Brix W.K., Wick M.R., Theodosakis N., Swenson B.R., et al. Fluorodeoxyglucose positron emission tomography and tumor marker expression in non-small cell lung cancer. J Thorac Cardiovasc Surg 2009, 137:43-48.