-
1
-
-
84856571938
-
-
ICH. Q8, Pharmaceutical Development (R1). Available at: . Accessed on 30 March 2011.
-
ICH. Q8, Pharmaceutical Development (R1). Available at: 2008. Accessed on 30 March 2011.
-
(2008)
-
-
-
2
-
-
34247474373
-
Design space for biotech products
-
Rathore AS. Design space for biotech products. BioPharm Int. 2007: 36-40.
-
(2007)
BioPharm Int
, pp. 36-40
-
-
Rathore, A.S.1
-
3
-
-
68749083515
-
Roadmap for implementation of quality by design (QbD) for biotechnology products
-
Rathore AS. Roadmap for implementation of quality by design (QbD) for biotechnology products. Trends Biotechnol. 2009; 27: 546-553.
-
(2009)
Trends Biotechnol
, vol.27
, pp. 546-553
-
-
Rathore, A.S.1
-
5
-
-
77950832203
-
Process analytical technology in biotechnology
-
Herwig C. Process analytical technology in biotechnology. Chem Ing Technol. 2010; 82: 405-414.
-
(2010)
Chem Ing Technol
, vol.82
, pp. 405-414
-
-
Herwig, C.1
-
6
-
-
38349060175
-
Development knowledge can increase manufacturing capability and facilitate quality by design
-
Somma R. Development knowledge can increase manufacturing capability and facilitate quality by design. J Pharm Innov. 2007; 2: 87-92.
-
(2007)
J Pharm Innov
, vol.2
, pp. 87-92
-
-
Somma, R.1
-
7
-
-
0036271397
-
Industrial control of recombinant E. coli fed-batch culture: new perspectives on traditional controlled variables
-
Johnston W, Cord-Ruwisch R, Cooney MJ. Industrial control of recombinant E. coli fed-batch culture: new perspectives on traditional controlled variables. Bioprocess Biosyst Eng. 2002; 25: 111-120.
-
(2002)
Bioprocess Biosyst Eng
, vol.25
, pp. 111-120
-
-
Johnston, W.1
Cord-Ruwisch, R.2
Cooney, M.J.3
-
8
-
-
35348958504
-
Controlled fed-batch by tracking the maximal culture capacity
-
Henes B, Sonnleitner B. Controlled fed-batch by tracking the maximal culture capacity. J Biotechnol. 2007; 132: 118-126.
-
(2007)
J Biotechnol
, vol.132
, pp. 118-126
-
-
Henes, B.1
Sonnleitner, B.2
-
9
-
-
0035811172
-
Determination of the maximum specific uptake capacities for glucose and oxygen in glucose-limited fed-batch cultivations of Escherichia coli
-
Lin HY, Mathiszik B, Xu B, Enfors SO, Neubauer P. Determination of the maximum specific uptake capacities for glucose and oxygen in glucose-limited fed-batch cultivations of Escherichia coli. Biotechnol Bioeng. 2001; 73: 347-357.
-
(2001)
Biotechnol Bioeng
, vol.73
, pp. 347-357
-
-
Lin, H.Y.1
Mathiszik, B.2
Xu, B.3
Enfors, S.O.4
Neubauer, P.5
-
10
-
-
0025132985
-
On-line fermentation gas analysis: error analysis and application of mass spectrometry
-
Heinzle E, Oeggerli A, Dettweiler B. On-line fermentation gas analysis: error analysis and application of mass spectrometry. Anal Chim Acta. 1990; 238: 101-115.
-
(1990)
Anal Chim Acta
, vol.238
, pp. 101-115
-
-
Heinzle, E.1
Oeggerli, A.2
Dettweiler, B.3
-
11
-
-
0042922828
-
Optical sensor systems for bioprocess monitoring
-
Ulber R, Frerichs J-G, Beutel S. Optical sensor systems for bioprocess monitoring. Anal Bioanal Chem. 2003; 376: 342-348.
-
(2003)
Anal Bioanal Chem
, vol.376
, pp. 342-348
-
-
Ulber, R.1
Frerichs, J.-G.2
Beutel, S.3
-
12
-
-
0032550840
-
Online estimation of biomass through pH control analysis in aerobic yeast fermentation systems
-
Vicente A, Castrillo JI, Teixeira JA, Ugalde U. Online estimation of biomass through pH control analysis in aerobic yeast fermentation systems. Biotechnol Bioeng. 1998; 58: 445-450.
-
(1998)
Biotechnol Bioeng
, vol.58
, pp. 445-450
-
-
Vicente, A.1
Castrillo, J.I.2
Teixeira, J.A.3
Ugalde, U.4
-
13
-
-
0038731394
-
On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy
-
Cannizzaro C, Gugerli R, Marison I, von Stockar U. On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy. Biotechnol Bioeng. 2003; 84: 597-610.
-
(2003)
Biotechnol Bioeng
, vol.84
, pp. 597-610
-
-
Cannizzaro, C.1
Gugerli, R.2
Marison, I.3
von Stockar, U.4
-
15
-
-
0025939770
-
On-line capillary gas chromatography with automated liquid sampling: a powerful tool in biotechnology
-
Filippini C, Moser JU, Sonnleitner B, Fiechter A. On-line capillary gas chromatography with automated liquid sampling: a powerful tool in biotechnology. Anal Chim Acta. 1991; 255: 91-96.
-
(1991)
Anal Chim Acta
, vol.255
, pp. 91-96
-
-
Filippini, C.1
Moser, J.U.2
Sonnleitner, B.3
Fiechter, A.4
-
16
-
-
0035852624
-
Progress in monitoring, modeling and control of bioprocesses during the last 20 years
-
Schugerl K. Progress in monitoring, modeling and control of bioprocesses during the last 20 years. J Biotechnol. 2001; 85: 149-173.
-
(2001)
J Biotechnol
, vol.85
, pp. 149-173
-
-
Schugerl, K.1
-
17
-
-
33745482610
-
Improvement of bioprocess monitoring: development of novel concepts
-
Clementschitsch F, Bayer K. Improvement of bioprocess monitoring: development of novel concepts. Microb Cell Fact. 2006; 5: 183-196.
-
(2006)
Microb Cell Fact
, vol.5
, pp. 183-196
-
-
Clementschitsch, F.1
Bayer, K.2
-
18
-
-
41449086291
-
Bioprocess analysis
-
Rehbock C, Beutel S, Brückerhoff T, Hitzmann B, Riechers D, Rudolph G, Stahl F, Scheper T und Friehs K. Bioprocess analysis. Chem Ing Tech. 2008; 80: 267-286.
-
(2008)
Chem Ing Tech
, vol.80
, pp. 267-286
-
-
Rehbock, C.1
Beutel, S.2
Brückerhoff, T.3
Hitzmann, B.4
Riechers, D.5
Rudolph, G.6
Stahl, F.7
Scheper, T.8
Friehs, K.9
-
20
-
-
32644446642
-
Near infrared spectroscopy for bioprocess monitoring and control: current status and future trends
-
Scarff M, Arnold SA, Harvey LM, McNeil B. Near infrared spectroscopy for bioprocess monitoring and control: current status and future trends. Crit Rev Biotechnol. 2006; 26: 17-39.
-
(2006)
Crit Rev Biotechnol
, vol.26
, pp. 17-39
-
-
Scarff, M.1
Arnold, S.A.2
Harvey, L.M.3
McNeil, B.4
-
21
-
-
73249118965
-
Application of near-infrared spectroscopy for monitoring and control of cell culture and fermentation
-
Cervera AE, Petersen N, Lantz AE, Larsen A, Gernaey KV. Application of near-infrared spectroscopy for monitoring and control of cell culture and fermentation. Biotechnol Prog. 2009; 25: 1561-1581.
-
(2009)
Biotechnol Prog
, vol.25
, pp. 1561-1581
-
-
Cervera, A.E.1
Petersen, N.2
Lantz, A.E.3
Larsen, A.4
Gernaey, K.V.5
-
22
-
-
77957345665
-
PAT method to gather bioprocess parameters in real time using simple input variables and first principle relationships
-
Wechselberger P, Seifert A, Herwig C. PAT method to gather bioprocess parameters in real time using simple input variables and first principle relationships. Chem Eng Soc. 2010; 65: 5734-5746.
-
(2010)
Chem Eng Soc
, vol.65
, pp. 5734-5746
-
-
Wechselberger, P.1
Seifert, A.2
Herwig, C.3
-
23
-
-
0035809780
-
On-line determination of animal cell concentration
-
Ducommun P, Bolzonella I, Rhiel M, Pugeaud P, von Stockar U, Marison IW. On-line determination of animal cell concentration. Biotechnol Bioeng. 2001; 72: 515-522.
-
(2001)
Biotechnol Bioeng
, vol.72
, pp. 515-522
-
-
Ducommun, P.1
Bolzonella, I.2
Rhiel, M.3
Pugeaud, P.4
von Stockar, U.5
Marison, I.W.6
-
24
-
-
0022736565
-
Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: formulation and verification of a hypothesis
-
Sonnleitner B, Kaeppeli O. Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: formulation and verification of a hypothesis. Biotechnol Bioeng. 1986; 28: 927-937.
-
(1986)
Biotechnol Bioeng
, vol.28
, pp. 927-937
-
-
Sonnleitner, B.1
Kaeppeli, O.2
-
26
-
-
0035813388
-
On-line stoichiometry and identification of metabolic state under dynamic process conditions
-
Herwig C, Marison I, Von Stockar U. On-line stoichiometry and identification of metabolic state under dynamic process conditions. Biotechnol Bioeng. 2001; 75: 345-354.
-
(2001)
Biotechnol Bioeng
, vol.75
, pp. 345-354
-
-
Herwig, C.1
Marison, I.2
Von Stockar, U.3
-
27
-
-
84856572089
-
-
Numerical Recipes in C++: The Art of Scientific Computing, 2nd ed. Press W, Teykolsky S, Vetterling W, Flannery B, editors
-
Crimins F.Numerical Recipes in C++: The Art of Scientific Computing, 2nd ed. Press W, Teykolsky S, Vetterling W, Flannery B, editors; 2003, Vol. 104.
-
(2003)
, vol.104
-
-
Crimins, F.1
-
28
-
-
0037009215
-
Quantitative analysis of the impact of HXK2 and REG1 deletion in Saccharomyces cerevisiae on invertase expression and respiration
-
Herwig C, Chetreanu F, Niederberger P, Marison I, von Stockar U. Quantitative analysis of the impact of HXK2 and REG1 deletion in Saccharomyces cerevisiae on invertase expression and respiration. Enzyme Microb Technol. 2002; 31: 505-515.
-
(2002)
Enzyme Microb Technol
, vol.31
, pp. 505-515
-
-
Herwig, C.1
Chetreanu, F.2
Niederberger, P.3
Marison, I.4
von Stockar, U.5
-
29
-
-
0028764687
-
Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates
-
van der Heijden RTJM, Romein B, Heijnen JJ, Hellinga C, Luyben KCAM. Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates. Biotechnol Bioeng. 1994; 43: 3-20.
-
(1994)
Biotechnol Bioeng
, vol.43
, pp. 3-20
-
-
van der Heijden, R.T.J.M.1
Romein, B.2
Heijnen, J.J.3
Hellinga, C.4
Luyben, K.C.A.M.5
-
30
-
-
0028764649
-
Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross errors
-
van der Heijden RTJM, Romein B, Heijnen JJ, Hellinga C, Luyben KCAM. Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross errors. Biotechnol Bioeng. 1994; 43: 11-20.
-
(1994)
Biotechnol Bioeng
, vol.43
, pp. 11-20
-
-
van der Heijden, R.T.J.M.1
Romein, B.2
Heijnen, J.J.3
Hellinga, C.4
Luyben, K.C.A.M.5
-
31
-
-
0028500729
-
Linear constraint relations in biochemical reaction systems: III. Sequential application of data reconciliation for sensitive detection of systematic errors
-
van der Heijden RTJM, Romein B, Heijnen JJ, Hellinga C, Luyben KCAM. Linear constraint relations in biochemical reaction systems: III. Sequential application of data reconciliation for sensitive detection of systematic errors. Biotechnol Bioeng. 1994; 44: 781-791.
-
(1994)
Biotechnol Bioeng
, vol.44
, pp. 781-791
-
-
van der Heijden, R.T.J.M.1
Romein, B.2
Heijnen, J.J.3
Hellinga, C.4
Luyben, K.C.A.M.5
-
32
-
-
0020812944
-
Application of macroscopic balances to the identification of gross measurement errors
-
Wang NS, Stephanopoulos G. Application of macroscopic balances to the identification of gross measurement errors. Biotechnol Bioeng. 1983; 25: 2177-2208.
-
(1983)
Biotechnol Bioeng
, vol.25
, pp. 2177-2208
-
-
Wang, N.S.1
Stephanopoulos, G.2
-
33
-
-
0037955821
-
Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing
-
Jobe AM, Herwig C, Surzyn M, Walker B, Marison I, von Stockar U. Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing. Biotechnol Bioeng. 2003; 82: 627-639.
-
(2003)
Biotechnol Bioeng
, vol.82
, pp. 627-639
-
-
Jobe, A.M.1
Herwig, C.2
Surzyn, M.3
Walker, B.4
Marison, I.5
von Stockar, U.6
-
35
-
-
0035726455
-
A small metabolic flux model to identify transient metabolic regulations in Saccharomyces cerevisiae
-
Herwig C, von Stockar U. A small metabolic flux model to identify transient metabolic regulations in Saccharomyces cerevisiae. Bioprocess Biosyst Eng. 2002; 24: 395-403.
-
(2002)
Bioprocess Biosyst Eng
, vol.24
, pp. 395-403
-
-
Herwig, C.1
von Stockar, U.2
-
36
-
-
56949093864
-
Model-based computer-aided framework for design of process monitoring and analysis systems
-
Singh R, Gernaey KV, Gani R. Model-based computer-aided framework for design of process monitoring and analysis systems. Comput Chem Eng. 2009; 33: 22-42.
-
(2009)
Comput Chem Eng
, vol.33
, pp. 22-42
-
-
Singh, R.1
Gernaey, K.V.2
Gani, R.3
-
37
-
-
0025939770
-
On-line capillary gas chromatography with automated liquid sampling: a powerful tool in biotechnology
-
Filippini C, Moser JU, Sonnleitner B, Fiechter A. On-line capillary gas chromatography with automated liquid sampling: a powerful tool in biotechnology. Anal Chim Acta. 1991; 255: 91-96.
-
(1991)
Anal Chim Acta
, vol.255
, pp. 91-96
-
-
Filippini, C.1
Moser, J.U.2
Sonnleitner, B.3
Fiechter, A.4
|