Heparin-binding epidermal growth factor-like growth factor is a potent regulator of invasion activity in oral squamous cell carcinoma

Oncology Reports

Volumn 27, Issue 4, 2012, Pages 954-958

  Ohnishi, Yuichi ^a   Inoue, Hiroshi ^a,b   Furukawa, Masayuki ^a   Kakudo, Kenji ^a   Nozaki, Masami ^b  

^a OSAKA DENTAL UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Ectodomain shedding; Epidermal growth factor receptor; Heparin binding epidermal growth factor like growth factor; Invasion; Matrix metalloproteinases; Oral cancer; Squamous cell carcinoma

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; GELATINASE B; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; TAPI 2; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; CELL INVASION; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; REGULATORY MECHANISM; SQUAMOUS CELL CARCINOMA; UPREGULATION;

ADAM PROTEINS; AUTOCRINE COMMUNICATION; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; HYDROXAMIC ACIDS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; PROTEASE INHIBITORS; PROTEIN KINASE INHIBITORS; QUINAZOLINES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TONGUE NEOPLASMS; TYRPHOSTINS;

EID: 84856566225     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1616     Document Type: Article

References (31)

1. Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453-458, 2003.
2. Nguyen DX, Bos PD and Massague J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284, 2009.
3. Bos PD, Zhang XH-F, Nadal C, et al: Genes that mediate breast cancer metastasis to the brain. Nature 459: 1005-1009, 2009.
4. Jorissen RN, Walker F, Pouliot N, Garrett TPJ, Ward CW and Burgess AW: Epidermal growth factor receptor: mechanisms of activation and signaling. Exp Cell Res 284: 31-53, 2003. (Pubitemid 36331965)
5. Hynes NE and Lane HA: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354, 2005. (Pubitemid 40637826)
6. Lu X and Kang Y: Epidermal growth factor signaling and bone metastasis. Br J Cancer 102: 457-461, 2010.
7. Yagi H, Yotsumoto F and Miyamoto S: Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition. Mol Cancer Ther 7: 3441-3451, 2008.
8. Goishi K, Higashiyama S, Klagsbrun M, et al: Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell 6: 967-980, 1995.
9. Higashiyama S, Abraham JA, Miller J, Fiddes JC and Klagsbrun M: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251: 936-939, 1991. (Pubitemid 21926188)
10. Higashiyama S, Abraham JA and Klagsbrun M: Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparin sulfate. J Cell Biol 122: 933-940, 1993. (Pubitemid 23241102)
11. Ongusaha PP, Kwak JC, Zwible AJ, et al: HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res 64: 5283-5290, 2004. (Pubitemid 39006548)
12. Miyamoto S, Hirata M, Yamazaki A, et al: Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy. Cancer Res 64: 5720-5727, 2004. (Pubitemid 39095570)
13. Freeman MR, Yoo JJ, Raab G, et al: Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. J Clin Invest 99: 1028-1036, 1997. (Pubitemid 27123640)
14. Weaver MA: Invadopodia: specialized cell structures of cancer invasion. Clin Exp Metastasis 23: 97-105, 2006.
15. Nakagawa M, Nabeshima K, Asano S, et al: Up-regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands. Cancer Sci 100: 654-662, 2009.
16. Cohen S: Origins of growth factors: NGF and EGF. Ann NY Acad Sci 1038: 98-102, 2004.
17. Iwasaki S, Aoyagi H and Yoshizawa H: Immunohistochemical detection of epidermal growth factor and epidermal growth factor receptor in the lingual mucosa of rats during the morphogenesis of fili form papileae. Acta Histochem 109: 37-44, 2007. (Pubitemid 46176045)
18. Iwamoto R and Mekada E: Heparin-binding EGF-like growth factor: a juxtacrine growth factor. Cytokine Growth Factor Rev 11: 335-344, 2000.
19. Izumi Y, Hirata M, Hasuwa H, et al: A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKC-delta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 17: 7260-7272, 1998. (Pubitemid 29002695)
20. Suzuki M, Raab G, Moses MA, Fernandez CA and Klagsbrun M: Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site. J Biol Chem 272: 31730-31737, 1997. (Pubitemid 28013322)
21. Fischer OM, Hart S, Gschwind A and Ullrich A: EGFR signal transactivation in cancer cells. Biochem Soc Trans 31: 1203-1208, 2003. (Pubitemid 38030939)
22. Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T and Mekada E: Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci 97: 341-347, 2006.
23. Razandi M, Pedram A, Park ST and Levin ER: Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chem 278: 2701-2712, 2003. (Pubitemid 36801351)
24. Gooz M, Gooz P, Luttrell LM and Raymond JR: 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bond epidermal growth factor-like grow factor (HB-EGF) shedding in mesangial cells. J Biol Chem 281: 21004-21012, 2006. (Pubitemid 44115441)
25. Horiuchi K, Le Gall S, Schulte M, et al: Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell 18: 176-188, 2007. (Pubitemid 46066719)
26. Sahin U, Weskamp G, Kelly K, et al: Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164: 769-779, 2004. (Pubitemid 38282960)
27. Zheng X, Jiang F, Katakowski M, Zhan ZG, Lu QE and Chopp M: ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol Ther 8: 1045-1054, 2009.
28. Liu PCC, Liu X, Li Y, et al: Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cell. Cancer Biol Ther 5: 657-664, 2006. (Pubitemid 44024721)
29. Wikstland CJ, Reist CJ, Archer GE, Zalutsky MR and Bigner DD: The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target. J Neurovirol 4: 148-158, 1998. (Pubitemid 28167490)
30. Tsujioka H, Yotsumoto F, Hikita S, Ueda T, Kuroki M and Miyamoto S: Targeting the heparin-binding epidermal growth factor-like growth factor in ovarian cancer therapy. Curr Opin Obstet Gynecol 23: 24-30, 2011.
31. Wang F, Sloss C, Zhang X, Lee SW and Cusack JC: Membrane-bound heparin-binding epidermal growth factor-like growth factor regulates E-cadherin expression in pancreatic carcinoma cells. Cancer Res 67: 8486-8493, 2007. (Pubitemid 47437422)