Difference in Th1 and Th17 lymphocyte adhesion to endothelium

Journal of Immunology

Volumn 188, Issue 3, 2012, Pages 1421-1430

  Alcaide, Pilar ^a   Maganto Garcia, Elena ^a   Newton, Gail ^a   Travers, Richard ^a   Croce, Kevin J ^a   Bu, De Xiu ^a   Luscinskas, Francis W ^a   Lichtman, Andrew H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR6; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; ENDOTHELIUM; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE ADHERENCE; LYMPHOCYTE FUNCTION; MICROSCOPY; MICROVASCULATURE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; WILD TYPE;

ANIMALS; CELL ADHESION; CHEMOKINE CCL20; E-SELECTIN; ENDOTHELIUM, VASCULAR; INTERCELLULAR ADHESION MOLECULE-1; MICE; TH1 CELLS; TH17 CELLS;

EID: 84856560521     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101647     Document Type: Article

References (57)

1. Zhu, J., and W. E. Paul. 2008. CD4 T cells: fates, functions, and faults. Blood 112: 1557-1569.
2. Harrington, L. E., P. R. Mangan, and C. T. Weaver. 2006. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 18: 349-356.
3. Park, E. J., J. R. Mora, C. V. Carman, J. Chen, Y. Sasaki, G. Cheng, U. H. von Andrian, and M. Shimaoka. 2007. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J. Clin. Invest. 117: 2526-2538. (Pubitemid 47494354)
4. Chung, Y., X. Yang, S. H. Chang, L. Ma, Q. Tian, and C. Dong. 2006. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res. 16: 902-907. (Pubitemid 44764200)
5. Langrish, C. L., Y. Chen, W. M. Blumenschein, J. Mattson, B. Basham, J. D. Sedgwick, T. McClanahan, R. A. Kastelein, and D. J. Cua. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201: 233-240. (Pubitemid 40189432)
6. Iwakura, Y., and H. Ishigame. 2006. The IL-23/IL-17 axis in inflammation. J. Clin. Invest. 116: 1218-1222.
7. Murphy, C. A., C. L. Langrish, Y. Chen, W. Blumenschein, T. McClanahan, R. A. Kastelein, J. D. Sedgwick, and D. J. Cua. 2003. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198: 1951-1957. (Pubitemid 38032126)
8. van der Fits, L., S. Mourits, J. S. Voerman, M. Kant, L. Boon, J. D. Laman, F. Cornelissen, A. M. Mus, E. Florencia, E. P. Prens, and E. Lubberts. 2009. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182: 5836-5845.
9. Weaver, C. T., R. D. Hatton, P. R. Mangan, and L. E. Harrington. 2007. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852. (Pubitemid 46697925)
10. Ley, K., and G. S. Kansas. 2004. Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat. Rev. Immunol. 4: 325-335. (Pubitemid 38649275)
11. Lichtman, A. H., H. Ding, L. Henault, G. Vachino, R. Camphausen, D. Cumming, and F. W. Luscinskas. 1997. CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow. J. Immunol. 158: 3640-3650. (Pubitemid 127488717)
12. Austrup, F., D. Vestweber, E. Borges, M. Löhning, R. Bräuer, U. Herz, H. Renz, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. Nature 385: 81-83. (Pubitemid 27024558)
13. Borges, E., W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber. 1997. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 185: 573-578. (Pubitemid 27078375)
14. Lim, Y. C., L. Henault, A. J. Wagers, G. S. Kansas, F. W. Luscinskas, and A. H. Lichtman. 1999. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J. Immunol. 162: 3193-3201. (Pubitemid 29313565)
15. Acosta-Rodriguez, E. V., L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto, and G. Napolitani. 2007. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8: 639-646. (Pubitemid 46785128)
16. Sato, W., T. Aranami, and T. Yamamura. 2007. Cutting edge: Human Th17 cells are identified as bearing CCR2+CCR5- phenotype. J. Immunol. 178: 7525-7529. (Pubitemid 46898020)
17. Campbell, J. J., D. J. O'Connell, and M. A. Wurbel. 2007. Cutting Edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions. J. Immunol. 178: 3358-3362. (Pubitemid 46417598)
18. Wang, C., S. G. Kang, J. Lee, Z. Sun, and C. H. Kim. 2009. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2: 173-183.
19. Yamazaki, T., X. O. Yang, Y. Chung, A. Fukunaga, R. Nurieva, B. Pappu, N. Martin-Orozco, H. S. Kang, L. Ma, A. D. Panopoulos, et al. 2008. CCR6 regulates the migration of inflammatory and regulatory T cells. J. Immunol. 181: 8391-8401.
20. Bullard, D. C., E. J. Kunkel, H. Kubo, M. J. Hicks, I. Lorenzo, N. A. Doyle, C. M. Doerschuk, K. Ley, and A. L. Beaudet. 1996. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 183: 2329-2336. (Pubitemid 26158923)
21. Yang, X. O., R. Nurieva, G. J. Martinez, H. S. Kang, Y. Chung, B. P. Pappu, B. Shah, S. H. Chang, K. S. Schluns, S. S. Watowich, et al. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29: 44-56.
22. Harrington, L. E., K. M. Janowski, J. R. Oliver, A. J. Zajac, and C. T. Weaver. 2008. Memory CD4 T cells emerge from effector T-cell progenitors. Nature 452: 356-360. (Pubitemid 351430787)
23. Alcaide, P., S. L. King, C. J. Dimitroff, Y. C. Lim, R. C. Fuhlbrigge, and F. W. Luscinskas. 2007. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J. Invest. Dermatol. 127: 1964-1972. (Pubitemid 47075363)
24. Korn, T., M. Mitsdoerffer, A. L. Croxford, A. Awasthi, V. A. Dardalhon, G. Galileos, P. Vollmar, G. L. Stritesky, M. H. Kaplan, A. Waisman, et al. 2008. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 105: 18460-18465.
25. Lim, Y. C., G. Garcia-Cardena, J. R. Allport, M. Zervoglos, A. J. Connolly, M. A. Gimbrone, Jr., and F. W. Luscinskas. 2003. Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am. J. Pathol. 162: 1591-1601. (Pubitemid 36512842)
26. Stefanidakis, M., G. Newton, W. Y. Lee, C. A. Parkos, and F. W. Luscinskas. 2008. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood 112: 1280-1289.
27. Ley, K., D. C. Bullard, M. L. Arbonés, R. Bosse, D. Vestweber, T. F. Tedder, and A. L. Beaudet. 1995. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. J. Exp. Med. 181: 669-675.
28. Yang, J., T. Hirata, K. Croce, G. Merrill-Skoloff, B. Tchernychev, E. Williams, R. Flaumenhaft, B. C. Furie, and B. Furie. 1999. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. J. Exp. Med. 190: 1769-1782. (Pubitemid 30013843)
29. Edwards, J. C., A. D. Sedgwick, and D. A. Willoughby. 1981. The formation of a structure with the features of synovial lining by subcutaneous injection of air: an in vivo tissue culture system. J. Pathol. 134: 147-156. (Pubitemid 11065839)
30. Bonder, C. S., S. R. Clark, M. U. Norman, P. Johnson, and P. Kubes. 2006. Use of CD44 by CD4+ Th1 and Th2 lymphocytes to roll and adhere. Blood 107: 4798-4806. (Pubitemid 43882631)
31. Mangan, P. R., D. O'Quinn, L. Harrington, C. S. Bonder, P. Kubes, D. F. Kucik, D. C. Bullard, and C. T. Weaver. 2005. Both Th1 and Th2 cells require P-selectin glycoprotein ligand-1 for optimal rolling on inflamed endothelium. Am. J. Pathol. 167: 1661-1675. (Pubitemid 41713318)
32. Atarashi, K., T. Hirata, M. Matsumoto, N. Kanemitsu, and M. Miyasaka. 2005. Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. J. Immunol. 174: 1424-1432.
33. Lim, Y. C., H. Xie, C. E. Come, S. I. Alexander, M. J. Grusby, A. H. Lichtman, and F. W. Luscinskas. 2001. IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J. Immunol. 167: 4476-4484. (Pubitemid 32954325)
34. Dransfield, I., C. Cabañas, A. Craig, and N. Hogg. 1992. Divalent cation regulation of the function of the leukocyte integrin LFA-1. J. Cell Biol. 116: 219-226.
35. Dustin, M. L., and T. A. Springer. 1989. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341: 619-624. (Pubitemid 19257309)
36. Matsumoto, M., K. Atarashi, E. Umemoto, Y. Furukawa, A. Shigeta, M. Miyasaka, and T. Hirata. 2005. CD43 functions as a ligand for E-Selectin on activated T cells. J. Immunol. 175: 8042-8050. (Pubitemid 41798366)
37. Liao, F., R. L. Rabin, C. S. Smith, G. Sharma, T. B. Nutman, and J. M. Farber. 1999. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J. Immunol. 162: 186-194. (Pubitemid 29018919)
38. Norman, M. U., L. Zbytnuik, and P. Kubes. 2008. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism. Eur. J. Immunol. 38: 1368-1380.
39. Tessier, P. A., P. H. Naccache, I. Clark-Lewis, R. P. Gladue, K. S. Neote, and S. R. McColl. 1997. Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. J. Immunol. 159: 3595-3602. (Pubitemid 127482119)
40. Ding, Z. M., J. E. Babensee, S. I. Simon, H. Lu, J. L. Perrard, D. C. Bullard, X. Y. Dai, S. K. Bromley, M. L. Dustin, M. L. Entman, et al. 1999. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J. Immunol. 163: 5029-5038. (Pubitemid 29501271)
41. Labow, M. A., C. R. Norton, J. M. Rumberger, K. M. Lombard-Gillooly, D. J. Shuster, J. Hubbard, R. Bertko, P. A. Knaack, R. W. Terry, M. L. Harbison, et al. 1994. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1: 709-720. (Pubitemid 124000734)
42. Ghannam, S., C. Dejou, N. Pedretti, J. P. Giot, K. Dorgham, H. Boukhaddaoui, V. Deleuze, F. X. Bernard, C. Jorgensen, H. Yssel, and J. Pène. 2011. CCL20 and b-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions. J. Immunol. 186: 1411-1420.
43. Ali, S., H. Robertson, J. H. Wain, J. D. Isaacs, G. Malik, and J. A. Kirby. 2005. A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation. J. Immunol. 175: 1257-1266. (Pubitemid 41095015)
44. Clish, C. B., J. A. O'Brien, K. Gronert, G. L. Stahl, N. A. Petasis, and C. N. Serhan. 1999. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. Proc. Natl. Acad. Sci. USA 96: 8247-8252. (Pubitemid 29328440)
45. Gladue, R. P., S. H. Cole, M. L. Roach, L. A. Tylaska, R. T. Nelson, R. M. Shepard, J. D. McNeish, K. T. Ogborne, and K. S. Neote. 2006. The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice. J. Immunol. 176: 3141-3148.
46. Eppihimer, M. J., B.Wolitzky, D. C. Anderson, M. A. Labow, and D. N. Granger. 1996. Heterogeneity of expression of E- and P-selectins in vivo. Circ. Res. 79: 560-569. (Pubitemid 26276916)
47. McEver, R. P. 2002. P-selectin and PSGL-1: exploiting connections between inflammation and venous thrombosis. Thromb. Haemost. 87: 364-365. (Pubitemid 34232474)
48. Buscher, K., S. B. Riese, M. Shakibaei, C. Reich, J. Dernedde, R. Tauber, and K. Ley. 2010. The transmembrane domains of L-selectin and CD44 regulate receptor cell surface positioning and leukocyte adhesion under flow. J. Biol. Chem. 285: 13490-13497.
49. DeGrendele, H. C., P. Estess, L. J. Picker, and M. H. Siegelman. 1996. CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel-lymphocyte-endothelial cell primary adhesion pathway. J. Exp. Med. 183: 1119- 1130.
50. Kunkel, E. J., and K. Ley. 1996. Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo. Circ. Res. 79: 1196-1204. (Pubitemid 26404152)
51. Ley, K., M. Allietta, D. C. Bullard, and S. Morgan. 1998. Importance of Eselectin for firm leukocyte adhesion in vivo. Circ. Res. 83: 287-294. (Pubitemid 28371318)
52. Yago, T., B. Shao, J. J. Miner, L. Yao, A. G. Klopocki, K. Maeda, K. M. Coggeshall, and R. P. McEver. 2010. E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. Blood 116: 485-494.
53. Yoshizaki, A., K. Yanaba, Y. Iwata, K. Komura, A. Ogawa, Y. Akiyama, E. Muroi, T. Hara, F. Ogawa, M. Takenaka, et al. 2010. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J. Immunol. 185: 2502-2515.
54. Ahern, P. P., C. Schiering, S. Buonocore, M. J. McGeachy, D. J. Cua, K. J. Maloy, and F. Powrie. 2010. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity 33: 279-288.
55. Abramson, O., S. Qiu, and D. J. Erle. 2001. Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7. Immunology 103: 155-163. (Pubitemid 32521344)
56. Bettelli, E., M. Oukka, and V. K. Kuchroo. 2007. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8: 345-350. (Pubitemid 46745409)
57. Dong, C. 2006. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat. Rev. Immunol. 6: 329-333.