IL-12, STAT4-dependent up-regulation of CD4+ T cell core 2 β-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands1

Journal of Immunology

Volumn 167, Issue 8, 2001, Pages 4476-4484

  Lim, Y ^a   Xie, H ^a   Come, C E ^a   Alexander, S I ^a   Grusby, M J ^a   Lichtman, A H ^a   Luscinskas, F W ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GENE PRODUCT; INTERLEUKIN 12; INTERLEUKIN 4; MONOCLONAL ANTIBODY; N ACETYLGLUCOSAMINYLTRANSFERASE; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; PROTEIN FUC T VII; STAT4 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE INDUCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TRANSGENE;

EID: 0035887765     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.8.4476     Document Type: Article

References (51)

1. Lymphocyte responses and cytokines
2. + T cells
3. Functional diversity of helper T lymphocytes
4. Lymphokine production by human T cells in disease states
5. T-cell subsets: Recruiting the right kind of help
6. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4
7. IL- 12 and IL-4 control T cell adhesion to endothelial selectins through opposite effects on FucT-VII gene expression
8. Selectins and their ligands: Current concepts and controversies
9. The biology of P-selectin glycoprotein ligand-1: Its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction
10. The α(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E- and P-selectin ligand biosynthesis
11. Core2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation
12. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells
13. + T cells
14. α(1,3)-fucosyltransferase VII and α(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites
15. Differential expression of α3 fucosyltransferases in Th1 and Th2 cells correlates with their ability to bind P-selectin
16. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
17. Requirement for STAT4 in interleukin-12-mediated responses of natural killer and T cells
18. Impaired IL-12 responses and enhanced development of Th2 cells in STAT4-deficient mice
19. A signal transducer and activator of transcription (STAT)4-independent pathway for the development of T helper type 1 cells
20. lc thymocytes in vivo
21. A colon carcinoma cell line exhibits adhesive interactions with P-selectin under flow via a PSGL-I-independent mechanisms
22. IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement
23. Core2 β-1,6-N-acetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin
24. Characterization of the activation-associated isoform of CD43 on murine T lymphocytes
25. + T lymphocytes in graft-versus-host disease
26. A novel CD8 T cell-restricted CD45RB epitope shared by CD43 is differentially affected by glycosylation
27. Differential requirements for the O-linked branching enzyme care2 β-16-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin
28. + T lymphocytes in vivo
29. - (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-I under flow
30. + T lymphocytes on tumor necrosis factor α-activated vascular endothelium under flow
31. Complementary acceptor and site specificities of Fuc-TIV and Fuc-VII allow effective biosynthesis of sialyl-triLex and related polyactosamines present on glycoprotein counterreceptors of selectins
32. Specialized contributions by α(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
33. Expression cloning of a functional glycoprotein ligand for P-selectin
34. Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin
35. P-selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration
36. A novel P-selectin glycoprotein ligand-1 (PSGL-1) monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin
37. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration
38. + T cells migrate into inflamed skin only if they express ligands for E- and P-selectin
39. P-selectin glycoprotein ligand-I is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells
40. The binding of T cell-expressed P-selectin glycoprotein ligand-1 to E- and P-selectin is differentially regulated
41. α(1,3)-fucasyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts
42. Identification of N-terminal residues on P-selectin glycoprotein ligand-I required for binding to P-selectin
43. Tissue-specific regulation of mouse core 2 β-1,6-N-acetylglucosaminyltransferase
44. STATs and gene regulation
45. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells
46. Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin
47. The E-selectin-ligand ESL- I is located in the Golgi as well as on microvilli on the cell surface
48. The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor
49. Severe impairment of leukocyte rolling in venules of core2 glucosaminyltransferase-deficient mice
50. Molecular cloning and expression of a novel β-1, 6-N-acetylglucosaminyltransferase that forms core2, core4 and I branches
51. Control of ο-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core2, β1, 6-N-acetylglucosaminyltransferase