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Volumn 145, Issue 1-2, 2012, Pages 340-349

Identification of Ehrlichia ruminantium proteins that activate cellular immune responses using a reverse vaccinology strategy

Author keywords

Ehrlichia ruminantium; Reverse vaccinology; Th1 cytokines

Indexed keywords

BACTERIAL VACCINE; EHRLICHIA RUMINANTIUM VACCINE; GAMMA INTERFERON; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 84856558651     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.12.003     Document Type: Article
Times cited : (27)

References (68)
  • 1
    • 72749089181 scopus 로고    scopus 로고
    • Trends in the control of heartwater
    • Allsopp B.A. Trends in the control of heartwater. Onderstepoort J. Vet. Res. 2009, 76:81-88.
    • (2009) Onderstepoort J. Vet. Res. , vol.76 , pp. 81-88
    • Allsopp, B.A.1
  • 2
    • 0042265058 scopus 로고    scopus 로고
    • Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens
    • Ariel N., Zvi A., Makarova K.S., Chitlaru T., Elhanany E., Velan B., Cohen S., Friedlander A.M., Shafferman A. Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens. Infect. Immun. 2003, 71:4563-4579.
    • (2003) Infect. Immun. , vol.71 , pp. 4563-4579
    • Ariel, N.1    Zvi, A.2    Makarova, K.S.3    Chitlaru, T.4    Elhanany, E.5    Velan, B.6    Cohen, S.7    Friedlander, A.M.8    Shafferman, A.9
  • 5
    • 0034769118 scopus 로고    scopus 로고
    • Nitric oxide and the immune response
    • Bogdan C. Nitric oxide and the immune response. Nat. Immunol. 2001, 2:907-916.
    • (2001) Nat. Immunol. , vol.2 , pp. 907-916
    • Bogdan, C.1
  • 6
    • 0037470208 scopus 로고    scopus 로고
    • Preparation of Ehrlichia ruminantium challenge material for quantifiable and reproducible challenge in mice and sheep
    • Brayton K.A., Collins N.E., van Strijp F., Allsopp B.A. Preparation of Ehrlichia ruminantium challenge material for quantifiable and reproducible challenge in mice and sheep. Vet. Parasitol. 2003, 112:63-73.
    • (2003) Vet. Parasitol. , vol.112 , pp. 63-73
    • Brayton, K.A.1    Collins, N.E.2    van Strijp, F.3    Allsopp, B.A.4
  • 7
    • 0034778154 scopus 로고    scopus 로고
    • Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection
    • Brown J.S., Ogunniyi A.D., Woodrow M.C., Holden D.W., Paton J.C. Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infect. Immun. 2001, 69:6702-6706.
    • (2001) Infect. Immun. , vol.69 , pp. 6702-6706
    • Brown, J.S.1    Ogunniyi, A.D.2    Woodrow, M.C.3    Holden, D.W.4    Paton, J.C.5
  • 9
    • 0034634658 scopus 로고    scopus 로고
    • CD8(+) T cell knockout mice are less susceptible to Cowdria ruminantium infection than athymic, CD4(+) T cell knockout, and normal C57BL/6 mice
    • Byrom B., Barbet A.F., Obwolo M., Mahan S.M. CD8(+) T cell knockout mice are less susceptible to Cowdria ruminantium infection than athymic, CD4(+) T cell knockout, and normal C57BL/6 mice. Vet. Parasitol. 2000, 93:159-172.
    • (2000) Vet. Parasitol. , vol.93 , pp. 159-172
    • Byrom, B.1    Barbet, A.F.2    Obwolo, M.3    Mahan, S.M.4
  • 10
    • 71549149451 scopus 로고    scopus 로고
    • A comprehensive assessment of N-terminal signal peptides prediction methods
    • Choo K.H., Tan T.W., Ranganathan S. A comprehensive assessment of N-terminal signal peptides prediction methods. BMC Bioinform. 2009, 10:S2.
    • (2009) BMC Bioinform. , vol.10
    • Choo, K.H.1    Tan, T.W.2    Ranganathan, S.3
  • 13
    • 0141454873 scopus 로고    scopus 로고
    • TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis
    • Core L., Perego M. TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis. Mol. Microbiol. 2003, 49:1509-1522.
    • (2003) Mol. Microbiol. , vol.49 , pp. 1509-1522
    • Core, L.1    Perego, M.2
  • 14
    • 1242298610 scopus 로고    scopus 로고
    • Adhesion of outer membrane proteins containing tandem repeats of Anaplasma and Ehrlichia species (Rickettsiales: Anaplasmataceae) to tick cells
    • De la Fuente J., Garcia-Garcia J.C., Barbet A.F., Blouin E.F., Kocan K.M. Adhesion of outer membrane proteins containing tandem repeats of Anaplasma and Ehrlichia species (Rickettsiales: Anaplasmataceae) to tick cells. Vet. Microbiol. 2004, 98:313-322.
    • (2004) Vet. Microbiol. , vol.98 , pp. 313-322
    • De la Fuente, J.1    Garcia-Garcia, J.C.2    Barbet, A.F.3    Blouin, E.F.4    Kocan, K.M.5
  • 15
    • 79953189362 scopus 로고    scopus 로고
    • Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells
    • Derrick S.C., Yabe I.M., Yang A., Morris S.L. Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells. Vaccine 2011, 29:2902-2909.
    • (2011) Vaccine , vol.29 , pp. 2902-2909
    • Derrick, S.C.1    Yabe, I.M.2    Yang, A.3    Morris, S.L.4
  • 16
    • 0026230262 scopus 로고
    • T cell-mediated immunity to Cowdria ruminantium in mice: the protective role of Lyt-2+ T cells
    • Du Plessis J.L., Berche P., Van Gas L. T cell-mediated immunity to Cowdria ruminantium in mice: the protective role of Lyt-2+ T cells. Onderstepoort J. Vet. Res. 1991, 58:171-179.
    • (1991) Onderstepoort J. Vet. Res. , vol.58 , pp. 171-179
    • Du Plessis, J.L.1    Berche, P.2    Van Gas, L.3
  • 17
    • 2442513537 scopus 로고    scopus 로고
    • Identification of Ehrlichia ruminantium (Gardel strain) IFN-gamma inducing proteins after vaccination with a killed vaccine
    • Esteves I., Martinez D., Totté P. Identification of Ehrlichia ruminantium (Gardel strain) IFN-gamma inducing proteins after vaccination with a killed vaccine. Vet. Microbiol. 2004, 100:233-240.
    • (2004) Vet. Microbiol. , vol.100 , pp. 233-240
    • Esteves, I.1    Martinez, D.2    Totté, P.3
  • 18
    • 15844431346 scopus 로고    scopus 로고
    • PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis
    • Gardy J.L., Laird M.R., Chen F., Rey S., Walsh C.J., Ester M., Brinkman F.S. PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis. Bioinformatics 2005, 21:617-623.
    • (2005) Bioinformatics , vol.21 , pp. 617-623
    • Gardy, J.L.1    Laird, M.R.2    Chen, F.3    Rey, S.4    Walsh, C.J.5    Ester, M.6    Brinkman, F.S.7
  • 19
    • 0036137702 scopus 로고    scopus 로고
    • IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites
    • Goff W.L., Johnson W.C., Parish S.M., Barrington G.M., Elsasser T.H., Davis W.C., Valdez R.A. IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites. Vet. Immunol. Immunopathol. 2002, 84:237-251.
    • (2002) Vet. Immunol. Immunopathol. , vol.84 , pp. 237-251
    • Goff, W.L.1    Johnson, W.C.2    Parish, S.M.3    Barrington, G.M.4    Elsasser, T.H.5    Davis, W.C.6    Valdez, R.A.7
  • 20
    • 0038362293 scopus 로고    scopus 로고
    • Rational antibacterial vaccine design through genomic technologies
    • Grandi G. Rational antibacterial vaccine design through genomic technologies. Int. J. Parasitol. 2003, 33:615-620.
    • (2003) Int. J. Parasitol. , vol.33 , pp. 615-620
    • Grandi, G.1
  • 21
    • 77953306949 scopus 로고    scopus 로고
    • IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo
    • Haeberlein S., Sebald H., Bogdan C., Schleicher U. IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo. Eur. J. Immunol. 2010, 40:1708-1717.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1708-1717
    • Haeberlein, S.1    Sebald, H.2    Bogdan, C.3    Schleicher, U.4
  • 23
    • 77954474139 scopus 로고    scopus 로고
    • Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells
    • Humann J., Lenz L.L. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J. Immunol. 2010, 184:5172-5178.
    • (2010) J. Immunol. , vol.184 , pp. 5172-5178
    • Humann, J.1    Lenz, L.L.2
  • 25
    • 55749108735 scopus 로고    scopus 로고
    • Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence
    • Juhas M., Crook D.W., Hood D.W. Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence. Cell Microbiol. 2008, 10:2377-2386.
    • (2008) Cell Microbiol. , vol.10 , pp. 2377-2386
    • Juhas, M.1    Crook, D.W.2    Hood, D.W.3
  • 26
    • 2142657817 scopus 로고    scopus 로고
    • A combined transmembrane topology and signal peptide prediction method
    • Käll L., Krogh A., Sonnhammer E.L. A combined transmembrane topology and signal peptide prediction method. J. Mol. Biol. 2004, 338:1027-1036.
    • (2004) J. Mol. Biol. , vol.338 , pp. 1027-1036
    • Käll, L.1    Krogh, A.2    Sonnhammer, E.L.3
  • 28
    • 78649736380 scopus 로고    scopus 로고
    • The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation
    • Kobayashi Y. The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation. J. Leukoc. Biol. 2010, 88:1157-1162.
    • (2010) J. Leukoc. Biol. , vol.88 , pp. 1157-1162
    • Kobayashi, Y.1
  • 29
    • 0035910270 scopus 로고    scopus 로고
    • Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
    • Krogh A., Larsson B., von Heijne G., Sonnhammer E.L. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 2001, 305:567-580.
    • (2001) J. Mol. Biol. , vol.305 , pp. 567-580
    • Krogh, A.1    Larsson, B.2    von Heijne, G.3    Sonnhammer, E.L.4
  • 33
    • 33646200337 scopus 로고    scopus 로고
    • Characterization of cytokine expression in milk somatic cells during intramammary infections with Escherichia coli or Staphylococcus aureus by real-time PCR
    • Lee J.-W., Bannerman D.D., Max J., Paape M.J., Huang M.-K., Zhao X. Characterization of cytokine expression in milk somatic cells during intramammary infections with Escherichia coli or Staphylococcus aureus by real-time PCR. Vet. Res. 2006, 37:219-229.
    • (2006) Vet. Res. , vol.37 , pp. 219-229
    • Lee, J.-W.1    Bannerman, D.D.2    Max, J.3    Paape, M.J.4    Huang, M.-K.5    Zhao, X.6
  • 34
    • 7744241494 scopus 로고    scopus 로고
    • Expression of an immunologically reactive merozoite surface protein (MSP-142) in E. coli
    • Leung W.H., Meng Z.Q., Hui G., Ho W.K. Expression of an immunologically reactive merozoite surface protein (MSP-142) in E. coli. Biochim. Biophys. Acta 2004, 1675:62-70.
    • (2004) Biochim. Biophys. Acta , vol.1675 , pp. 62-70
    • Leung, W.H.1    Meng, Z.Q.2    Hui, G.3    Ho, W.K.4
  • 35
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 36
    • 34248341795 scopus 로고    scopus 로고
    • Immunogenicity of Anaplasma marginale type IV secretion system proteins in a protective outer membrane vaccine
    • Lopez J.E., Palmer G.H., Brayton K.A., Dark M.J., Leach S.E., Brown W.C. Immunogenicity of Anaplasma marginale type IV secretion system proteins in a protective outer membrane vaccine. Infect. Immun. 2007, 75:2333-2342.
    • (2007) Infect. Immun. , vol.75 , pp. 2333-2342
    • Lopez, J.E.1    Palmer, G.H.2    Brayton, K.A.3    Dark, M.J.4    Leach, S.E.5    Brown, W.C.6
  • 37
    • 0036414844 scopus 로고    scopus 로고
    • Sequencing of a 15-kb Ehrlichia ruminantium clone and evaluation of the cpg1 open reading frame for protection against heartwater
    • Louw E., Brayton K.A., Collins N.E., Pretorius A., Van Strijp F., Allsopp B.A. Sequencing of a 15-kb Ehrlichia ruminantium clone and evaluation of the cpg1 open reading frame for protection against heartwater. Ann. N.Y. Acad. Sci. 2002, 969:147-150.
    • (2002) Ann. N.Y. Acad. Sci. , vol.969 , pp. 147-150
    • Louw, E.1    Brayton, K.A.2    Collins, N.E.3    Pretorius, A.4    Van Strijp, F.5    Allsopp, B.A.6
  • 38
    • 0028118365 scopus 로고
    • Concanavalin A stimulated bovine T-cell supernatants inhibit growth of Cowdria ruminantium in bovine endothelial cells in vitro
    • Mahan S.M., Smith G.E., Byrom B. Concanavalin A stimulated bovine T-cell supernatants inhibit growth of Cowdria ruminantium in bovine endothelial cells in vitro. Infect. Immun. 1994, 62:747-750.
    • (1994) Infect. Immun. , vol.62 , pp. 747-750
    • Mahan, S.M.1    Smith, G.E.2    Byrom, B.3
  • 40
    • 0033973889 scopus 로고    scopus 로고
    • Microbial metalloproteases and pathogenesis
    • Miyoshi S., Shinoda S. Microbial metalloproteases and pathogenesis. Microbes Infect. 2000, 2:91-98.
    • (2000) Microbes Infect. , vol.2 , pp. 91-98
    • Miyoshi, S.1    Shinoda, S.2
  • 41
    • 34249042613 scopus 로고    scopus 로고
    • The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials
    • Muzzi A., Masignani V., Rappuoli R. The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials. Drug Discov. Today 2007, 12:429-439.
    • (2007) Drug Discov. Today , vol.12 , pp. 429-439
    • Muzzi, A.1    Masignani, V.2    Rappuoli, R.3
  • 42
    • 0036178092 scopus 로고    scopus 로고
    • Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
    • Mwangi D.M., McKeever D.J., Nyanjui J.K., Barbet A.F., Mahan S.M. Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent. Vet. Immunol. Immunopathol. 2002, 85:23-32.
    • (2002) Vet. Immunol. Immunopathol. , vol.85 , pp. 23-32
    • Mwangi, D.M.1    McKeever, D.J.2    Nyanjui, J.K.3    Barbet, A.F.4    Mahan, S.M.5
  • 44
    • 0030614959 scopus 로고    scopus 로고
    • Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
    • Nielsen H., Engelbrecht J., Brunak S., von Heijne G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng. 1997, 10:1-6.
    • (1997) Protein Eng. , vol.10 , pp. 1-6
    • Nielsen, H.1    Engelbrecht, J.2    Brunak, S.3    von Heijne, G.4
  • 45
    • 0037081477 scopus 로고    scopus 로고
    • DNA vaccination with map1 gene followed by protein boost augments protection against challenge with Cowdria ruminantium, the agent of heartwater
    • Nyika A., Barbet A.F., Burridge M.J., Mahan S.M. DNA vaccination with map1 gene followed by protein boost augments protection against challenge with Cowdria ruminantium, the agent of heartwater. Vaccine 2002, 20:1215-1225.
    • (2002) Vaccine , vol.20 , pp. 1215-1225
    • Nyika, A.1    Barbet, A.F.2    Burridge, M.J.3    Mahan, S.M.4
  • 48
    • 33846889969 scopus 로고    scopus 로고
    • Protection against heartwater by DNA immunisation with four Ehrlichia ruminantium open reading frames
    • Pretorius A., Collins N.E., Steyn H.C., van Strijp F., van Kleef M., Allsopp B.A. Protection against heartwater by DNA immunisation with four Ehrlichia ruminantium open reading frames. Vaccine 2007, 25:2316-2324.
    • (2007) Vaccine , vol.25 , pp. 2316-2324
    • Pretorius, A.1    Collins, N.E.2    Steyn, H.C.3    van Strijp, F.4    van Kleef, M.5    Allsopp, B.A.6
  • 49
    • 47649101528 scopus 로고    scopus 로고
    • A heterologous prime/boost immunisation strategy protects against virulent E. ruminantium Welgevonden needle challenge but not against tick challenge
    • Pretorius A., van Kleef M., Collins N.E., Tshikudo N., Louw E., Faber F.E., van Strijp M.F., Allsopp B.A. A heterologous prime/boost immunisation strategy protects against virulent E. ruminantium Welgevonden needle challenge but not against tick challenge. Vaccine 2008, 26:4363-4371.
    • (2008) Vaccine , vol.26 , pp. 4363-4371
    • Pretorius, A.1    van Kleef, M.2    Collins, N.E.3    Tshikudo, N.4    Louw, E.5    Faber, F.E.6    van Strijp, M.F.7    Allsopp, B.A.8
  • 51
    • 1842588471 scopus 로고    scopus 로고
    • Molecular cloning and characterization of cgt, the Brucella abortus cyclic beta-1,2-glucan transporter gene, and its role in virulence
    • Roset M.S., Ciocchini A.E., Ugalde R.A., Iñón de Iannino N. Molecular cloning and characterization of cgt, the Brucella abortus cyclic beta-1,2-glucan transporter gene, and its role in virulence. Infect. Immun. 2004, 72:2263-2271.
    • (2004) Infect. Immun. , vol.72 , pp. 2263-2271
    • Roset, M.S.1    Ciocchini, A.E.2    Ugalde, R.A.3    Iñón de Iannino, N.4
  • 52
    • 79953270009 scopus 로고    scopus 로고
    • Mycobacterial PE/PPE proteins at the host-pathogen interface
    • Sampson S.L. Mycobacterial PE/PPE proteins at the host-pathogen interface. Clin. Dev. Immunol. 2011, 2011:497203.
    • (2011) Clin. Dev. Immunol. , vol.2011 , pp. 497203
    • Sampson, S.L.1
  • 53
    • 77956265695 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of five low molecular weight proteins of Ehrlichia ruminantium as potential vaccine components
    • Sebatjane S.I., Pretorius A., Liebenberg J., Steyn H., Van Kleef M. In vitro and in vivo evaluation of five low molecular weight proteins of Ehrlichia ruminantium as potential vaccine components. Vet. Immunol. Immunopathol. 2010, 137:217-225.
    • (2010) Vet. Immunol. Immunopathol. , vol.137 , pp. 217-225
    • Sebatjane, S.I.1    Pretorius, A.2    Liebenberg, J.3    Steyn, H.4    Van Kleef, M.5
  • 54
    • 77958454595 scopus 로고    scopus 로고
    • Reverse vaccinology: developing vaccines in the era of genomics
    • Sette A., Rappuoli R. Reverse vaccinology: developing vaccines in the era of genomics. Immunity 2010, 33:530-541.
    • (2010) Immunity , vol.33 , pp. 530-541
    • Sette, A.1    Rappuoli, R.2
  • 55
    • 35448975514 scopus 로고    scopus 로고
    • Differential cytokine gene expression profiles in the three pathological forms of sheep paratuberculosis
    • Smeed J.A., Watkins C.A., Rhind S.M., Hopkins J. Differential cytokine gene expression profiles in the three pathological forms of sheep paratuberculosis. BMC Vet. Res. 2007, 3:18.
    • (2007) BMC Vet. Res. , vol.3 , pp. 18
    • Smeed, J.A.1    Watkins, C.A.2    Rhind, S.M.3    Hopkins, J.4
  • 56
    • 33947407688 scopus 로고    scopus 로고
    • Evaluation and comparison of mammalian subcellular localization prediction methods
    • Sprenger J., Fink J.L., Teasdale R.D. Evaluation and comparison of mammalian subcellular localization prediction methods. BMC Bioinform. 2006, 7(Suppl. 5):S3.
    • (2006) BMC Bioinform. , vol.7 , Issue.SUPPL. 5
    • Sprenger, J.1    Fink, J.L.2    Teasdale, R.D.3
  • 57
    • 34548418026 scopus 로고    scopus 로고
    • Associations between cytokine gene expression and pathology in Mycobacterium bovis infected cattle
    • Thacker T.C., Palmer M.V., Waters W.R. Associations between cytokine gene expression and pathology in Mycobacterium bovis infected cattle. Vet. Immunol. Immunopathol. 2007, 119:204-213.
    • (2007) Vet. Immunol. Immunopathol. , vol.119 , pp. 204-213
    • Thacker, T.C.1    Palmer, M.V.2    Waters, W.R.3
  • 58
    • 0030245902 scopus 로고    scopus 로고
    • Recombinant bovine interferon gamma inhibits the growth of Cowdria ruminantium but fails to induce major histocompatibility complex class II following infection of endothelial cells
    • Totté P., Vachiéry N., Martinez D., Trap I., Ballingall K.T., MacHugh N.D., Bensaid A., Wérenne J. Recombinant bovine interferon gamma inhibits the growth of Cowdria ruminantium but fails to induce major histocompatibility complex class II following infection of endothelial cells. Vet. Immunol. Immunopathol. 1996, 53:61-71.
    • (1996) Vet. Immunol. Immunopathol. , vol.53 , pp. 61-71
    • Totté, P.1    Vachiéry, N.2    Martinez, D.3    Trap, I.4    Ballingall, K.T.5    MacHugh, N.D.6    Bensaid, A.7    Wérenne, J.8
  • 60
    • 33744946277 scopus 로고    scopus 로고
    • Optimisation of the inactivated vaccine dose against heartwater and in vitro quantification of Ehrlichia ruminantium challenge material
    • Vachiéry N., Lefrançois T., Esteves I., Molia S., Sheikboudou C., Kandassamy Y., Martinez D. Optimisation of the inactivated vaccine dose against heartwater and in vitro quantification of Ehrlichia ruminantium challenge material. Vaccine 2006, 24:4747-4756.
    • (2006) Vaccine , vol.24 , pp. 4747-4756
    • Vachiéry, N.1    Lefrançois, T.2    Esteves, I.3    Molia, S.4    Sheikboudou, C.5    Kandassamy, Y.6    Martinez, D.7
  • 62
    • 77950860206 scopus 로고    scopus 로고
    • New insights into molecular Ehrlichia chaffeensis-host interactions
    • Wakeel A., Zhu B., Yu X.J., McBride J.W. New insights into molecular Ehrlichia chaffeensis-host interactions. Microbes Infect. 2010, 12:337-345.
    • (2010) Microbes Infect. , vol.12 , pp. 337-345
    • Wakeel, A.1    Zhu, B.2    Yu, X.J.3    McBride, J.W.4
  • 64
    • 33744505197 scopus 로고    scopus 로고
    • Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination?
    • Werling D., Piercy J., Coffey T.J. Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination?. Vet. Immunol. Immunopathol. 2006, 112:2-11.
    • (2006) Vet. Immunol. Immunopathol. , vol.112 , pp. 2-11
    • Werling, D.1    Piercy, J.2    Coffey, T.J.3
  • 65
    • 73949099857 scopus 로고    scopus 로고
    • Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia
    • Winder A.A., Wohlford-Lenane C., Scheetz T.E., Nardy B.N., Manzel L.J., Look D.C., McCray P.B. Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. Respir. Res. 2009, 10:96.
    • (2009) Respir. Res. , vol.10 , pp. 96
    • Winder, A.A.1    Wohlford-Lenane, C.2    Scheetz, T.E.3    Nardy, B.N.4    Manzel, L.J.5    Look, D.C.6    McCray, P.B.7
  • 66
    • 1942505330 scopus 로고    scopus 로고
    • Predicting subcellular localization of proteins for Gram-negative bacteria by support vector machines based on n-peptide compositions
    • Yu C.S., Lin C.J., Hwang J.K. Predicting subcellular localization of proteins for Gram-negative bacteria by support vector machines based on n-peptide compositions. Protein Sci. 2004, 13:1402-1406.
    • (2004) Protein Sci. , vol.13 , pp. 1402-1406
    • Yu, C.S.1    Lin, C.J.2    Hwang, J.K.3
  • 67
    • 77954199597 scopus 로고    scopus 로고
    • PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
    • Yu N.Y., Wagner J.R., Laird M.R., Melli G., Rey S., Lo R., Dao P., Sahinalp S.C., Ester M., Foster L.J., Brinkman F.S. PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes. Bioinformatics 2010, 26:1608-1615.
    • (2010) Bioinformatics , vol.26 , pp. 1608-1615
    • Yu, N.Y.1    Wagner, J.R.2    Laird, M.R.3    Melli, G.4    Rey, S.5    Lo, R.6    Dao, P.7    Sahinalp, S.C.8    Ester, M.9    Foster, L.J.10    Brinkman, F.S.11
  • 68
    • 70349417835 scopus 로고    scopus 로고
    • Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
    • Zhu B., Nethery K.A., Kuriakose J.A., Wakeel A., Zhang X., McBride J.W. Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements. Infect. Immun. 2009, 77:4243-4255.
    • (2009) Infect. Immun. , vol.77 , pp. 4243-4255
    • Zhu, B.1    Nethery, K.A.2    Kuriakose, J.A.3    Wakeel, A.4    Zhang, X.5    McBride, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.