Rational antibacterial vaccine design through genomic technologies

International Journal for Parasitology

Volumn 33, Issue 5-6, 2003, Pages 615-620

  Grandi, Guido ^a  

^a CHIRON VACCINES   (Italy)

Author keywords

Chlamydia pneumoniae; DNA microarray; Genome; Meningococcus B; Proteome; Transcriptome

Indexed keywords

BACTERIAL VACCINE; CHLAMYDIA PNEUMONIAE VACCINE; INACTIVATED VACCINE; LIVE VACCINE; MENINGOCOCCUS VACCINE; POLYSACCHARIDE VACCINE; RECOMBINANT VACCINE; SUBUNIT VACCINE; UNCLASSIFIED DRUG;

VACCINATION;

ALGORITHM; ANTIGEN DETECTION; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL TRANSMISSION; BACTERIUM ADHERENCE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CHLAMYDOPHILA PNEUMONIAE; CLINICAL RESEARCH; COMPUTER ANALYSIS; DNA MICROARRAY; FLUORESCENCE ACTIVATED CELL SORTING; GENOME ANALYSIS; GENOMICS; INFECTION PREVENTION; LUNG INFILTRATE; MENINGOCOCCOSIS; MOLECULAR CLONING; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEOMICS; REVIEW; WESTERN BLOTTING;

ANIMALIA; CHLAMYDIA; CHLAMYDOPHILA PNEUMONIAE;

EID: 0038362293     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(03)00059-6     Document Type: Review

References (25)

1. Avery O.T., Goebel W.F. Chemo-immunological studies on conjugated carbohydrate-proteins. II Immunological specificity of synthetic sugar-proteins. J. Exp. Med. 50:1929;521-533.
2. Bjune G., Hoiby E.A., Gronnesby J.K., Arnesen O., Fredriksen J.H., Halstensen A., Holten E., Lindbak A.K., Nokleby H., Rosenqvist E., Solberg L.K., Closs O., Eng J., Froholm L.O., Lystad A., Bakketeig L.S., Hareide B. Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. Lancet. 338:1991;1093-1096.
3. de Moraes J.C., Perkins B.A., Camargo M.C., Hidalgo N.T., Barbosa H.A., Sacchi C.T., Land Gral I.M., Gattas V.L., Vasconcelos H.G., Plikaytis B.D., Wenger J.D., Broome C.V. Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil. Lancet. 340:1992;1074-1078.
4. Gaydos C.A., Summersgill J.T., Sahney N.N., Ramirez J.A., Quinn T.C. Replication of Chlamydia penumoniae in vitro in human macrophages, endothelial cells, and aortic smooth muscle cells. Infect. Immun. 64:1996;1614-1620.
5. Glenny A.T., Hopkins B.E. Diphtheria toxoid as an immunising agent. Br. J. Exp. Med. 4:1923;283-287.
6. Goldschneider I., Gotschlich E.C., Artenstrain M.S. Human immunity to the meningococcus. I. The role of humoral antibodies. J. Exp. Med. 129:1969;1307-1326.
7. Goth S.R., Stephens R.S. Rapid, transient phosphatidylserine externalisation induced in host cells by infection with Chlamydia spp. Infect. Immun. 69:2001;1109-1119.
8. Gotschlich E.C., Goldschneider I., Artenstein M.S. Human immunity to the meningococcus. IV. Immunogenicity of group A and group C meningococcal polysaccharides in human volunteers. J. Exp. Med. 129:1969;1367-1384.
9. Gotschlich E.C., Liu T.Y., Artenstein M.S. Human immunity to meningococcus. III. Preparation and immunochemical properties of the group A, group B and group C meningococcal polysaccharides. J. Exp. Med. 129:1969;1349-1365.
10. Grandi G. Antibacterial vaccine design using genomics and proteomics. Trends Biotech. 19:2001;181-188.
11. Grayston J.T. Background and current knowledge of Chlamydia penumoniae and atherosclerosis. J. Infect. Dis. 181:2000;S402-S410.
12. Grifantini R., Bartolini E., Muzzi A., Draghi M., Frigimelica E., Berger J., Ratti G., Petracca R., Galli G., Agnusdei M., Giuliani M.M., Santini L., Brunelli B., Tettelin H., Rappuoli R., Randazzo F., Grandi G. Previously unrecognised vaccine candidates against group B meningococcus identified by DNA microarrays. Nat. Biotech. 20:2002;914-921.
13. Gupta S., Leatham E.W., Carrington D., Mendall M.A., Kaski J.C., Camm A.J. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation. 96:1997;404-407.
14. Gurfinkel E., Bozovich G., Daroca A., Beck E., Mautner B. Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study. Lancet. 350:1997;404-407.
15. Krull M., Klucken A.C., Wuppermann F.N., Fuhrmann O., Magerl C., Seybold J., Hippenstiel S., Hegemann J.H., Jantos C.A., Suttorp N. Signal transduction pathways activated in endothelial cells following infection with Chlamydia penumoniae. J. Immunol. 162:1999;4834-4841.
16. Montigiani S., Falugi F., Scarselli M., Finco O., Petracca R., Galli G., Mariani M., Manetti R., Agnusdei M., Cevenini R., Donati M., Nogarotto R., Norais N., Garaguso I., Nuti S., Saletti G., Rosa D., Ratti G., Grandi G. Genomic approach for the analysis of surface proteins in Chlamydia pneumoniae. Infect. Immun. 70:2002;368-379.
17. Nassif X., Pujol C., Morand P., Eugène E. Interactions of pathogenic Neisseria with host cells. Is it possible to assemble the puzzle? Mol. Microbiol. 32:1999;1124-1132.
18. Pizza M., Scarlato V., Masignani V., Giuliani M.M., Aricò B., Comanducci M., Jennings G.T., Baldi L., Bartolini E., Capecchi B., Galeotti C.L., Luzzi E., Manetti R., Marchetti E., Mora M., Nuti S., Ratti G., Santini L., Savino S., Scarselli M., Storni E., Zuo P., Broeker M., Hundt E., Knapp B., Blair E., Mason T., Tettelin H., Hood D.W., Jeffries A.C., Saunders N.J., Granoff D.M., Venter J.C., Moxon E.R., Grandi G., Rappuoli R. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science. 287:2000;1816-1820.
19. Poolman J.T. Development of a meningococcal vaccine. Infect. Agents Dis. 4:1995;13-28.
20. Saikku P., Leinonen M., Mattila K., Ekman M.R., Nieminen M.S., Makela P.H., Huttunen J.K., Valtonen V. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic heart disease and acute myocardial infarction. Lancet. 2:1988;983-986.
21. Scholten R.J., Bijlmer H.A., Poolman J.T., Kuipers B., Caugant D.A., Van Alphen L., Dankert J., Valkenburg H.A. Meningococcal disease in The Netherlands, 1958-1990: a steady increase in the incidence since 1982 partially caused by new serotypes on Neisseria meningitidis. Clin. Infect. Dis. 16:1993;237-246.
22. Stephens R.S. Chlamydia: Intracellular Biology, Pathogenesis, and Immunity. 1999;American Society for Microbiology, Washington, DC.
23. Tappero J.W., Lagos R., Ballestreros A.M., Plikaytis B., Williams D., Dykes J., Gheesling L.L., Carlone G.M., Hoiby E.A., Holst J., Nokleby H., Rosenqvist E., Sierra G., Campa C., Sotolongo F., Vega J., Garcia J., Herrera P., Poolman J.T., Perkins B.A. Immunogenicity of 2 serogroup B pouter-membrane protein meningococcal vaccines: a randomised controlled trial in Chile. J. Am. Med. Assoc. 281:1999;1520-1527.
24. Taraktchoglou M., Pacey A.A., Turnbull J.E., Eley A. Infectivity of Chlamydia thrachomatis serovar LGV but not E is dependent on host cell heparan sulphate. Infect. Immun. 69:2001;968-976.
25. Tettelin H., Saunders H.J., Heidelberg J., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science. 287:2000;1809-1815.