Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro

Experimental Neurology

Volumn 233, Issue 2, 2012, Pages 783-790

  Lv, Lei ^a   Han, Xiang ^a   Sun, Yan ^b   Wang, Xin ^c   Dong, Qiang ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

HDAC inhibitor; Neurons; Spinal cord injury; Valproic acid

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HISTONE H3; MYELIN PROTEIN; VALPROIC ACID;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE ESCALATION; DRUG EFFECT; EMBRYO; FEMALE; GROWTH INHIBITION; HIPPOCAMPUS; HISTONE ACETYLATION; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; NERVE CELL CULTURE; NERVE CELL GROWTH; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPINAL CORD INJURY; THERAPY DELAY; UPREGULATION;

ANIMALS; AXONS; FEMALE; MOTOR ACTIVITY; NEURONS; RATS; RATS, WISTAR; SPINAL CORD INJURIES; VALPROIC ACID;

EID: 84856533762     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.11.042     Document Type: Article

References (47)

1. Abel T., Zukin R.S. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr. Opin. Pharmacol. 2008, 8:57-64.
2. Abematsu M., Tsujimura K., Yamano M., Saito M., Kohno K., Kohyama J., Namihira M., Komiya S., Nakashima K. Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury. J. Clin. Investig. 2010, 120:3255-3266.
3. Basso D.M., Beattie M.S., Bresnahan J.C. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 1996, 139:244-256.
4. Biermann J., Grieshaber P., Goebel U., Martin G., Thanos S., Di Giovanni S., Lagreze W.A. Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells. Investig. Ophthalmol. Vis. Sci. 2010, 51:526-534.
5. Boato F., Hendrix S., Huelsenbeck S.C., Hofmann F., Grosse G., Djalali S., Klimaschewski L., Auer M., Just I., Ahnert-Hilger G., Holtje M. C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J. Cell Sci. 2010, 123:1652-1662.
6. Bredy T.W., Wu H., Crego C., Zellhoefer J., Sun Y.E., Barad M. Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn. Mem. 2007, 14:268-276.
7. Brichta L., Holker I., Haug K., Klockgether T., Wirth B. In vivo activation of SMN in spinal muscular atrophy carriers and patients treated with valproate. Ann. Neurol. 2006, 59:970-975.
8. Brill J., Lee M., Zhao S., Fernald R.D., Huguenard J.R. Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami. J. Neurosci. 2006, 26:6813-6822.
9. Cafferty W.B., Duffy P., Huebner E., Strittmatter S.M. MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma. J. Neurosci. 2010, 30:6825-6837.
10. Castro L.M., Gallant M., Niles L.P. Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells. J. Neurochem. 2005, 95:1227-1236.
11. Chen P.S., Peng G.S., Li G., Yang S., Wu X., Wang C.C., Wilson B., Lu R.B., Gean P.W., Chuang D.M., Hong J.S. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol. Psychiatry 2006, 11:1116-1125.
12. Choi D.C., Lee J.Y., Moon Y.J., Kim S.W., Oh T.H., Yune T.Y. Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury. Neurobiol. Dis. 2010, 39:272-282.
13. Chuang D.-M., Leng Y., Marinova Z., Kim H.-J., Chiu C.-T. Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci. 2009, 32:591-601.
14. Cui S.S., Yang C.P., Bowen R.C., Bai O., Li X.M., Jiang W., Zhang X. Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats. Brain Res. 2003, 975:229-236.
15. Dash P.K., Orsi S.A., Zhang M., Grill R.J., Pati S., Zhao J., Moore A.N. Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS One 2010, 5:e11383.
16. Einat H., Yuan P., Gould T.D., Li J., Du J., Zhang L., Manji H.K., Chen G. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J. Neurosci. 2003, 23:7311-7316.
17. Fukumoto T., Morinobu S., Okamoto Y., Kagaya A., Yamawaki S. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology 2001, 158:100-106.
18. GrandPre T., Nakamura F., Vartanian T., Strittmatter S.M. Identification of the Nogo inhibitor of axon regeneration as a reticulon protein. Nature 2000, 403:439-444.
19. Hu Q., Ma Q., Zhan Y., He Z., Tang J., Zhou C., Zhang J. Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion. Stroke 2011, 42:1750-1756.
20. Kidd S.K., Schneider J.S. Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience 2011, 194:189-194.
21. Li L., Zuo Z. Isoflurane postconditioning induces neuroprotection via Akt activation and attenuation of increased mitochondrial membrane permeability. Neuroscience 2011.
22. Loscher W., Honack D. Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats. Epilepsia 1995, 36:929-937.
23. Lv L., Sun Y., Han X., Xu C.C., Tang Y.P., Dong Q. Valproic acid improves outcome after rodent spinal cord injury: potential roles of histone deacetylase inhibition. Brain Res. 2011, 1396:60-68.
24. Lv L., Tang Y.P., Han X., Wang X., Dong Q. Therapeutic Application of Histone Deacetylase Inhibitors for Stroke. Cent. Nerv. Syst. Agents Med. Chem. 2011, 11:138-149.
25. Nalivaeva N.N., Belyaev N.D., Turner A.J. Sodium valproate: an old drug with new roles. Trends Pharmacol. Sci. 2009, 30:509-514.
26. Natori T., Kodaira F., Hirasawa T., Gao Y.Y., Nagai K. Augmentation of polysialic acid by valproic acid in early postnatal mouse hippocampus and primary cultured hippocampal neurons. J. Biosci. Bioeng. 2008, 105:164-167.
27. Nissinen J., Pitkanen A. Effect of antiepileptic drugs on spontaneous seizures in epileptic rats. Epilepsy Res. 2007, 73:181-191.
28. Pearse D.D., Pereira F.C., Marcillo A.E., Bates M.L., Berrocal Y.A., Filbin M.T., Bunge M.B. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat. Med. 2004, 10:610-616.
29. Penas C., Verdu E., Asensio-Pinilla E., Guzman-Lenis M.S., Herrando-Grabulosa M., Navarro X., Casas C. Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury. Neuroscience 2011, 178:33-44.
30. Piepers S., Veldink J.H., de Jong S.W., van der Tweel I., van der Pol W.L., Uijtendaal E.V., Schelhaas H.J., Scheffer H., de Visser M., de Jong J., Wokke J.H.J., Groeneveld G.J., van den Berg L.H. Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis. Ann. Neurol. 2009, 66:227-234.
31. Qing H., He G., Ly P.T., Fox C.J., Staufenbiel M., Cai F., Zhang Z., Wei S., Sun X., Chen C.H., Zhou W., Wang K., Song W. Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J. Exp. Med. 2008, 205:2781-2789.
32. Ren M., Leng Y., Jeong M., Leeds P.R., Chuang D.M. Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction. J. Neurochem. 2004, 89:1358-1367.
33. Rouaux C., Panteleeva I., Rene F., de Aguilar J.L.G., Echaniz-Laguna A., Dupuis L., Menger Y., Boutillier A.L., Loeffler J.P. Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J. Neurosci. 2007, 27:5535-5545.
34. Sinn D.I., Kim S.J., Chu K., Jung K.H., Lee S.T., Song E.C., Kim J.M., Park D.K., Lee S.K., Kim M., Roh J.K. Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation. Neurobiol. Dis. 2007, 26:464-472.
35. Sung Y.H., Lee S.H., Sung J.K., Han J.H., Kim H., Kim C.J., Kang J.M. Preconditioning of isoflurane on spinal cord ischemia can increase the number of inducible nitric oxide synthase-expressing motor neurons in rat. Korean J Anesthesiol. 2010, 58:70-75.
36. Thuret S., Moon L.D.F., Gage F.H. Therapeutic interventions after spinal cord injury. Nat. Rev. Neurosci. 2006, 7:628-643.
37. Valentim A.M., Di Giminiani P., Ribeiro P.O., Rodrigues P., Olsson I.A., Antunes L.M. Lower isoflurane concentration affects spatial learning and neurodegeneration in adult mice compared with higher concentrations. Anesthesiology 2010, 113:1099-1108.
38. van Bergeijk J., Haastert K., Grothe C., Claus P. Valproic acid promotes neurite outgrowth in PC12 cells independent from regulation of the survival of motoneuron protein. Chem. Biol. Drug Des. 2006, 67:244-247.
39. Walz J.C., Frey B.N., Andreazza A.C., Cereser K.M., Cacilhas A.A., Valvassori S.S., Quevedo J., Kapczinski F. Effects of lithium and valproate on serum and hippocampal neurotrophin-3 levels in an animal model of mania. J. Psychiatr. Res. 2008, 42:416-421.
40. Wang X. The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci. Ther. 2009, 15:345-357.
41. Williams R.S., Cheng L., Mudge A.W., Harwood A.J. A common mechanism of action for three mood-stabilizing drugs. Nature 2002, 417:292-295.
42. Wu X.F., Chen P.S., Dallas S., Wilson B., Block M.L., Wang C.C., Kinyamu H., Lu N., Gao X., Leng Y., Chuang D.M., Zhang W.Q., Lu R.B., Hong J.S. Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. Int. J. Neuropsychopharmacol. 2008, 11:1123-1134.
43. Yamauchi J., Miyamoto Y., Murabe M., Fujiwara Y., Sanbe A., Fujita Y., Murase S., Tanoue A. Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells. Exp. Cell Res. 2007, 313:1886-1896.
44. Yamauchi J., Torii T., Kusakawa S., Sanbe A., Nakamura K., Takashima S., Hamasaki H., Kawaguchi S., Miyamoto Y., Tanoue A. The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway. J. Neurosci. Res. 2010, 88:3189-3197.
45. Yuan P.X., Huang L.D., Jiang Y.M., Gutkind J.S., Manji H.K., Chen G. The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. J. Biol. Chem. 2001, 276:31674-31683.
46. Zadori D., Geisz A., Vamos E., Vecsei L., Klivenyi P. Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease. Pharmacol. Biochem. Behav. 2009, 94:148-153.
47. Zhou Z.G., Peng X.M., Fink D.J., Mata M. HSV-mediated transfer of artemin overcomes myelin inhibition to improve outcome after spinal cord injury. Mol. Ther. 2009, 17:1173-1179.