The relationship of developmental changes in white matter to the onset of psychosis

Current Pharmaceutical Design

Volumn 18, Issue 4, 2012, Pages 422-433

  Karlsgodt, Katherine H ^a   Jacobson, Sarah C ^a   Seal, Marc ^b   Fusar Poli, Paolo ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Adolescence; Development; Diffusion tensor imaging; High risk; Myelination; Neuroimaging; Schizophrenia; White matter

Indexed keywords

ADOLESCENCE; ADOLESCENT; ADULT; BRAIN DEVELOPMENT; DIFFUSION TENSOR IMAGING; GENETIC ANALYSIS; HUMAN; MENTAL DISEASE; MYELINATION; NERVE CELL DIFFERENTIATION; NEUROIMAGING; NONHUMAN; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; RISK ASSESSMENT; SCHIZOPHRENIA; WHITE MATTER;

AGE FACTORS; AGE OF ONSET; BRAIN; DIFFUSION TENSOR IMAGING; HUMANS; NERVE FIBERS, MYELINATED; NEURAL PATHWAYS; PSYCHOTIC DISORDERS;

EID: 84856533236     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799316073     Document Type: Review

References (150)

1. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci 1995; 3(2): 89-97.
2. Weinberger DR, Berman KF, Suddath R, Torrey EF. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. Am J Psychiatry 1992; 149(7): 890-7.
3. Weinberger DR, Aloia MS, Goldberg TE, Berman KF. The frontal lobes and schizophrenia. J Neuropsychiatry Clin Neurosci 1994; 6(4): 419-27.
4. Bullmore ET, Frangou S, Murray RM. The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia. Schizophr Res 1997; 28(2-3): 143-56.
5. Davis KL, Stewart DG, Friedman JI, et al. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry 2003; 60(5): 443-56.
6. Cannon TD, van Erp TG, Huttunen M, et al. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry 1998; 55(12): 1084-91.
7. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 2000; 157(1): 16-25.
8. Sachdev P, Brodaty H. Quantitative study of signal hyperintensities on T2-weighted magnetic resonance imaging in late-onset schizophrenia. Am J Psychiatry 1999; 156(12): 1958-67.
9. Hof PR, Haroutunian V, Copland C, Davis KL, Buxbaum JD. Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia. Neurochem Res 2002; 27(10): 1193-200.
10. Hakak Y, Walker JR, Li C, et al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 2001; 98(8): 4746-51.
11. Yung AR, McGorry PD. The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophr Bull 1996; 22(2): 353-70.
12. Cannon TD, van Erp TG, Bearden CE, Loewy R, Thompson P, Toga AW, Huttunen MO, Keshavan MS, Seidman LJ, Tsuang MT. Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions. Schiz Res 2003; 29(4): 653-69.
13. Salvati S, Attorri L, Avellino C, Di Biase A, Sanchez M. Diet, lipids and brain development. Dev Neurosci 2000; 22(5-6): 481-7.
14. Paus T, Zijdenbos A, Worsley K, et al. Structural maturation of neural pathways in children and adolescents: in vivo study. Science 1999; 283(5409): 1908-11.
15. Baumann N, Pham-Dinh D. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 2001; 81(2): 871-927.
16. Yakovlev P, Lecours A. Regional development of the brain in early life. Boston: Blackwell Scientific Publications; 1967.
17. Benes FM. Myelination of cortical-hippocampal relays during late adolescence. Schizophr Bull 1989; 15(4): 585-93.
18. Arnold SE, Rioux L. Challenges, status, and opportunities for studying developmental neuropathology in adult schizophrenia. Schizophr Bull 2001; 27(3): 395-416.
19. Durston S, Davidson MC, Tottenham N, et al. A shift from diffuse to focal cortical activity with development. Dev Sci 2006; 9(1): 1-8.
20. Paus T, Collins DL, Evans AC, Leonard G, Pike B, Zijdenbos A. Maturation of white matter in the human brain: a review of magnetic resonance studies. Brain Res Bull 2001; 54(3): 255-66.
21. O'Brien JS. Stability of the Myelin Membrane. Science 1965; 147: 1099-107.
22. Crawford MA, Sinclair AJ. The limitations of whole tissue analysis to define linolenic acid deficiency. J Nutr 1972; 102(10): 1315-21.
23. Arvindakshan M, Ghate M, Ranjekar PK, Evans DR, Mahadik SP. Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophr Res 2003; 62(3): 195-204.
24. Sastry PS. Lipids of nervous tissue: composition and metabolism. Prog Lipid Res 1985; 24(2): 69-176.
25. Kobayashi T, Shinnoh N, Kondo A, Yamada T. Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism. Biochem Biophys Res Commun 1997; 232(3): 631-6.
26. Wiggins RC. Myelin development and nutritional insufficiency. Brain Res 1982; 257(2): 151-75.
27. McKenna MC, Campagnoni AT. Effect of pre- and postnatal essential fatty acid deficiency on brain development and myelination. J Nutr 1979; 109(7): 1195-204.
28. Berkow SE, Campagnoni AT. Essential fatty acid deficiency: effects of cross-fostering mice at birth on brain growth and myelination. J Nutr 1981; 111(5): 886-94.
29. DeWille JW, Farmer SJ. Postnatal dietary fat influences mRNAS involved in myelination. Dev Neurosci 1992; 14(1): 61-8.
30. Connor JR, Menzies SL. Altered cellular distribution of iron in the central nervous system of myelin deficient rats. Neuroscience 1990; 34(1): 265-71.
31. Barres BA, Raff MC. Axonal control of oligodendrocyte development. J Cell Biol 1999; 147(6): 1123-8.
32. Waxman SG, Sims TJ. Specificity in central myelination: evidence for local regulation of myelin thickness. Brain Res 1984; 292(1): 179-85.
33. Sanchez I, Hassinger L, Paskevich PA, Shine HD, Nixon RA. Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J Neurosci 1996; 16(16): 5095-105.
34. Schwab M, Schnell L. Region-specific appearance of myelin constitutents in the developing rat spinal cord. J Neurocytol 1991; 18: 709-21.
35. Lewis DA. The human brain revisited: opportunities and challenges in postmortem studies of psychiatric disorders. Neuropsychopharmacology 2002; 26(2): 143-54.
36. Peled S, Gudbjartsson H, Westin C, Kikinis R, Jolesz F. Magnetic resonance imaging shows orientation and asymmetry of white matter fiber tracts. Brain Res 1998: 27-33.
37. Westin Cfmsekbepjfa, Kikinis R. Image Processing for Diffusion Tensor Magnetic Resonance Imaging 1999.
38. Pierpaoli C, Barnett A, Pajevic S, et al. Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture. Neuroimage 2001; 13(6 Pt 1): 1174-85.
39. Wozniak JR, Lim KO. Advances in white matter imaging: a review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging. Neurosci Biobehav Rev 2006; 30(6): 762-74.
40. Song AW, Harshbarger T, Li T, et al. Functional activation using apparent diffusion coefficient-dependent contrast allows better spatial localization to the neuronal activity: Evidence using diffusion tensor imaging and fiber tracking. Neuroimage 2003.
41. Song SK, Yoshino J, Le TQ, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005; 26(1): 132-40.
42. Catani M, Howard RJ, Pajevic S, Jones DK. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 2002; 17(1): 77-94.
43. Klingberg T, Vaidya CJ, Gabrieli JD, Moseley ME, Hedehus M. Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study. Neuroreport 1999; 10(13): 2817-21.
44. Giorgio A, Watkins KE, Chadwick M, et al. Longitudinal changes in grey and white matter during adolescence. Neuroimage 2010; 49(1): 94-103.
45. Kochunov P, Glahn DC, Lancaster J, et al. Fractional anisotropy of cerebral white matter and thickness of cortical gray matter across the lifespan. Neuroimage 2011; 58(1): 41-9.
46. Westlye LT, Walhovd KB, Dale AM, et al. Life-span changes of the human brain white matter: Diffusion tensor imaging (DTI) and volumetry. Cereb Cortex 2010; 20(9): 2055-68.
47. Schmithorst VJ, Yuan W. White matter development during adolescence as shown by diffusion MRI. Brain Cogn 2010; 72(1): 16-25.
48. Lenroot RK, Schmitt JE, Ordaz SJ, et al. Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence. Hum Brain Mapp 2009; 30(1): 163-74.
49. Kochunov P, Williamson DE, Lancaster J, et al. Fractional anisotropy of water diffusion in cerebral white matter across the lifespan. Neurobiol Aging 2010 Jan 30.
50. Paus T. Growth of white matter in the adolescent brain: Myelin or axon? Brain Cogn 2010; 72: 26-35.
51. De Bellis MD, Keshavan MS, Beers SR, et al. Sex differences in brain maturation during childhood and adolescence. Cereb Cortex 2001; 11(6): 552-7.
52. Asato MR, Terwilliger R, Woo J, Luna B. White Matter Development in Adolescence: A DTI Study. Cereb Cortex 2010 Jan 5.
53. Bava S, Boucquey V, Goldenberg D, et al. Sex differences in adolescent white matter architecture. Brain Res 2011; 1375: 41-8.
54. Johansen-Berg H. Behavioural relevance of variation in white matter microstructure. Curr Opin Neurol 2010; 23(4): 351-8.
55. Tamnes CK, vòstby Y, Fjell AM, Westlye LT, Due-Tvnnessen P, Walhovd KB. Brain maturation in adolescence and young adulthood: Regional age-related changes in cortical thickness and white matter volume and microstructure. Cereb Cortex 2010; 20(3): 534-48.
56. Olson EA, Collins PF, Hooper CJ, Muetzel R, Lim KO, Luciana M. White matter integrity predicts delay discounting behavior in 9- to 23-year-olds: A diffusion tensor imaging study. J Cogn Neurosci 2009; 21(7): 1406-21.
57. Bava S, Thayer R, Jacobus J, Ward M, Jernigan TL, Tapert SF. Longitudinal characterization of white matter maturation during adolescence. Brain Res 2010; 1327: 38-46.
58. Friston KJ. The disconnection hypothesis. Schizophr Res 1998; 30(2): 115-25.
59. Andreasen NC. A unitary model of schizophrenia: Bleuler's fragmented phrene as schizencephaly. Arch Gen Psychiatry 1999; 56(9): 781-7.
60. Buchsbaum MS. The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophr Bull 1990; 16(3): 379-89.
61. Csernansky JG, Bardgett ME. Limbic-cortical neuronal damage and the pathophysiology of schizophrenia. Schizophr Bull 1998; 24(2): 231-48.
62. Kapur S, Mamo D. Half a century of antipsychotics and still a central role for dopamine D2 receptors. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27(7): 1081-90.
63. Hugdahl K, Rund BR, Lund A, Asbjornsen A, Egeland J, Ersland L, et al. Brain activation measured with fMRI during a mental arithmetic task in schizophrenia and major depression. Am J Psychiatry 2004; 161(2): 286-93.
64. Quintana J, Wong T, Ortiz-Portillo E, et al. Prefrontal-posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations. Biol Psychiatry 2003; 53(1): 12-24.
65. Kim H, Samsonenko DG, Yoon M, et al. Temperature-triggered gate opening for gas adsorption in microporous manganese formate. Chem Commun (Camb) 2008; 21(39): 4697-9.
66. Benetti S, Mechelli A, Picchioni M, Broome M, Williams S, McGuire P. Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state. Brain 2009; 132(Pt 9): 2426-36.
67. Whalley HC, Simonotto E, Marshall I, et al. Functional disconnectivity in subjects at high genetic risk of schizophrenia. Brain 2005; 128(Pt 9): 2097-108.
68. Borgwardt SJ, Riecher-Rossler A, Dazzan P, et al. Regional gray matter volume abnormalities in the at risk mental state. Biol Psychiatry 2007; 61(10): 1148-56.
69. Broome MR, Matthiasson P, Fusar-Poli P, et al. Neural correlates of movement generation in the 'at-risk mental state'. Acta Psychiatr Scand 2010; 122(4): 295-301.
70. Pantelis C, Velakoulis D, McGorry PD, et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 2003; 361(9354): 281-8.
71. Akbarian S, Kim JJ, Potkin SG, Hetrick WP, Bunney WE, Jr., Jones EG. Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients. Arch Gen Psychiatry 1996; 53(5): 425-36.
72. Kirkpatrick B, Conley RC, Kakoyannis A, Reep RL, Roberts RC. Interstitial cells of the white matter in the inferior parietal cortex in schizophrenia: An unbiased cell-counting study. Synapse 1999; 34(2): 95-102.
73. Kirkpatrick B, Messias NC, Conley RR, Roberts RC. Interstitial cells of the white matter in the dorsolateral prefrontal cortex in deficit and nondeficit schizophrenia. J Nerv Ment Dis 2003; 191(9): 563-7.
74. Konrad A, Winterer G. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? Schizophr Bull 2008; 34(1): 72-92.
75. Lim KO, Hedehus M, Moseley M, de Crespigny A, Sullivan EV, Pfefferbaum A. Compromised White Matter Tract Integrity in Schizophrenia Inferred from diffusion Tensor imaging. Arch Gen Psychiatry 1999; 56: 367-74.
76. Ellison-Wright I, Bullmore E. Meta-analysis of diffusion tensor imaging studies in schizophrenia. Schizophr Res 2009; 108(1-3): 3-10.
77. Kubicki M, McCarley R, Westin CF, et al. A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res 2007; 41(1-2): 15-30.
78. Zalesky A, Fornito A, Seal ML, et al. Disrupted axonal fiber connectivity in schizophrenia. Biol Psychiatry 2011; 69(1): 80-9.
79. Seal ML, Yucel M, Fornito A, et al. Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivity. Schizophr Res 2008; 101(1-3): 106-10.
80. Petrides M, Pandya DN. Association pathways of the prefrontal cortex and functional observations. Principles of Frontal Lobe Function. New York: Oxford University Press; 2002.
81. Szeszko PR, Robinson DG, Ashtari M, et al. Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology 2008; 33(5): 976-84.
82. Karlsgodt K, van Erp TG, Poldrack R, Bearden CE, Nuechterlein KH, Cannon TD. Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia. Biol Psychiatry 2008; 63(5): 512-8.
83. Perez-Iglesias R, Tordesillas-Gutierrez D, McGuire PK, et al. White matter integrity and cognitive impairment in first-episode psychosis. Am J Psychiatry 2010; 167(4): 451-8.
84. Luck D, Buchy L, Czechowska Y, et al. Fronto-temporal disconnectivity and clinical short-term outcome in first episode psychosis: a DTI-tractography study. J Psychiatr Res 2011; 45(3): 369-77.
85. Laurens KR, Ngan ET, Bates AT, Kiehl KA, Liddle PF. Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia. Brain 2003; 126(Pt 3): 610-22.
86. Polli FE, Barton JJ, Thakkar KN, et al. Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain 2008; 131(Pt 4): 971-86.
87. Mori S, Wakana S, Nagae-Poetscher LM, van Zijl PC. MRI Atlas of Human White Matter. Amsterdam: Elsevier; 2005.
88. Agartz I, Andersson JLR, Skare S. Abnormal brain white matter in schizophrenia: A diffusion tensor imaging study. Neuroreport: For Rapid Communication of Neuroscience Research 2001; 12(10): 2251-4.
89. Kalus P, Buri C, Slotboom J, et al. Volumetry and diffusion tensor imaging of hippocampal subregions in schizophrenia. Neuroreport 2004 Apr 9; 15(5): 867-71.
90. Kubicki M, Westin C, Nestor PG, et al. Cingulate fasiculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biol Psychiatry 2003; in press.
91. Wang F, Sun Z, Cui L, et al. Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. Am J Psychiatry 2004; 161(3): 573-5.
92. Weiss AP, Heckers S. Neuroimaging of declarative memory in schizophrenia. Scand J Psychol 2001; 42(3): 239-50.
93. Fujiwara H, Namiki C, Hirao K, et al. Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: a diffusion tensor imaging study. Schizophr Res 2007; 95(1-3): 215-22.
94. White T, Kendi AT, Lehericy S, et al. Disruption of hippocampal connectivity in children and adolescents with schizophrenia--a voxel-based diffusion tensor imaging study. Schizophr Res 2007; 90(1-3): 302-7.
95. Schlosser RG, Nenadic I, Wagner G, et al. White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study. Schizophr Res 2007; 89(1-3): 1-11.
96. Giedd JN, Blumenthal J, Jeffries NO, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 1999; 2(10): 861-3.
97. Giedd JN, Snell JW, Lange N, et al. Quantitative magnetic resonance imaging of human brain development: ages 4-18. Cereb Cortex 1996; 6(4): 551-60.
98. Thompson PM, Vidal C, Giedd JN, et al. Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proc Natl Acad Sci U S A 2001; 98(20): 11650-5.
99. Vidal CN, Rapoport JL, Hayashi KM, et al. Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophrenia. Arch Gen Psychiatry 2006; 63(1): 25-34.
100. Kyriakopoulos M, Perez-Iglesias R, Woolley JB, et al. Effect of age at onset of schizophrenia on white matter abnormalities. Br J Psychiatry 2009; 195(4): 346-53.
101. Douaud G, Mackay C, Andersson J, et al. Schizophrenia delays and alters maturation of the brain in adolescence. Brain 2009; 132(Pt 9): 2437-48.
102. Paus T. Mapping brain maturation and cognitive development during adolescence. Trends Cogn Sci 2005; 9(2): 60-8.
103. Toga AW, Thompson PM, Sowell ER. Mapping brain maturation. Trends Neurosci 2006; 29(3): 148-59.
104. Muetzel RL, Collins PF, Mueller BA, A MS, Lim KO, Luciana M. The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents. Neuroimage 2008; 39(4): 1918-25.
105. Hao Y, Yan Q, Liu H, et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophr Res 2009; 114(1-3): 128-35.
106. Munoz Maniega S, Lymer GK, Bastin ME, et al. A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia. Schizophr Res 2008; 106(2-3): 132-9.
107. DeLisi LE, Szulc KU, Bertisch H, et al. Early detection of schizophrenia by diffusion weighted imaging. Psychiatry Res 2006; 148(1): 61-6.
108. Karlsgodt K, Niendam TA, Bearden CE, Cannon TD. White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis. Biol Psychiatry 2009; 66(6): 562-9.
109. Hoptman MJ, Nierenberg J, Bertisch HC, et al. A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr Res 2008 Dec; 106(2-3): 115-24.
110. Winterer G, Konrad A, Vucurevic G, Musso F, Stoeter P, Dahmen N. Association of 5' end neuregulin-1 (NRG1) gene variation with subcortical medial frontal microstructure in humans. Neuroimage 2008; 40(2): 712-8.
111. Stefansson H, Sarginson J, Kong A, et al. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet 2003; 72(1): 83-7.
112. McIntosh AM, Moorhead TW, Job D, et al. The effects of a neuregulin 1 variant on white matter density and integrity. Mol Psychiatry 2008; 13(11): 1054-9.
113. Zuliani R, Moorhead TW, Bastin ME, et al. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Res 2011; 191(2): 133-7.
114. Voineskos AN, Lerch JP, Felsky D, et al. The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses. Neuropsychopharmacology 2011; 36(9): 1871-8.
115. Power JD, Fair DA, Schlaggar BL, Petersen SE. The development of human functional brain networks. Neuron 2010; 67(5): 735-48.
116. Bloemen OJ, de Koning MB, Schmitz N, et al. White-matter markers for psychosis in a prospective ultra-high-risk cohort. Psychol Med 2010; 40(8): 1297-304.
117. Jacobson S, Kelleher I, Harley M, et al. Structural and functional brain correlates of subclinical psychotic symptoms in 11-13 year old schoolchildren. Neuroimage 2010; 49(2): 1875-85.
118. Witthaus H, Brune M, Kaufmann C, et al. White matter abnormalities in subjects at ultra high-risk for schizophrenia and first-episode schizophrenic patients. Schizophr Res 2008; 102(1-3): 141-9.
119. Fusar-Poli P, Crossley N, Woolley J, Carletti F, Perez-Iglesias R, Broome M, et al. White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study. J Psychiatry Neurosci 2011; 36(4): 239-48.
120. Ziermans TB, Schothorst PF, Schnack HG, et al. Progressive Structural Brain Changes During Development of Psychosis. Schizophr Bull 2010.
121. Fusar-Poli P, Crossley N, Woolley J, et al. White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study. J Psychiatry Neurosci 2011 Jul; 36(4): 239-48.
122. McCarley RW, Shenton ME, O'Donnell BF, et al. Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch Gen Psychiatry 1993 Mar; 50(3): 190-7.
123. McCarley RW, Salisbury DF, Hirayasu Y, et al. Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia. Arch Gen Psychiatry 2002 Apr; 59(4): 321-31.
124. Frommann I, Brinkmeyer J, Ruhrmann S, Hack E, et al. Auditory P300 in individuals clinically at risk for psychosis. Int J Psychophysiol 2008; 70(3): 192-205.
125. Peters BD, de Haan L, Dekker N, et al. White matter fibertracking in first-episode schizophrenia, schizoaffective patients and subjects at ultra-high risk of psychosis. Neuropsychobiology 2008; 58(1): 19-28.
126. Peters BD, Blaas J, de Haan L. Diffusion tensor imaging in the early phase of schizophrenia: what have we learned? J Psychiatr Res 2010; 44(15): 993-1004.
127. Ward RE, Huang W, Curran OE, Priestley JV, Michael-Titus AT. Docosahexaenoic acid prevents white matter damage after spinal cord injury. J Neurotrauma 2010; 27(10): 1769-80.
128. King VR, Huang WL, Dyall SC, Curran OE, Priestley JV, Michael- Titus AT. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci 2006; 26(17): 4672-80.
129. Lang-Lazdunski L, Blondeau N, Jarretou G, Lazdunski M, Heurteaux C. Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. J Vasc Surg 2003; 38(3): 564-75.
130. Dyall SC, Michael-Titus AT. Neurological benefits of omega-3 fatty acids. Neuromolecular Med 2008; 10(4): 219-35.
131. Peet M, Stokes C. Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs 2005; 65(8): 1051-9.
132. Peet M. Eicosapentaenoic acid in the treatment of schizophrenia and depression: rationale and preliminary double-blind clinical trial results. Prostaglandins Leukot Essent Fatty Acids 2003; 69(6): 477-85.
133. Sethom MM, Fares S, Bouaziz N, et al. Polyunsaturated fatty acids deficits are associated with psychotic state and negative symptoms in patients with schizophrenia. Prostaglandins Leukot Essent Fatty Acids 2010; 83(3): 131-6.
134. Fenton WS, Hibbeln J, Knable M. Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. Biol Psychiatry 2000; 47(1): 8-21.
135. Fusar-Poli P, Berger G. Eicosapentaneioc acid interventions in schizophrenia: meta analysis of randomized placebo controlled studies. J Clin Psychiatry. in press.
136. Amminger GP, Schafer MR, Papageorgiou K, et al. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 2010; 67(2): 146-54.
137. Fusar-Poli P, Crossley N, Woolley J, et al. Gray matter alterations related to P300 abnormalities in subjects at high risk for psychosis: longitudinal MRI-EEG study. Neuroimage 2011; 55(1): 320-8.
138. Smieskova R, Fusar-Poli P, Allen P, et al. Neuroimaging predictors of transition to psychosis--a systematic review and meta-analysis. Neurosci Biobehav Rev 2010; 34(8): 1207-22.
139. Fusar-Poli P, Perez J, Broome M, et al. Neurofunctional correlates of vulnerability to psychosis: a systematic review and metaanalysis. Neurosci Biobehav Rev 2007; 31(4): 465-84.
140. Howes OD, Montgomery AJ, Asselin MC, Murray RM, Grasby PM, McGuire PK. Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis. Br J Psychiatry Suppl 2007; 51: s13-8.
141. Brugger S, Davis JM, Leucht S, Stone JM. Proton magnetic resonance spectroscopy and illness stage in schizophrenia--a systematic review and meta-analysis. Biol Psychiatry 2011 Mar 1; 69(5): 495-503.
142. Berger GE, Wood SJ, Wellard RM, et al. Ethyl-eicosapentaenoic acid in first-episode psychosis. A 1H-MRS study. Neuropsychopharmacology 2008; 33(10): 2467-73.
143. Sinha RA, Khare P, Rai A, et al. Anti-apoptotic role of omega-3- fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci 2009; 27(4): 377-83.
144. Berger GE, Wood SJ, Pantelis C, Velakoulis D, Wellard RM, McGorry PD. Implications of lipid biology for the pathogenesis of schizophrenia. Aust N Z J Psychiatry 2002; 36(3): 355-66.
145. Stone JM, Day F, Tsagaraki H, et al. Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume. Biol Psychiatry 2009; 66(6): 533-9.
146. Fusar-Poli P, Stone JM, Broome MR, et al. Thalamic Glutamate Levels as a Predictor of Cortical Response During Executive Functioning in Subjects at High Risk for Psychosis. Arch Gen Psychiatry 2011 May 2.
147. Stone JM, Howes OD, Egerton A, et al. Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis. Biol Psychiatry 2010; 68(7): 599-602.
148. Oliet SH, Piet R, Poulain DA. Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science 2001; 292(5518): 923-6.
149. Gur RE, Cowell P, Turetsky BI, et al. A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch Gen Psychiatry 1998; 55(2): 145-52.
150. Yakovlev PI, Lecours AR. The myelogenetic cycles of regional maturation of the brain. In: Minkowski A, editor. Regional Development of the Brain in Early Life. Oxford: Blackwell; 1966. p. 3-70.