메뉴 건너뛰기




Volumn 43, Issue 2, 2012, Pages 499-506

Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke model

Author keywords

antiplatelet drugs; brain ischemia; ICH; murine model; thrombolysis

Indexed keywords

ACETYLSALICYLIC ACID; CILOSTAZOL; CYCLIC AMP; FIBRINOLYTIC AGENT; GELATINASE B; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84856506320     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.635417     Document Type: Article
Times cited : (38)

References (54)
  • 1
    • 1542315556 scopus 로고    scopus 로고
    • Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS ECASS and NINDS rtPA stroke trials
    • Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rtPA stroke trials. Lancet. 2004; 363:768-774.
    • (2004) Lancet , vol.363 , pp. 768-774
    • Hacke, W.1    Donnan, G.2    Fieschi, C.3    Kaste, M.4    Von Kummer, R.5    Broderick, J.P.6
  • 3
    • 0035240664 scopus 로고    scopus 로고
    • New insights on thrombolytic treatment of acute ischemic stroke
    • Meschia JF, Brott TG. New insights on thrombolytic treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2001;1:19-25.
    • (2001) Curr Neurol Neurosci Rep , vol.1 , pp. 19-25
    • Meschia, J.F.1    Brott, T.G.2
  • 4
    • 33644855615 scopus 로고    scopus 로고
    • Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke
    • DOI 10.1161/01.STR.0000196942.84707.71, PII 0000767020060200000090
    • Trouillas P, von Kummer R. Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke. Stroke. 2006;37: 556-561. (Pubitemid 43732026)
    • (2006) Stroke , vol.37 , Issue.2 , pp. 556-561
    • Trouillas, P.1    Von Kummer, R.2
  • 5
    • 0035130531 scopus 로고    scopus 로고
    • Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: A secondary analysis of the European-Australasian Acute Stroke Study (ECASS II)
    • Larrue V, von Kummer RR, Muller A, Bluhmki E. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: A secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke. 2001;32: 438-441. (Pubitemid 32155231)
    • (2001) Stroke , vol.32 , Issue.2 , pp. 438-441
    • Larrue, V.1    Von Kummer, R.2    Muller, A.3    Bluhmki, E.4
  • 6
    • 0042243483 scopus 로고    scopus 로고
    • Acetylsalicylic acid pretreatment, concomitant heparin therapy and the risk of early intracranial hemorrhage following systemic thrombolysis for acute ischemic stroke
    • DOI 10.1159/000071114
    • Schmulling S, Rudolf J, Strotmann-Tack T, Grond M, Schneweis S, Sobesky J, et al. Acetylsalicylic acid pretreatment, concomitant heparin therapy and the risk of early intracranial hemorrhage following systemic thrombolysis for acute ischemic stroke. Cerebrovasc Dis. 2003;16: 183-190. (Pubitemid 36928607)
    • (2003) Cerebrovascular Diseases , vol.16 , Issue.3 , pp. 183-190
    • Schmulling, S.1    Rudolf, J.2    Strotmann-Tack, T.3    Grond, M.4    Schneweis, S.5    Sobesky, J.6    Thiel, A.7    Heiss, W.-D.8
  • 7
    • 77449115795 scopus 로고    scopus 로고
    • Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset
    • Diedler J, Ahmed N, Sykora M, Uyttenboogaart M, Overgaard K, Luijckx GJ, et al. Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset. Stroke. 2010;41: 288-294.
    • (2010) Stroke , vol.41 , pp. 288-294
    • Diedler, J.1    Ahmed, N.2    Sykora, M.3    Uyttenboogaart, M.4    Overgaard, K.5    Luijckx, G.J.6
  • 8
    • 0034745236 scopus 로고    scopus 로고
    • Clinical deterioration following improvement in the NINDS rtPA stroke trial
    • Grotta JC, Welch KM, Fagan SC, Lu M, Frankel MR, Brott T, et al. Clinical deterioration following improvement in the NINDS rtPA stroke trial. Stroke. 2001;32:661-668.
    • (2001) Stroke , vol.32 , pp. 661-668
    • Grotta, J.C.1    Welch, K.M.2    Fagan, S.C.3    Lu, M.4    Frankel, M.R.5    Brott, T.6
  • 11
    • 0037167558 scopus 로고    scopus 로고
    • Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator
    • Alexandrov AV, Grotta JC. Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. Neurology. 2002;59: 862-867.
    • (2002) Neurology , vol.59 , pp. 862-867
    • Alexandrov, A.V.1    Grotta, J.C.2
  • 12
    • 0032827021 scopus 로고    scopus 로고
    • Changes in coagulation and fibrinolysis markers in acute ischemic stroke treated with recombinant tissue plasminogen activator
    • Fassbender K, Dempfle CE, Mielke O, Schwartz A, Daffertshofer M, Eschenfelder C, et al. Changes in coagulation and fibrinolysis markers in acute ischemic stroke treated with recombinant tissue plasminogen activator. Stroke. 1999;30:2101-2104. (Pubitemid 29473255)
    • (1999) Stroke , vol.30 , Issue.10 , pp. 2101-2104
    • Fassbender, K.1    Dempfle, C.-E.2    Mielke, O.3    Schwartz, A.4    Daffertshofer, M.5    Eschenfelder, C.6    Dollman, M.7    Hennerici, M.8
  • 13
    • 33745955858 scopus 로고    scopus 로고
    • Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke
    • DOI 10.1161/01.STR.0000226897.43749.27, PII 0000767020060700000047
    • Tanne D, Macko RF, Lin Y, Tilley BC, Levine SR. Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke. Stroke. 2006;37:1798-1804. (Pubitemid 44297732)
    • (2006) Stroke , vol.37 , Issue.7 , pp. 1798-1804
    • Tanne, D.1    Macko, R.F.2    Lin, Y.3    Tilley, B.C.4    Levine, S.R.5
  • 14
    • 77951993902 scopus 로고    scopus 로고
    • A randomised controlled trial of antiplatelet therapy in combination with rtPA thrombolysis in ischemic stroke: Rationale and design of the ARTIS-trial
    • Zinkstok SM, Vermeulen M, Stam J, de Haan RJ, Roos YB. A randomised controlled trial of antiplatelet therapy in combination with rtPA thrombolysis in ischemic stroke: rationale and design of the ARTIS-trial. Trials. 2010;11:51.
    • (2010) Trials , vol.11 , pp. 51
    • Zinkstok, S.M.1    Vermeulen, M.2    Stam, J.3    De Haan, R.J.4    Roos, Y.B.5
  • 15
    • 77956884231 scopus 로고    scopus 로고
    • Cilostazol for prevention of secondary stroke (CSPS 2): An aspirin-controlled, double-blind, randomised non-inferiority trial
    • Shinohara Y, Katayama Y, Uchiyama S, Yamaguchi T, Handa S, Matsuoka K, et al. Cilostazol for prevention of secondary stroke (CSPS 2): An aspirin-controlled, double-blind, randomised non-inferiority trial. Lancet Neurol. 2010;9:959-968.
    • (2010) Lancet Neurol , vol.9 , pp. 959-968
    • Shinohara, Y.1    Katayama, Y.2    Uchiyama, S.3    Yamaguchi, T.4    Handa, S.5    Matsuoka, K.6
  • 16
    • 79952268676 scopus 로고    scopus 로고
    • Cilostazol versus aspirin for secondary prevention of vascular events after stroke of arterial origin
    • Kamal AK, Naqvi I, Husain MR, Khealani BA. Cilostazol versus aspirin for secondary prevention of vascular events after stroke of arterial origin. Cochrane Database Syst Rev. 2011;1:CD008076.
    • (2011) Cochrane Database Syst Rev. , vol.1
    • Kamal, A.K.1    Naqvi, I.2    Husain, M.R.3    Khealani, B.A.4
  • 17
    • 0141954237 scopus 로고    scopus 로고
    • Managing PAD with multiple platelet inhibitors: The effect of combination therapy on bleeding time
    • DOI 10.1016/S0741-5214(03)01029-2
    • Wilhite DB, Comerota AJ, Schmieder FA, Throm RC, Gaughan JP, Rao AK. Managing pad with multiple platelet inhibitors: the effect of combination therapy on bleeding time. J Vasc Surg. 2003;38:710-713. (Pubitemid 37254796)
    • (2003) Journal of Vascular Surgery , vol.38 , Issue.4 , pp. 710-713
    • Wilhite, D.B.1    Comerota, A.J.2    Schmieder, F.A.3    Throm, R.C.4    Gaughan, J.P.5    Rao, A.K.6
  • 18
    • 77953120379 scopus 로고    scopus 로고
    • Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia
    • Kasahara Y, Taguchi A, Uno H, Nakano A, Nakagomi T, Hirose H, et al. Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia. Brain Res. 2010;1340:70-80.
    • (2010) Brain Res , vol.1340 , pp. 70-80
    • Kasahara, Y.1    Taguchi, A.2    Uno, H.3    Nakano, A.4    Nakagomi, T.5    Hirose, H.6
  • 19
    • 0032544365 scopus 로고    scopus 로고
    • Marked, sustained expression of a novel 150-kDa oxygen-regulated stress protein, in severely ischemic mouse neurons
    • DOI 10.1016/S0169-328X(98)00174-0, PII S0169328X98001740
    • Matsushita K, Matsuyama T, Nishimura H, Takaoka T, Kuwabara K, Tsukamoto Y, et al. Marked, sustained expression of a novel 150-kDa oxygen-regulated stress protein, in severely ischemic mouse neurons. Brain Res Mol Brain Res. 1998;60:98-106. (Pubitemid 28433199)
    • (1998) Molecular Brain Research , vol.60 , Issue.1 , pp. 98-106
    • Matsushita, K.1    Matsuyama, T.2    Nishimura, H.3    Takaoka, T.4    Kuwabara, K.5    Tsukamoto, Y.6    Sugita, M.7    Ogawa, S.8
  • 20
    • 80052415706 scopus 로고    scopus 로고
    • Cilostazol, not aspirin, reduces ischemic brain injury via endothelial protection in spontaneously hypertensive rats
    • Oyama N, Yagita Y, Kawamura M, Sugiyama Y, Terasaki Y, Omura-Matsuoka E, et al. Cilostazol, not aspirin, reduces ischemic brain injury via endothelial protection in spontaneously hypertensive rats. Stroke. 2011;42:2571-2577.
    • (2011) Stroke , vol.42 , pp. 2571-2577
    • Oyama, N.1    Yagita, Y.2    Kawamura, M.3    Sugiyama, Y.4    Terasaki, Y.5    Omura-Matsuoka, E.6
  • 22
    • 76349116295 scopus 로고    scopus 로고
    • Cilostazol, a phosphodiesterase inhibitor, attenuates photothrombotic focal ischemic brain injury in hypertensive rats
    • Ito H, Hashimoto A, Matsumoto Y, Yao H, Miyakoda G. Cilostazol, a phosphodiesterase inhibitor, attenuates photothrombotic focal ischemic brain injury in hypertensive rats. J Cereb Blood Flow Metab. 2010;30: 343-351.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 343-351
    • Ito, H.1    Hashimoto, A.2    Matsumoto, Y.3    Yao, H.4    Miyakoda, G.5
  • 23
    • 0036195260 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats
    • DOI 10.1161/hs0302.104542
    • Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke. 2002;33:831-836. (Pubitemid 34204013)
    • (2002) Stroke , vol.33 , Issue.3 , pp. 831-836
    • Sumii, T.1    Lo, E.H.2
  • 24
    • 63949085383 scopus 로고    scopus 로고
    • Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
    • Yamashita T, Kamiya T, Deguchi K, Inaba T, Zhang H, Shang J, et al. Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain. J Cereb Blood Flow Metab. 2009; 29:715-725.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 715-725
    • Yamashita, T.1    Kamiya, T.2    Deguchi, K.3    Inaba, T.4    Zhang, H.5    Shang, J.6
  • 26
    • 33845538722 scopus 로고    scopus 로고
    • 1 receptor antagonists in the brain
    • DOI 10.1007/s10571-006-9009-0, Proceedings of the 5th International Symposium on Experimental and Clinical Neurobiology, High Tatras, Slovakia, September 2005
    • Saavedra JM, Benicky J, Zhou J. Mechanisms of the anti-ischemic effect of angiotensin II AT(1) receptor antagonists in the brain. Cell Mol Neurobiol. 2006;26:1099-1111. (Pubitemid 44924033)
    • (2006) Cellular and Molecular Neurobiology , vol.26 , Issue.7-8 , pp. 1099-1111
    • Saavedra, J.M.1    Benicky, J.2    Zhou, J.3
  • 28
    • 0038222577 scopus 로고    scopus 로고
    • Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: Preclinical experience
    • DOI 10.1161/01.STR.0000068170.80517.B3
    • Aronowski J, Strong R, Shirzadi A, Grotta JC. Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience. Stroke. 2003;34:1246-1251. (Pubitemid 36547523)
    • (2003) Stroke , vol.34 , Issue.5 , pp. 1246-1251
    • Aronowski, J.1    Strong, R.2    Shirzadi, A.3    Grotta, J.C.4
  • 30
    • 0025766358 scopus 로고
    • Cerebral hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits
    • Clark WM, Madden KP, Lyden PD, Zivin JA. Cerebral hemorrhagic risk of aspirin or heparin therapy with thrombolytic treatment in rabbits. Stroke. 1991;22:872-876.
    • (1991) Stroke , vol.22 , pp. 872-876
    • Clark, W.M.1    Madden, K.P.2    Lyden, P.D.3    Zivin, J.A.4
  • 31
    • 78649649463 scopus 로고    scopus 로고
    • PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions
    • Park S, DiMaio TA, Scheef EA, Sorenson CM, Sheibani N. PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions. Am J Physiol Cell Physiol. 2010;299:C1468-1484.
    • (2010) Am J Physiol Cell Physiol. , vol.299
    • Park, S.1    Dimaio, T.A.2    Scheef, E.A.3    Sorenson, C.M.4    Sheibani, N.5
  • 32
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • DOI 10.1038/sj.jcbfm.9600375, PII 9600375
    • Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab. 2007;27: 697-709. (Pubitemid 46474608)
    • (2007) Journal of Cerebral Blood Flow and Metabolism , vol.27 , Issue.4 , pp. 697-709
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 33
    • 0345824713 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein
    • DOI 10.1172/JCI200319212
    • Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest. 2003;112:1533-1540. (Pubitemid 38056279)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.10 , pp. 1533-1540
    • Yepes, M.1    Sandkvist, M.2    Moore, E.G.3    Bugge, T.H.4    Strickland, D.K.5    Lawrence, D.A.6
  • 34
  • 35
    • 0034065040 scopus 로고    scopus 로고
    • Serine protease inhibitors: Novel therapeutic targets for stroke?
    • Vivien D, Buisson A. Serine protease inhibitors: novel therapeutic targets for stroke? J Cereb Blood Flow Metab. 2000;20:755-764. (Pubitemid 30317049)
    • (2000) Journal of Cerebral Blood Flow and Metabolism , vol.20 , Issue.5 , pp. 755-764
    • Vivien, D.1    Buisson, A.2
  • 36
    • 27744434763 scopus 로고    scopus 로고
    • Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: Relevance of interactions between thrombotic material and thrombolytic agent
    • DOI 10.1016/j.vph.2005.07.008, PII S153718910500159X
    • Kahles T, Foerch C, Sitzer M, Schroeter M, Steinmetz H, Rami A, et al. Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: relevance of interactions between thrombotic material and thrombolytic agent. Vascul Pharmacol. 2005;43: 254-259. (Pubitemid 41586212)
    • (2005) Vascular Pharmacology , vol.43 , Issue.4 , pp. 254-259
    • Kahles, T.1    Foerch, C.2    Sitzer, M.3    Schroeter, M.4    Steinmetz, H.5    Rami, A.6    Neumann-Haefelin, T.7
  • 37
    • 24644519846 scopus 로고    scopus 로고
    • Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
    • DOI 10.1161/01.STR.0000177517.01203.eb
    • Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, et al. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005;36:1954-1959. (Pubitemid 41266533)
    • (2005) Stroke , vol.36 , Issue.9 , pp. 1954-1959
    • Tsuji, K.1    Aoki, T.2    Tejima, E.3    Arai, K.4    Lee, S.-R.5    Atochin, D.N.6    Huang, P.L.7    Wang, X.8    Montaner, J.9    Lo, E.H.10
  • 39
    • 50049104201 scopus 로고    scopus 로고
    • Clinical features associated with early hospital arrival after acute intracerebral hemorrhage: Challenges for new trials
    • Valiente RA, de Miranda-Alves MA, Silva GS, Gomes DL, Brucki SM, Rocha MS, et al. Clinical features associated with early hospital arrival after acute intracerebral hemorrhage: challenges for new trials. Cerebrovasc Dis. 2008;26:404-408.
    • (2008) Cerebrovasc Dis , vol.26 , pp. 404-408
    • Valiente, R.A.1    De Miranda-Alves, M.A.2    Silva, G.S.3    Gomes, D.L.4    Brucki, S.M.5    Rocha, M.S.6
  • 40
    • 41049095791 scopus 로고    scopus 로고
    • Spontaneous intracerebral haemorrhage in adults: A literature overview
    • discussion 379
    • Hanggi D, Steiger HJ. Spontaneous intracerebral haemorrhage in adults: A literature overview. Acta Neurochir (Wien). 2008;150:371-379; discussion 379.
    • (2008) Acta Neurochir (Wien) , vol.150 , pp. 371-379
    • Hanggi, D.1    Steiger, H.J.2
  • 41
    • 58149357100 scopus 로고    scopus 로고
    • Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST)
    • Wahlgren N, Ahmed N, Eriksson N, Aichner F, Bluhmki E, Davalos A, et al. Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST). Stroke. 2008;39:3316-3322.
    • (2008) Stroke , vol.39 , pp. 3316-3322
    • Wahlgren, N.1    Ahmed, N.2    Eriksson, N.3    Aichner, F.4    Bluhmki, E.5    Davalos, A.6
  • 43
    • 33144482404 scopus 로고    scopus 로고
    • Cilostazol: Potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding
    • DOI 10.1016/j.atherosclerosissup.2005.09.002, PII S1567568805000656
    • Goto S. Cilostazol: potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding. Atheroscler Suppl. 2005; 6:3-11. (Pubitemid 43263084)
    • (2005) Atherosclerosis Supplements , vol.6 , Issue.4 , pp. 3-11
    • Goto, S.1
  • 44
    • 72049117774 scopus 로고    scopus 로고
    • The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits
    • Lapchak PA, Han MK. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits. Brain Res. 2009;1303:144-150.
    • (2009) Brain Res , vol.1303 , pp. 144-150
    • Lapchak, P.A.1    Han, M.K.2
  • 45
    • 50049112333 scopus 로고    scopus 로고
    • Lipid profile, statin use, and outcome after intravenous thrombolysis for acute ischaemic stroke
    • Uyttenboogaart M, Koch MW, Koopman K, Vroomen PC, Luijckx GJ, De Keyser J. Lipid profile, statin use, and outcome after intravenous thrombolysis for acute ischaemic stroke. J Neurol. 2008;255:875-880.
    • (2008) J Neurol , vol.255 , pp. 875-880
    • Uyttenboogaart, M.1    Koch, M.W.2    Koopman, K.3    Vroomen, P.C.4    Luijckx, G.J.5    De Keyser, J.6
  • 46
    • 60549111009 scopus 로고    scopus 로고
    • Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator
    • Yagi K, Kitazato KT, Uno M, Tada Y, Kinouchi T, Shimada K, et al. Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Stroke. 2009; 40:626-631.
    • (2009) Stroke , vol.40 , pp. 626-631
    • Yagi, K.1    Kitazato, K.T.2    Uno, M.3    Tada, Y.4    Kinouchi, T.5    Shimada, K.6
  • 47
    • 77950516409 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
    • Bauer AT, Burgers HF, Rabie T, Marti HH. Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. J Cereb Blood Flow Metab. 2010;30:837-848.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 837-848
    • Bauer, A.T.1    Burgers, H.F.2    Rabie, T.3    Marti, H.H.4
  • 48
    • 38149067309 scopus 로고    scopus 로고
    • Cilostazol attenuates MCP-1 and MMP-9 expression in vivo in LPSadministrated balloon-injured rabbit aorta and in vitro in LPS-treated monocytic THP-1 cells
    • Tsai CS, Lin FY, Chen YH, Yang TL, Wang HJ, Huang GS, et al. Cilostazol attenuates MCP-1 and MMP-9 expression in vivo in LPSadministrated balloon-injured rabbit aorta and in vitro in LPS-treated monocytic THP-1 cells. J Cell Biochem. 2008;103:54-66.
    • (2008) J Cell Biochem , vol.103 , pp. 54-66
    • Tsai, C.S.1    Lin, F.Y.2    Chen, Y.H.3    Yang, T.L.4    Wang, H.J.5    Huang, G.S.6
  • 49
    • 0142026252 scopus 로고    scopus 로고
    • Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways
    • DOI 10.1016/S0014-4827(03)00354-9
    • Ishizaki T, Chiba H, Kojima T, Fujibe M, Soma T, Miyajima H, et al. Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and-independent pathways. Exp Cell Res. 2003;290:275-288. (Pubitemid 37272172)
    • (2003) Experimental Cell Research , vol.290 , Issue.2 , pp. 275-288
    • Ishizaki, T.1    Chiba, H.2    Kojima, T.3    Fujibe, M.4    Soma, T.5    Miyajima, H.6    Nagasawa, K.7    Wada, I.8    Sawada, N.9
  • 50
    • 0031018716 scopus 로고    scopus 로고
    • Hypoxia-induced modulation of endothelial cell properties: Regulation of barrier function and expression of interleukin-6
    • Yan SF, Ogawa S, Stern DM, Pinsky DJ. Hypoxia-induced modulation of endothelial cell properties: regulation of barrier function and expression of interleukin-6. Kidney Int. 1997;51:419-425. (Pubitemid 27088153)
    • (1997) Kidney International , vol.51 , Issue.2 , pp. 419-425
    • Yan, S.F.1    Ogawa, S.2    Stern, D.M.3    Pinsky, D.J.4
  • 51
    • 33846565008 scopus 로고    scopus 로고
    • Cilostazol inhibits the redistribution of the actin cytoskeleton and junctional proteins on the blood-brain barrier under hypoxia/reoxygenation
    • DOI 10.1016/j.phrs.2006.10.010, PII S1043661806002027
    • Torii H, Kubota H, Ishihara H, Suzuki M. Cilostazol inhibits the redistribution of the actin cytoskeleton and junctional proteins on the blood-brain barrier under hypoxia/reoxygenation. Pharmacol Res. 2007; 55:104-110. (Pubitemid 46186035)
    • (2007) Pharmacological Research , vol.55 , Issue.2 , pp. 104-110
    • Torii, H.1    Kubota, H.2    Ishihara, H.3    Suzuki, M.4
  • 52
    • 67650716517 scopus 로고    scopus 로고
    • Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2-and P38 MAPKdependent pathways
    • Lim JH, Woo JS, Shin YW. Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2-and P38 MAPKdependent pathways. Korean J Intern Med. 2009;24:113-122.
    • (2009) Korean J Intern Med , vol.24 , pp. 113-122
    • Lim, J.H.1    Woo, J.S.2    Shin, Y.W.3
  • 54
    • 77953335543 scopus 로고    scopus 로고
    • Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo
    • Aoki C, Hattori Y, Tomizawa A, Jojima T, Kasai K. Anti-inflammatory role of cilostazol in vascular smooth muscle cells in vitro and in vivo. J Atheroscler Thromb. 2010;17:503-509.
    • (2010) J Atheroscler Thromb , vol.17 , pp. 503-509
    • Aoki, C.1    Hattori, Y.2    Tomizawa, A.3    Jojima, T.4    Kasai, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.