Tocotrienol-rich fraction of palm oil reduced pancreatic damage and oxidative stress in streptozotocin-induced diabetic rats

Australian Journal of Basic and Applied Sciences

Volumn 5, Issue 12, 2011, Pages 2367-2374

  Budin, Siti Balkis ^a   Yusof, Khairunnisa' Md ^a   Idris, Muhd Hanis Md ^a   Hamid, Zariyantey Abd ^a   Mohamed, Jamaludin ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

Antioxidants; Histology; Lipid peroxidation; Protein oxidation; Type 1 diabetes mellitus

Indexed keywords

EID: 84856501181     PISSN: 19918178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Abdel-Wahab, M.H. and A.R. Abd-Allah, 2000. Possible protective effect of melatonin and/or desferrioxamine against streptozotocininduced hyperglycaemia in mice. Pharmacol. Res., 41: 533-537.
2. Abdul Mutalib, M.S., H. Khazaiai and K.W.J. Wahle, 2003. Palm-tocotrienol rich fraction (TRF) is a more effective inhibitor of LDL oxidation and endothelial cell lipid peroxidation than tocopherol in vitro. Food Res. Int., 36(5): 405-413.
3. Aksoy, N., H. Vural, T. Sabuncu, O. Arslan and S. Aksoy, 2005. Beneficial effects of Vitamin C and E against oxidative stress in diabetic rats. Nutrition Research, 25: 625-630.
4. Ardestani, A., R. Yazdanparast and R. Jamshidi, 2008. Therapeutic effect of Teucrium polium extract on oxidative stress in pancreas of streptozotocin-induces diabetic rats. Journal of Medicinal Food, 11: 525-532.
5. Asayama, K., T. Nakane, N. Uchida, H. Hayashibe, K. Dobashi and S. Nakazawa, 1994. Serum antioxidant status in streptozotocin induced diabetic rat. Hormone & Metabolism Research, 26(7): 313-315.
6. Bagri, P., M. Ali, V. Aeri, M. Bhowmik and S. Sultana, 2009. Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem. Toxicol., 47: 50-54.
7. Beyer, W.F. and I. Fridovich, 1987. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. Anal. Biochem., 161: 559-566.
8. Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254.
9. Brownlee, M., 2001. Biochemistry and molecular cell biology of diabetic complications. Nature, 414: 813-820.
10. Budin, S.B., F. Othman, S.R. Louis, M.A. Bakar, S. Das and J. Mohamed, 2009.The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats. Clinics (Sao Paulo), 64(3): 235-244.
11. Budin, S.B., K.P. Kee, M.Y. Swee Eng, K. Osman, M. Abu Bakar and J. Mohamed. 2007. Alpha lipoic acid prevents pancreatic islet cells damage and dyslipidemia in streptozotocin-induced diabetic. Malaysia J. Med Sci. 14: 47-53.
12. Coats, B.C. and R. Ahola, 1979. Aloe vera the silent healer: a modern study of Aloe vera. Bill C. Coats, Dallas, pp: 288-294.
13. Coskun, O., M. Kanter, A. Korkmaz and S. Oter, 2005. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol. Res., 51: 117-123.
14. Dominguez, C., E. Ruiz, A. Gussinye and A. Carrascosa, 1998. Oxidative stress at onset and early stages of type 1 in children and adolescent. Diabetes Care, 17: 1736-1742.
15. Ellman, G.L., 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82: 70-77.
16. Evans, J.L., I.D. Goldfine, B.A. Maddux and G.M. Grodsky, 2002. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev., 23: 599-622.
17. Gallou, G., A. Ruelland, B. Legras, D. Maugendre, H. Allannic and L. Cloarec, 1993. Plasma malondialdehyde in type 1 and 2 diabetic patients. Clin. Chim. Acta, 214: 227-234.
18. Gomori, G., 1950. Aldehyde-fuchsin: a new stain for elastic tissue. Am. J. Clin. Pathol., 20: 665-666.
19. Gumieniczek, A., 2005. Effects of repaglinide on oxidative stress in tissues of diabetic rabbits. Diabetes Res. Clin. Pract., 68: 89-95.
20. Horwitt, M.K., 1986. Interpretations of requirements for thiamin, riboflavin, niacin-tryptophan, and vitamin E plus comments on balance studies and vitamin B6. Am. J. Clin. Nutr., 44: 973-85.
21. Jang, Y.Y., J.H. Song, Y.K. Shin, E.S. Han and C.S. Lee, 2000. Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats. Pharmacol. Res., 42(4): 361-371.
22. Jin, L., H.Y. Xue, L.J. Jin, S.Y. Li and Y.P. Xu, 2008. Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes. Eur. J. Pharmacol., 582: 162-167.
23. Kakkar, R., S.V. Mantha, J. Radhi, K. Prasad and J. Kalra, 1998. Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes, Clin. Sci. (Lond), 94: 623-632.
24. Kamalakkannan, N. and P.S.M. Prince, 2006. Rutin improves the antioxidant status in streptozotocininduced diabetic rat tissues. Mol. Cell. Biochem., 293: 211-219.
25. Kaneto, H., J. Fujii, H.G. Seop, K. Suzuki, T. Matsuoka and M. Nakamura et al., 1995. Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells. Diabetes, 44: 733-788.
26. Kamat, J.P. and T.P. Devasagayam, 1995. Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci. Lett., 195: 179-182.
27. Kuhad, A., M. Bishnoi, V. Tiwari and K. Chopra, 2009. Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacol. Biochem. Behav., 92: 251-259.
28. Levine, R.L., D. Garland, C.N. Oliver, A. Amici, I. Climent, A.G. Lenz, B.W. Ahn, S. Shaltiel and E.R. Stadman, 1990. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol., 186: 464-478.
29. Luostarinen, R., R. Wallin, L. Wibel and T. Saldeen, 1995. Vitamin E supplementation counteracts the fish oil-induced increase of blood glucose in humans. Nutr. Res., 15(7): 953-968.
30. Lenzen, S., J. Drinkgern and M. Tiedge, 1996. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues, Free Radic. Biol. Med., 20: 463-466.
31. Maritim, A.C., R.A. Sanders and J.B. Watkins, 2003. Diabetes,oxidative stress and antioxidants: A review. J. Biochem. Mol. Toxicol., 17(1): 24-38.
32. Musalmah, M., A.H. Muhd Fairuz, M.T. Gapor and W.Z. Wan Ngah, 2001. Effect of tocotrienol-rich fraction on wound healing in streptozotocin-induced diabetic rats. Malaysian J. Biochem. Mol. Biol., 6: 34-39.
33. Rajasekaran, S., K. Sivagnanam and S. Subramanian, 2005. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol. Rep., 57: 90-96.
34. Ramachandran, B., R. Kasiappan Ravi, V. Narayanan, M. Kandaswamy and S. Subramanian, 2004. Protective effect of macrocyclic binuclear oxovanadium complex on oxidative stress in pancreas of streptozotocin induced diabetic rats. Chem. Biol. Interact., 149: 9-21.
35. Schleicher, E.D., E. Wagner and A.G. Nerlich, 1997. Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl) lysine in human tissues in diabetes and aging. J. Clin. Invest., 99: 457-468.
36. Sefi, M., H. Fetoui, M. Makni and N. Zeghal, 2010. Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food Chem. Toxicol., 48: 1986-1993.
37. Serbinova, E., S. Khwaja, J. Catudioc, J. Ericson, Z. Torres, A. Gapor, V. Kagan and L. Packer, 1992. Palm oil vitamin E protects against ischemia/reperfusion injury in the isolated perfused langendorff heart. Nutr. Res. Suppl., 12: S203-S215.
38. Stocks, D. and T.L. Dormandy, 1971. The auto oxidation of red cell lipids induced by hydrogen peroxide. Br. J. Hematol., 20: 95-111.
39. Suzuki, Y.J., M. Tsuchiya and S.R. Wassall, 1993. Structural and dynamic membrane properties of tocopherol and tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry, 32: 10692-10699.
40. Weber, C., M. Podda, M. Rallis, J.J. Thiele, M.G. Traber and L. Packer, 1997. Efficacy of tropically applied tocopherols and tocotrienols in protection of murine skin from oxidative damage induced by UV-radiation. Free Radic. Biol. Med., 22(5): 761-769.
41. WHO. 1999. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. World Health Organization, Geneva, pp: 2-3.