-
1
-
-
33244496656
-
Alzheimer's disease: MRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling
-
Emilsson L, Saetre P, Jazin E. Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling. Neurobiol Dis. 2006;21(3): 618-625.
-
(2006)
Neurobiol Dis.
, vol.21
, Issue.3
, pp. 618-625
-
-
Emilsson, L.1
Saetre, P.2
Jazin, E.3
-
2
-
-
62649172167
-
Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity
-
Diaz JC, Simakova O, Jacobson KA, et al. Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity. Proc Natl Acad Sci U S A. 2009; 106(9):3348-3353.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, Issue.9
, pp. 3348-3353
-
-
Diaz, J.C.1
Simakova, O.2
Jacobson, K.A.3
-
3
-
-
77951251848
-
Calcium signaling and amyloid toxicity in Alzheimer disease
-
Demuro A, Parker I, Stutzmann GE. Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem. 2010;285(17): 12463-12468.
-
(2010)
J Biol Chem.
, vol.285
, Issue.17
, pp. 12463-12468
-
-
Demuro, A.1
Parker, I.2
Stutzmann, G.E.3
-
4
-
-
0034319190
-
Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: Channel formation and disruption of calcium homeostasis
-
Kawahara M, Kuroda Y. Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis. Brain Res Bull. 2000;53(4):389-397.
-
(2000)
Brain Res Bull.
, vol.53
, Issue.4
, pp. 389-397
-
-
Kawahara, M.1
Kuroda, Y.2
-
5
-
-
50249135503
-
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
-
Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci. 2008; 31(9):454-463.
-
(2008)
Trends Neurosci.
, vol.31
, Issue.9
, pp. 454-463
-
-
Bezprozvanny, I.1
Mattson, M.P.2
-
6
-
-
34347359673
-
'Rejuvenation'protects neurons inmouse models of Parkinson's disease
-
Chan CS, Guzman JN, Ilijic E, et al. 'Rejuvenation'protects neurons inmouse models of Parkinson's disease. Nature. 2007; 447:1081-1086.
-
(2007)
Nature.
, vol.447
, pp. 1081-1086
-
-
Chan, C.S.1
Guzman, J.N.2
Ilijic, E.3
-
7
-
-
67651180986
-
The amyloid hypothesis for Alzheimer's disease: A critical reappraisal
-
Hardy J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J Neurochem. 2009;110:1129-1134.
-
(2009)
J Neurochem.
, vol.110
, pp. 1129-1134
-
-
Hardy, J.1
-
8
-
-
78349309295
-
L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease
-
Anekonda TS, Quinn JF, Harris C, et al. L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease. Neurobiol Dis. 2011;41:62-70.
-
(2011)
Neurobiol Dis.
, vol.41
, pp. 62-70
-
-
Anekonda, T.S.1
Quinn, J.F.2
Harris, C.3
-
9
-
-
60349108170
-
Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs
-
Zhang GR, Cheng XR, Zhou WX, et al. Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs. Neuroscience. 2009;159(1):308-315.
-
(2009)
Neuroscience.
, vol.159
, Issue.1
, pp. 308-315
-
-
Zhang, G.R.1
Cheng, X.R.2
Zhou, W.X.3
-
10
-
-
0033059445
-
Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies
-
Kelliher M, Fastbom J, Cowburn RF, et al. Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies. Neuroscience. 1999;92(2):499-513.
-
(1999)
Neuroscience.
, vol.92
, Issue.2
, pp. 499-513
-
-
Kelliher, M.1
Fastbom, J.2
Cowburn, R.F.3
-
11
-
-
33846847860
-
The xbp-1 gene is essential for development in Drosophila
-
Souid S, Lepesant JA, Yanicostas C. The xbp-1 gene is essential for development in Drosophila. Dev Genes Evol. 2007;217(2): 159-167.
-
(2007)
Dev Genes Evol.
, vol.217
, Issue.2
, pp. 159-167
-
-
Souid, S.1
Lepesant, J.A.2
Yanicostas, C.3
-
12
-
-
39149122810
-
Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
-
Reddy PH, Beal MF. Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med. 2008;14:45-53.
-
(2008)
Trends Mol Med.
, vol.14
, pp. 45-53
-
-
Reddy, P.H.1
Beal, M.F.2
-
13
-
-
33746089859
-
Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease
-
Zhu X, Perry G, Moreira PI, et al. Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. J Alzheimers Dis. 2006; 9(2):147-153.
-
(2006)
J Alzheimers Dis.
, vol.9
, Issue.2
, pp. 147-153
-
-
Zhu, X.1
Perry, G.2
Moreira, P.I.3
-
14
-
-
36348930592
-
Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm
-
Wells RC, Picton LK, Williams SC, et al. Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm. J Biol Chem. 2007; 282:33769-33775.
-
(2007)
J Biol Chem.
, vol.282
, pp. 33769-33775
-
-
Wells, R.C.1
Picton, L.K.2
Williams, S.C.3
-
16
-
-
68149103297
-
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion
-
Song ZY, Ghochani M, McCaffery JM, et al. Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell. 2009;20:3525-3532.
-
(2009)
Mol Biol Cell.
, vol.20
, pp. 3525-3532
-
-
Song, Z.Y.1
Ghochani, M.2
McCaffery, J.M.3
-
17
-
-
33947356299
-
Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis
-
Meuer K, Suppanz IE, Lingor P, et al. Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis. Cell Death Differ. 2007;14:651-661.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 651-661
-
-
Meuer, K.1
Suppanz, I.E.2
Lingor, P.3
-
18
-
-
64249133725
-
S-nitrosylation of Drp1 mediates betaamyloid-related mitochondrial fission and neuronal injury
-
Cho DH, Nakamura T, Fang J, et al. S-nitrosylation of Drp1 mediates betaamyloid-related mitochondrial fission and neuronal injury. Science. 2009;324:102-105.
-
(2009)
Science.
, vol.324
, pp. 102-105
-
-
Cho, D.H.1
Nakamura, T.2
Fang, J.3
-
19
-
-
34547958816
-
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
-
Lee S, Jeong SY, Lim WC, et al. Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem. 2007;282:22977-22983.
-
(2007)
J Biol Chem.
, vol.282
, pp. 22977-22983
-
-
Lee, S.1
Jeong, S.Y.2
Lim, W.C.3
-
20
-
-
67650732998
-
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
-
Wang X, Su B, Lee HG, et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci. 2009; 29:9090-9103.
-
(2009)
J Neurosci.
, vol.29
, pp. 9090-9103
-
-
Wang, X.1
Su, B.2
Lee, H.G.3
-
21
-
-
48749085779
-
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients
-
Wang X, Su B, Fujioka H, et al. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol. 2008;173:470-482.
-
(2008)
Am J Pathol.
, vol.173
, pp. 470-482
-
-
Wang, X.1
Su, B.2
Fujioka, H.3
-
22
-
-
58049218922
-
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
-
Wang X, Su B, Siedlak SL, et al. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A. 2008;105:19318-19323.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 19318-19323
-
-
Wang, X.1
Su, B.2
Siedlak, S.L.3
-
23
-
-
34548299424
-
Developing pharmacological therapies for Alzheimer disease
-
Iqbal K, Grundke-Iqbal I. Developing pharmacological therapies for Alzheimer disease. Cell Mol Life Sci. 2007;64:2234-2244.
-
(2007)
Cell Mol Life Sci.
, vol.64
, pp. 2234-2244
-
-
Iqbal, K.1
Grundke-Iqbal, I.2
-
24
-
-
39749165656
-
Differential regulation of dynein and kinesin motor proteins by tau
-
Dixit R, Ross JL, Goldman YE, et al. Differential regulation of dynein and kinesin motor proteins by tau. Science. 2008;319: 1086-1089.
-
(2008)
Science.
, vol.319
, pp. 1086-1089
-
-
Dixit, R.1
Ross, J.L.2
Goldman, Y.E.3
-
25
-
-
73649098791
-
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria
-
Area-Gomez E, De Groof AJ, Boldogh I, et al. Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol. 2009;175:1810-1816.
-
(2009)
Am J Pathol.
, vol.175
, pp. 1810-1816
-
-
Area-Gomez, E.1
De Groof, A.J.2
Boldogh, I.3
-
26
-
-
67650556426
-
Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: Implications for the pathogenesis of Alzheimer disease
-
Quintanilla RA, Matthews-Roberson TA, Dolan PJ, and et al. Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease. J Biol Chem. 2009;284: 18754-18766.
-
(2009)
J Biol Chem.
, vol.284
, pp. 18754-18766
-
-
Quintanilla, R.A.1
Matthews-Roberson, T.A.2
Dolan, P.J.3
-
27
-
-
52049093250
-
Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death
-
Matthews-Roberson TA, Quintanilla RA, Ding H, et al. Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death. Brain Res. 2008;1234:206-212.
-
(2008)
Brain Res.
, vol.1234
, pp. 206-212
-
-
Matthews-Roberson, T.A.1
Quintanilla, R.A.2
Ding, H.3
-
28
-
-
51349134160
-
Hope in Alzheimer's fight emerges from unexpected places
-
Gura T. Hope in Alzheimer's fight emerges from unexpected places. Nat Med. 2008;14:894.
-
(2008)
Nat Med.
, vol.14
, pp. 894
-
-
Gura, T.1
-
29
-
-
67649803186
-
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease
-
Reddy PH. Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp Neurol. 2009;218:286-292.
-
(2009)
Exp Neurol.
, vol.218
, pp. 286-292
-
-
Reddy, P.H.1
-
30
-
-
66449121454
-
Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
-
Brooks C, Wei Q, Cho SG, et al. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest. 2009;119:1275-1285.
-
(2009)
J Clin Invest.
, vol.119
, pp. 1275-1285
-
-
Brooks, C.1
Wei, Q.2
Cho, S.G.3
-
31
-
-
69249084890
-
PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons
-
Wareski P, Vaarmann A, Choubey V, et al. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem. 2009; 284:21379-21385.
-
(2009)
J Biol Chem.
, vol.284
, pp. 21379-21385
-
-
Wareski, P.1
Vaarmann, A.2
Choubey, V.3
-
32
-
-
62449166389
-
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
-
Qin W, Haroutunian V, Katsel P, et al. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol. 2009;66:352-361.
-
(2009)
Arch Neurol.
, vol.66
, pp. 352-361
-
-
Qin, W.1
Haroutunian, V.2
Katsel, P.3
-
33
-
-
20444415656
-
Juliflorine: A potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy
-
Choudhary MI, Nawaz SA, Zaheer-ul-Haq, et al. Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy. Biochem Biophys Res Commun. 2005;332(4):1171-1177.
-
(2005)
Biochem Biophys Res Commun.
, vol.332
, Issue.4
, pp. 1171-1177
-
-
Choudhary, M.I.1
Nawaz, S.A.2
Zaheer-ul-Haq3
-
34
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng H, Dodson MW, Huang H, et al. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A. 2008;105: 14503-14508.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
-
35
-
-
68549136513
-
Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology
-
Grunewald A, Gegg ME, Taanman JW, et al. Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Exp Neurol. 2009;219:266-273.
-
(2009)
Exp Neurol.
, vol.219
, pp. 266-273
-
-
Grunewald, A.1
Gegg, M.E.2
Taanman, J.W.3
-
36
-
-
57749194390
-
The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
-
Park J, Lee G, Chung J. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem Biophys Res Commun. 2009;378:518-523.
-
(2009)
Biochem Biophys Res Commun.
, vol.378
, pp. 518-523
-
-
Park, J.1
Lee, G.2
Chung, J.3
-
37
-
-
58949099388
-
Effects of overexpression of huntingtin proteins on mitochondrial integrity
-
Wang H, Lim PJ, Karbowski M, et al. Effects of overexpression of huntingtin proteins on mitochondrial integrity. Hum Mol Genet. 2009;18:737-752.
-
(2009)
Hum Mol Genet.
, vol.18
, pp. 737-752
-
-
Wang, H.1
Lim, P.J.2
Karbowski, M.3
-
38
-
-
40849147435
-
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking
-
Orr AL, Li S, Wang CE, et al. N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J Neurosci. 2008;28:2783-2792.
-
(2008)
J Neurosci.
, vol.28
, pp. 2783-2792
-
-
Orr, A.L.1
Li, S.2
Wang, C.E.3
-
39
-
-
43149115834
-
6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells
-
Gomez Lazaro M, Bonekamp NA, Galindo MF, et al. 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radic Biol Med. 2008;44:1960-1969.
-
(2008)
Free Radic Biol Med.
, vol.44
, pp. 1960-1969
-
-
Gomez Lazaro, M.1
Bonekamp, N.A.2
Galindo, M.F.3
-
40
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
Yang Y, Ouyang Y, Yang L, et al. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A. 2008;105:7070-7075.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 7070-7075
-
-
Yang, Y.1
Ouyang, Y.2
Yang, L.3
|