-
1
-
-
0035976575
-
Prostaglandins and leukotrienes: Advances in eicosanoid biology
-
DOI 10.1126/science.294.5548.1871
-
Funk, C.D. (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294 , 1871-1875. (Pubitemid 33101574)
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1871-1875
-
-
Funk, C.D.1
-
2
-
-
23844530173
-
Leukotriene modifiers as potential therapeutics for cardiovascular disease
-
DOI 10.1038/nrd1796
-
Funk, C.D. (2005) Leukotriene modifiers as potential therapeutics for cardiovascular disease. Nat Drug Disc 4 , 664-672. (Pubitemid 41149760)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.8
, pp. 664-672
-
-
Funk, C.D.1
-
3
-
-
38749113897
-
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases
-
Evans, J.F., Ferguson, A.D., Mosley, R.T., and Hutchinson, J.H. (2008) What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol Sci 292 , 72-78.
-
(2008)
Trends Pharmacol Sci
, vol.292
, pp. 72-78
-
-
Evans, J.F.1
Ferguson, A.D.2
Mosley, R.T.3
Hutchinson, J.H.4
-
4
-
-
57149118054
-
Leukotriene modifiers in the treatment of cardiovascular diseases
-
DOI 10.1189/jlb.0808476
-
Riccioni, G., Capra, V., D'Orazio, N., Bucciarelli, T., and Bazzano, L.A. (2008) Leukotriene modifiers in the treatment of cardiovascular diseases. J Leukoc Biol. 8 , 1374-1378. (Pubitemid 352774472)
-
(2008)
Journal of Leukocyte Biology
, vol.84
, Issue.6
, pp. 1374-1378
-
-
Riccioni, G.1
Capra, V.2
D'Orazio, N.3
Bucciarelli, T.4
Bazzano, L.A.5
-
5
-
-
66349101349
-
5-Lipoxygenase: Mechanisms of regulation
-
Rådmark, O., and Samuelsson, B. (2009). 5-Lipoxygenase: mechanisms of regulation. J Lipid Res 50 , 40-45.
-
(2009)
J Lipid Res
, vol.50
, pp. 40-45
-
-
Rådmark, O.1
Samuelsson, B.2
-
6
-
-
70449336472
-
FLAP inhibitors for the treatment of inflammatory diseases
-
Sampson, A.P. (2009) FLAP inhibitors for the treatment of inflammatory diseases. Curr Opin Invest Drugs 10 , 1163-1172.
-
(2009)
Curr Opin Invest Drugs
, vol.10
, pp. 1163-1172
-
-
Sampson, A.P.1
-
7
-
-
0035839572
-
Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes
-
Evans, J., Spencer, D., Zweifach, A., and Leslie, C. (2001) Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes. J Biol Chem 276 , 30150-30160.
-
(2001)
J Biol Chem
, vol.276
, pp. 30150-30160
-
-
Evans, J.1
Spencer, D.2
Zweifach, A.3
Leslie, C.4
-
8
-
-
33745233039
-
Metabolism of arachidonic acid to eicosanoids within the nucleus
-
DOI 10.1016/j.bbalip.2006.02.018, PII S138819810600045X
-
Luo, M., Flamand, N., and Brock, T. (2006) Metabolism of arachidonic acid to eicosanoids within the nucleus. Biochim Biophys Acta 1761 , 618-625. (Pubitemid 43928863)
-
(2006)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
, vol.1761
, Issue.5-6
, pp. 618-625
-
-
Luo, M.1
Flamand, N.2
Brock, T.G.3
-
9
-
-
0025022489
-
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
-
Dixon, R.A.F. et al. (1990) Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 , 282-284.
-
(1990)
Nature
, vol.343
, pp. 282-284
-
-
Dixon, R.A.F.1
-
10
-
-
0025021789
-
Identification and isolation of a membrane protein necessary for leukotriene production
-
Miller, D.K. et al . (1990) Identification and isolation of a membrane protein necessary for leukotriene production. Nature 343 , 278-281.
-
(1990)
Nature
, vol.343
, pp. 278-281
-
-
Miller, D.K.1
-
11
-
-
0029098680
-
Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages
-
Brock, T.G., McNish, R.W., and Peters-Golden, M. (1995) Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J Biol Chem 270 , 21652-21658.
-
(1995)
J Biol Chem
, vol.270
, pp. 21652-21658
-
-
Brock, T.G.1
McNish, R.W.2
Peters-Golden, M.3
-
12
-
-
33748684386
-
Eicosanoid transcellular biosynthesis: From cell-cell interactions to in vivo tissue responses
-
DOI 10.1124/pr.58.3.8
-
Folco, G., and Murphy, R.C. (2006) Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev 58 , 375-388. (Pubitemid 44394907)
-
(2006)
Pharmacological Reviews
, vol.58
, Issue.3
, pp. 375-388
-
-
Folco, G.1
Murphy, R.C.2
-
13
-
-
0024348059
-
L-663,536 (MK-886)(3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol- 2-yl]- ,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor
-
Gillard, J. et al . (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t- butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol 67 , 456-464. (Pubitemid 19186702)
-
(1989)
Canadian Journal of Physiology and Pharmacology
, vol.67
, Issue.5
, pp. 456-464
-
-
Gillard, J.1
Ford-Hutchinson, A.W.2
Chan, C.3
Charleson, S.4
Denis, D.5
Foster, A.6
Fortin, R.7
Leger, S.8
McFarlane, C.S.9
Morton, H.10
Piechuta, H.11
Riendeau, D.12
Rouzer, C.A.13
Rokach, J.14
Young, R.15
MacIntyre, D.E.16
Peterson, L.17
Bach, T.18
Eiermann, G.19
-
14
-
-
0027428711
-
BAY X1005, a new inhibitor of leukotriene synthesis: In vivo inflammation pharmacology and pharmacokinetics
-
Müller-Peddinghaus, R. et al . (1993) BAY X1005, a new inhibitor of leukotriene synthesis: In vivo inflammation pharmacology and pharmacokinetics. J Pharm Exp Ther 267 , 51-57. (Pubitemid 23324988)
-
(1993)
Journal of Pharmacology and Experimental Therapeutics
, vol.267
, Issue.1
, pp. 51-57
-
-
Muller-Peddinghaus, R.1
Kohlsdorfer, C.2
Theisen-Popp, P.3
Fruchtmann, R.4
Perzborn, E.5
Beckermann, B.6
Buhner, K.7
Ahr, H.-J.8
Mohrs, K.-H.9
-
15
-
-
0026760732
-
Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(tbutylthio)-5- (quinolin-2-ylmethoxy)-indol-2- yl]-2,2-dimethylpropanoic acid), a potent, orally active leukotriene biosynthesis inhibitor
-
Brideau, C. et al . (1992) Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl) -3-(tbutylthio)-5-(quinolin-2-ylmethoxy)-indol-2- yl]-2,2-dimethylpropanoic acid), a potent, orally active leukotriene biosynthesis inhibitor . Can J Physiol Pharmacol 70 , 799-807.
-
(1992)
Can J Physiol Pharmacol
, vol.70
, pp. 799-807
-
-
Brideau, C.1
-
16
-
-
0027000935
-
A new class of leukotriene biosynthesis inhibitor: The development of MK-0591
-
Prasit, P. et al. (1993) A new class of leukotriene biosynthesis inhibitor: the development of MK-0591. J Lipid Mediat 6 , 239-244.
-
(1993)
J Lipid Mediat
, vol.6
, pp. 239-244
-
-
Prasit, P.1
-
17
-
-
0025823424
-
5-Lipoxygenaseactivating protein is the target of a quinoline class of leukotriene synthesis inhibitors
-
Evans, J.F. et al . (1991) 5-Lipoxygenaseactivating protein is the target of a quinoline class of leukotriene synthesis inhibitors. Mol Pharmacol 40 , 22-27.
-
(1991)
Mol Pharmacol
, vol.40
, pp. 22-27
-
-
Evans, J.F.1
-
18
-
-
0027504207
-
5-Lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes
-
DOI 10.1084/jem.178.6.1935
-
Woods, J. et al. (1993) 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 178 , 1935-1946. (Pubitemid 23344852)
-
(1993)
Journal of Experimental Medicine
, vol.178
, Issue.6
, pp. 1935-1946
-
-
Woods, J.W.1
Evans, J.F.2
Ethier, D.3
Scott, S.4
Vickers, P.J.5
Hearn, L.6
Heibein, J.A.7
Charleson, S.8
Singer, I.I.9
-
19
-
-
0027416398
-
5-Lipoxygenase-activating protein is an arachidonate binding protein
-
DOI 10.1016/0014-5793(93)80528-3
-
Mancini, J. et al. (1993) 5-lipoxygenase-activating protein is an arachidonate binding protein. FEBS Letters 318 , 277-281. (Pubitemid 23071752)
-
(1993)
FEBS Letters
, vol.318
, Issue.3
, pp. 277-281
-
-
Mancini, J.A.1
Abramovitz, M.2
Cox, M.E.3
Wong, E.4
Charleson, S.5
Perrier, H.6
Wang, Z.7
Prasit, P.8
Vickers, P.J.9
-
20
-
-
0028223174
-
The binding of leukotriene biosynthesis inhibitors to site-directed mutants of human 5-lipoxygenaseactivating protein
-
Mancini, J., Coppolino, M., Klassen, J., Charleson, S., and Vickers, P. (1994) The binding of leukotriene biosynthesis inhibitors to site-directed mutants of human 5-lipoxygenaseactivating protein. Life Sci 54 , 137-142.
-
(1994)
Life Sci
, vol.54
, pp. 137-142
-
-
Mancini, J.1
Coppolino, M.2
Klassen, J.3
Charleson, S.4
Vickers, P.5
-
21
-
-
0025098441
-
MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes
-
Rouzer, C., Ford-Hutchinson, A., Morton, H., and Gillard, J. (1990) MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes. J Biol Chem 265 , 1436-1442.
-
(1990)
J Biol Chem
, vol.265
, pp. 1436-1442
-
-
Rouzer, C.1
Ford-Hutchinson, A.2
Morton, H.3
Gillard, J.4
-
22
-
-
0033011878
-
Common structural features of MAPEG - A widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism
-
Jakobsson, P.J., Morgenstern, R., Mancini, J., Ford-Hutchinson, A., and Persson, B. (1999) Common structural features of MAPEG - a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism. Protein Sci 8 , 689-692. (Pubitemid 29117984)
-
(1999)
Protein Science
, vol.8
, Issue.3
, pp. 689-692
-
-
Jakobsson, P.-J.1
Morgenstern, R.2
Mancini, J.3
Ford-Hutchinson, A.4
Persson, B.5
-
23
-
-
20244389729
-
Bioinformatic and enzymatic characterization of the MAPEG superfamily
-
DOI 10.1111/j.1742-4658.2005.04596.x
-
Bresell, A. et al. (2005). Bioinformatic and enzymatic characterization of the MAPEG superfamily. FEBS J 272 , 1688-1703. (Pubitemid 40516219)
-
(2005)
FEBS Journal
, vol.272
, Issue.7
, pp. 1688-1703
-
-
Bresell, A.1
Weinander, R.2
Lundqvist, G.3
Raza, H.4
Shimoji, M.5
Sun, T.-H.6
Balk, L.7
Wiklund, R.8
Eriksson, J.9
Jansson, C.10
Persson, B.11
Jakobsson, P.-J.12
Morgenstern, R.13
-
24
-
-
30044446862
-
5-Lipoxygenase-activating protein homodimer in human neutrophils: Evidence for a role in leukotriene biosynthesis
-
DOI 10.1042/BJ20050669
-
Plante, H., Picard, S., Mancini, J., and Borgeat, P. (2006) 5-Lipoxygenase-activating protein homodimer in human neutrophils: evidence for a role in leukotriene biosynthesis. Biochem J 393 , 211-218. (Pubitemid 43049317)
-
(2006)
Biochemical Journal
, vol.393
, Issue.1
, pp. 211-218
-
-
Plante, H.1
Picard, S.2
Mancini, J.3
Borgeat, P.4
-
25
-
-
34547560098
-
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein
-
DOI 10.1126/science.1144346
-
Ferguson, A.D. et al . (2007) Crystal structure of inhibitor bound 5-lipoxygenase-activating protein. Science 317 , 510-512. (Pubitemid 47196114)
-
(2007)
Science
, vol.317
, Issue.5837
, pp. 510-512
-
-
Ferguson, A.D.1
McKeever, B.M.2
Xu, S.3
Wisniewski, D.4
Miller, D.K.5
Yamin, T.-T.6
Spencer, R.H.7
Chu, L.8
Ujjainwalla, F.9
Cunningham, B.R.10
Evans, J.F.11
Becker, J.W.12
-
26
-
-
0031045585
-
Preparation of selenomethionyl proteins for phase determination
-
DOI 10.1016/S0076-6879(97)76075-0
-
Doublié, S. (1997) Preparation of selenomethionyl proteins for phase determination. Meth Enzymol 276 , 523-530. (Pubitemid 27085620)
-
(1997)
Methods in Enzymology
, vol.276
, pp. 523-530
-
-
Doublie, S.1
-
27
-
-
0027091994
-
Characterization of a 5-lipoxygenase-activating protein binding assay: Correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition
-
Charleson, S. et al. (1992) Characterization of a 5-lipoxygenase- activating protein binding assay: Correlation of affinity for 5-lipoxygenaseactivating protein with leukotriene synthesis inhibition. Mol Pharmacol 41 , 873-879. (Pubitemid 23023330)
-
(1992)
Molecular Pharmacology
, vol.41
, Issue.5
, pp. 873-879
-
-
Charleson, S.1
Prasit, P.2
Leger, S.3
Gillard, J.W.4
Vickers, P.J.5
Mancini, J.A.6
Charleson, P.7
Guay, J.8
Ford-Hutchinson, A.W.9
Evans, J.F.10
-
28
-
-
0027070829
-
Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors
-
Vickers, P.J. et al. (1992) Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors. Mol Pharmacol 42 , 94-102. (Pubitemid 23026132)
-
(1992)
Molecular Pharmacology
, vol.42
, Issue.1
, pp. 94-102
-
-
Vickers, P.J.1
Adam, M.2
Charleson, S.3
Coppolino, M.G.4
Evans, J.F.5
Mancini, J.A.6
-
29
-
-
7044272757
-
Membrane proteins, lipids and detergents: Not just a soap opera
-
DOI 10.1016/j.bbamem.2004.04.011, PII S0005273604001610, Lipid-Protein Interactions
-
Seddon, A.M., Curnow, P., and Booth, P.J. (2004). Membrane proteins, lipids and detergents: not just a soap opera. Biochimica et Biophysica Acta 1666 , 105-117. (Pubitemid 39425201)
-
(2004)
Biochimica et Biophysica Acta - Biomembranes
, vol.1666
, Issue.1-2
, pp. 105-117
-
-
Seddon, A.M.1
Curnow, P.2
Booth, P.J.3
-
30
-
-
7044274626
-
Lipids in membrane protein structures
-
DOI 10.1016/j.bbamem.2004.06.012, PII S0005273604001567, Lipid-Protein Interactions
-
Palsdottir, H., and Hunte, C. (2004). Lipids in membrane protein structures Biochimica et Biophysica Acta 1666 , 2-18. (Pubitemid 39425195)
-
(2004)
Biochimica et Biophysica Acta - Biomembranes
, vol.1666
, Issue.1-2
, pp. 2-18
-
-
Palsdottir, H.1
Hunte, C.2
-
31
-
-
7044241302
-
How lipids affect the activities of integral membrane proteins
-
DOI 10.1016/j.bbamem.2004.05.012, PII S0005273604001592, Lipid-Protein Interactions
-
Lee, A.G. (2004). How lipids affect the activities of integral membrane proteins. Biochimica et Biophysica Acta 1666 , 62-87. (Pubitemid 39425199)
-
(2004)
Biochimica et Biophysica Acta - Biomembranes
, vol.1666
, Issue.1-2
, pp. 62-87
-
-
Lee, A.G.1
-
32
-
-
1842555070
-
Rational protein crystallization by mutational surface engineering
-
Derewenda, Z.S. (2004). Rational protein crystallization by mutational surface engineering. Structure 12 , 529-5535.
-
(2004)
Structure
, vol.12
, pp. 529-5535
-
-
Derewenda, Z.S.1
-
33
-
-
33644874674
-
Entropy and surface engineering in protein crystallization
-
Derewenda, Z.S., and Vekilov, P.G. (2006). Entropy and surface engineering in protein crystallization. Acta Cryst D 62 , 116-124.
-
(2006)
Acta Cryst D
, vol.62
, pp. 116-124
-
-
Derewenda, Z.S.1
Vekilov, P.G.2
-
34
-
-
36849083574
-
Expression, purification and crystallization of human 5-lipoxygenase- activating protein with leukotriene-biosynthesis inhibitors
-
DOI 10.1107/S1744309107055571, PII S1744309107055571
-
Xu, S. et al. (2007) Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors. Acta Cryst F 63 , 1054-1057. (Pubitemid 350224348)
-
(2007)
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
, vol.63
, Issue.12
, pp. 1054-1057
-
-
Xu, S.1
McKeever, B.M.2
Wisniewski, D.3
Miller, D.K.4
Spencer, R.H.5
Chu, L.6
Ujjainwalla, F.7
Yamin, T.-T.8
Evans, J.F.9
Becker, J.W.10
Ferguson, A.D.11
-
35
-
-
0026095584
-
Determination of macromolecular structures from anomalous diffraction of synchrotron radiation
-
Hendrickson, W.A. (1991) Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. Science 254 , 51-58. (Pubitemid 21917315)
-
(1991)
Science
, vol.254
, Issue.5028
, pp. 51-58
-
-
Hendrickson, W.A.1
-
37
-
-
0242460576
-
Generation, representation and flow of phase information in structure determination: Recent developments in and around SHARP 2.0
-
DOI 10.1107/S0907444903017694
-
Bricogne, G., Vonrhein, C., Flensburg, C., Schiltz, M., and Paciorek, W. (2003) Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0. Acta Cryst D 59 , 2023-2030. (Pubitemid 37399336)
-
(2003)
Acta Crystallographica Section D: Biological Crystallography
, vol.59
, Issue.11
, pp. 2023-2030
-
-
Bricogne, G.1
Vonrhein, C.2
Flensburg, C.3
Schiltz, M.4
Paciorek, W.5
-
38
-
-
36549027357
-
Automated structure solution with autoSHARP
-
DOI 10.1385/1-59745-266-1:215, Macromolecular Crystallography Protocols, Volume 2: Structure Determination
-
Vonrhein, C., Blanc, E., Roversi, P., and Bricogne, G. (2006). Automated structure solution with autoSHARP. Meth Mol Biol 364 , 215-230. (Pubitemid 350183137)
-
(2007)
Methods in Molecular Biology
, vol.364
, pp. 215-230
-
-
Vonrhein, C.1
Blanc, E.2
Roversi, P.3
Bricogne, G.4
-
39
-
-
0347383760
-
ARP/wARP and automatic interpretation of protein electron density maps
-
DOI 10.1016/S0076-6879(03)74011-7
-
Morris, R.J., Perrakis, A., and Lamzin, V.S. (2003) ARP/wARP and automatic interpretation of protein electron density maps. Meth Enzymol 374 , 229-244. (Pubitemid 37531812)
-
(2003)
Methods in Enzymology
, vol.374
, pp. 229-244
-
-
Morris, R.J.1
Perrakis, A.2
Lamzin, V.S.3
-
40
-
-
2142750049
-
Breaking good resolutions with ARP/wARP
-
DOI 10.1107/S090904950302394X
-
Morris, R.J. et al. (2004) Breaking good resolutions with ARP/wARP. J Synchrotron Radiat 11 , 56-59. (Pubitemid 40085634)
-
(2004)
Journal of Synchrotron Radiation
, vol.11
, Issue.1
, pp. 56-59
-
-
Morris, R.J.1
Zwart, P.H.2
Cohen, S.3
Fernandez, F.J.4
Kakaris, M.5
Kirillova, O.6
Vonrhein, C.7
Perrakis, A.8
Lamzin, V.S.9
-
41
-
-
16644377724
-
Towards complete validated models in the next generation of ARP/wARP
-
DOI 10.1107/S0907444904027556
-
Cohen, S.X. et al. (2004) Towards complete validated models in the next generation of ARP/wARP. Acta Cryst D 60 , 2222-2229. (Pubitemid 41742774)
-
(2004)
Acta Crystallographica Section D: Biological Crystallography
, vol.60
, Issue.12
, pp. 2222-2229
-
-
Cohen, S.X.1
Morris, R.J.2
Fernandez, F.J.3
Jelloul, M.B.4
Kakaris, M.5
Parthasarathy, V.6
Lamzin, V.S.7
Kleywegt, G.J.8
Perrakis, A.9
-
43
-
-
14844321328
-
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT
-
DOI 10.1107/S0907444904016427
-
Blanc, E. et al. (2004) Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT. Acta Cryst D 60 , 2210-2221. (Pubitemid 41742773)
-
(2004)
Acta Crystallographica Section D: Biological Crystallography
, vol.60
, Issue.12
, pp. 2210-2221
-
-
Blanc, E.1
Roversi, P.2
Vonrhein, C.3
Flensburg, C.4
Lea, S.M.5
Bricogne, G.6
-
44
-
-
0028204213
-
Functional and structural membrane topology of rat liver microsomal glutathione transferase
-
DOI 10.1016/0167-4838(94)90021-3
-
Andersson, C., Weinander, R., Lundqvist, G., DePierre, J.W., and Morgenstern, R. (1994) Functional and structural membrane topology of rat liver microsomal glutathione transferase. Biochim Biophys Acta 1204 , 298-304. (Pubitemid 24074859)
-
(1994)
Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
, vol.1204
, Issue.2
, pp. 298-304
-
-
Andersson, C.1
Weinander, R.2
Lundqvist, G.3
DePierre, J.W.4
Morgenstern, R.5
-
45
-
-
0030911870
-
Structural and functional aspects of rat microsomal glutathione transferase: The roles of cysteine 49, arginine 107, lysine 67, histidine, and tyrosine residues
-
DOI 10.1074/jbc.272.14.8871
-
Weinander, R. et al. (1997) Structural and functional aspects of rat microsomal glutathione transferase. The roles of cysteine 49, arginine 107, lysine 67, histidine, and tyrosine residues. J Biol Chem 272 , 8871-8877. (Pubitemid 27154881)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.14
, pp. 8871-8877
-
-
Weinander, R.1
Ekstrom, L.2
Andersson, C.3
Raza, H.4
Bergman, T.5
Morgenstern, R.6
-
46
-
-
0030924807
-
4 synthase
-
DOI 10.1074/jbc.272.21.13923
-
Lam, B.K., Penrose, J.F., Xu, K., Baldasaro, M.H., and Austen, K.F. (1997) Site-directed mutagenesis of human leukotriene C4 synthase. J Biol Chem 272 , 13923-13928. (Pubitemid 27224836)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.21
, pp. 13923-13928
-
-
Lam, B.K.1
Penrose, J.F.2
Xu, K.3
Baldasaro, M.H.4
Austen, K.F.5
-
47
-
-
34547631962
-
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
-
DOI 10.1038/nature05936, PII NATURE05936
-
Ago, H. et al. (2007) Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 448 , 609-612. (Pubitemid 47206929)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 609-612
-
-
Ago, H.1
Kanaoka, Y.2
Irikura, D.3
Lam, B.K.4
Shimamura, T.5
Austen, K.F.6
Miyano, M.7
-
48
-
-
34547688876
-
4 synthase
-
DOI 10.1038/nature06009, PII NATURE06009
-
Molina, D.M. et al. (2007) Structural basis for synthesis of inflammatory mediators by human leukotriene C 4 synthase. Nature 448 , 613-616. (Pubitemid 47208483)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 613-616
-
-
Molina, D.M.1
Wetterholm, A.2
Kohl, A.3
McCarthy, A.A.4
Niegowski, D.5
Ohlson, E.6
Hammarberg, T.7
Eshaghi, S.8
Haeggstrom, J.Z.9
Nordlund, P.10
-
49
-
-
33845343261
-
Membrane-protein topology
-
DOI 10.1038/nrm2063, PII NRM2063
-
von Heijne, G. (2006) Membrane-protein topology. Nat Rev Mol Cell Biol 7 , 909-918. (Pubitemid 44871417)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.12
, pp. 909-918
-
-
Von Heijne, G.1
-
50
-
-
33745938162
-
Structural basis for detoxification and oxidative stress protection in membranes
-
DOI 10.1016/j.jmb.2006.05.056, PII S0022283606006565
-
Holm, P. et al. (2006) Structural basis for detoxification and oxidative stress protection in membranes. J Mol Biol 360 , 934-945. (Pubitemid 44062511)
-
(2006)
Journal of Molecular Biology
, vol.360
, Issue.5
, pp. 934-945
-
-
Holm, P.J.1
Bhakat, P.2
Jegerschold, C.3
Gyobu, N.4
Mitsuoka, K.5
Fujiyoshi, Y.6
Morgenstern, R.7
Hebert, H.8
-
51
-
-
7944228810
-
4 synthase at 4.5 Å resolution in projection
-
DOI 10.1016/j.str.2004.08.008, PII S0969212604003351
-
Schmidt-Krey, I. et al. (2004) Human leukotriene C(4) synthase at 4.5 A resolution in projection. Structure 12 , 2009-2014. (Pubitemid 39469398)
-
(2004)
Structure
, vol.12
, Issue.11
, pp. 2009-2014
-
-
Schmidt-Krey, I.1
Kanaoka, Y.2
Mills, D.J.3
Irikura, D.4
Haase, W.5
Lam, B.K.6
Austen, K.F.7
Kuhlbrandt, W.8
-
52
-
-
0038266571
-
Human microsomal prostaglandin E synthase-1: Purification, functional characterization, and projection structure determination
-
DOI 10.1074/jbc.M303227200
-
Thoren, S. et al. (2003) Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem 278 , 22199-22209. (Pubitemid 36830265)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.25
, pp. 22199-22209
-
-
Thoren, S.1
Weinander, R.2
Saha, S.3
Jegerschold, C.4
Pettersson, P.L.5
Samuelsson, B.6
Hebert, H.7
Hamberg, M.8
Morgenstern, R.9
Jakobsson, P.-J.10
-
53
-
-
0026996758
-
Amino acid residues of 5-lipoxygenase-activating protein critical for the binding of leukotriene biosynthesis inhibitors
-
Vickers, P. et al. (1993) Amino acid residues of 5-lipoxygenase- activating protein critical for the binding of leukotriene biosynthesis inhibitors. J Lipid Mediat 6 , 31-42.
-
(1993)
J Lipid Mediat
, vol.6
, pp. 31-42
-
-
Vickers, P.1
-
54
-
-
0032484135
-
Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15- hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5- lipoxygenase-activating protein
-
DOI 10.1074/jbc.273.49.32842
-
Mancini, J.A., Waterman, H., and Riendeau, D. (1998) Cellular oxygenation of 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid by 5-lipoxygenase is stimulated by 5-lipoxygenase-activating protein. J Biol Chem 273 , 32842-32847. (Pubitemid 28557673)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.49
, pp. 32842-32847
-
-
Mancini, J.A.1
Waterman, H.2
Riendeau, D.3
-
55
-
-
0034710715
-
Symmetrical Bis (heteroarylmethoxyphenyl)alkylcarboxylic acids as inhibitors of leukotriene biosynthesis
-
Kolasa, T. et al . (2000) Symmetrical Bis (heteroarylmethoxyphenyl) alkylcarboxylic acids as inhibitors of leukotriene biosynthesis. J Med Chem 43 , 3322-3334.
-
(2000)
J Med Chem
, vol.43
, pp. 3322-3334
-
-
Kolasa, T.1
-
56
-
-
40749090775
-
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein
-
Macdonald, D. et al. (2008) Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. Bioorg Med Chem Lett 18 , 2023-2027.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 2023-2027
-
-
MacDonald, D.1
-
57
-
-
70349648499
-
5-lipoxygenaseactivating protein inhibitors: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxypyridin-3-yl)-benzyl]-5-(pyridin-2- ylmethoxy)-1 H-indol-2-yl]-2,2-dimethylpropionic acid (AM103)
-
Hutchinson, J.H. et al. (2009) 5-lipoxygenaseactivating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxypyridin-3-yl)- benzyl]-5-(pyridin-2-ylmethoxy)-1 H-indol-2-yl]-2,2-dimethylpropionic acid (AM103). J Med Chem 52 , 5803-5815.
-
(2009)
J Med Chem
, vol.52
, pp. 5803-5815
-
-
Hutchinson, J.H.1
-
58
-
-
73349142021
-
Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4- (6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1 H-indol-2-yl]-2,2- dimethylpropionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation
-
Lorrain, D.S. et al. (2009) Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4- (6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2- ylmethoxy)-1 H-indol-2-yl]-2,2-dimethylpropionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. J Pharmacol Exp Ther 331 , 1042-1050.
-
(2009)
J Pharmacol Exp Ther
, vol.331
, pp. 1042-1050
-
-
Lorrain, D.S.1
-
59
-
-
77953810969
-
Pharmacology of AM803, a novel selective five-lipoxygenaseactivating protein (FLAP) inhibitor in rodent models of acute inflammation
-
Lorrain, D.S. et al. (2010) Pharmacology of AM803, a novel selective five-lipoxygenaseactivating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol 640 , 211-218.
-
(2010)
Eur J Pharmacol
, vol.640
, pp. 211-218
-
-
Lorrain, D.S.1
-
60
-
-
72049104422
-
5-Lipoxygenaseactivating protein inhibitors. Part 2: 3-{5-((S)-1- Acetyl-2,3-dihydro-1 H-indol-2-ylmethoxy)-3-ter t-butylsulfanyl-1-[4-(5- methoxypyrimidin-2-yl)-benzyl]-1 H-indol-2-yl}-2,2- dimethyl-propionic acid (AM679) - A potent FLAP inhibitor
-
Stock, N. et al . (2010) 5-Lipoxygenaseactivating protein inhibitors. Part 2: 3-{5-((S)-1- Acetyl-2,3-dihydro-1 H-indol-2-ylmethoxy)-3-ter t-butylsulfanyl-1-[4-(5-methoxypyrimidin-2-yl)-benzyl]-1 H-indol-2-yl}-2,2- dimethyl-propionic acid (AM679)-a potent FLAP inhibitor. Bioorg Med Chem Lett 20 , 213-217.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 213-217
-
-
Stock, N.1
-
61
-
-
0036430199
-
Proline-induced distortions of transmembrane helices
-
DOI 10.1016/S0022-2836(02)01006-9
-
Cordes, F., Bright, J., and Sansom, M. (2002) Proline-induced distortions of transmembrane helices. J Mol Biol 323 , 951-960. (Pubitemid 35341067)
-
(2002)
Journal of Molecular Biology
, vol.323
, Issue.5
, pp. 951-960
-
-
Cordes, F.S.1
Bright, J.N.2
Sansom, M.S.P.3
-
62
-
-
0028176268
-
Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein
-
Charleson, S. et al. (1994) Structural requirements for the binding of fatty acids to 5-lipoxygenase-activating protein. Eur J Pharmacol 267 , 275-280.
-
(1994)
Eur J Pharmacol
, vol.267
, pp. 275-280
-
-
Charleson, S.1
-
63
-
-
33644857422
-
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils
-
DOI 10.1074/jbc.M506513200
-
Flamand, N., Lefebvre, J., Surette, M., Picard, S., and Borgeat, P. (2006) Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. J Biol Chem 281 , 129-136. (Pubitemid 43671171)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.1
, pp. 129-136
-
-
Flamand, N.1
Lefebvre, J.2
Surette, M.E.3
Picard, S.4
Borgeat, P.5
-
64
-
-
0037066761
-
Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase
-
DOI 10.1074/jbc.M112393200
-
Kulkarni, S., Das, S., Funk, C., Murray, D., and Cho, W. (2002) Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase. J Biol Chem 277 , 13167-13174. (Pubitemid 34952687)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.15
, pp. 13167-13174
-
-
Kulkarni, S.1
Das, S.2
Funk, C.D.3
Murray, D.4
Cho, W.5
-
65
-
-
0037397016
-
The organization and consequences of eicosanoid signaling
-
DOI 10.1172/JCI200318338
-
Soberman, R., and Christmas, P. (2003) The organization and consequences of eicosanoid signaling. J Clin Invest 111 , 1107-1113. (Pubitemid 36519924)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.8
, pp. 1107-1113
-
-
Soberman, R.J.1
Christmas, P.2
-
66
-
-
2342503757
-
The membrane organization of leukotriene synthesis
-
DOI 10.1073/pnas.0308523101
-
Mandal, A.K. et al . (2004) The membrane organization of leukotriene synthesis. Proc Nat Acad Sci USA 101 , 6587-6592. (Pubitemid 38586018)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.17
, pp. 6587-6592
-
-
Mandal, A.K.1
Skoch, J.2
Bacskai, B.J.3
Hyman, B.T.4
Christmas, P.5
Millers, D.6
Yamin, T.-T.D.7
Xu, S.8
Wisniewski, D.9
Evans, J.F.10
Soberman, R.J.11
-
67
-
-
62649099134
-
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein
-
Strid, T., Svartz, J., Franck, N., Hallin, E., Ingelsson, B., Söderström, and M., Hammarström, S. (2009) Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein. Biochem Biophys Res Commun 381 , 518-522.
-
(2009)
Biochem Biophys Res Commun
, vol.381
, pp. 518-522
-
-
Strid, T.1
Svartz, J.2
Franck, N.3
Hallin, E.4
Ingelsson, B.5
Söderström, M.6
Hammarström, S.7
-
68
-
-
77955495763
-
Location, location, location: Compartmentalization of early events in leukotriene biosynthesis
-
Newcomer, M.E., and Gilbert, N.C. (2010) Location, location, location: compartmentalization of early events in leukotriene biosynthesis. J Biol Chem 285 , 25109-25114.
-
(2010)
J Biol Chem
, vol.285
, pp. 25109-25114
-
-
Newcomer, M.E.1
Gilbert, N.C.2
|