HCXCR1 and hCXCR2 antagonists derived from combinatorial peptide libraries

Cytokine

Volumn 57, Issue 3, 2012, Pages 322-331

  Houimel, Mehdi ^a   Mazzucchelli, Luca ^b  

^a PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^b INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Antagonist; HCXCL8; HCXCR1; HCXCR2; Peptide

Indexed keywords

ALANINE; AMINO ACID DERIVATIVE; ARGININE; ASPARAGINE; ASPARTIC ACID; CALCIUM; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; CYSTEINE; DISULFIDE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GLUTAMIC ACID; GLYCINE; HEXAPEPTIDE; HISTIDINE; INTERLEUKIN 8 ANTIBODY; IODINE 125; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; PHENYLALANINE; SERINE; TRYPTOPHAN; VALINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOPANNING; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; ELUTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; MOUSE; NEUTROPHIL; NONHUMAN; PEPTIDE LIBRARY; PHAGE DISPLAY; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BACTERIOPHAGES; BINDING, COMPETITIVE; CALCIUM; CHEMOTAXIS; CHROMATOGRAPHY, AFFINITY; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; INTRACELLULAR SPACE; MICE; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; TRANSFECTION;

MURINAE;

EID: 84856406619     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.11.022     Document Type: Article

References (30)

1. Rollins B.J. Chemokines. Blood 1997, 90:909-928.
2. Mantovani A. The chemokine system: redundancy for robust outputs. Immunol Today 1999, 20:254-257.
3. Baggiolini M. Chemokines and leukocyte traffic. Nature 1998, 392:565-568.
4. Horuk R. Chemokine receptors. Cytokine Growth Factor Rev 2001, 12:313-335.
5. Nickoloff B.J., Karabin G.D., Barker J.N., Griffiths C.E., Sarma V., Mitra R.S., et al. Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am J Pathol 1991, 138:129-140.
6. Mahida Y.R., Ceska M., Effenberger F., Kurlak L., Lindley I., Hawkey C.J. Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis. Clin Sci (Lond) 1992, 82:273-275.
7. Chishti A.D., Shenton B.K., Kirby J.A., Baudouin S.V. Neutrophil chemotaxis and receptor expression in clinical septic shock. Intensive Care Med 2004, 30:605-611.
8. White J.R., Lee J.M., Young P.R., Hertzberg R.P., Jurewicz A.J., Chaikin M.A., et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 1998, 273:10095-10098.
9. White J.R., Lee J.M., Dede K., Imburgia C.S., Jurewicz A.J., Chan G., et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem 2000, 275:36626-36631.
10. Horuk R., Ng H.P. Chemokine receptor antagonists. Med Res Rev 2000, 20:155-168.
11. Bizzarri C., Beccari A.R., Bertini R., Cavicchia M.R., Giorgini S., Allegretti M. ELR+CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets. Pharmacol Ther 2006, 112:139-149.
12. Clark-Lewis I., Moser B., Walz A., Baggiolini M., Scott G.J., Aebersold R. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. Biochemistry 1991, 30:3128-3135.
13. Loetscher P., Seitz M., Clark-Lewis I., Baggiolini M., Moser B. Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett 1994, 341:187-192.
14. Houimel M., Mach J.P., Corthesy-Theulaz I., Corthesy B., Fisch I. New inhibitors of Helicobacter pylori urease holoenzyme selected from phage-displayed peptide libraries. Eur J Biochem 1999, 262:774-780.
15. von Tscharner V., Prod'hom B., Baggiolini M., Reuter H. Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. Nature 1986, 324:369-372.
16. Moser B., Dewald B., Barella L., Schumacher C., Baggiolini M., Clark-Lewis I. Interleukin-8 antagonists generated by N-terminal modification. J Biol Chem 1993, 268:7125-7128.
17. Jones S.A., Dewald B., Clark-Lewis I., Baggiolini M. Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2. J Biol Chem 1997, 272:16166-16169.
18. Clark-Lewis I., Dewald B., Geiser T., Moser B., Baggiolini M. Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg. Proc Natl Acad Sci USA 1993, 90:3574-3577.
19. Clark-Lewis I., Dewald B., Loetscher M., Moser B., Baggiolini M. Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids. J Biol Chem 1994, 269:16075-16081.
20. Clark-Lewis I., Schumacher C., Baggiolini M., Moser B. Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities. J Biol Chem 1991, 266:23128-23134.
21. Miller E.J., Kurdowska A., Nagao S., Carr F.K., Hayashi S., Atkinson M.A., et al. A synthetic peptide which specifically inhibits heat-treated interleukin-8 binding and chemotaxis for neutrophils. Agents Actions 1993, 40:200-208.
22. Clark-Lewis I., Kim K.S., Rajarathnam K., Gong J.H., Dewald B., Moser B., et al. Structure-activity relationships of chemokines. J Leukoc Biol 1995, 57:703-711.
23. Hayashi S., Kurdowska A., Miller E.J., Albright M., Girten B.E., Cohen A.B. Synthetic hexa- and heptapeptides that inhibit IL-8 from binding to and activating human blood neutrophils. J Immunol 1995, 154:814-824.
24. Schraufstatter I.U., Barritt D.S., Ma M., Oades Z.G., Cochrane C.G. Multiple sites on IL-8 responsible for binding to alpha and beta IL-8 receptors. J Immunol 1993, 151:6418-6428.
25. Hammond M.E., Shyamala V., Siani M.A., Gallegos C.A., Feucht P.H., Abbott J., et al. Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket. J Biol Chem 1996, 271:8228-8235.
26. Skelton N.J., Quan C., Reilly D., Lowman H. Structure of a CXC chemokine-receptor fragment in complex with interleukin-8. Structure 1999, 7:157-168.
27. Hemmerich S., Paavola C., Bloom A., Bhakta S., Freedman R., Grunberger D., et al. Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2. Biochemistry 1999, 38:13013-13025.
28. Baldwin E.T., Weber I.T., St Charles R., Xuan J.C., Appella E., Yamada M., et al. Crystal structure of interleukin 8: symbiosis of NMR and crystallography. Proc Natl Acad Sci USA 1991, 88:502-506.
29. Podolin P.L., Bolognese B.J., Foley J.J., Schmidt D.B., Buckley P.T., Widdowson K.L., et al. A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol 2002, 169:6435-6444.
30. Rajarathnam K., Prado G.N., Fernando H., Clark-Lewis I., Navarro J. Probing receptor binding activity of interleukin-8 dimer using a disulfide trap. Biochemistry 2006, 45:7882-7888.