Concanavalin A application to the olfactory epithelium reveals different sensory neuron populations for the odour pair D- and L-carvone

Behavioural Brain Research

Volumn 138, Issue 2, 2003, Pages 201-206

  Kirner, Alexandra ^a   Deutsch, Swetlana ^a   Weiler, Elke ^a,c   Polak, Ernest H ^b   Apfelbach, Raimund ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Change of odor quality; Chemoreception; Chiral molecules; Lectin inhibition; Odor detection; Olfactory coding

Indexed keywords

ACETIC ACID ETHYL ESTER; CARVONE; CONCANAVALIN A; CYCLIC AMP; METHACRYLIC ACID; RECEPTOR BLOCKING AGENT;

AIR; ANIMAL EXPERIMENT; ARTICLE; CELL POPULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; ENANTIOMER; INSTRUMENTAL CONDITIONING; ISOMER; MALE; NONHUMAN; NOSE CAVITY; OLFACTORY DISCRIMINATION; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; RAT; RECEPTOR SENSITIVITY; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; TASK PERFORMANCE;

ANIMALS; CHEMORECEPTORS; CONCANAVALIN A; DISCRIMINATION LEARNING; MALE; MONOTERPENES; OLFACTORY MUCOSA; RATS; RATS, WISTAR; SENSORY THRESHOLDS; SMELL; STEREOISOMERISM; TERPENES;

EID: 0037460118     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(02)00242-5     Document Type: Article

References (36)

1. Apfelbach R., Russ D., Slotnick B.M. Ontogenetic changes in odor sensitivity, olfactory receptor area and olfactory receptor density in the rat. Chem. Senses. 16:1991;209-218.
2. Apfelbach R., Weiler E., Asselbergs W.F., Polak E.H., Slotnick B.M. Selective and reversible reduction of odor sensitivity in the rat by concanavalin A. Physiol. Behav. 65:(3):1998;513-516.
3. Breer H. Molecular reaction cascades in olfactory signal transduction. J. Steroid Biochem. Molec. Biol. 39:(4B):1991;621-625.
4. Cowart B.J. Olfactory responses to enantiomers. Chem. Senses. 15:1990;562-563.
5. Duchamp-Viret P., Duchamp A., Chaput M.A. Peripheral odor coding in the rat and frog: quality and intensity specification. J. Neuro. Sci. 20:(6):2000;2383-2390.
6. Field B.F., Slotnick B.M. A multi-purpose photocell and touch circuit amplifier. Physiol. Behav. 40:1984;127-129.
7. Gabius H.J., Rüdiger H., Uhlenbruck G. Lektine. Spektr Wiss. 11:1988;50-60.
8. Hirono J., Sato T. Odorant discrimination between enantiomers of carvones in mouse olfactory receptor neurons. Chem. Senses. 27:(2):2002;179.
9. Hormann C.A., Cowart B.J. Olfactory discrimination of carvone enantiomers. Chem. Senses. 18:1993;573.
10. Kalinoski D.L., Bruch R.C., Brand J.G. Differential interaction of lectins with chemosensory receptors. Brain Res. 418:1987;34-40.
11. Kirner, A. Selektiver Einfluß von Lektinen auf Duftstoffdetektion und Duftinduzierte Neuronale Aktivität im Bulbus Olfactorius der Ratte. Dissertation, Universität Tübingen, 2000:140.
12. Kirner A., Weiler E., Apfelbach R. The use of lectins as a non-invasive approach to the study of odour detection in mammals. Behav. Proc. 48:(2):1999;89-99.
13. Krieger J., Schleicher S., Strotmann J., Wanner I., Boekhoff I., Raming K., et al. Probing olfactory receptors with sequence-specific antibodies. Eur. J. Biochem. 219:(3):1994;829-835.
14. Laska M., Teubner P. Olfactory discrimination ability of human subjects for ten pairs of enantiomers. Chem. Senses. 24:1999;161-170.
15. Laska M., Liesen A., Teubner P. Enantioselectivity of odor perception in squirrel monkeys and humans. Am. J. Physiol. 277:1999;R1098-1103.
16. Linster C., Johnson B.A., Yue E., Morse A., Xu Z., Hingco E.E., et al. Perceptual correlates of neural representations evoked by odorant enantiomers. J. Neurosci. 21:2001;9837-9843.
17. Ma M., Shepherd G.M. Functional mosaic organization of mouse olfactory receptor neurons. Proc. Natl. Acad. Sci. USA. 97:(23):2000;12869-12874.
18. Menco B.P.M. Lectins bind differentially to cilia and microvilli of major and minor cell populations in olfactory and nasal respiratory epithelia. Micros. Res. Tech. 23:1992;181-199.
19. Mutschler E.V.on, Lambrecht G., Moser U. Chirale Duftstoffe als Werkzeuge zur Subklassifizierung pharmakologischer Rezeptoren. Dtsch Apoth Ztg. 126:1986;2012-2019.
20. Ohloff G. Scent and fragrances. The fascination of odors and their chemical perspectives. 1994;Springer, Berlin, Heidelberg.
21. Pastor L.M., Graña L., Frutos M.J., Villaverde R., Ramos D. Lectin histochemistry of the olfactory surface in two teleostian fishes. Acta histochem. 90:1991;173-1801.
22. Pickenhagen W., Brönner-Schindler H. Enantioselective synthesis of (+)- and (-)-cis-2-methyl-4-propyl-1,3-oxathiane and their olfactive properties. Helv. Chim. Acta. 67:1984;947-952.
23. Pike L.M., Enns M.P., Hornung D.E. Quality and intensity differences of carvone enantiomers when tested separately and in mixtures. Chem. Senses. 13:(2):1988;307-309.
24. Polak E.H. Multiple profile-multiple receptor site model for vertebrate olfaction. J. Theor. Biol. 40:(3):1973;469-484.
25. Polak E.H., Fombon A.M., Tilquin C., Punter P.H. Sensory evidence for olfactory receptors with opposite chiral selectivity. Behav. Brain Res. 31:1989;199-206.
26. Rubin B.D., Katz L.C. Spatial coding of enantiomers in the rat olfactory bulb. Nat. Neurosci. 4:2001;355-356.
27. Shirley S.G., Polak E.H., Mather R.A., Dodd G.H. The effect of concanavalin A on the rat electro-olfactogram. Biochem. J. 245:1987;175-184.
28. Simmons D.P., Reichlin D., Skuy D., Margot C. Stereoselectivity of odor perception: odorless enantiomers of strong perfumes. Chem. Senses. 17:1992;881.
29. Silverstein R.M. Chemical ecology: odor communication in animals. Riitter F.J. Proceeding of the Advanced Research Institute. 1978;133-153 Elsevier, Amsterdam.
30. Slotnick B.M., Schellinck H. Methods in olfactory research with rodents. Simon S.A., Nicolelis M. Frontiers and Methods in Chemosenses. 2001;21-61 CRC Press, New York.
31. Stewart W.B., Touloukian C.E. Lotus lectin labels subpopulation of olfactory receptor cells. Chem. Senses. 21:1996;13-18.
32. Sullivan S.L., Dryer L. Information processing in mammalian olfactory system. J. Neurobiol. 30:1996;20-36.
33. Testa B. Chiral aspects of drug metabolism. Trends Pharmacol. Sci. 7:1986;60-64.
34. Theimer E.T., Yoshida T., Klaiber E.M. Olfaction and molecular shape: chirality as a requisite for odor. J. Agric. Food Chem. 25:1977;1168-1177.
35. Youngentob S.L., Markert L.M., Mozell M.M., Hornung D.E. A method for establishing a five odorant identification confusion matrix task in rats. Physiol. Behav. 49:1990;1293-1296.
36. Xu F., Greer C.A., Shepherd G.M. Odor maps in the olfactory bulb. J. Comp. Neurol. 422:2000;489-495.